2024
Sorafenib or anthracycline‐based chemotherapy for progressive desmoid tumors
Costa P, Arora A, Fernandez Y, Yi I, Bakkila B, Tan H, Coelho P, Campoverde L, Hardy N, Bialick S, Freire A, D’Amato G, Chang Y, Mesenger J, Subhawong T, Haims A, Hurwitz M, Olino K, Turaga K, Deshpande H, Trent J. Sorafenib or anthracycline‐based chemotherapy for progressive desmoid tumors. Cancer 2024, 131: e35647. PMID: 39543805, DOI: 10.1002/cncr.35647.Peer-Reviewed Original ResearchProgression-free survivalAnthracycline-containing regimensAnthracycline-based therapyDesmoid tumorsAdverse eventsOne-year progression-free survivalMulti-institutional retrospective analysisAnthracycline-containing regimenCommon grade 1Desmoid tumor patientsGrade 3 eventsAnthracycline-based chemotherapyHand-foot syndromeSecondary end pointsActivity of sorafenibProgressive desmoid tumorsYear of treatmentMedian TTRBaseline characteristicsTumor patientsLocal invasionTreatment responseSorafenibAnthracyclinesEnd points
2009
A Dosing/Cross‐Development Study of the Multikinase Inhibitor Sorafenib in Patients With Pulmonary Arterial Hypertension
Gomberg‐Maitland M, Maitland M, Barst R, Sugeng L, Coslet S, Perrino T, Bond L, LaCouture M, Archer S, Ratain M. A Dosing/Cross‐Development Study of the Multikinase Inhibitor Sorafenib in Patients With Pulmonary Arterial Hypertension. Clinical Pharmacology & Therapeutics 2009, 87: 303-310. PMID: 20010555, PMCID: PMC3291104, DOI: 10.1038/clpt.2009.217.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionInhibitor sorafenibArterial hypertensionPulmonary arterial hypertension patientsAdministered to cancer patientsSafety of sorafenibMultikinase inhibitor sorafenibActivity of sorafenibOpen-label trialModerate skin reactionsDose escalationStable diseaseParenteral prostanoidsDosing regimenSingle-centerAdverse eventsPhase IbSorafenibClinical evaluationCancer patientsSkin reactionsFunction testsPatientsAnticancer agentsTherapeutic activity
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