Gerard Sanacora, PhD, MD

Professor of Psychiatry; Director, Yale Depression Research Program; Co-Director, Yale New Haven Hospital Interventional Psychiatry Service

Physician Biography

Dr. Sanacora is a Professor of Psychiatry at Yale University and the Director of the Yale Depression Research Program. Dr. Sanacora’s work has focused largely on elucidating the pathophysiological mechanisms associated with mood and other neuropsychiatric disorders and using this information to inform the development of novel treatment strategies. His preclinical research laboratory explores the effects of stress and pharmaceutical agents on cellular biology, neurophysiology and behavior. His clinical laboratory employs novel imaging methodologies to investigate the pathophysiology of mood and other neuropsychiatric disorders. In addition, he has served as principal investigator on several large clinical trials investigating the efficacy and safety of newly developed therapeutic agents for the treatment of mood disorders. Dr. Sanacora received the Anna-Monkia Stiftung international award for the investigation of the biological substrate and functional disturbances of depression in 2009, the Joel Elkes Research Award for Outstanding contributions to Psychopharmacology from the American College of Neuropsychopharmacology (ACNP) in 2011, and is a Fellow of the ACNP.

Clinical Interests

  • Adult
  • Depression

Patient Care

Accepts new patients? Yes
Patient Type: Adult; Geriatric
Referrals: From physicians only

Patient Care Organizations

Psychiatry: Adult Psychiatry | Clinical Neuroscience Research Unit | Connecticut Mental Health Center | Yale Depression Research Program

Diabetes Research Center

Yale Medicine

Office of Cooperative Research

Clinical Trials

Conditions Study Title
Mental Health & Behavioral Research Effect of Sleep Deprivation on Brain Imaging and Function
Mental Health & Behavioral Research Imaging SV2A in mood disorders
Diseases of the Nervous System, Mental Health & Behavioral Research Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder
Children's Health, Mental Health & Behavioral Research Ketamine Infusion for Adolescent Depression
Mental Health & Behavioral Research A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression (SUSTAIN-2)
Aging, Mental Health & Behavioral Research A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression (TRANSFORM-3)
Addictive Behaviors, Alcohol Addiction, Diseases of the Nervous System, Mental Health & Behavioral Research Role of Acetate in Heavy Drinking
Mental Health & Behavioral Research Fast-Fail Trials in Mood and Anxiety Spectrum Disorders; Kappa Opioid Receptor Phase 2a (FASTMAS_Kor2)
Addictive Behaviors PET Imaging of mGLuR5 With Drug Challenge
Mental Health & Behavioral Research Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling
Mental Health & Behavioral Research Glutamate-Glutamine Cycling (VCYC) During Cocaine Abstinence Using 13C-MRS

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Contact Info

Gerard Sanacora, PhD, MD
Patient Care Locations
Clinical Neuroscience Research UnitConnecticut Mental Health Center
34 Park Street

New Haven, CT 06519
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Yale Depression Research Clinic100 York Street, Ste 2J
New Haven, CT 06511
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Office Locations
Connecticut Mental Health Center
34 Park Street, Ste 333 A

New Haven, CT 06519
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Yale Depression Research Clinic100 York Street, Ste 2J
New Haven, CT 06511
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Mailing Address
Department of Psychiatry100 York St.
Suite 2J

New Haven, CT 06511

Yale Depression Program