2021
Immunomodifying and neuroprotective effects of noscapine: Implications for multiple sclerosis, neurodegenerative, and psychiatric disorders
Altinoz M, Guloksuz S, Ozpinar A. Immunomodifying and neuroprotective effects of noscapine: Implications for multiple sclerosis, neurodegenerative, and psychiatric disorders. Chemico-Biological Interactions 2021, 352: 109794. PMID: 34963564, DOI: 10.1016/j.cbi.2021.109794.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyotrophic Lateral SclerosisAnimalsBradykininHistamine AntagonistsHumansImmunomodulating AgentsIon ChannelsMental DisordersMultiple SclerosisNeurodegenerative DiseasesNeuroprotective AgentsNoscapineOligodendrogliaParkinsonian DisordersReceptors, G-Protein-CoupledSignal TransductionStrokeConceptsNeuroprotective effectsMultiple sclerosisInflammatory transcription factor NF-κBIschemic brain damageNeonatal rat pupsPilot clinical studyAmyotrophic lateral sclerosisTranscription factor NF-κBCortical neuronal cellsSignificant therapeutic efficacyFactor NF-κBBitter taste receptorsHistaminergic systemBrain damageRat pupsClinical studiesSK channelsLateral sclerosisParkinson's diseaseAnxiolytic activityPsychiatric disordersChemical injuryNF-κBAnimal modelsPsychiatric diseases
2019
Involvement of hemoglobins in the pathophysiology of Alzheimer's disease
Altinoz M, Guloksuz S, Schmidt-Kastner R, Kenis G, Ince B, Rutten B. Involvement of hemoglobins in the pathophysiology of Alzheimer's disease. Experimental Gerontology 2019, 126: 110680. PMID: 31382012, DOI: 10.1016/j.exger.2019.110680.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseNeurodegenerative disordersPathogenesis of ADCourse of ADNitric oxideIncreased Hb levelsTangle-bearing neuronsInner mitochondrial membraneBlood-brain barrierAD brain samplesLevels of HbCentral nervous systemHeme-containing proteinsRole of HbFunction of intracellularMultiple beneficial effectsHb transcriptionHb levelsAD brainImmunohistochemical studyMitochondrial membranePossible candidate moleculesBiological processesCellular respirationNervous system