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Robert Malison, MD, BA

Professor of Psychiatry; Director, Clinical Neuroscience Research Unit; Director, Neuroscience Research Training Program

Contact Information

Robert Malison, MD, BA

Mailing Address

  • Psychiatry

    34 Park Street

    New Haven, CT, 06519

    United States

Appointments

Biography

We write today to share the sad news that Robert T. Malison, MD ’87, HS ’91, professor of psychiatry, passed away unexpectedly on Saturday, July 25, 2020.

He was recognized as a pioneer in addiction research, a pillar of neuroscience education, and a wonderful mentor. The obituary below was prepared by his wife, Eugenia (Jean) Vining, MD, and John Krystal, MD.

Sincerely,

Nancy J. Brown, MD Jean and David W. Wallace Dean of Medicine C.N.H. Long Professor of Internal Medicine

John H. Krystal, MD Robert L. McNeil, Jr, Professor of Translational Research Professor of Psychiatry, Neuroscience, and Psychology Co-Director, Yale Center for Clinical Investigation Chair, Department of Psychiatry, YSM Chief of Psychiatry and Behavioral Science, YNHH

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In Memoriam: Robert T. Malison, MD ’87, HS ’91 1959–2020

The Department of Psychiatry sadly shares the news of the unexpected death of Robert T. Malison, MD, professor of psychiatry, on Saturday, July 25, 2020, at the age of 60. Bob, an avid outdoorsman, cellist, and tennis player, passed away peacefully in his bed after an acute cardiac event.

At the time of his death, Bob was director of the Clinical Neuroscience Research Unit of the Abraham Ribicoff Research Facilities of the Connecticut Mental Health Center. He was leader of the Neuroscience Research Training Program (T32 grant), the neuroscience research track of the Yale Psychiatry Residency. He also led the Integrated Mentored Patient-Oriented Research Training (IMPORT) in Psychiatry (NIMH R25), and an addiction training grant based in Thailand. At the same time, he was principal investigator on two independent project grants (RO1s).

Bob was a polymath translational neuroscientist and pioneer in addiction research. He came to Yale as a magna cum laude and Phi Beta Kappa graduate of Williams College. An AOA graduate of Yale School of Medicine (YSM’87), he studied molecular mechanisms regulating GABA receptor function in the laboratory of Eric Nestler, MD, PhD. Continuing at Yale for psychiatry residency, he worked with Robert Innis, MD, PhD, to learn SPECT and, later, PET molecular imaging. After an addiction fellowship at the University of Pennsylvania, he returned to Yale for the remainder of his career. While he initially studied depression, over time, he shifted his focus to cocaine addiction. In 1996, he established the Cocaine Research Clinic of the Clinical Neuroscience Research Unit. There, he initially studied the regulation of the dopamine transporter, the primary target for cocaine, in the context of the development and recovery from cocaine use disorder. Throughout his career, Bob identified George Heninger, MD, as one of his most inspiring mentors.

He studied substance use disorders from multiple perspectives. In order to study the pharmacologic and behavioral mechanisms underlying human cocaine addiction, he adapted the devices used to intravenously self-administer pain medications (PCA pumps) to enable people in the laboratory to self-administer cocaine. Using this procedure, he was able to generate insights into the addiction process and to test novel approaches to the treatment of cocaine use disorder. At the time of his death, he was particularly interested in mechanisms associated with vitamin D-related signaling. With Peter Morgan, MD, PhD, Bob applied sleep EEG analyses to identify an occult form of insomnia that contributed to relapse. They showed that during recovery, EEG signals associated with restful sleep deteriorated even though patients reported sleeping well. In addition, working with Yale geneticist, Joel Gelernter, MD, he studied the molecular genetics of addiction using a distinctive approach, i.e., studying population isolates with distinctively high rates of substance use disorders. This led him to Thailand to study particular populations, such as the Hmong and other hill tribes.

However, Bob may be best remembered as a pillar of neuroscience education in psychiatry at Yale. In 1996, he became associate director and in 2002, director of the Clinical Neuroscience Research Unit (CNRU). In this role, he led one of the few inpatient psychiatry clinical research centers in the world. This Unit is the home of the Neuroscience Research Training Program (NRTP), a research track of the Yale Psychiatry Residency and a postdoctoral program for psychiatric neuroscience. Bob co-led or led this nationally prominent program for the past 23 years. NRTP picnics at the Malison-Vining home were an annual highlight.

Bob was the recipient of a number of national and international honors. However, it is likely that his most treasured honor was being voted “Teacher of the Year” by the Yale Psychiatry Residents Association in 2010.

Bob was brilliant, generous, upbeat, and constructive. He was a wonderful colleague. Emails exchanged after Bob’s death universally recall his ubiquitous smile, his kindness, his ready laughter, his availability to trainees, and his supportiveness. Alumni of the Neuroscience Training Program from the roughly 20 years of Bob’s leadership identified him as one of the key reasons they came to Yale, a key figure in their thriving at Yale, and someone with whom they remained in contact after graduation. He was an effective teacher, a skilled and successful mentor, and an extremely good psychiatrist. He was a careful scientist who conveyed the importance of scientific rigor to his mentees. He was also an accomplished cellist, who performed with the Yale Medical Symphony Orchestra.

Bob was devoted to his family. He is survived by his wife, Eugenia (Jean) Vining, MD ’87, HS ’92), assistant professor of surgery, a noted otolaryngologist and outgoing president of the YNHH Medical Staff. He is also survived by their daughters Katie, a Yale College student, and Emily, a recent graduate of MIT. Family came first. When their daughters were in high school, Bob reduced his faculty effort to spend more time at home. Bob was extremely proud of both of his daughters.

“I am in shock, deeply saddened, by Bob’s death. In 1983, as a first-year Yale medical student, Bob attended a “Psych 101” seminar in which I, then a fourth-year medical student, served as the student teacher. I remember two standout students in that section who, it seemed, often sat next to each other, Bob and Jean Vining. We have been friends and colleagues since that time. I was Bob’s resident when he completed his psychiatry clerkship. I was Bob’s attending, when he was chief resident. And, I write with disbelief, I am his chair at the time of his death,” said John Krystal, MD.

This has been a terrible year with respect to losses for the Yale Department of Psychiatry. Just a few months ago, we unexpectedly lost Ronald Duman, PhD, a friend and mentor to Bob. Each was distinguished by personal qualities that made their scientific and mentoring achievements shine even brighter. Each died too young and at the peak of their scientific and academic impact. Bob is sorely missed by all who knew him. We send our condolences to Jean, Katie, and Emily. Details about his funeral will be forthcoming.

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Dr. Malison completed his undergraduate degree at Williams College, before obtaining his M.D. degree at Yale University School of Medicine. He remained at Yale for psychiatry residency training as part of the Clinical Neuroscience Research Training Program in Psychiatry. After a one-year addiction fellowship at the University of Pennsylvania, he returned to Yale to join faculty and became a Professor in the Department of Psychiatry. Dr. Malison devoted 20 years to patient-oriented research into the neurobiology, neuropharmacology, and genetics of stimulant, including both cocaine and methamphetamine, addiction. His research applied numerous clinical-translational approaches, including stimulant administration (cocaine, methylphenidate, and amphetamine), medications development (e.g., modafinil), drug-drug interaction (e.g., disulfiram-cocaine), human genetic, brain activation (e.g., fMRI), and neurochemical brain imaging (e.g., SPECT/PET) methods. His group applied these techniques to studies of the regulation of stimulant self-administration behavior, drug-induced neuroplasticity, and individual (including genetic) differences in vulnerability to stimulant effects. He was Director of the Clinical Neuroscience Research Unit at the Connecticut Mental Health Center and Program Director / Principal Investigator of three NIH-funded research training programs, including the Clinical Neuroscience Research Training Program in Psychiatry.

Education & Training

  • MD
    Yale University (1987)
  • BA
    Williams College, Chemistry (1982)
  • Fellow
    University of Pennsylvania School of Medicine
  • Resident
    Yale University School of Medicine

Activities

  • Genetic study of methamphetamine dependence
    Bangkok, Thailand 2015
    Genetic study of methamphetamine dependence

Honors & Recognition

AwardAwarding OrganizationDate
Top Doctors, Addiction PsychiatryCastle Connelly2015
Teacher of the YearYale Psychiatry Residents Association (PRA)2015

Departments & Organizations