2000
Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse
Messer C, Eisch A, Carlezon W, Whisler K, Shen L, Wolf D, Westphal H, Collins F, Russell D, Nestler E. Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse. Neuron 2000, 26: 247-257. PMID: 10798408, PMCID: PMC4451194, DOI: 10.1016/s0896-6273(00)81154-x.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDrugs of abuseAnti-GDNF antibodyIntra-VTA infusionDopaminergic brain regionsSubsequent drug exposureChronic morphineDrug exposureTegmental areaChronic cocaineCocaine exposureRewarding effectsGDNF geneGDNF pathwayBrain regionsGDNFBehavioral sensitivityCocaineDrugsMorphineInfusionPresent studyExposureNull mutationAbuse
1994
Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro.
Widnell K, Russell D, Nestler E. Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 10947-10951. PMID: 7971989, PMCID: PMC45143, DOI: 10.1073/pnas.91.23.10947.Peer-Reviewed Original ResearchConceptsLocus coeruleusCREB expressionCREB immunoreactivityCell linesChronic morphine administrationLocus coeruleus neuronsCRE-binding activityResponse element-binding proteinCAMP pathwayCREB mRNA levelsCAMP response element-binding proteinMorphine administrationChronic morphineCoeruleus neuronsBrain regionsCRE bindingOpiate addictionElement-binding proteinPC12 pheochromocytoma cellsCAMP response elementMRNA levelsPheochromocytoma cellsCoeruleusImmunoreactivityCREB mRNA