1999
Regulation of Phospholipase Cγ in the Mesolimbic Dopamine System by Chronic Morphine Administration
Wolf D, Numan S, Nestler E, Russell D. Regulation of Phospholipase Cγ in the Mesolimbic Dopamine System by Chronic Morphine Administration. Journal Of Neurochemistry 1999, 73: 1520-1528. PMID: 10501197, PMCID: PMC1993239, DOI: 10.1046/j.1471-4159.1999.0731520.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDopamineDrug ImplantsGene Expression RegulationGene Expression Regulation, EnzymologicInsulin Receptor Substrate ProteinsIntracellular Signaling Peptides and ProteinsIsoenzymesLimbic SystemMaleMorphineNeuronsOrgan SpecificityPhosphatidylinositol 3-KinasesPhospholipase C gammaPhosphoproteinsRatsRats, Sprague-DawleyRNA, MessengerTegmentum MesencephaliTranscription, GeneticType C PhospholipasesConceptsRas-ERK pathwayInsulin receptor substrateVentral tegmental areaNeurotrophic signaling pathwaysMesolimbic dopamine systemPhospholipase Cgamma1Receptor substratePhospholipase CγSignaling pathwaysPathway proteinsDopamine systemProteinPLCgamma1MRNA levelsChronic morphine exposureChronic morphine administrationRegulationPathwayAppreciable levelsMRNA expressionMorphine exposureMorphine administrationDopaminergic neuronsNeurotrophic factorTegmental area
1994
Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro.
Widnell K, Russell D, Nestler E. Regulation of expression of cAMP response element-binding protein in the locus coeruleus in vivo and in a locus coeruleus-like cell line in vitro. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 10947-10951. PMID: 7971989, PMCID: PMC45143, DOI: 10.1073/pnas.91.23.10947.Peer-Reviewed Original ResearchConceptsLocus coeruleusCREB expressionCREB immunoreactivityCell linesChronic morphine administrationLocus coeruleus neuronsCRE-binding activityResponse element-binding proteinCAMP pathwayCREB mRNA levelsCAMP response element-binding proteinMorphine administrationChronic morphineCoeruleus neuronsBrain regionsCRE bindingOpiate addictionElement-binding proteinPC12 pheochromocytoma cellsCAMP response elementMRNA levelsPheochromocytoma cellsCoeruleusImmunoreactivityCREB mRNA