2016
Sleep Perception and Misperception in Chronic Cocaine Users During Abstinence
Hodges SE, Pittman B, Morgan PT. Sleep Perception and Misperception in Chronic Cocaine Users During Abstinence. Sleep 2016, 40: zsw069. PMID: 28364419, PMCID: PMC5806585, DOI: 10.1093/sleep/zsw069.Peer-Reviewed Original ResearchConceptsChronic cocaine usersSleep state misperceptionWeeks of abstinenceTotal sleep timeOccult insomniaCocaine usersState misperceptionSleep onsetSleep timeCocaine-dependent personsInpatient research facilitySleep latencyDiary questionnairesSleep perceptionPolysomnographic sleep recordingsDiary measurementsAbstinenceTreatment studiesFinal awakeningMisperceptionsNight 3Objective worseningParticipantsInsomniaSleep recordings
2014
Correlates of polysomnographic sleep changes in cocaine dependence: Self-administration and clinical outcomes
Angarita GA, Canavan SV, Forselius E, Bessette A, Morgan PT. Correlates of polysomnographic sleep changes in cocaine dependence: Self-administration and clinical outcomes. Drug And Alcohol Dependence 2014, 143: 173-180. PMID: 25124303, PMCID: PMC4207081, DOI: 10.1016/j.drugalcdep.2014.07.025.Peer-Reviewed Original ResearchConceptsClinical outcomesWithdrawal symptomsNegative urineAmount of cocaineCocaine dependenceInpatient stayDays abstinentRapid eye movement (REM) sleepWeekly cognitive behavioral therapyCocaine self-administration studiesRandomized clinical trialsAbnormal sleep architectureEye movement sleepCocaine self-administration sessionsTotal sleep timeSlow-wave sleepChronic cocaine useSelf-administration sessionsSelf-administration studiesCognitive behavioral therapyRelevance of sleepPlacebo armSelf-reported useMovement sleepOutpatient treatment
2013
Abstinence-related changes in sleep during treatment for cocaine dependence
Angarita GA, Canavan SV, Forselius E, Bessette A, Pittman B, Morgan PT. Abstinence-related changes in sleep during treatment for cocaine dependence. Drug And Alcohol Dependence 2013, 134: 343-347. PMID: 24315572, PMCID: PMC4396819, DOI: 10.1016/j.drugalcdep.2013.11.007.Peer-Reviewed Original ResearchConceptsTotal sleep timeExtended abstinenceOutpatient cognitive behavioral therapyAbstinence-related changesDecreased slow wave sleepInpatient substance abuse treatmentCognitive behavioral therapySleep timeCocaine usersPolysomnographic sleepChronic cocaine usersCocaine-dependent participantsSubstance abuse treatmentThrice weekly urine toxicologyBehavioral therapyWeeks of abstinenceOverall sleep qualityAbuse treatmentDays abstinentDependent participantsREM sleep latencySleep qualityCocaine dependenceSlow-wave sleepAbstinence
2012
Cortical GABA Levels in Primary Insomnia
Morgan PT, Pace-Schott EF, Mason GF, Forselius E, Fasula M, Valentine GW, Sanacora G. Cortical GABA Levels in Primary Insomnia. Sleep 2012, 35: 807-814. PMID: 22654200, PMCID: PMC3353043, DOI: 10.5665/sleep.1880.Peer-Reviewed Original ResearchConceptsGABA levelsSleep complaintsPrimary insomniaSleep onsetCortical GABA levelsGABA/creatine ratiosOccipital GABA levelsPolysomnographic sleep measuresBrain GABA levelsBody mass indexMain outcome measuresUniversity research clinicPrimary insomnia groupAllostatic responseProton magnetic resonance spectroscopyMaintenance of sleepGABA contentUse of cigarettesUse of caffeineMass indexOutpatient studyCreatine ratioOutcome measuresResearch clinicTwo-group comparison study
2010
A multistudy analysis of the effects of early cocaine abstinence on sleep
Matuskey D, Pittman B, Forselius E, Malison RT, Morgan PT. A multistudy analysis of the effects of early cocaine abstinence on sleep. Drug And Alcohol Dependence 2010, 115: 62-66. PMID: 21144676, PMCID: PMC3081928, DOI: 10.1016/j.drugalcdep.2010.10.015.Peer-Reviewed Original ResearchNormalizing Effects of Modafinil on Sleep in Chronic Cocaine Users
Morgan PT, Pace-Schott E, Pittman B, Stickgold R, Malison RT. Normalizing Effects of Modafinil on Sleep in Chronic Cocaine Users. American Journal Of Psychiatry 2010, 167: 331-340. PMID: 20080983, PMCID: PMC5857958, DOI: 10.1176/appi.ajp.2009.09050613.Peer-Reviewed Original ResearchMeSH KeywordsAdultBenzhydryl CompoundsCentral Nervous System StimulantsCocaineCocaine-Related DisordersDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleHumansMaleMiddle AgedModafinilPolysomnographySleep Wake DisordersSubstance Abuse Treatment CentersSubstance Withdrawal SyndromeWakefulnessConceptsMultiple sleep latency testSlow-wave sleep timeSleep latency testEffects of modafinilTotal sleep timeSleep latencyCocaine-dependent participantsSleep timeChronic cocaine usersDaytime sleepinessLatency testCocaine usersShorter REM sleep latencyDaytime sleep latencyLonger total sleep timeREM sleep latencySubjective daytime sleepinessSleep architecture variablesPolysomnographic sleep recordingsSleep architectureNocturnal sleepHealthy comparison participantsAbstinent cocaine usersDay 1Day 2
2009
Retrograde effects of triazolam and zolpidem on sleep‐dependent motor learning in humans
MORGAN PT, KEHNE JH, SPRENGER KJ, MALISON RT. Retrograde effects of triazolam and zolpidem on sleep‐dependent motor learning in humans. Journal Of Sleep Research 2009, 19: 157-164. PMID: 19682231, DOI: 10.1111/j.1365-2869.2009.00757.x.Peer-Reviewed Original ResearchConceptsTotal sleep timeSleep timeMotor learningSleep-dependent motor learningRapid eye movement (REM) sleepLonger total sleep timeGamma-aminobutyric acid receptor complexEye movement sleepREM onset latencyHealthy male subjectsStage 2 sleepMemory consolidationRetrograde effectsTriazolam conditionZolpidem conditionSkill memory consolidationMovement sleepSleep-dependent memory consolidationSufficient dosesHealthy peopleSleep laboratoryPlacebo conditionBenzodiazepine siteOnset latencyMale subjects
2008
Sleep architecture, cocaine and visual learning
Morgan PT, Pace‐Schott E, Sahul ZH, Coric V, Stickgold R, Malison RT. Sleep architecture, cocaine and visual learning. Addiction 2008, 103: 1344-1352. PMID: 18855824, PMCID: PMC3690941, DOI: 10.1111/j.1360-0443.2008.02233.x.Peer-Reviewed Original ResearchConceptsChronic cocaine usersVisual learningProgressive abstinenceVisual texture discrimination taskLate night REM sleepSlow wave activityAbstinence-related changesTexture discrimination taskCocaine usersSleep architectureCocaine useVisual performanceREM sleepOvernight enhancementDays of abstinenceDiscrimination taskCocaine self-administration sessionsSelf-administration sessionsCognitive functionChronic cocaine useLearning deficitsCognitive dysfunctionRapid eye movement (REM) sleepAbstinenceCocaine abstinencePilot Study of Lorazepam and Tiagabine Effects on Sleep, Motor Learning, and Impulsivity in Cocaine Abstinence
Morgan PT, Malison RT. Pilot Study of Lorazepam and Tiagabine Effects on Sleep, Motor Learning, and Impulsivity in Cocaine Abstinence. The American Journal Of Drug And Alcohol Abuse 2008, 34: 692-702. PMID: 18850496, DOI: 10.1080/00952990802308221.Peer-Reviewed Original ResearchConceptsSleep-dependent learningCocaine-dependent personsEffects of lorazepamCognitive effectsCognitive functionMotor learningTotal sleep timeDependent learningImpulsivitySlow-wave sleepCocaine abstinenceSleep latencyAbstinenceSleep timeSleepDependent personsLearningLight sleepCognitionCocaine administrationSedative hypnoticsPilot studyLorazepamParticipantsDifferent GABA
2007
Cocaine and Sleep: Early Abstinence
Morgan PT, Malison RT. Cocaine and Sleep: Early Abstinence. The Scientific World JOURNAL 2007, 7: 223-230. PMID: 17982597, PMCID: PMC5900952, DOI: 10.1100/tsw.2007.209.Peer-Reviewed Original ResearchMeSH KeywordsCocaineCocaine-Related DisordersHumansPolysomnographySleepSleep DeprivationTime FactorsConceptsSubjective reportsCognitive performance declineCompulsive cocaine useCocaine useDiminished sleepWeeks of abstinenceEarly abstinenceSubjective measuresPerformance declineSleep disturbancesAbstinenceSleepIndication of recoveryRelevant literatureDisordersMeasuresCocaineSignificant deteriorationChronic useRelationshipDysregulation