John Krystal, MD

Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry and of Neuroscience; Chair, Department of Psychiatry; Chief of Psychiatry, Yale-New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSD

Departments & Organizations

Psychiatry: Adult Psychiatry | Center for the Translational Neuroscience of Alcoholism | Clinical Neuroscience Research Unit | Neurocognition, Neurocomputation, and Neurogenetics, Division of | Neuroscience Research Training Program (NRTP) | Obsessive Compulsive Disorder Research Clinic

Dean's Workshops

Diabetes Research Center

Drug use, Addiction, and HIV Research Scholars (DAHRS)

Interdepartmental Neuroscience Program

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Neuroscience

Yale Medicine

Department of Psychology

Office of Cooperative Research


Dr. Krystal is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.

He is a member of the U.S. National Academy of Medicine. He also serves in a variety of advisory and review capacities for NIAAA, NIMH, Wellcome Trust, Brain and Behavior Research Foundation, the Broad Institute, and the Karolinska Institutet.

Dr. Krystal previously served on the National Alcohol Abuse and Alcoholism Advisory Council (NIAAA), the Department of Defense Psychological Health Advisory Committee, and the NIMH Board of Scientific Counselors (chair, 2005-2007). He has led the American College of Neuropsychopharmacology (president, 2012), and International College of Neuropsychophamacology (president, 2016-2018).

Currently, he is co-chair of the Neuroscience Forum (NeuroForum) of the National Academies of Sciences, Engineering, and Medicine, a member of the NIMH National Mental Health Advisory Council, and he edits the journal, Biological Psychiatry (impact factor: 11.982).

Education & Training

MD Yale University (1984)
BA University of Chicago, Behavioral Sciences (1980)
Residency Yale University School of Medicine
Board Certification AB of Psychiatry & Neurology, Psychiatry (1991)

Honors & Recognition

  • E.M. Jellinek Award for Alcohol ResearchE.M. Jellinek Foundation (2016)

  • Henri Begleiter Award for Research ExcellenceResearch Society on Alcoholism (2015)

  • Paul Hoch Research AwardAmerican Psychopathological Association (2014)

  • Exemplary Psychiatrist AwardNational Alliance on Mental Illness (2011)

  • MemberU.S. National Academy of Medicine (2010)

  • Jack Mendelson Award for Clinical ResearchNational Institute on Alcohol Abuse and Alcoholism (2010)

  • Stanley Dean Award for Schizophrenia ResearchAmerican College of Psychiatry (2010)

  • Anna-Monika Prize in Depression ResearchAnna-Monika Foundation, Munich, Germany (2009)

  • Kempf Award for Contributions to Schizophrenia Research through Research and MentorshipAmerican Psychiatric Association (2005)

  • Joel Elkes AwardAmerican College of Neuropsychopharmacology (2001)

Professional Service

  • Neuroscience Forum, National Academies of Sciences, Engineering, and Medicine (2018 - Present) Co-Director

  • International College of Neuropsychopharmacology (2016 - 2018) President

  • NIMH (2016 - Present) NIMH National Mental Health Advisory Council

  • American College of Neuropsychopharmacology (2011 - 2012) President


  • Schizophrenia Treatment Taichung, Taiwan (2013 - 2014)

    Consulting regarding novel treatments for schizophrenia and ketamine-related psychosis.

  • Neuroimaging studies of schizophrenia and related disorders Chengdu, China (2012 - 2014)

    Neuroimaging studies of brain structure and function associated with psychosis

  • Rapid Acting Antidepressant Treatment Taipei, Taiwan (2012 - 2014)

    Consulting to a study conducted evaluating the antidepressant effects of ketamine, led by Dr. Tung-Ping (Tom) Su.

  • Studies of the impact of sexual trauma Bergen, Norway (2011 - 2016)

    I am collaborating with Iris Steine, a Ph.D. candidate at the University of Bergen, as well has her mentors and colleagues, on studies on the clinical features and neurobiology of sexual trauma and its complications, including PTSD

  • Ketamine Psychosis Guangzhou, China (2010 - 2014)

    Studying the phenomenology and genetics of ketamine psychosis in relation to schizophrenia

  • Clinical Archives Project Cherite Hospital Berlin, Germany (2006 - 2014)

    The Department of Psychiatry at Cherite Hospital in Berlin has long been a home to ethical and compassionate treatment of patients. However, in the period leading up to World War II, its psychiatry leadership involved the hospital in the emerging eugenics movement. This work, contributed to the...

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