2006
Protecting Motor Neurons from Toxic Insult by Antagonism of Adenosine A2a and Trk Receptors
Mojsilovic-Petrovic J, Jeong GB, Crocker A, Arneja A, David S, Russell D, Kalb RG. Protecting Motor Neurons from Toxic Insult by Antagonism of Adenosine A2a and Trk Receptors. Journal Of Neuroscience 2006, 26: 9250-9263. PMID: 16957081, PMCID: PMC6674510, DOI: 10.1523/jneurosci.1856-06.2006.Peer-Reviewed Original ResearchConceptsMotor neuronsAmyotrophic lateral sclerosisAdenosine A2A receptorsA2A receptorsBrain-derived neurotrophic factor (BDNF) activationReceptor tyrosine kinase BAbility of BDNFTyrosine kinase BMotor neuron diseaseSrc family kinasesAbnormal axonal transportFamilial motor neuron diseaseDirect kinase inhibitionExcitotoxic insultALS patientsNeuron diseaseAdenosine A2ALateral sclerosisTrk receptorsToxic insultsAxonal transportNeuronsInsultTransactivation pathwayFactor activation
2000
Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse
Messer C, Eisch A, Carlezon W, Whisler K, Shen L, Wolf D, Westphal H, Collins F, Russell D, Nestler E. Role for GDNF in Biochemical and Behavioral Adaptations to Drugs of Abuse. Neuron 2000, 26: 247-257. PMID: 10798408, PMCID: PMC4451194, DOI: 10.1016/s0896-6273(00)81154-x.Peer-Reviewed Original ResearchConceptsVentral tegmental areaDrugs of abuseAnti-GDNF antibodyIntra-VTA infusionDopaminergic brain regionsSubsequent drug exposureChronic morphineDrug exposureTegmental areaChronic cocaineCocaine exposureRewarding effectsGDNF geneGDNF pathwayBrain regionsGDNFBehavioral sensitivityCocaineDrugsMorphineInfusionPresent studyExposureNull mutationAbuse