2023
Associations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis
Ku B, Addington J, Bearden C, Cadenhead K, Cannon T, Compton M, Cornblatt B, Druss B, Gülöksüz S, Mathalon D, Perkins D, Tsuang M, Walker E, Woods S, Carrión R. Associations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2023, 49: 1437-1446. PMID: 37358832, PMCID: PMC10686327, DOI: 10.1093/schbul/sbad093.Peer-Reviewed Original ResearchConceptsClinical high riskHealthy comparisonsSocial functioningHigh riskPoor social functioningNorth American Prodrome Longitudinal StudyImportant risk factorRisk factorsPsychotic disordersEffective interventionsHealthy youthChildhoodLongitudinal studyAdulthoodPsychosisAssociationAdultsMaladaptationRiskSocial deficitsFurther researchFunctioningCommunity levelAssociations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls
Lin B, Vermeulen J, Bolhuis K, Chang X, Schirmbeck F, van Eijk K, investigators G, Alizadeh B, Bartels-Velthuis A, van Amelsvoort T, Bruggeman R, Cahn W, de Haan L, Rutten B, Guloksuz S, Luykx J, van Os J, Simons C, van Winkel R, Guloksuz S, Blankers M, van den Brink W, de Haan L, Luykx J. Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls. Psychiatry Research 2023, 323: 115143. PMID: 36948018, DOI: 10.1016/j.psychres.2023.115143.Peer-Reviewed Original ResearchConceptsHealthy controlsSmoking behaviorPsychotic symptomsSchizophrenia symptomsUnaffected siblingsProspective cohort studySix-year followMental health symptomsSymptom dimensionsCohort studyRisk factorsDepressive symptomsPsychotic disordersPatientsPositive symptomsHealth symptomsNegative symptomsSimilar effect sizesSymptomsLinear mixed-effects modelsMixed-effects modelsGenetic riskMean numberPolygenic scoresOverall sampleGender differences underlying the link between exposome and psychosis
Guloksuz S. Gender differences underlying the link between exposome and psychosis. European Psychiatry 2023, 66: s29-s30. PMCID: PMC10417599, DOI: 10.1192/j.eurpsy.2023.114.Peer-Reviewed Original ResearchGender-related differencesPsychosis riskChildhood adversitySubstance abuse comorbidityAssociation of psychosisObstetric complicationsDifferent symptom dimensionsSeason of birthHigh prevalencePsychotic disordersPubMed databaseSystematic reviewSubstance abusePsychosisSubstance useEnvironmental exposuresWomenUrban upbringingChildhood abuseSymptom dimensionsMenEarly ageRiskExposomeFuture studies
2022
Gender differences in the association between environment and psychosis
Pence AY, Pries LK, Ferrara M, Rutten BPF, van Os J, Guloksuz S. Gender differences in the association between environment and psychosis. Schizophrenia Research 2022, 243: 120-137. PMID: 35287098, DOI: 10.1016/j.schres.2022.02.039.Peer-Reviewed Original ResearchConceptsGender-related differencesChildhood adversityPsychosis riskSubstance useSubstance abuse comorbidityEnvironmental exposuresOnset of illnessAssociation of psychosisObstetric complicationsDifferent symptom dimensionsSeason of birthPsychosis spectrum disordersHigh prevalencePsychotic disordersPubMed databaseSystematic reviewPsychosisWomenChildhood abuseSymptom dimensionsMenEarly ageAssociationPsychosis expressionFurther investigation
2021
Impact of the first COVID-19 outbreak on mental health service utilisation at a Dutch mental health centre: retrospective observational study
Chow M, Noorthoorn E, Wierdsma A, van der Horst M, de Boer N, Guloksuz S, Luykx J. Impact of the first COVID-19 outbreak on mental health service utilisation at a Dutch mental health centre: retrospective observational study. BJPsych Open 2021, 7: e213. PMID: 34784994, PMCID: PMC8632375, DOI: 10.1192/bjo.2021.1049.Peer-Reviewed Original ResearchMental health service utilisationHealth service utilisationService utilisationFirst COVID-19 outbreakCare contactsPatient contactPsychotic disordersVideo consultationsCOVID-19 outbreakDiagnostic categoriesRetrospective observational studyMental healthcare deliveryMental health centersCOVID-19 pandemicDifferent diagnostic categoriesPre-pandemic periodRetrospective studyHealth centersObservational studyMental illnessPatientsHealthcare deliveryHealthcare institutesTelepsychiatryCOVID-19 lockdown
2020
Phenome-wide and genome-wide analyses of quality of life in schizophrenia
Pazoki R, Lin B, van Eijk K, Schijven D, de Zwarte S, Alizadeh B, van Amelsvoort T, Bartels-Velthuis A, van Beveren N, Bruggeman R, Cahn W, de Haan L, Delespaul P, Luykx J, Myin-Germeys I, Kahn R, Schirmbeck F, Simons C, van Os J, van Winkel R, Guloksuz S, Luykx J. Phenome-wide and genome-wide analyses of quality of life in schizophrenia. BJPsych Open 2020, 7: e13. PMID: 33295273, PMCID: PMC7791571, DOI: 10.1192/bjo.2020.140.Peer-Reviewed Original ResearchPolygenic risk scoresRisk scoreClinical phenotypeNon-genetic contributing factorsMajor depressive disorderQuality of lifeDepressive disorderHealthy controlsVulnerable patientsStudy populationHypothesis-generating approachPatientsPsychotic disordersQoLSmall studyClinical interventionsSchizophreniaGenotypic determinantsScoresContributing factorDisordersPhenotypeAssociationEvidence for an interrelated cluster of Hallucinatory experiences in the general population: an incidence study
Moriyama T, Drukker M, Guloksuz S, Have M, de Graaf R, van Dorsselaer S, Gunther N, Bak M, van Os J. Evidence for an interrelated cluster of Hallucinatory experiences in the general population: an incidence study. Psychological Medicine 2020, 51: 2034-2043. PMID: 32317030, DOI: 10.1017/s0033291720000793.Peer-Reviewed Original ResearchConceptsRisk factorsProspective general population cohortGeneral population cohortIncidence of hallucinationsNon-psychotic disordersEnvironmental risk factorsTerms of prevalenceSelf-reported ratesYearly incidenceOlfactory hallucinationsVisual hallucinationsFunctional impairmentNEMESIS-2General populationPsychotic disordersHallucinatory experiencesPopulation cohortIncidence studyAuditory hallucinationsDelusional ideationCommon underlying mechanismMental disordersIncidenceNEMESIS-1Subsequent course
2019
White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?
Schepers E, Lousberg R, Guloksuz S, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, Rutten B, van Os J. White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder? Frontiers In Psychiatry 2019, 10: 676. PMID: 31607966, PMCID: PMC6774265, DOI: 10.3389/fpsyt.2019.00676.Peer-Reviewed Original ResearchReplicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study
van Os J, Pries L, Delespaul P, Kenis G, Luykx J, Lin B, Richards A, Akdede B, Binbay T, Altınyazar V, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Ulaş H, Cankurtaran E, Kaymak S, Mihaljevic M, Petrovic S, Mirjanic T, Bernardo M, Cabrera B, Bobes J, Saiz P, García-Portilla M, Sanjuan J, Aguilar E, Santos J, Jiménez-López E, Arrojo M, Carracedo A, López G, González-Peñas J, Parellada M, Maric N, Atbaşoğlu C, Ucok A, Alptekin K, Saka M, Arango C, O'Donovan M, Rutten B, Guloksuz S. Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene–environment interaction. The EUGEI study. Psychological Medicine 2019, 50: 1884-1897. PMID: 31414981, DOI: 10.1017/s003329171900196x.Peer-Reviewed Original ResearchConceptsPsychotic disordersPolygenic riskSchizophrenia polygenic riskGene-environment interactionsGenetic riskRelatives of patientsFirst-degree relativesPsychosis phenotypeAverage genetic riskIntermediate phenotypesHealthy siblingsCognitive intermediate phenotypesControl groupAnalysis of associationAverage riskPatientsOrganization framework and preliminary findings from the Athens First‐Episode Psychosis Research Study
Xenaki L, Kollias C, Stefanatou P, Ralli I, Soldatos R, Dimitrakopoulos S, Hatzimanolis A, Triantafyllou T, Kosteletos I, Vlachos I, Selakovic M, Foteli S, Mantonakis L, Ermiliou V, Voulgaraki M, Psarra E, Gülöksüz S, van Os J, Stefanis N. Organization framework and preliminary findings from the Athens First‐Episode Psychosis Research Study. Early Intervention In Psychiatry 2019, 14: 343-355. PMID: 31402581, DOI: 10.1111/eip.12865.Peer-Reviewed Original ResearchConceptsRisk factorsMild functional improvementLongitudinal cohort studySymptom severity criteriaPoor cognitive performanceOutcome of psychosisPreliminary findingsPatients 16Cohort studyAntipsychotic treatmentClinical pictureFEP patientsClinical managementFunctional improvementFamily historyEmergency unitBaseline presentationSeverity criteriaPsychiatric hospitalPsychotic disordersClinical InterviewDrug usePotential associationGene-environment interaction studiesBiochemical parameters
2017
Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience
van Os J, van der Steen Y, Islam M, Gülöksüz S, Rutten B, Simons C. Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine 2017, 47: 2421-2437. PMID: 28436345, DOI: 10.1017/s0033291717000915.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresHealthy comparison subjectsPsychotic disordersAttribution of salienceAffective episodesComparison subjectsIntelligence quotientTotal scorePolygenic riskFirst-degree relativesElevated genetic riskLower intelligence quotientManic episodesHealthy relativesRisk scoreNeurodevelopmental alterationsDepression subscaleLifetime ratesSimilar associationPsychosis riskFloor effectsGenetic riskPositive subscalePsychosis phenotypeDisorders