Ariadna Forray, MD

Research Interests

Behavior Therapy; Tobacco Use Disorder; Cognitive Therapy; Depression, Postpartum; Substance-Related Disorders; Postpartum Period; Motivational Interviewing

Research Organizations

Psychiatry: Addictions, Division of | Center for Nicotine and Tobacco Use Research at Yale (CENTURY) | Center for Wellbeing of Women and Mothers | Psychological Medicine Service | Psychotherapy Development Center

Faculty Research

Yale Cancer Center

Research Summary

The intersection between the brain and behavior is something that has interested me throughout my educational and professional development. The overarching goal of my research is to narrow the gap in our understanding of the effect of substance abuse and reproductive hormones on the psychophysiology of women throughout their reproductive years. My current research focuses on the the development of novel treatments for perinatal substance use that lead to sustained abstinence beyond the perinatal period.

Selected Publications

• Perinatal substance use: a prospective evaluation of abstinence and relapse

  Forray A, Merry B, Lin H, Ruger JP, Yonkers K. Perinatal substance use: a prospective evaluation of abstinence and relapse. Drug and Alcohol Dependence. 2015; Epub

• Progesterone for the reduction of cocaine use in postpartum women with a cocaine use disorder: a randomized, double-blind, placebo-controlled, pilot study

  Yonkers KA, Forray A, Nich C, Carroll CM, Hine C, Merry BC, Howard S, Howard J, Sofuoglu M. Progesterone for the reduction of cocaine use in postpartum women with a cocaine use disorder: a randomized, double-blind, placebo-controlled, pilot study. Lancet Psychiatry. 2014; 1(5):360-367.

• Perinatal Smoking and Depression in Women with Concurrent Substance Use

  Forray A, Gotman N, Kershaw T, Yonkers KA. Perinatal Smoking and Depression in Women with Concurrent Substance Use. Addict Behav. 2014; 39(4):749-56.

• Pregnant women with posttraumatic stress disorder and risk of preterm birth

  Yonkers KA, Smith MV, Forray A, Epperson CN, Costello D, Kin H, Belanger K. Pregnant women with posttraumatic stress disorder and risk of preterm birth. JAMA Psychiatry. 2014; 71(8):897-904.

• Motivational Enhancement Therapy Coupled with Cognitive Behavioral Therapy versus Brief Advice: A Randomized Trial for Treatment of Hazardous Substance Use in Pregnancy and After Delivery

  Yonkers KA, Forray A, Howell HB, Gotman N, Kershaw T, Rounsaville BJ, Carroll KM. Motivational Enhancement Therapy Coupled with Cognitive Behavioral Therapy versus Brief Advice: A Randomized Trial for Treatment of Hazardous Substance Use in Pregnancy and After Delivery. Gen Hosp Psychiatry. 2012; 34(5):439-49.

• Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum period

  Forray A, Focseneanu M, Pittman B, McDougle CJ, Epperson CN. Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum period. J Clin Psychiatry. 2010;71(8):1061-8.

• Prevalence of Posttraumatic Stress Disorder in Pregnant Women with Prior Pregnancy Complications

  Forray A, Magriples U, Mayes L, Epperson, CN. Prevalence of Posttraumatic Stress Disorder in Pregnant Women with Prior Pregnancy Complications. J Matern Fetal Neonatal Med. 2009;22(6):522-7.

Full List of PubMed Publications

• Martino S, Ondersma SJ, Forray A, Olmstead TA, Gilstad-Hayden K, Howell HB, Kershaw T, Yonkers KA: A randomized controlled trial of screening and brief interventions for substance misuse in reproductive health. Am J Obstet Gynecol. 2018 Mar; 2017 Dec 14. PMID: 29247636
• Forray A, Gilstad-Hayden K, Suppies C, Bogen D, Sofuoglu M, Yonkers KA: Progesterone for smoking relapse prevention following delivery: A pilot, randomized, double-blind study. Psychoneuroendocrinology. 2017 Dec; 2017 Sep 14. PMID: 28926762
• Yonkers KA, Gilstad-Hayden K, Forray A, Lipkind HS: Association of Panic Disorder, Generalized Anxiety Disorder, and Benzodiazepine Treatment During Pregnancy With Risk of Adverse Birth Outcomes. JAMA Psychiatry. 2017 Nov 1. PMID: 28903165
• Yonkers KA, Forray A, Smith MV: Maternal Antidepressant Use and Pregnancy Outcomes. JAMA. 2017 Aug 15. PMID: 28810017
• Forray A: Substance use during pregnancy. F1000Res. 2016; 2016 May 13. PMID: 27239283
• Forray A, Foster D: Substance Use in the Perinatal Period. Curr Psychiatry Rep. 2015 Nov. PMID: 26386836
• Martino S, Zimbrean P, Forray A, Kaufman J, Desan P, Olmstead TA, Gueorguieva R, Howell H, McCaherty A, Yonkers KA: See One, Do One, Order One: a study protocol for cluster randomized controlled trial testing three strategies for implementing motivational interviewing on medical inpatient units. Implement Sci. 2015 Sep 29; 2015 Sep 29. PMID: 26420671
• Forray A, Merry B, Lin H, Ruger JP, Yonkers KA: Perinatal substance use: a prospective evaluation of abstinence and relapse. Drug Alcohol Depend. 2015 May 1; 2015 Mar 3. PMID: 25772437
• Yonkers KA, Forray A, Nich C, Carroll KM, Hine C, Merry BC, Shaw H, Shaw J, Sofuoglu M: Progesterone Reduces Cocaine Use in Postpartum Women with a Cocaine Use Disorder: A Randomized,Double-Blind Study. Lancet Psychiatry. 2014 Oct 1. PMID: 25328863
• Yonkers KA, Smith MV, Forray A, Epperson CN, Costello D, Lin H, Belanger K: Pregnant women with posttraumatic stress disorder and risk of preterm birth. JAMA Psychiatry. 2014 Aug. PMID: 24920287
• Fucito LM, Bars MP, Forray A, Rojewski AM, Shiffman S, Selby P, West R, Foulds J, Toll BA, Writing Committee for the SRNT Policy and Treatment Networks.: Addressing the evidence for FDA nicotine replacement therapy label changes: a policy statement of the Association for the Treatment of Tobacco use and Dependence and the Society for Research on Nicotine and Tobacco. Nicotine Tob Res. 2014 Jul; 2014 Jun 11. PMID: 24919399
• Forray A, Gotman N, Kershaw T, Yonkers KA: Perinatal smoking and depression in women with concurrent substance use. Addict Behav. 2014 Apr; 2013 Dec 17. PMID: 24447885
• Forray A, Sofuoglu M: Future pharmacological treatments for substance use disorders. Br J Clin Pharmacol. 2014 Feb. PMID: 23039267
• Yonkers KA, Forray A, Howell HB, Gotman N, Kershaw T, Rounsaville BJ, Carroll KM: Motivational enhancement therapy coupled with cognitive behavioral therapy versus brief advice: a randomized trial for treatment of hazardous substance use in pregnancy and after delivery. Gen Hosp Psychiatry. 2012 Sep-Oct; 2012 Jul 12. PMID: 22795046
• Yonkers KA, Gotman N, Smith MV, Forray A, Belanger K, Brunetto WL, Lin H, Burkman RT, Zelop CM, Lockwood CJ: Does antidepressant use attenuate the risk of a major depressive episode in pregnancy? Epidemiology. 2011 Nov. PMID: 21900825
• Yonkers KA, Gotman N, Kershaw T, Forray A, Howell HB, Rounsaville BJ: Screening for prenatal substance use: development of the Substance Use Risk Profile-Pregnancy scale. Obstet Gynecol. 2010 Oct. PMID: 20859145
• Forray A, Focseneanu M, Pittman B, McDougle CJ, Epperson CN: Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum period. J Clin Psychiatry. 2010 Aug; 2010 May 18. PMID: 20492843
• Forray A, Mayes LC, Magriples U, Epperson CN: Prevalence of post-traumatic stress disorder in pregnant women with prior pregnancy complications. J Matern Fetal Neonatal Med. 2009 Jun. PMID: 19488936
• Forray A, Ostroff RB: The use of electroconvulsive therapy in postpartum affective disorders. J ECT. 2007 Sep. PMID: 17804998

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