2019
TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample
Pries L, Snijders C, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Guloksuz S, van Os J, Rutten B. TwinssCan — Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample. Twin Research And Human Genetics 2019, 22: 460-466. PMID: 31708010, DOI: 10.1017/thg.2019.96.Peer-Reviewed Original ResearchConceptsNeurocognitive processesSalience attributionSocial defeatGeneral population twin sampleExecutive functioningCognitive phenotypesExperimental paradigmSeverity of psychopathologyAffective dysregulationSubclinical expressionDimensional phenotypesMental ill healthClinical psychopathologyTwin sampleOnset of disorderPsychotic experiencesPsychopathologyProtective factorsSchizophrenia ProjectAttributionIll healthIntermediate phenotypesGene-environment interactionsMemoryFunctioning
2018
O4.4. DOES POLYGENIC RISK SCORE FOR SCHIZOPHRENIA MODERATE THE MOMENTARY AFFECTIVE AND PSYCHOTIC REACTIONS TO DAILY-LIFE STRESSORS?
Pries L, Guloksuz S, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Klingenberg B, Cinar O, Lin B, Luykx J, Rutten B, van Os J. O4.4. DOES POLYGENIC RISK SCORE FOR SCHIZOPHRENIA MODERATE THE MOMENTARY AFFECTIVE AND PSYCHOTIC REACTIONS TO DAILY-LIFE STRESSORS? Schizophrenia Bulletin 2018, 44: s84-s84. PMCID: PMC5887471, DOI: 10.1093/schbul/sby015.210.Peer-Reviewed Original ResearchEvent-related stressMomentary stressStress reactivityMain effectSocial stressPsychotic experiencesYoung adult twin sampleEffect of PRSHeightened emotional reactivityAdditional explorative analysesAdult twin sampleEmotion regulationSignificant main effectEmotion reactivityNeuropsychological mechanismsEmotional reactivityMultilevel regression analysisEmotional fluctuationsMinor stressorsLife stressorsSubjective experiencePolygenic risk scoresDiary techniqueDiary methodTwin sample