Yann Mineur, MS, PhD
Research Scientist in PsychiatryDownloadHi-Res Photo
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Psychiatry
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Research Scientist in Psychiatry
Appointments
Psychiatry
Research ScientistPrimary
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Education & Training
- Post-doctoral associate
- Yale University School of Medicine (2008)
- PhD
- UMASS Medical School, Neuroscience (Behavioral Neurogenetics) (2004)
- PhD
- University of Paris (2004)
- MS
- University of Paris School of Medicine (V) (France), Cellular Biology (2000)
- BS
- University of Orléans (France), Molecular Genetics and Physiology (1999)
Research
Overview
Medical Research Interests
Chemicals and Drugs; Diseases; Psychiatry and Psychology
ORCID
0000-0002-8030-6776
Research at a Glance
Yale Co-Authors
Frequent collaborators of Yann Mineur's published research.
Publications Timeline
A big-picture view of Yann Mineur's research output by year.
Marina Picciotto, PhD
Sherry McKee, PhD
MacKenzie Peltier, PhD
Kelly Cosgrove, PhD
Ralitza Gueorguieva, PhD
Terril Luce, PhD
43Publications
1,642Citations
Publications
2025
The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour
Yoshida T, Nguyen M, Zhang L, Lu B, Zhu B, Murray K, Mineur Y, Zhang C, Xu D, Lin E, Luchsinger J, Bhatta S, Waizman D, Coden M, Ma Y, Israni-Winger K, Russo A, Wang H, Song W, Al Souz J, Zhao H, Craft J, Picciotto M, Grutzendler J, Distasio M, Palm N, Hafler D, Wang A. The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour. Nature 2025, 1-10. PMID: 40437096, DOI: 10.1038/s41586-025-09050-7.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMeningeal T cellsCentral nervous systemT cellsSubfornical organCD4 T cellsInnate immune compartmentGut-brain axisSteady-state brainGut microbiotaSpecialized immune cellsCentral nervous system homeostasisAdaptive immune systemBiological functionsImmune compartmentGut-derived T cellsImmune cellsWhite adiposeImmune systemNervous systemAdipose tissueComposition of adipose tissueGastrointestinal tissuesWell-characterizedHomeostasisBrainSex differences in the microglial response to stress and chronic alcohol exposure in mice
Soares A, Garcia-Rivas V, Fai C, Thomas M, Zheng X, Picciotto M, Mineur Y. Sex differences in the microglial response to stress and chronic alcohol exposure in mice. Biology Of Sex Differences 2025, 16: 19. PMID: 40038827, PMCID: PMC11881309, DOI: 10.1186/s13293-025-00701-y.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsResponse to stressSex differencesAlcohol exposureStress-induced alcohol drinkingHeightened reactivity to stressInescapable footshock stressDevelopment of AUDReactivity to stressChronic alcohol exposureProminent sex differencesIncreased alcohol intakeCharacterize sex differencesFemale C57BL/6J miceDark paradigmComorbid moodFootshock stressStress disorderLimbic circuitsNeurobiological processesModify drinkingNeuroimmune signalingAdministered alcoholFemale rodentsMicroglial densityAlcohol drinkingSpecification of claustro-amygdalar and palaeocortical neurons and circuits
Kaur N, Kovner R, Gulden F, Pletikos M, Andrijevic D, Zhu T, Silbereis J, Shibata M, Shibata A, Liu Y, Ma S, Salla N, de Martin X, Klarić T, Burke M, Franjic D, Cho H, Yuen M, Chatterjee I, Soric P, Esakkimuthu D, Moser M, Santpere G, Mineur Y, Pattabiraman K, Picciotto M, Huang H, Sestan N. Specification of claustro-amygdalar and palaeocortical neurons and circuits. Nature 2025, 638: 469-478. PMID: 39814878, PMCID: PMC11821539, DOI: 10.1038/s41586-024-08361-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBasolateral amygdala complexPrefrontal cortex connectivityPrefrontal cortexNeuropsychiatric disordersExcitatory neuronsSymptoms of neuropsychiatric disordersEarly-life disruptionAmygdala complexPiriform cortexTemporal cortexDevelopmental shiftReciprocal connectionsCortexClaustrumBehavior modificationSensory informationTranscription factor SOX4DisordersTfap2dNeuronsSimilar alterationsCross-species analysisPiriformSOX11Transcription factors
2024
Alcohol drinking is attenuated by PDE4 inhibition but partial microglia depletion is not sufficient to block stress-induced escalation of alcohol intake in female mice
Garcia-Rivas V, Soares A, Thomas M, Na J, Smith A, Picciotto M, Mineur Y. Alcohol drinking is attenuated by PDE4 inhibition but partial microglia depletion is not sufficient to block stress-induced escalation of alcohol intake in female mice. Alcohol 2024, 122: 31-42. PMID: 39725336, DOI: 10.1016/j.alcohol.2024.12.004.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAlcohol use disorderEthanol drinkingStress exposureEthanol intakeExposure to foot-shock stressDevelopment of alcohol use disordersTreatment of alcohol use disordersEscalation of alcohol intakeFemale miceReduced ethanol intakeFoot-shock stressIdentified sex differencesInhibitor of phosphodiesterase type 4Alcohol intakeEthanol reinforcementPharmacological depletion of microgliaLimbic circuitsUse disorderChronic ethanolNeuroinflammatory triggerDecreased preferenceC57BL/6J malesPhosphodiesterase type 4Sex differencesBinge drinkingMedial prefrontal cortex acetylcholine signaling mediates the ability to learn an active avoidance response following learned helplessness training
Abdulla Z, Mineur Y, Crouse R, Etherington I, Yousuf H, Na J, Picciotto M. Medial prefrontal cortex acetylcholine signaling mediates the ability to learn an active avoidance response following learned helplessness training. Neuropsychopharmacology 2024, 50: 488-496. PMID: 39362985, PMCID: PMC11631976, DOI: 10.1038/s41386-024-02003-0.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMedial prefrontal cortexACh levelsInescapable stressorEscape performanceExposure to inescapable stressorsAcetylcholine signalingLearned helplessness taskLearned helplessness trainingStress-related circuitsActive avoidance taskActive avoidance testActive avoidance responseElevation of acetylcholineIncreased ACh levelsStress-related behaviorsImpaired escape performanceIncreased brain levelsTop-down controlHelplessness trainingPrefrontal cortexAvoidance taskChemogenetic inhibitionMaladaptive behaviorsAvoidance testNegative encodingThe role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications
Peltier M, Verplaetse T, Altemus M, Zakiniaeiz Y, Ralevski E, Mineur Y, Gueorguieva R, Picciotto M, Cosgrove K, Petrakis I, McKee S. The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications. Frontiers In Neuroendocrinology 2024, 73: 101119. PMID: 38184208, PMCID: PMC11185997, DOI: 10.1016/j.yfrne.2023.101119.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPosttraumatic stress disorderAlcohol use disorderStress disorderContext of PTSDPTSD/AUDConcurrent posttraumatic stress disorderUnderlying neurobiological mechanismsUse disordersAlcohol-related variablesNeurobiological mechanismsPTSD diagnosisTreatment developmentTreatment implicationsBody of literatureNovel interventionsClinical literatureRole of neurosteroidsDisordersTreatment outcomesYears of researchAlcohol consumptionExogenous pregnenolonePharmacological treatmentBiological variablesAllopregnanolone
2023
How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches
Mineur Y, Picciotto M. How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches. Journal Of Neurochemistry 2023, 167: 3-15. PMID: 37621094, PMCID: PMC10616967, DOI: 10.1111/jnc.15943.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsDeveloping Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs
Zakiniaeiz Y, Peltier M, Mineur Y, Gueorguieva R, Picciotto M, Petrakis I, Cosgrove K, McKee S. Developing Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs. Journal Of Women's Health 2023, 32: 852-857. PMID: 37585509, PMCID: PMC10457604, DOI: 10.1089/jwh.2023.0015.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsPathophysiology of nAChRs: Limbic circuits and related disorders
Mineur Y, Soares A, Etherington I, Abdulla Z, Picciotto M. Pathophysiology of nAChRs: Limbic circuits and related disorders. Pharmacological Research 2023, 191: 106745. PMID: 37011774, DOI: 10.1016/j.phrs.2023.106745.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDepressive disorderMedication developmentLimbic system areasPreclinical pharmacological studiesHuman epidemiological studiesHuman affective disordersNicotinic acetylcholine receptorsAntidepressant efficacyClinical evidenceLimbic circuitsNicotine intakePreclinical modelsSpecific nAChRsEpidemiological studiesCurrent therapeuticsAffective disordersAcetylcholine receptorsRelated disordersPharmacological studiesStress disorderDisordersEtiology of anxietyNAChRsRelevant targetsEfficacy
2022
Activity of a direct VTA to ventral pallidum GABA pathway encodes unconditioned reward value and sustains motivation for reward
Zhou WL, Kim K, Ali F, Pittenger ST, Calarco CA, Mineur YS, Ramakrishnan C, Deisseroth K, Kwan AC, Picciotto MR. Activity of a direct VTA to ventral pallidum GABA pathway encodes unconditioned reward value and sustains motivation for reward. Science Advances 2022, 8: eabm5217. PMID: 36260661, PMCID: PMC9581470, DOI: 10.1126/sciadv.abm5217.Peer-Reviewed Original ResearchCitationsAltmetric
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