Selected Publications

Kwako LE, Spagnolo PA, Schwandt ML, Thorsell A, George DT, Momenan R, Rio DE, Huestis M, Anizan S, Concheiro M, Sinha R, Heilig M: The corticotropin releasing hormone-1 (CRH1) receptor antagonist pexacerfont in alcohol dependence: a randomized controlled experimental medicine study. Neuropsychopharmacology. 2015 Mar 13; 2015 Mar 13. PMID: 25409596

Fox H, Sofuoglu M, Sinha R: Guanfacine enhances inhibitory control and attentional shifting in early abstinent cocaine-dependent individuals. J Psychopharmacol. 2015 Mar; 2015 Jan 7. PMID: 25567555

McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten AF, Picciotto MR, Weinberger AH, Ashare R, Sinha R: A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation. J Psychopharmacol. 2015 Mar; 2014 Dec 16. PMID: 25516371

Jastreboff AM, Lacadie C, Seo D, Kubat J, Van Name MA, Giannini C, Savoye M, Constable RT, Sherwin RS, Caprio S, Sinha R: Leptin is associated with exaggerated brain reward and emotion responses to food images in adolescent obesity. Diabetes Care. 2014 Nov; 2014 Aug 19. PMID: 25139883

Van Dam NT, Rando K, Potenza MN, Tuit K, Sinha R: Childhood maltreatment, altered limbic neurobiology, and substance use relapse severity via trauma-specific reductions in limbic gray matter volume. JAMA Psychiatry. 2014 Aug. PMID: 24920451

Seo D, Tsou KA, Ansell EB, Potenza MN, Sinha R: Cumulative adversity sensitizes neural response to acute stress: association with health symptoms. Neuropsychopharmacology. 2014 Feb; 2013 Sep 20. PMID: 24051900

Seo D, Lacadie CM, Tuit K, Hong KI, Constable RT, Sinha R: Disrupted ventromedial prefrontal function, alcohol craving, and subsequent relapse risk. JAMA Psychiatry. 2013 Jul. PMID: 23636842

Sinha R, Jastreboff AM: Stress as a common risk factor for obesity and addiction. Biol Psychiatry. 2013 May 1; 2013 Mar 26. PMID: 23541000

Xu J, Li Y, Lin H, Sinha R, Potenza MN: Body mass index correlates negatively with white matter integrity in the fornix and corpus callosum: a diffusion tensor imaging study. Hum Brain Mapp. 2013 May; 2011 Dec 3. PMID: 22139809

Rudenga KJ, Sinha R, Small DM: Acute stress potentiates brain response to milkshake as a function of body weight and chronic stress. Int J Obes (Lond). 2013 Feb; 2012 Mar 20. PMID: 22430303

Page KA, Chan O, Arora J, Belfort-Deaguiar R, Dzuira J, Roehmholdt B, Cline GW, Naik S, Sinha R, Constable RT, Sherwin RS: Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. JAMA. 2013 Jan 2. PMID: 23280226

Sinha R: Modeling relapse situations in the human laboratory. Curr Top Behav Neurosci. 2013. PMID: 21769721

Ansell EB, Rando K, Tuit K, Guarnaccia J, Sinha R: Cumulative adversity and smaller gray matter volume in medial prefrontal, anterior cingulate, and insula regions. Biol Psychiatry. 2012 Jul 1; 2012 Jan 3. PMID: 22218286

Fox HC, Seo D, Tuit K, Hansen J, Kimmerling A, Morgan PT, Sinha R: Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings. J Psychopharmacol. 2012 Jul; 2012 Jan 9. PMID: 22234929

Potenza MN, Hong KI, Lacadie CM, Fulbright RK, Tuit KL, Sinha R: Neural correlates of stress-induced and cue-induced drug craving: influences of sex and cocaine dependence. Am J Psychiatry. 2012 Apr. PMID: 22294257

Xu K, Hong KA, Zhou Z, Hauger RL, Goldman D, Sinha R: Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes. Psychoneuroendocrinology. 2012 Apr; 2011 Sep 13. PMID: 21917383

Arnsten A, Mazure CM, Sinha R: This is your brain in meltdown. Sci Am. 2012 Apr. PMID: 22486116

Ashare RL, Sinha R, Lampert R, Weinberger AH, Anderson GM, Lavery ME, Yanagisawa K, McKee SA: Blunted vagal reactivity predicts stress-precipitated tobacco smoking. Psychopharmacology (Berl). 2012 Mar; 2011 Sep 21. PMID: 21938416

Fox HC, Anderson GM, Tuit K, Hansen J, Kimmerling A, Siedlarz KM, Morgan PT, Sinha R: Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findings. Alcohol Clin Exp Res. 2012 Feb; 2011 Sep 15. PMID: 21919922

Spann MN, Mayes LC, Kalmar JH, Guiney J, Womer FY, Pittman B, Mazure CM, Sinha R, Blumberg HP: Childhood abuse and neglect and cognitive flexibility in adolescents. Child Neuropsychol. 2012; 2011 Sep 26. PMID: 21942637

Edmiston EE, Wang F, Mazure CM, Guiney J, Sinha R, Mayes LC, Blumberg HP: Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment. Arch Pediatr Adolesc Med. 2011 Dec. PMID: 22147775

Seo D, Jia Z, Lacadie CM, Tsou KA, Bergquist K, Sinha R: Sex differences in neural responses to stress and alcohol context cues. Hum Brain Mapp. 2011 Nov; 2010 Dec 15. PMID: 21162046

Sinha R, Shaham Y, Heilig M: Translational and reverse translational research on the role of stress in drug craving and relapse. Psychopharmacology (Berl). 2011 Nov; 2011 Apr 15. PMID: 21494792

D'Sa C, Fox HC, Hong AK, Dileone RJ, Sinha R: Increased serum brain-derived neurotrophic factor is predictive of cocaine relapse outcomes: a prospective study. Biol Psychiatry. 2011 Oct 15; 2011 Jul 8. PMID: 21741029

Sinha R: New findings on biological factors predicting addiction relapse vulnerability. Curr Psychiatry Rep. 2011 Oct. PMID: 21792580

Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R: Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. J Clin Invest. 2011 Oct; 2011 Sep 19. PMID: 21926468

Sinha R, Fox HC, Hong KI, Hansen J, Tuit K, Kreek MJ: Effects of adrenal sensitivity, stress- and cue-induced craving, and anxiety on subsequent alcohol relapse and treatment outcomes. Arch Gen Psychiatry. 2011 Sep; 2011 May 2. PMID: 21536969

Schepis TS, McFetridge A, Chaplin TM, Sinha R, Krishnan-Sarin S: A pilot examination of stress-related changes in impulsivity and risk taking as related to smoking status and cessation outcome in adolescents. Nicotine Tob Res. 2011 Jul; 2011 Feb 28. PMID: 21357729

Arnsten AF: Prefrontal cortical network connections: key site of vulnerability in stress and schizophrenia. Int J Dev Neurosci. 2011 May; 2011 Feb 21. PMID: 21345366

McKee SA, Sinha R, Weinberger AH, Sofuoglu M, Harrison EL, Lavery M, Wanzer J: Stress decreases the ability to resist smoking and potentiates smoking intensity and reward. J Psychopharmacol. 2011 Apr; 2010 Sep 3. PMID: 20817750

Fox HC, Bergquist KL, Casey J, Hong KA, Sinha R: Selective cocaine-related difficulties in emotional intelligence: relationship to stress and impulse control. Am J Addict. 2011 Mar-Apr; 2010 Dec 28. PMID: 21314758

Rando K, Hong KI, Bhagwagar Z, Li CS, Bergquist K, Guarnaccia J, Sinha R: Association of frontal and posterior cortical gray matter volume with time to alcohol relapse: a prospective study. Am J Psychiatry. 2011 Feb; 2010 Nov 15. PMID: 21078704

Breese GR, Sinha R, Heilig M: Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse. Pharmacol Ther. 2011 Feb; 2010 Oct 15. PMID: 20951730

Chaplin TM, Freiburger MB, Mayes LC, Sinha R: Prenatal cocaine exposure, gender, and adolescent stress response: a prospective longitudinal study. Neurotoxicol Teratol. 2010 Nov-Dec; 2010 Sep 17. PMID: 20826209

Blanton RE, Chaplin TM, Sinha R: Sex differences in the correlation of emotional control and amygdala volumes in adolescents. Neuroreport. 2010 Oct 6. PMID: 20729768

Fox HC, Bergquist KL, Peihua G, Rajita S: Interactive effects of cumulative stress and impulsivity on alcohol consumption. Alcohol Clin Exp Res. 2010 Aug; 2010 May 17. PMID: 20491738

Chaplin TM, Hong K, Fox HC, Siedlarz KM, Bergquist K, Sinha R: Behavioral arousal in response to stress and drug cue in alcohol and cocaine addicted individuals versus healthy controls. Hum Psychopharmacol. 2010 Jul. PMID: 20589926

Chaplin TM, Casey J, Sinha R, Mayes LC: Gender differences in caregiver emotion socialization of low-income toddlers. New Dir Child Adolesc Dev. 2010 Summer. PMID: 20552657

Bergquist KL, Fox HC, Sinha R: Self-reports of interoceptive responses during stress and drug cue-related experiences in cocaine- and alcohol-dependent individuals. Exp Clin Psychopharmacol. 2010 Jun. PMID: 20545387

Hu J, Henry S, Gallezot JD, Ropchan J, Neumaier JF, Potenza MN, Sinha R, Krystal JH, Huang Y, Ding YS, Carson RE, Neumeister A: Serotonin 1B receptor imaging in alcohol dependence. Biol Psychiatry. 2010 May 1; 2010 Feb 20. PMID: 20172504

Fox HC, Hong KI, Siedlarz KM, Bergquist K, Anderson G, Kreek MJ, Sinha R: Sex-specific dissociations in autonomic and HPA responses to stress and cues in alcohol-dependent patients with cocaine abuse. Alcohol Alcohol. 2009 Nov-Dec; 2009 Sep 30. PMID: 19793926

Brewer JA, Sinha R, Chen JA, Michalsen RN, Babuscio TA, Nich C, Grier A, Bergquist KL, Reis DL, Potenza MN, Carroll KM, Rounsaville BJ: Mindfulness training and stress reactivity in substance abuse: results from a randomized, controlled stage I pilot study. Subst Abus. 2009 Oct-Dec. PMID: 19904666

Chaplin TM, Fahy T, Sinha R, Mayes LC: Emotional arousal in cocaine exposed toddlers: prediction of behavior problems. Neurotoxicol Teratol. 2009 Sep-Oct; 2009 May 21. PMID: 19465113

Fox HC, Jackson ED, Sinha R: Elevated cortisol and learning and memory deficits in cocaine dependent individuals: relationship to relapse outcomes. Psychoneuroendocrinology. 2009 Sep; 2009 Apr 16. PMID: 19375236

Sinha R: Stress and addiction: a dynamic interplay of genes, environment, and drug intake. Biol Psychiatry. 2009 Jul 15. PMID: 19555787

Mangieri RA, Hong KI, Piomelli D, Sinha R: An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics. Psychopharmacology (Berl). 2009 Jul; 2009 Apr 3. PMID: 19343330

Arnsten AF: Stress signalling pathways that impair prefrontal cortex structure and function. Nat Rev Neurosci. 2009 Jun. PMID: 19455173

Sinha R, Fox HC, Hong KA, Bergquist K, Bhagwagar Z, Siedlarz KM: Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology. 2009 Apr; 2008 Jun 18. PMID: 18563062

Sinha R: Modeling stress and drug craving in the laboratory: implications for addiction treatment development. Addict Biol. 2009 Jan; 2008 Oct 20. PMID: 18945295

Fox HC, Sinha R: Sex differences in drug-related stress-system changes: implications for treatment in substance-abusing women. Harv Rev Psychiatry. 2009. PMID: 19373619