Julio Nunes, MD
Psychiatry ResidentCards
About
Research
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Featured Publications
Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic
De Aquino J, Sloan M, Nunes J, Costa G, Katz J, de Oliveira D, Ra J, Tang V, Petrakis I. Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic. American Journal Of Psychiatry 2024, 181: 391-402. PMID: 38706339, PMCID: PMC11521207, DOI: 10.1176/appi.ajp.20230886.Peer-Reviewed Original ResearchConceptsAlcohol use disorderChronic painAUD studiesChronic pain disordersChronic pain outcomesRisk of relapseAlcohol withdrawal syndromeAssessment of painHigher levels of alcohol consumptionLevels of alcohol consumptionWithdrawal syndromePain disordersPain outcomesAcute toleranceNeurobiological changesClinical significanceUse disorderPainClinical relevanceSelf-reportAlcohol intoxicationAlcohol consumptionGeneral populationMedical conditionsNarrative reviewFrom taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder
Weleff J, Nunes J, Costa G, Sofuoglu M, MacLean R, De Aquino J. From taboo to treatment: The emergence of psychedelics in the management of pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3036-3053. PMID: 38627909, PMCID: PMC11480258, DOI: 10.1111/bcp.16045.Peer-Reviewed Original ResearchOpioid use disorderChronic painLong-term opioid therapyManagement of chronic painPain management alternativeOpioid-induced analgesiaInnovative treatment optionsManagement of painReverse painCentral sensitizationOpioid therapyPain controlTreatment optionsClinical challengeClinical trialsPainPotential therapeutic applicationsPain experiencePotential of psychedelicsNovel therapeuticsHuman evidenceOpioid crisisNeurobiological substratesOpioidExploration of novel therapeuticsAssessing pain in persons with opioid use disorder: Approaches, techniques and special considerations
Nunes J, Costa G, Weleff J, Rogan M, Compton P, De Aquino J. Assessing pain in persons with opioid use disorder: Approaches, techniques and special considerations. British Journal Of Clinical Pharmacology 2024, 90: 2985-3002. PMID: 38556851, DOI: 10.1111/bcp.16055.Peer-Reviewed Original ResearchOpioid use disorderAssess painPain assessmentPain experienceConcomitant chronic painChronic opioid therapyQuantitative sensory testingVisual analogue scalePain assessment methodsPain assessment toolsComplex psychosocial backgroundImprove pain assessmentOpioid therapyOpioid usePain responseChronic painAnalogue scaleTraditional self-report methodsPainRisk factorsUse disorderOpioidNarrative reviewSelf-report methodsMultidisciplinary teamThe impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies
Costa G, Nunes J, Heringer D, Anand A, De Aquino J. The impact of cannabis on non-medical opioid use among individuals receiving pharmacotherapies for opioid use disorder: a systematic review and meta-analysis of longitudinal studies. The American Journal Of Drug And Alcohol Abuse 2024, 50: 12-26. PMID: 38225727, DOI: 10.1080/00952990.2023.2287406.Peer-Reviewed Original ResearchConceptsNon-medical opioid useOpioid use disorderOpioid useCannabis useOpioid use disorder pharmacotherapyUse disorderImpact of cannabis useAverage follow-up timeFollow-up timeMeta-analysisEvidence of moderate heterogeneityImpact of cannabisPooled odds ratioOpioids non-medicallyRandom-effects modelMeta-analysis of longitudinal studiesCannabis abstinenceTreatment modalitiesOdds ratioModerate heterogeneityPharmacotherapyCannabisOpioidComprehensive searchPublication biasWhat Would Equitable Harm Reduction Look Like?
Jegede O, Nunes J, Tumenta T, Black C, DeAquino J. What Would Equitable Harm Reduction Look Like? The AMA Journal Of Ethic 2024, 26: e572-579. PMID: 38958426, DOI: 10.1001/amajethics.2024.572.Peer-Reviewed Original ResearchConceptsDeterminants of health frameworkHarm reductionPerson-centered interventionsReduction programsPromote harm reductionHarm reduction strategiesHarm reduction programsHealth equityHealth frameworkEthnic inequalitiesSocial justiceDrug usePWUDOrganizational policiesMargin ExperimentReduction strategiesHarmCareStigmaProgramHealthRaciallyAntiracistInterventionJusticeDisentangling the effects of racism-related stress on opioid use disorder and chronic pain outcomes
Nunes J, Jegede O, De Aquino J. Disentangling the effects of racism-related stress on opioid use disorder and chronic pain outcomes. The American Journal Of Drug And Alcohol Abuse 2024, 50: 455-461. PMID: 39018662, PMCID: PMC12036823, DOI: 10.1080/00952990.2024.2369866.Peer-Reviewed Original ResearchOpioid use disorderUse disorderRacism-related stressChronic pain outcomesOpioid overdose mortality ratesOverdose mortality ratesHealthcare disparitiesBiopsychosocial burdenPain outcomesPrescribed opioidsUndertreated painChronic painPain managementOpioid mortalityPerpetuate stigmaTreat painPain experienceOpioidPainRisk factorsMinoritized populationsMinoritized peopleMortality rateDisparitiesAddiction treatmentGeneral Anxiety Disorder-7 Questionnaire as a marker of low socioeconomic status and inequity.
Nunes JC, Carroll MK, Mahaffey KW, Califf RM, Doraiswamy PM, Short S, Shah SH, Swope S, Williams D, Hernandez AF, Hong DS. General Anxiety Disorder-7 Questionnaire as a marker of low socioeconomic status and inequity. Journal Of Affective Disorders 2022, 317: 287-297. PMID: 36031002, DOI: 10.1016/j.jad.2022.08.085.Peer-Reviewed Original ResearchThe bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study
Costa G, Nunes J, Suh R, Sofuoglu M, Aquino J. The bidirectional relationship between pain and tobacco use: Insights from the longitudinal Population Assessment of Tobacco and Health (PATH) study. Drug And Alcohol Dependence 2025, 268: 112552. PMID: 39848133, PMCID: PMC11832315, DOI: 10.1016/j.drugalcdep.2025.112552.Peer-Reviewed Original ResearchConceptsDaily smokingDaily cigarette smokingChronic painDevelopment of painCigarette smokingTobacco smokePopulation Assessment of Tobacco and Health StudyBaseline painAlternative tobacco product usePersistent painTobacco product useDevelopment of persistent painYears of longitudinal dataHealth StudyTobacco useNo/low painPreventable causeSmoking outcomesBidirectional relationshipSurvival analysisSmokingPopulation AssessmentAge categoriesIncreased riskSurvey population
2025
Patient-Selection of a Clinical Trial Primary Outcome: The ENHANCE-AF Outcomes Survey.
Stafford RS, Rice EN, Shah R, Hills MT, Nunes JC, DeSutter K, Lin A, Lhamo K, Lin B, Lu Y, Wang PJ. Patient-Selection of a Clinical Trial Primary Outcome: The ENHANCE-AF Outcomes Survey. PLoS One 2025, 20: e0318858. PMID: 40053524, DOI: 10.1371/journal.pone.0318858.Peer-Reviewed Original Research
2024
Prevalence of Patient Suicide and Its Impact on Health Care Professionals: A Systematic Review
Jupina M, Mercer M, Weleff J, Hackett L, Nunes J, Sebastian D, Anand A. Prevalence of Patient Suicide and Its Impact on Health Care Professionals: A Systematic Review. Psychiatric Services 2024, 75: 999-1008. PMID: 39350634, DOI: 10.1176/appi.ps.20230351.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Teaching & Mentoring
News
News
- June 26, 2025Source: Alcohol, Clinical and Experimental Research
Pain Interference, Alcohol Use, and Metabolic Health: Insights From a Nationally Representative Study
- April 07, 2025
Nunes, Costa, Prudente Honored with 2025 College on Problems of Drug Dependence Travel Awards
- March 21, 2025
Nunes, Paredes Naveda Receive Travel Scholarships for ASHP Annual Meeting
- February 04, 2025
Nunes to Run Bank of America Chicago Marathon for American Foundation for Suicide Prevention
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