1998
Differential Regulation of Neurotrophin and trkReceptor mRNAs in Catecholaminergic Nuclei during Chronic Opiate Treatment and Withdrawal
Numan S, Lane-Ladd S, Zhang L, Lundgren K, Russell D, Seroogy K, Nestler E. Differential Regulation of Neurotrophin and trkReceptor mRNAs in Catecholaminergic Nuclei during Chronic Opiate Treatment and Withdrawal. Journal Of Neuroscience 1998, 18: 10700-10708. PMID: 9852605, PMCID: PMC6793370, DOI: 10.1523/jneurosci.18-24-10700.1998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain-Derived Neurotrophic FactorDrug Administration ScheduleDrug ImplantsGene Expression RegulationLocus CoeruleusMaleMesencephalonMorphineNerve Growth FactorsNeurotrophin 3RatsRats, Sprague-DawleyReceptor Protein-Tyrosine KinasesReceptor, Ciliary Neurotrophic FactorReceptor, trkCReceptors, Nerve Growth FactorRNA, MessengerTime FactorsVentral Tegmental AreaConceptsBrain-derived neurotrophic factorVentral tegmental areaChronic morphine treatmentChronic opiate treatmentLocus coeruleusHr of withdrawalMorphine treatmentNeurotrophin-3TrkC mRNAOpiate treatmentNeurotrophin brain-derived neurotrophic factorNT-3 mRNA expressionLevels of TrkBOpiate-induced plasticityTrkB mRNA levelsChronic morphine exposureNT-3 mRNATrkC mRNA levelsMRNA levelsEndogenous neurotrophinsExogenous neurotrophinsTrk mRNABDNF mRNAMorphine exposureTrkB mRNA
1994
Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro.
Widnell K, Russell D, Nestler E. Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 10947-10951. PMID: 7971989, PMCID: PMC45143, DOI: 10.1073/pnas.91.23.10947.Peer-Reviewed Original ResearchConceptsLocus coeruleusCREB expressionCREB immunoreactivityCell linesChronic morphine administrationLocus coeruleus neuronsCRE-binding activityResponse element-binding proteinCAMP pathwayCREB mRNA levelsCAMP response element-binding proteinMorphine administrationChronic morphineCoeruleus neuronsBrain regionsCRE bindingOpiate addictionElement-binding proteinPC12 pheochromocytoma cellsCAMP response elementMRNA levelsPheochromocytoma cellsCoeruleusImmunoreactivityCREB mRNA