The safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial
Zarrabi M, Akbari M, Amanat M, Majmaa A, Moaiedi A, Montazerlotfelahi H, Nouri M, Hamidieh A, Badv R, Karimi H, Rabbani A, Mohebbi A, Rahimi-Dehgolan S, Rahimi R, Dehghan E, Vosough M, Abroun S, Shamsabadi F, Tavasoli A, Alizadeh H, Pak N, Zamani G, Mohammadi M, Javadzadeh M, Ghofrani M, Hassanpour S, Heidari M, Taghdiri M, Mohseni M, Noparast Z, Masoomi S, Goudarzi M, Mohamadpour M, Shodjaee R, Samimi S, Mohammad M, Gholami M, Vafaei N, Koochakzadeh L, Valizadeh A, Malamiri R, Ashrafi M. The safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial. BMC Neurology 2022, 22: 123. PMID: 35351020, PMCID: PMC8966246, DOI: 10.1186/s12883-022-02636-y.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCerebral PalsyChildChild, PreschoolDiffusion Tensor ImagingDouble-Blind MethodFemaleFetal BloodHumansMaleQuality of LifeConceptsUmbilical cord blood mononuclear cellsCord blood mononuclear cellsSpastic cerebral palsyBlood mononuclear cellsCerebral palsyHuman leukocyte antigenPosterior thalamic radiationUCB-MNCAdverse eventsFractional anisotropyMononuclear cellsCorticospinal tractWhite matter structuresMean changeDouble-blind sham-controlled clinical trialControl groupMean GMFM-66 scoresGross Motor Function MeasureSham-controlled clinical trialExperimental groupCommon adverse eventsDouble-blind studyMotor Function MeasureGMFM-66 scoresTrial registrationThe study