Pharmacologic Treatment of Severe Irritability and Problem Behaviors in Autism: A Systematic Review and Meta-analysis
Fung L, Mahajan R, Nozzolillo A, Bernal P, Krasner A, Jo B, Coury D, Whitaker A, Veenstra-Vanderweele J, Hardan A. Pharmacologic Treatment of Severe Irritability and Problem Behaviors in Autism: A Systematic Review and Meta-analysis. Pediatrics 2016, 137: s124-s135. PMID: 26908468, DOI: 10.1542/peds.2015-2851k.Peer-Reviewed Original ResearchConceptsPharmacologic treatmentSide effectsPrimary study outcome measureAutism spectrum disorderPlacebo-controlled RCTsExtrapyramidal side effectsStudy outcome measuresEnd of treatmentRisk of biasParallel group designYouth ages 2Potential side effectsPublic health issueDetails of interventionsEffect sizeMedication groupAdverse reactionsSevere irritabilityOutcome measuresSignificant efficacyLarge effect sizesMeta-AnalysisSystematic reviewStudy participantsWeight gain