Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial
Yale Department of Psychiatry and Yale Child Study Center researchers conducted the first randomized placebo-controlled clinical trial of intravenous ketamine in adolescents with depression.Source: American Journal of Psychiatry
Yale, VA Researchers Investigate Eating Disorders in Iraq and Afghanistan War-Era Veterans
Researchers at Yale School of Medicine and the VA Connecticut Healthcare System, in a pair of complementary studies, investigated eating disorders in Iraq and Afghanistan war-era veterans, a group thought to be at high risk for the disorders.
Suicide Risk Jumps Soon After Dementia Diagnosis
Older patients recently diagnosed with dementia are at a significantly increased risk for suicide compared to their peers without dementia. Investigators found that individuals who were diagnosed with dementia had a 54% increased risk for suicide within the first year after diagnosis. The risk was particularly high among those aged 74 years and younger. Timothy Schmutte, PsyD, Assistant Professor of Psychiatry, was the study investigator.Source: Medscape
Research Begun by WHRY Continues to Show Possible Pathway to Derail Dementia
Research is revealing the mechanisms that underlie the role of estradiol in memory so that next generation treatments for Alzheimer's disease and other dementias can specifically target these mechanisms and avoid the potential for negative side effects of systemic estrogen therapy.
Grilo Guest Co-Editor of Special Issue of Clinical Therapeutics
Carlos Grilo, PhD, Professor of Psychiatry and of Psychology and Director of the Yale Program for Obesity Weight and Eating Research, served as guest co-editor on the January 2021 special issue of Clinical Therapeutics, centered on the topic of eating disorders.
Genetic Analysis of Symptoms Yields New Insights Into PTSD
Attempts to identify the genetic causes of neuropsychiatric diseases such as post-traumatic stress disorder (PTSD) through large-scale genome-wide analyses have yielded thousands of potential links. The challenge is further complicated by the wide range of symptoms exhibited by those who have PTSD. For instance, does extreme arousal, anger, or irritation experienced by some have the same genetic basis as the tendency to re-experience traumatic events, another symptom of the disorder? A new study led by researchers at Yale and the University of California-San Diego (UCSD) provides answers to some of these questions and uncovers intriguing genetic similarities between PTSD and other mental health disorders such as anxiety, bipolar disorder, and schizophrenia.Source: Yale News
Childhood Maltreatment and Impact on Clinical Features of Major Depression in Adults
William Prueitt, MD, a second-year resident, is co-author of a paper published in Psychiatry Research that explores the relationship between childhood maltreatment and the clinical features of major depression in adults.Source: Psychiatry Research
Correlates of Homelessness Among Patients in Methadone Maintenance Treatment
Marina Gaeta, a fourth-year Yale School of Medicine student, and Declan Barry, PhD, Associate Professor of Psychiatry, are first and senior authors, respectively, of a paper published in Medical Care that evaluates the correlates of homelessness among patients enrolled in low-barrier-to-treatment-access methadone maintenance treatment programs for opioid use disorder.Source: Medical Care
WHRY Funds Study on How CBD Affects the Brain
Women’s Health Research at Yale announced funding to investigate how the presumably non-intoxicating cannabis ingredient cannabidiol (CBD) affects the brain, and if it affects women and men differently. CBD use is growing in popularity exponentially, yet the safety and effectiveness of this non-regulated category of products are unknown.
Simulation in Addiction Education
In recent years, high-fidelity simulation has proven to be a significantly effective teaching tool in psychiatry and specifically in the treatment of addiction and substance abuse. High-fidelity simulation recreates real-life medical scenarios in a safe learning environment and results in improved medical care and better patient outcomes.Source: Simulation in Addiction Education
Preliminary in vivo evidence of lower hippocampal synaptic density in cannabis use disorder
Adolescent and adult rodents exposed to repeated administration of cannabinoids show persistent microstructural changes in the hippocampus both pre- and post-synaptically, a new study by Yale Psychiatry researchers has found.Source: Molecular Psychiatry
Antipsychotic Medication Prescriptions for Homeless and Unstably Housed Veterans in the VA Health Care System
Jack Tsai, PhD, Associate Professor Adjunct of Psychiatry, and Rajiv Radhakrishnan, MD, Assistant Professor of Psychiatry, are co-authors of a study that examined antipsychotic medication use and correlates of antipsychotic medication prescriptions among homeless and unstably housed veterans.Source: The Journal of Clinical Psychiatry
Why Are Some Scientists Turning Away From Brain Scans?
Joy Hirsch, PhD, Elizabeth Mears and House Jameson Professor of Psychiatry and Professor of Comparative Medicine and of Neuroscience, is using an alternative to brain scans to study the "social brain" - what happens when people talk, touch or make eye contact.Source: The Associated Press
The Association Between Binge Eating, Obesity, and Addiction
Stephanie Yarnell-Mac Grory, MD, PhD, Clinical Instructor in Psychiatry; Robert "Blake" Werner, MD, Assistant Professor of Psychiatry; and Luming Li, MD, Assistant Professor of Psychiatry, co-authored a chapter in the soon-to-be-published book Textbook of Addiction Treatment.Source: Textbook of Addiction Treatment
Yale Study: Suicide During COVID-19 Quarantine
Thomas Mitchell, MD, a third-year resident, and Luming Li, MD, Assistant Professor of Psychiatry are co-authors of a paper that studied suicide mortality data during the period of strict stay-at-home quarantine measures in Connecticut during the COVID-19 pandemic.Source: Psychiatry Research
Rhee: Trends in Co-Prescribing of Opioids and Opioid Potentiators Among U.S. Adults, 2007–2018
Lead author Greg Rhee, PhD, Assistant Professor Adjunct in the Department of Psychiatry, explores trends in co-prescribing opioids and opioid potentiators among U.S. adults in a recent article published in the American Journal of Preventive Medicine.Source: American Journal of Preventive Medicine