2023
Neural Circuit Transitions Supporting Developmentally Specific Social Behavior.
Ferrara NC, Che A, Briones B, Padilla-Coreano N, Lovett-Barron M, Opendak M. Neural Circuit Transitions Supporting Developmentally Specific Social Behavior. J Neurosci 2023, 43: 7456-7462. PMID: 37940586, DOI: 10.1523/JNEUROSCI.1377-23.2023.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
An in vivo Calcium Imaging Approach for the Identification of Cell-Type Specific Patterns in the Developing Cortex.
Che A, De Marco García NV. An in vivo Calcium Imaging Approach for the Identification of Cell-Type Specific Patterns in the Developing Cortex. Frontiers In Neural Circuits 2021, 15: 747724. PMID: 34690708, PMCID: PMC8528153, DOI: 10.3389/fncir.2021.747724.Peer-Reviewed Original Research
2020
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction
Inda MC, Joshi S, Wang T, Bolaender A, Gandu S, Koren III J, Che AY, Taldone T, Yan P, Sun W, Uddin M, Panchal P, Riolo M, Shah S, Barlas A, Xu K, Chan LYL, Gruzinova A, Kishinevsky S, Studer L, Fossati V, Noggle SA, White JR, de Stanchina E, Sequeira S, Anthoney KH, Steele JW, Manova-Todorova K, Patil S, Dunphy MP, Pillarsetty N, Pereira AC, Erdjument-Bromage H, Neubert TA, Rodina A, Ginsberg SD, De Marco Garcia N, Luo W, Chiosis G. The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction. Nature Communications 2020, 11: 319. PMID: 31949159, PMCID: PMC6965647, DOI: 10.1038/s41467-019-14082-5.Peer-Reviewed Original ResearchAssemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex.
Modol L, Bollmann Y, Tressard T, Baude A, Che A, Duan ZRS, Babij R, De Marco García NV, Cossart R. Assemblies of Perisomatic GABAergic Neurons in the Developing Barrel Cortex. Neuron 2020, 105: 93-105.e4. PMID: 31780328, PMCID: PMC7537946, DOI: 10.1016/j.neuron.2019.10.007.Peer-Reviewed Original ResearchGABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex.
Duan ZRS, Che A, Chu P, Modol L, Bollmann Y, Babij R, Fetcho RN, Otsuka T, Fuccillo MV, Liston C, Pisapia DJ, Cossart R, De Marco García NV. GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex. Neuron 2020, 105: 75-92.e5. PMID: 31780329, PMCID: PMC6982374, DOI: 10.1016/j.neuron.2019.10.008.Peer-Reviewed Original Research
2018
Layer I Interneurons Sharpen Sensory Maps during Neonatal Development.
Che A, Babij R, Iannone AF, Fetcho RN, Ferrer M, Liston C, Fishell G, De Marco García NV. Layer I Interneurons Sharpen Sensory Maps during Neonatal Development. Neuron 2018, 99: 98-116.e7. PMID: 29937280, PMCID: PMC6152945, DOI: 10.1016/j.neuron.2018.06.002.Peer-Reviewed Original Research
2017
Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α.
Kabir ZD, Che A, Fischer DK, Rice RC, Rizzo BK, Byrne M, Glass MJ, De Marco Garcia NV, Rajadhyaksha AM. Rescue of impaired sociability and anxiety-like behavior in adult cacna1c-deficient mice by pharmacologically targeting eIF2α. Molecular Psychiatry 2017, 22: 1096-1109. PMID: 28584287, PMCID: PMC5863913, DOI: 10.1038/mp.2017.124.Peer-Reviewed Original Research
2015
Tracking and transforming neocortical progenitors by CRISPR/Cas9 gene targeting and piggyBac transposase lineage labeling.
Chen F, Rosiene J, Che A, Becker A, LoTurco J. Tracking and transforming neocortical progenitors by CRISPR/Cas9 gene targeting and piggyBac transposase lineage labeling. Development (Cambridge, England) 2015, 142: 3601-11. PMID: 26400094, PMCID: PMC4631763, DOI: 10.1242/dev.118836.Peer-Reviewed Original ResearchMutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex.
Che A, Truong DT, Fitch RH, LoTurco JJ. Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex. Cerebral Cortex 2015, 26: 3705-3718. PMID: 26250775, PMCID: PMC5004750, DOI: 10.1093/cercor/bhv168.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate receptor antagonistFunctional synaptic circuitryEvoked glutamate releaseGlutamatergic synaptic transmissionLayer 4 neuronsExcitatory transmissionGlutamate releaseThalamocortical connectionsAmbient glutamateMK-801Receptor antagonistAcute applicationProbability of releaseSomatosensory cortexSynaptic circuitryNMDAR activationSynaptic transmissionSynaptic releaseExcitatory connectivityPostsynaptic NMDARsCortical connectivitySomatosensory neocortexMouse neocortexNMDARNeocortex
2014
DCDC2 Mutations Cause a Renal-Hepatic Ciliopathy by Disrupting Wnt Signaling
Schueler M, Braun DA, Chandrasekar G, Gee HY, Klasson TD, Halbritter J, Bieder A, Porath JD, Airik R, Zhou W, LoTurco JJ, Che A, Otto EA, Böckenhauer D, Sebire NJ, Honzik T, Harris PC, Koon SJ, Gunay-Aygun M, Saunier S, Zerres K, Bruechle NO, Drenth JP, Pelletier L, Tapia-Páez I, Lifton RP, Giles RH, Kere J, Hildebrandt F. DCDC2 Mutations Cause a Renal-Hepatic Ciliopathy by Disrupting Wnt Signaling. American Journal Of Human Genetics 2014, 96: 81-92. PMID: 25557784, PMCID: PMC4289677, DOI: 10.1016/j.ajhg.2014.12.002.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsBeta CateninCiliaComputational BiologyDishevelled ProteinsExonsHEK293 CellsHumansKidneyKidney Diseases, CysticMiceMicroscopy, Electron, TransmissionMicrotubule-Associated ProteinsMutationNIH 3T3 CellsPhenotypePhosphoproteinsWnt Signaling PathwayZebrafishConceptsNPHP-RCWnt inhibitorsΒ-catenin-dependent WntMitotic spindle fibersImportance of WntCiliary axonemeHuman mutationsRenal tubulogenesisWntCiliopathiesSpindle fibersCiliogenesisMutationsDCDC2Dependent mannerKnockdownCentral roleRecessive diseaseInhibitorsMutantsDCDC2 mutationsTubulogenesisAxonemePhenotypeDvlMutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability.
Truong DT, Che A, Rendall AR, Szalkowski CE, LoTurco JJ, Galaburda AM, Holly Fitch R. Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability. Genes, Brain, And Behavior 2014, 13: 802-11. PMID: 25130614, PMCID: PMC4241168, DOI: 10.1111/gbb.12170.Peer-Reviewed Original Research
2013
The Dyslexia-Associated Gene Dcdc2 Is Required for Spike-Timing Precision in Mouse Neocortex
Che A, Girgenti MJ, LoTurco J. The Dyslexia-Associated Gene Dcdc2 Is Required for Spike-Timing Precision in Mouse Neocortex. Biological Psychiatry 2013, 76: 387-396. PMID: 24094509, PMCID: PMC4025976, DOI: 10.1016/j.biopsych.2013.08.018.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAction PotentialsAnimalsDyslexiaExcitatory Amino Acid AntagonistsGene ExpressionMembrane PotentialsMiceMice, KnockoutMicroelectrodesMicrotubule-Associated ProteinsNeocortexPatch-Clamp TechniquesPhenolsPiperidinesPyramidal CellsReceptors, N-Methyl-D-AspartateReverse Transcriptase Polymerase Chain ReactionSequence Analysis, RNATissue Culture TechniquesConceptsAmino-5-phosphonovaleric acidWhole-cell patch-clamp recordingsActivity of NMDARsAction potential firingWild-type micePatch-clamp recordingsTranscriptase-polymerase chain reactionSpike-timing precisionPyramidal neuronsElectrophysiological assessmentNMDAR antagonistsPolymerase chain reactionRo 25Neocortical activationClamp recordingsNeuronal physiologyElectrophysiological propertiesMouse neocortexRibonucleic acid sequencingFunctional increaseTemporal precisionChain reactionSequencing screenGene expressionNeocortex
2012
Loss of the dyslexia susceptibility gene Dcdc2 increases synaptic connectivity in the mouse neocortex.
Loturco JJ, Tarkar A, Che AY. Loss of the dyslexia susceptibility gene Dcdc2 increases synaptic connectivity in the mouse neocortex. Developmental Dyslexia: Early Precursors, Neurobehavioral Markers, and Biological Substrate. 2012.Books
2011
Mutation of the dyslexia-associated gene Dcdc2 impairs LTM and visuo-spatial performance in mice.
Gabel LA, Marin I, LoTurco JJ, Che A, Murphy C, Manglani M, Kass S. Mutation of the dyslexia-associated gene Dcdc2 impairs LTM and visuo-spatial performance in mice. Genes, Brain, And Behavior 2011, 10: 868-75. PMID: 21883923, PMCID: PMC3212622, DOI: 10.1111/j.1601-183X.2011.00727.x.Peer-Reviewed Original Research