Antidepressants Are Safe: Final Word?
Results from a large umbrella review of 45 meta-analyses that included > 1000 observational studies show that “there is no convincing evidence of a link between antidepressant use and adverse health outcomes.” According to Medscape: “Some experts urge caution in interpreting the results. "While the methods of this review are sound … and the discussion of these meta-analyses is balanced, an important limitation of meta-analysis and umbrella reviews is the risk of reductionism," write Michael Bloch, MD, Victor Avila-Quintero, MD, and Jose Flores, MD, PhD, all from Yale University School of Medicine. The editorialists say determining the risks of medication exposure during pregnancy is "important and of great concern" to families, physicians, and children. "Systematic reviews, meta-analyses, and the umbrella reviews will report more precise estimates of associations that are subject to confounding and bias, leading to false accuracy and certainty," they conclude.
Treatment Resistant Depression&Rapid-Acting Antidepressants
Ketamine, originally used as an anesthesia medicine and later abused as a "club drug," may be one of the most important developments for treating depression. Dr. John H. Krystal, M.D., chair of the Yale School of Medicine Department of Psychiatry and professor of translational research, psychiatry and neuroscience, discusses his groundbreaking study on the subject.
Krystal Among New Leaders of YCCI
The Yale Center for Clinical Investigation (YCCI) has announced the appointment of Brian R. Smith, MD, and John H. Krystal, MD ’84, as co-directors of the center and co-principal investigators of Yale’s Clinical and Translational Science Award (CTSA). Eric Jose Velazquez, MD, becomes deputy director of clinical trials innovation for YCCI.
Krystal and Nunez-Smith Are Honored by Association for Clinical and Translational Science
John H. Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research, chair and professor of psychiatry, and professor of neuroscience; and Marcella Nunez-Smith, MD, MHS, associate professor of medicine (general medicine) and of epidemiology (chronic diseases), have been chosen for awards by the Association for Clinical and Translational Science.
Yale Child Study Center to Partner with Scholastic on New Literacy Research
The Yale Child Study Center and Scholastic have launched a new joint research endeavor: the Yale Child Study Center–Scholastic Collaborative for Child & Family Resilience. The collaborative will focus on the intersection of literacy and health across a range of education content areas — i.e. early childhood, social emotional learning and teaching, equity and social justice, and family and community engagement — with the ultimate goal of improving academic and mental health outcomes for children and their families.
Researchers Describe Novel Interventions for Borderline Personality Disorder
Sarah Fineberg MD PhD was one of four speakers in an APA Symposium in May 2018 focused on novel treatments for Borderline Personality Disorder (BPD). She discussed a new clinical trial she is starting at Yale testing Ketamine as a treatment for BPD.
Videogame boosts sex health IQ and attitudes in minority teens
A videogame designed by Yale researchers to promote health and reduce risky behavior in teens improves sexual health knowledge and attitudes among minority youth, according to a new study. The findings validate the value of the videogame as a tool to engage and educate teens at risk for HIV and other sexually transmitted infections (STIs), said the researchers.
CESI Team Awarded £2m Grant to Establish Global Research Group on ECD for Peacebuilding
An interdisciplinary research team from the Centre for Evidence and Social Innovation (CESI) has been awarded a £2m grant to study the potential for ECD (early childhood development) programmes to promote sustainable development and peacebuilding. The CESI team, led by Professor Paul Connolly (education), will work with several strategic partners, including UNICEF, the Yale Child Study Center, the Harvard Humanitarian Initiative, the Global TIES for Children research center at New York University and the Early Childhood Peace Consortium.