Yale Radiology and Psychiatry Researchers Join with Penn Medicine to Create a New Center to Study Opioid Use Disorders
Opioid use disorder has reached epidemic levels in the United States. Over the last two decades, opioid-related overdose deaths increased by more than 50 percent, with nearly 50,000 in 2018, according to the Centers for Disease Control and Prevention. Researchers from Yale School of Medicine (YSM) and Penn Medicine, which comprises the Perelman School of Medicine at the University of Pennsylvania, have created a new center that focuses on neuroimaging to improve our understanding of opioid use disorders and find new treatments.
Marriage of imaging and genetics opens new view of brain function
Neuroimaging has revolutionized the study of the brain, but can provide no information about what is actually happening at molecular level in humans. Scientists at Yale have developed new approaches to link gene expression patterns to brain signals captured by imaging.
Yale scientists apply new imaging tool to common brain disorders
A Yale-led team of researchers developed a new approach to scanning the brain for changes in synapses that are associated with common brain disorders. The technique may provide insights into the diagnosis and treatment of a broad range of disorders, including epilepsy and Alzheimer’s disease.
Yale brain-imaging innovator wins Fulbright award for research in Israel
Evan D. Morris, PhD, associate professor of diagnostic radiology, of biomedical engineering, and of psychiatry, has been awarded a Fulbright Scholar grant to conduct research and teach next winter at Hadassah Hospital and Hebrew University in Jerusalem.
Research in the News: Brain at rest yields clues to origins of mental illness
While at rest, multiple regions of the brain remain engaged in a highly heritable, stable pattern of activity called the default mode network. Researchers have found that this network is often disrupted in people with schizophrenia and bipolar disorder, which appear to share underlying genetic causes. This network is often abnormal in their unaffected close relatives, suggesting common genetic roots.
How neurofeedback helps patients tamp down their fears
Tiny parts of the brain, School of Medicine researchers are discovering, can have a huge impact on our lives. Michelle Hampson, Ph.D., and Judson A. Brewer, M.D., Ph.D., are leading teams that use real-time fMRI and what’s known as neurofeedback to try to teach people how to control brain activity and combat such problems as anxiety, addiction, Tourette syndrome, and post-traumatic stress disorder (PTSD), as well as more mundane self-imposed roadblocks to success.
Levels of key brain chemicals predict children’s reading ability
Reading-impaired young children have higher levels of the metabolites glutamate and choline in their brains, and these higher levels continue to be indicative of difficulties in developing typical reading and language skills, a Yale study has found. The study appears in the Journal of Neuroscience.
Mapmakers of the living human body
Imagine trying to develop a drug and being able to see how and where that drug acts inside the body of a living person. Just such a tool is provided by positron emission tomography (PET), an imaging technology that is aiding drug development and research on the mechanisms of disease at the School of Medicine’s state-of-the-art PET Center.Source: Medicine@Yale
The Yale Vascular Malformations Program (VaMP) identifies a culprit gene mutation implicated in the pathogenesis of "hepatic hemangiomas".
The Yale New Haven Hospital Vascular Malformations Program (VaMP), via a collaborative multidisciplinary effort, has identified somatic mosaic gene mutations (GJA4 encoding connexin 37) implicated in the pathogenesis of so-called “HEPATIC HEMANGIOMAS” in adult patients. This discovery questions the validity of the very term “hemangioma” in this particular anatomic distribution; and renders – for the first time - objective scientific support to the radiographically and clinically suspected notion that these lesions actually represent VENOUS MALFORMATIOMS - an entity with a completely different natural history, hemodynamics, angioarchitectural profile, and ergo therapeutic susceptibility.Source: Cutaneous and hepatic vascular lesions due to a recurrent somatic GJA4 mutation reveal a pathway for vascular malformation
Yale Faculty Pioneer Development and Testing of Portable MRI Device
Yale researchers have agreed to develop, deploy, and test a new portable MRI scanner, a device its developer hopes will cost a fraction of that of traditional MRIs and make the new imaging technology available in clinics in the U.S. and around the world.
Study Reaches Multidisciplinary Consensus on Imaging for Kidney Stones
A multidisciplinary group of researchers conducted a systematic review of the scientific literature and engaged in a structured consensus process to determine scenarios where CT scans could be avoided in the diagnosis of renal colic.
Point-of-care Ultrasound's Global Potential
Yale School of Medicine (YSM) faculty, residents, and students are engaged with point-of-care ultrasound (POCUS) initiatives far from the Yale campus, such as in Chile, the Dominican Republic, Rwanda, and Uganda. With its portability and immediacy, POCUS is a powerful diagnostic tool, which also can enhance medical education, both on campus, and worldwide.
Journal Ranked Second in Radiology, Nuclear Medicine and Medical Imaging
Medical Image Analysis, co-founded in 1996 by James Duncan, PhD, the Ebenezer K. Hunt Professor of Biomedical Engineering and Radiology & Biomedical Imaging, is the second-ranked journal in radiology, nuclear medicine and medical imaging, with an Impact Factor of 8.8, according to the Journal Citation Report.
Jason Cai, PhD, Awarded NIH Grant for PET Ligand Development
Zhengxin (Jason) Cai, PhD, Assistant Professor, Yale University PET Center, has been awarded an Exploratory/Development R21 grant from the National Institutes of Health (NIH). Dr. Cai’s research project titled, "Development of BBB Permeable PD-L1 PET Imaging Agents,” will involve synthesis and radiolabeling a library of small molecule PD-L1 ligands as potential PET imaging probes, aiming to find one probe that could penetrate the blood-brain barrier (BBB) and allow for the quantification of PD-L1 in brain tumor or metastasis.