2025
A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases
Lukas E, Veeneman R, Smit D, Ahluwalia T, Vermeulen J, Pathak G, Polimanti R, Verweij K, Treur J. A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases. Translational Psychiatry 2025, 15: 1. PMID: 39755697, PMCID: PMC11700205, DOI: 10.1038/s41398-024-03197-z.Peer-Reviewed Original ResearchPosttraumatic stress disorderMendelian randomizationCardiovascular diseaseCausal pathwaysData of genome-wide association studiesGenetic liabilityMultivariable Mendelian randomizationWaist-to-hip ratioPotential mediatorsWaist-to-hipRisk of cardiovascular diseaseGenome-wide association studiesPotential causal pathwaysPrevent cardiovascular diseaseStress disorderIncreased risk of cardiovascular diseaseGenomic structural equationSignificant genetic correlationsPsychosocial factorsEffects of posttraumatic stress disorderAssociation studiesIncreased riskPosttraumatic stress disorder patientsCausal effectsTraumatic events
2021
Posttraumatic Stress Disorder and Cardiovascular Disease
O’Donnell C, Longacre L, Cohen BE, Fayad ZA, Gillespie CF, Liberzon I, Pathak GA, Polimanti R, Risbrough V, Ursano RJ, Vander Heide R, Yancy CW, Vaccarino V, Sopko G, Stein MB. Posttraumatic Stress Disorder and Cardiovascular Disease. JAMA Cardiology 2021, 6: 1207-1216. PMID: 34259831, DOI: 10.1001/jamacardio.2021.2530.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAssociation of PTSDStress disorderTreatment of PTSDFunctional brain imaging studiesViolent personal assaultSevere psychological traumaBrain imaging studiesPotential causal connectionsMaladaptive reactionsPsychological traumaTraumatic eventsPTSD pathophysiologyHuman translational researchCardiovascular diseaseCVD outcomesAnatomical brain regionsPersonal assaultHuman-made disastersMilitary combatBrain regionsBrain changesHuman tissue biobanksBehavioral mechanismsRisk factors
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