2015
Decoding Neural Circuits that Control Compulsive Sucrose Seeking
Nieh E, Matthews G, Allsop S, Presbrey K, Leppla C, Wichmann R, Neve R, Wildes C, Tye K. Decoding Neural Circuits that Control Compulsive Sucrose Seeking. Cell 2015, 160: 528-541. PMID: 25635460, PMCID: PMC4312417, DOI: 10.1016/j.cell.2015.01.003.Peer-Reviewed Original ResearchConceptsVentral tegmental areaVentral tegmental area dopamineNeural circuitsReward-predictive cuesFeeding-related behaviorsSucrose seekingReward omissionReward processingReward availabilityTegmental areaHungry miceGABA neuronsLH neuronsGABAergic projectionsDopamineRewardLearning actionsInhibitory inputsNeuronsTherapeutic interventionsSeekingCuesDisordersGABAFood consumption
2014
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop S, Vander Weele C, Wichmann R, Tye K. Optogenetic insights on the relationship between anxiety-related behaviors and social deficits. Frontiers In Behavioral Neuroscience 2014, 8: 241. PMID: 25076878, PMCID: PMC4099964, DOI: 10.3389/fnbeh.2014.00241.Peer-Reviewed Original ResearchAnxiety-related behaviorAutism spectrum disorderAnxiety disordersSocial deficitsSocial behaviorBasolateral amygdalaVentral hippocampusSpectrum disorderPathogenesis of social anxiety disorderModulating anxiety-related behaviorsRates of co-morbiditySocial anxiety disorderModulate social behaviorPsychiatric disease statesNeural circuit mechanismsComplex emotional statesPsychiatric illnessPsychiatric diseasesInvestigation of neural circuitsCircuit mechanismsAnxietyNeural circuitsEmotional statesSocial domainsDeficits