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Ania Jastreboff, MD, PhD

Associate Professor of Medicine (Endocrinology); Director, Yale Obesity Research Center (Y-Weight); Co-Director, Yale Center for Weight Management

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Ania Jastreboff, MD, PhD

Patient Care Locations

Y-Weight: Yale Obesity Research Center

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Biography

Ania M. Jastreboff, MD, PhD is an Associate Professor in Medicine and Pediatrics at Yale School of Medicine. She serves as the director of the Yale Obesity Research Center (Y-Weight) and the co-director of the Yale Center for Weight Management. She is trained in both adult endocrinology and pediatric endocrinology, is an obesity medicine physician-scientist, and an international leader in research and clinical application of anti-obesity pharmacotherapeutics. Her work has included working to develop Obesity Clinical Practice Guidelines (AACE/ACE 2016), serving on the Board of Directors for the American Board of Obesity Medicine, educating the next generation of Obesity Medicine physicians by teaching at national and international obesity treatment courses, and conducting cutting-edge clinical-translational obesity research. Her research includes large, multi-center clinical outcomes trials using novel anti-obesity pharmacotherapeutics and studies examining the neurobiology underlying obesity and mechanisms of anti-obesity medications (supported by the NIH/NIDDK). Recently, she has served as lead author for trials investigating potential novel nutrient-stimulated hormone-based therapies for obesity including dual hormone receptor agonist tirzepatide (NEJM) a novel GIP/GLP-1 receptor agonist (Jastreboff, et al., NEJM, 2022) and triple hormone receptor agonist retatrutide (NEJM) a novel GIP/GLP-1/Glucagon receptor agonist (Jastreboff, et al., NEJM, 2023).

Videos of Dr. Jastreboff and colleagues from the NEJM about:

- What causes obesity: https://www.nejm.org/doi/full/...

- Supporting patients with obesity: https://www.nejm.org/doi/full/...

- Medications and surgery for obesity treatment: https://www.nejm.org/doi/full/...

Podcast (Yale Talk) with the president of Yale University, Dr. Peter Salovey, speaking with Dr. Jastreboff.

Video with Dr. Jastreboff about anti-obesity medications and the biology of obesity.

Clinically, Dr. Jastreboff specializes in sophisticated use of anti-obesity medication combinations to help patients reach their weight and health goals.

Education & Training

  • Clinical Research Scholar
    Yale University School of Medicine (2013)
  • PhD
    Yale University Graduate School of Arts and Sciences (2011)
  • Endocrinology Postdoctoral Fellowship
    Yale University (2011)
  • Pediatric Endocrinology Postdoctoral Fellowship
    Yale University (2011)
  • Chief Resident
    University of Maryland (2006)
  • Residency
    University of Maryland School of Medicine (2006)
  • MD
    University of Maryland at Baltimore (2002)
  • BA
    Bucknell University, Art History (1998)

Activities

  • Pharmacotherapy for the treatment of adolescents with obesity
    Santiago, Santiago Metropolitan Region, Chile 2020
    Pharmacotherapy for the treatment of adolescents with obesity
  • Pharmacotherapy for the treatment of adolescent obesity: Where are we now? Where are we going?
    Rio de Janeiro, RJ, Brazil 2020
    34th Brazilian Congress of Endocrinology and Metabolism
  • Obesity Pharmacotherapy
    Boston, MA, United States 2020
    Obesity Pharmacotherapy
  • Overcoming barriers to use of anti-obesity pharmacotherapy
    Boston, MA, United States 2020
    Overcoming barriers to use of anti-obesity pharmacotherapy
  • Pharmacotherapy for the treatment of adolescents with obesity
    Cleveland, OH, United States 2020
    Pharmacotherapy for the treatment of adolescents with obesity
  • Pharmacotherapy for the treatment of adolescents with obesity: Where are we now? Where are we going?
    Worcester, MA, United States 2020
    Pharmacotherapy for the treatment of adolescents with obesity: Where are we now? Where are we going?
  • Pharmacological treatment of adolescents with obesity
    San Francisco, CA, United States 2020
    Pharmacological treatment of adolescents with obesity
  • The best strategy for diabetes remission using obesity treatments is... pharmacotherapy
    Chicago, IL, United States 2020
    The best strategy for diabetes remission using obesity treatments is... pharmacotherapy
  • Teenage Brains on Sugar: Neural Response to Monosaccharide Ingestion in Adolescent Obesity.
    Rio de Janeiro, RJ, Brazil 2020
    Teenage Brains on Sugar: Neural Response to Monosaccharide Ingestion in Adolescent Obesity.
  • Obesity Pharmacotherapy Workshops and Meet the Expert
    Boston, MA, United States 2020
    Obesity Pharmacotherapy Workshops and Meet the Expert
  • Hold ‘em or Draw? Pharmacological Treatment on Adolescents with Obesity
    Las Vegas, NV, United States 2019
    Hold ‘em or Draw? Pharmacological Treatment on Adolescents with Obesity
  • Obesity Pharmacotherapy
    Boston, MA, United States 2019
    Obesity Pharmacotherapy
  • Overcoming Barriers to use of Anti-Obesity Pharmacotherapy
    Boston, MA, United States 2019
    Overcoming Barriers to use of Anti-Obesity Pharmacotherapy
  • Neuroimaging and Modulation in Obesity and Diabetes Research
    Bethesda, MD, United States 2019
    Neuroimaging and Modulation in Obesity and Diabetes Research
  • Teenage Brains on Sugar: Neural Response to Monosaccharide Ingestion in Adolescent Obesity
    New York, NY, United States 2019
    Teenage Brains on Sugar: Neural Response to Monosaccharide Ingestion in Adolescent Obesity
  • Obesity Pathophysiology: the role of the brain
    New York, NY, United States 2019
    Obesity Pathophysiology: the role of the brain
  • Pharmacologic Treatment of Obesity
    Las Vegas, NV, United States 2019
    Pharmacologic Treatment of Obesity
  • Treating patients with Diabetes and Obesity: the Role of Bariatric Surgery and Pharmacotherapy
    Ledyard, CT, United States 2019
    Treating patients with Diabetes and Obesity: the Role of Bariatric Surgery and Pharmacotherapy
  • Obesity is Highly Prevalent Among Patients Admitted to an Emergency Department Chest Pain Observation Unit.
    Las Vegas, NV, United States 2019
    Obesity is Highly Prevalent Among Patients Admitted to an Emergency Department Chest Pain Observation Unit.
  • Obesity Is Highly Prevalent among Patients Admitted to an Emergency Department Chest Pain Observation Unit
    Las Vegas, NV, United States 2019
    Obesity Is Highly Prevalent among Patients Admitted to an Emergency Department Chest Pain Observation Unit
  • Does Hyperinsulinemia in Obesity Elicit Brain Responses that Provoke Greater Motivation for Food?
    Bethesda, MD, United States 2019
    Does Hyperinsulinemia in Obesity Elicit Brain Responses that Provoke Greater Motivation for Food?
  • Obesity Is Associated with Reduced 11-beta-Hydoxysteroid Dehydrogenase Type I Levels in the Human Brain
    Bethesda, MD, United States 2019
    Obesity Is Associated with Reduced 11-beta-Hydoxysteroid Dehydrogenase Type I Levels in the Human Brain
  • Investigating GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration
    Orlando, FL, United States 2019
    Investigating GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration
  • Mindfulness based stress reduction for older couples with metabolic syndrome
    Vancouver, BC, Canada 2019
    Mindfulness based stress reduction for older couples with metabolic syndrome
  • Characterizing Obesity and Outcomes among Emergency Department Patients Admitted to a Chest Pain Observation Unit
    Worcester, MA, United States 2019
    Characterizing Obesity and Outcomes among Emergency Department Patients Admitted to a Chest Pain Observation Unit
  • Obesity Pharmacotherapy Workshops and Meet the Expert
    Boston, MA, United States 2019
    Obesity Pharmacotherapy Workshops and Meet the Expert
  • Pharmacologic Treatment of Obesity
    Phoenix, AZ, United States 2018
    Pharmacologic Treatment of Obesity
  • Obesity Pharmacotherapy Workshops and Meet the Expert
    Boston, MA, United States 2018
    Obesity Pharmacotherapy Workshops and Meet the Expert
  • Special Considerations in Use of Hybrid Closed Loop
    Charlotte, NC, United States 2018
    Special Considerations in Use of Hybrid Closed Loop
  • Teenage Brains of Sugar: Neural Responses to Monosaccharide Ingestion in Adolescent Obesity
    Iowa City, IA, United States 2018
    Obesity Physiology and Genetics
  • Special Considerations in Use of Hybrid Closed Loop
    Fort Lauderdale, FL, United States 2018
    Special Considerations in Use of Hybrid Closed Loop
  • Obesity Physiology and Genetics
    New York, NY, United States 2018
    Obesity Physiology and Genetics
  • Hyperinsulinemia Invokes Greater Cerebral Blood Flow in Reward and Motivation Regions in Obesity
    Orlando, FL, United States 2018
    Hyperinsulinemia Invokes Greater Cerebral Blood Flow in Reward and Motivation Regions in Obesity
  • Reduction of 11β-hydroxysteroid dehydrogenase type 1 enzyme levels with increasing body mass index: A Brain PET imaging study
    Philadelphia, PA, United States 2018
    Reduction of 11β-hydroxysteroid dehydrogenase type 1 enzyme levels with increasing body mass index: A Brain PET imaging study
  • Obesity is associated with reduced 11β-Hydroxysteroid Dehydrogenase Type 1 levels in the Human Brain
    Chicago, IL, United States 2018
    Obesity is associated with reduced 11β-Hydroxysteroid Dehydrogenase Type 1 levels in the Human Brain
  • Severe Hypercalemia and acute pancreatitis in a postpartum woman
    Boston, MA, United States 2018
    Severe Hypercalemia and acute pancreatitis in a postpartum woman
  • Hedonic Eating/Food Reward and Appetite Regulation and then Development of Severe Adolescent Obesity in Adolescents
    Bethesda, MD, United States 2017
    Developing Precision Medicine Approaches to the Treatment of Severe Obesity in Adolescents
  • Obesity Medicine: a new frontier
    Butler, PA, United States 2017
    Obesity Medicine: a new frontier
  • Obesity Pharmacotherapy Workshops and Meet the Expert
    Boston, MA, United States 2017
    Obesity Pharmacotherapy Workshops
  • Special Considerations in Use of Hybrid Closed Loop
    New Haven, CT, United States 2017
    Special Considerations in Use of Hybrid Closed Loop
  • Obesity Physiology and Genetics
    New York, NY, United States 2017
    Obesity Physiology and Genetics
  • Hedonic Eating/Food Reward and Appetite Regulation and the Development of Severe Obesity in Adolescents
    Bethesda, MD, United States 2017
    Hedonic Eating/Food Reward and Appetite Regulation and the Development of Severe Obesity in Adolescents
  • Does Hyperinsulinemia in Obesity Elicit Brain Responses that Provoke Greater Motivation for Food?
    San Diego, CA, United States 2017
    Does Hyperinsulinemia in Obesity Elicit Brain Responses that Provoke Greater Motivation for Food?
  • Preventing childhood obesity through a mindfulness-based parenting intervention for stress reduction
    Washington, DC, United States 2017
    Preventing childhood obesity through a mindfulness-based parenting intervention for stress reduction
  • Lower insulin sensitivity with increasing BMI is associated with greater high-calorie food intake
    Washington, DC, United States 2017
    Lower insulin sensitivity with increasing BMI is associated with greater high-calorie food intake
  • Neural Response to Glucose Ingestion in Obese Adolescents
    Katowice, Silesian Voivodeship, Poland 2016
    The Polish Society of Endocrinology, 21st Congress
  • Obesity Pharmacotherapy Workshops and Meet the Expert
    Boston, MA, United States 2016
    29th Annual Blackburn Course in Obesity Medicine
  • Cushing's disease: The case of whipped cream clouds
    Boston, MA, United States 2016
    Obesity Medicine Interhospital Rounds
  • AACE/ACE Comprehensive Clinical Practice Guidelines for the Medical Care of Patients with Obesity - Benefits of weight loss therapy
    Orlando, FL, United States 2016
    American Association of Clinical Endocrinologists (AACE) annual meeting
  • Preventing Childhood Obesity through a Family-Based Mindfulness Intervention
    Bethesda, MD, United States 2016
    Preventing Childhood Obesity through a Family-Based Mindfulness Intervention
  • Obesity Medicine: A New Frontier
    Albany, NY, United States 2016
    Obesity Medicine: A New Frontier
  • Glucose Ingestion: Are Adolescents Different From Adults?
    Vancouver, BC, Canada 2015
    International Diabetes Federation
  • Relationship between insulin resistance, brain activity, and prospective weight gain
    Boston, MA, United States 2015
    Relationship between insulin resistance, brain activity, and prospective weight gain
  • Agonism for Blocking Cocaine Euphoria and Self-Administration
    Washington, DC, United States 2015
    Agonism for Blocking Cocaine Euphoria and Self-Administration
  • Neural correlates of food-cue-induced food craving in obesity: association with insulin resistance
    Bethesda, MD, United States 2013
    NIH/NIDDK Intramural Program
  • Response to Food Cues in Obese and Lean Adolescents
    Chicago, IL, United States 2013
    Response to Food Cues in Obese and Lean Adolescents
  • Neural Response to Food Cues and Stress in Obese Individuals
    Baltimore, MD, United States 2010
    Neural Response to Food Cues and Stress in Obese Individuals
  • Running: The Good, the Bad, and the Not So Ugly
    Baltimore, MD, United States 2006
    Running: The Good, the Bad, and the Not So Ugly
  • Pediatric Obesity in Old Order Amish
    Baltimore, MD, United States 2006
    Pediatric Obesity in Old Order Amish

Honors & Recognition

AwardAwarding OrganizationDate
Young Physician-Scientist AwardAmerican Association for Clinical Investigation (ASCI)2013
First Place Poster Award, Yale Multi-Disciplinary Endocrinology & Metabolism RetreatYale Univeristy2013
American Diabetes Association Young Investigator Travel Grant AwardAmerican Diabetes Association (ADA)2013
Burroughs Wellcome Fund Travel Award, Translational Science Meeting 2013Burroughs Wellcome Fund2013
Translational Science Poster Award Association for Clinical Research Training and Society for Clinical and Translational Science2013
Diabetes Endocrinology Research Center (DRC), Poster AwardeeYale University2011
Yale Pediatric Fellows’ Research Day, Oral presentation award winnerYale University2011

Professional Service

OrganizationRoleDate
WTNH (Channel 8)WTNH (Channel 8) On Call: Keto Diet – TV interview on news station: https://www.wtnh.com/news/health/news-8-on-call-keto-diet/2020
WTNH (Channel 8)WTNH (Channel 8). Top 3 dieting trends of 2020. Live TV interview on news station: https://www.wtnh.com/on-air/gmct-at-nine/top-3-dieting-trends-of-2020/2020
Better HealthBetter Health. 12 diets you should never try, according to health experts. https://www.eatthis.com/unhealthiest-diets-experts/2019
Better HealthBetter Health. Healthy gifts that are doctor recommended. https://www.eatthis.com/healthy-gifts/2019
WTNH (Channel 8)WTNH (Channel 8) On Call: New policy for children with severe obesity – TV interview on news station: https://www.wtnh.com/lifestyle/health-news/news-8-on-call-new-policy-for-children-with-severe-obesity/2019
Huffington PostHuffington Post. This is your body on Keto. https://www.huffpost.com/entry/keto-effects-body_l_5d9b58abe4b099389803e4412019
Health CentralHealth Central. When diet and exercise aren’t enough. https://www.healthcentral.com/article/obesity-treatments2019
WTNH (Channel 8)WTNH (Channel 8) Dealing with Diabetes on Campus – Live TV interview on news station: https://www.wtnh.com/on-air/dealing-with-diabetes-on-campus/2019
ADA (American Diabetes Association)Obesity/Pathogenesis of Obesity Subcommittee2019 - Present
NIHNIH Study Section ad hoc reviewer KNOD: Kidney, Nutrition, Obesity, and Diabetes2019
The Endocrine SocietyHormone Health Network (HHN) committee2019 - Present
NPRNational Public Radio (NPR) live interview on Where We Live with David Deroches and Lydia Brown: America’s Diet Craving. http://www.wnpr.org/post/americas-diet-craving2018
The Obesity SocietyClinical Committee2018 - Present
MedPage TodayMedPage Today: Progress in Type 2 Diabetes Care – interview (videos): (1) Treating the Root Cause: Obesity Medicine: https://www.medpagetoday.com/resource-centers/progress-in-type-2-diabetes-care/obesity-medicine/19 (2) How Effective is Weight Loss as Therapy for Type 2 Diabetes? https://www.medpagetoday.com/resource-centers/progress-in-type-2-diabetes-care/weight-loss-as-therapy-for-type-2-diabetes/3 (3) Diets in Diabetes: One Size Doesn’t Fit All: ): https://www.medpagetoday.com/resource-centers/progress-in-type-2-diabetes-care/diet-in-diabetes/22 (4) Beating the Set Point and Maintaining Weight Loss: https://www.medpagetoday.com/resource-centers/progress-in-type-2-diabetes-care/maintaining-weight-loss/20 (5) Potential Risks of Anti-obesity Medications in Patients with T2D: https://www.medpagetoday.com/resource-centers/progress-in-type-2-diabetes-care/potential-risks-of-anti-obesity-medications/212017
Department of Chronic Disease EpidemiologyFaculty Search Committee2017 - 2018
American Association of Clinical Endocrinology (AACE) and American College of EndocrinologyAACE 2nd Consensus Conference on Obesity Writing Task Force2017 - 2018
NIHNIH Study Section ad hoc reviewer PRDP: Psychosocial Risk and Disease Prevention2017
The Obesity SocietyGrant Reviewer (Scientific Review Committee)2017 - Present
The Obesity Societyco-chair neuroimaging program planning committee 2019-2020, committee member 2016-present2016 - 2020
Yale MedicineYale Medicine: Why Obesity is a Disease – interview (video) Obesity is a growing epidemic in America. Ania Jastreboff, MD, PhD discusses why obesity is a disease with biological underpinnings. In addition, she discusses treatment options and medications. https://www.yalemedicine.org/conditions/why-obesity-is-a-disease/2016
American Association of Clinical Endocrinology (AACE) and American College of EndocrinologyTask Force for the development of Clinical Practice Guidelines for the Comprehensive Medical Care of Patients with Obesity2015 - 2016
The Obesity SocietyObesity Medicine Fellowship Curriculum Development Committee2015 - 2016
The Obesity SocietyDevelopment of "Contributors to Obesity" infographic for organizational use and the Surgeon General (Committee)2015
American Association of Clinical Endocrinology (AACE) and American College of EndocrinologyTask Force for the Obesity Algorithm2015 - 2016

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