The Dyslexia-Associated Gene Dcdc2 Is Required for Spike-Timing Precision in Mouse Neocortex
Che A, Girgenti MJ, LoTurco J. The Dyslexia-Associated Gene Dcdc2 Is Required for Spike-Timing Precision in Mouse Neocortex. Biological Psychiatry 2013, 76: 387-396. PMID: 24094509, PMCID: PMC4025976, DOI: 10.1016/j.biopsych.2013.08.018.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAction PotentialsAnimalsDyslexiaExcitatory Amino Acid AntagonistsGene ExpressionMembrane PotentialsMiceMice, KnockoutMicroelectrodesMicrotubule-Associated ProteinsNeocortexPatch-Clamp TechniquesPhenolsPiperidinesPyramidal CellsReceptors, N-Methyl-D-AspartateReverse Transcriptase Polymerase Chain ReactionSequence Analysis, RNATissue Culture TechniquesConceptsAmino-5-phosphonovaleric acidWhole-cell patch-clamp recordingsActivity of NMDARsAction potential firingWild-type micePatch-clamp recordingsTranscriptase-polymerase chain reactionSpike-timing precisionPyramidal neuronsElectrophysiological assessmentNMDAR antagonistsPolymerase chain reactionRo 25Neocortical activationClamp recordingsNeuronal physiologyElectrophysiological propertiesMouse neocortexRibonucleic acid sequencingFunctional increaseTemporal precisionChain reactionSequencing screenGene expressionNeocortex