2025
Equitable Collaboration Between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research.
Cabrera-Mendoza B, Burmeister M, Rietschel M, Crepaz-Keay D, Balhara YPS, Seedat S, Marshe V, Hemmings S, Peterson R, Kaushik R, Viswanath B, Sud R, Haldar P, Johnstone M, Cherian AV, Lencz T, Zinkstok J, Polimanti R, Mueller DJ, Lázaro-Muñoz G, Liu C, John N 1st, Nicolini H, Walss-Bass C, Santoro M, Satapathy S, Behera C, Docherty AR. Equitable Collaboration Between LMIC and HIC Researchers, Part I: A Preliminary Framework for Capacity Building in Psychiatric Genetics Research. Am J Med Genet B Neuropsychiatr Genet 2025, e33042. PMID: 40635475, DOI: 10.1002/ajmg.b.33042.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe Psychiatric Genomics Consortium: discoveries and directions
Agrawal A, Bulik C, Abebe D, Andreassen O, Atkinson E, Choi K, Corvin A, Davies H, Davis L, Docherty A, Edenberg H, Franke B, Gelernter J, Giusti-Rodríguez P, Hettema J, Hjerling-Leffler J, Huang H, Johnson E, Lewis C, Lu Y, Lynall M, Martin J, McIntosh A, Montalvo-Ortiz J, Mullins N, Nievergelt C, O'Connell K, O'Donovan M, Okewole A, Peterson R, Posthuma D, Sebat J, Smoller J, Sud R, Viswanath B, Walters J, Won H, Wray N, Sullivan P, Consortium T. The Psychiatric Genomics Consortium: discoveries and directions. The Lancet Psychiatry 2025 PMID: 40582370, DOI: 10.1016/s2215-0366(25)00124-5.Peer-Reviewed Original ResearchPsychiatric Genomics ConsortiumGenome-wide association studiesFunctional genomics dataRare genetic variationPsychiatric disordersGenomic dataAssociation studiesGenetic variationGenomic discoveriesNeurodevelopmental conditionsPolygenic riskPolygenic scoresGenomics ConsortiumGenetic causeRare variantsRare variationImplementation processGlobal morbidityFunctional attributesPriority areasIntegrated findingsMultiple psychiatric disordersNext phaseVariantsDiscoveryCross-jurisdictional factors linked to gambling frequency in adolescents from 28 European countries: a machine learning approach
Testa G, Ruiz-Iniesta A, García O, Tarragón E, Soriano V, Benedetti E, Cerrai S, Molinaro S, Brand M, Potenza M, Mestre-Bach G. Cross-jurisdictional factors linked to gambling frequency in adolescents from 28 European countries: a machine learning approach. Psychiatry Research 2025, 351: 116602. PMID: 40578225, DOI: 10.1016/j.psychres.2025.116602.Peer-Reviewed Original ResearchSingle-cell transcriptomic and chromatin dynamics of the human brain in PTSD
Hwang A, Skarica M, Xu S, Coudriet J, Lee C, Lin L, Terwilliger R, Sliby A, Wang J, Nguyen T, Li H, Wu M, Dai Y, Duan Z, Srinivasan S, Zhang X, Lin Y, Cruz D, Deans P, Huber B, Levey D, Glausier J, Lewis D, Gelernter J, Holtzheimer P, Friedman M, Gerstein M, Sestan N, Brennand K, Xu K, Zhao H, Krystal J, Young K, Williamson D, Che A, Zhang J, Girgenti M. Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD. Nature 2025, 1-11. PMID: 40533550, DOI: 10.1038/s41586-025-09083-y.Peer-Reviewed Original ResearchPost-traumatic stress disorderPrefrontal cortexDorsolateral prefrontal cortexHuman prefrontal cortexTraumatic stress responseHuman brainDepressive disorderStress disorderTrauma exposureCell type-specific contextRegulatory mechanismsGABAergic transmissionCell-type clusteringCell type-specific mannerMolecular regulatory mechanismsGlucocorticoid signalingGene expression changesChromatin dynamicsCredible variantsDisordersTranscriptional regulationEpigenetic dataCortexPersistent effectsPolygenic disorderFor Whom Is Sexual Abuse Related to Compulsive Sexual Behaviors? Timing of Abuse and Sociodemographic Characteristics as Potential Moderators Across 42 Countries
Vaillancourt-Morel M, Bergeron S, Gewirtz-Meydan A, Zippan N, Nagy L, Koós M, Kraus S, Demetrovics Z, Potenza M, Bőthe B. For Whom Is Sexual Abuse Related to Compulsive Sexual Behaviors? Timing of Abuse and Sociodemographic Characteristics as Potential Moderators Across 42 Countries. Archives Of Sexual Behavior 2025, 1-20. PMID: 40481341, DOI: 10.1007/s10508-025-03162-x.Peer-Reviewed Original ResearchCompulsive sexual behaviorSexual abuseSexual orientationCategory of sexual abuseTime of abuseOnline self-report measuresSexual behaviorComplex pattern of findingsUnwanted sexual experiencesCountry of residenceSelf-report measuresPansexual participantsPattern of findingsAbusive relationsSex surveysCisgender menSmall effect sizesSexual experienceRelationship statusPotential moderatorsCross-cultural studiesAbuse categoriesAbuseYounger participantsEffect sizeSmartphone Apps for Problematic Pornography Use: A Review of Content and Quality
Hart-Derrick V, Virani S, Zadeh O, Genovese N, Engel J, Ponce Martinez C, Potenza M, McCurdy L. Smartphone Apps for Problematic Pornography Use: A Review of Content and Quality. Current Addiction Reports 2025, 12: 54. DOI: 10.1007/s40429-025-00669-0.Peer-Reviewed Original ResearchMobile App Rating ScaleProblematic pornography usePornography useMHealth appsCognitive-behavioral therapyEfficacious psychosocial treatmentsCognitive-behavioral skillsNegative psychosocial consequencesPsychosocial treatmentsRelationship difficultiesPsychological distressRating ScaleEngagement subscalesReview of contentSexual expectationsPsychosocial consequencesAccess treatmentSummaryOur resultsGoal settingHigher scoresMHealthSmartphone appMindfulness/meditationApp StorePornographyCortisol response patterns to stress correlated to white matter integrity and duration of illness in patients with schizophrenia
Jiang X, Gou M, Yin Y, Chen W, Li Y, Chen S, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Wang J, Li H, Yu T, Wang Z, Zhang P, Huang J, Tian L, Kochunov P, Li C, Hong L, Tan Y. Cortisol response patterns to stress correlated to white matter integrity and duration of illness in patients with schizophrenia. Psychoneuroendocrinology 2025, 179: 107501. PMID: 40479922, DOI: 10.1016/j.psyneuen.2025.107501.Peer-Reviewed Original ResearchCortisol response patternsDuration of illnessDiffusion tensor imagingCortisol levelsWM integrityPositive and Negative Syndrome ScaleResponse to acute stress exposureHC groupPaced Auditory Serial Addition TaskResponse patternsNegative Syndrome ScaleFirst-episode schizophreniaBiomarkers of schizophreniaAcute stress exposureWhite matter integrityWM microstructural integrityWM tract integritySalivary cortisol levelsSyndrome ScaleChronic schizophreniaClinical psychopathologyCortisol reactivitySchizophrenia pathogenesisWhite matterBrain regionsPsychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults
Didriksen M, Daníelsdottir H, Bjarnadóttir M, Overstreet C, Choi K, Christoffersen L, Mikkelsen C, Aspelund T, Hauksdóttir A, Thordardottir E, Jakobsdóttir J, Tómasson G, Erikstrup C, Aagaard B, Bruun M, Ullum H, Sørensen E, Fischer I, Pietrzak R, Gelernter J, Campbell-Sills L, Stein M, Werge T, Pedersen O, Valdimarsdóttir U, Ostrowski S, Schork A. Psychometric properties and socio-demographic correlates of the Connor-Davidson Resilience Scale in three large population-based cohorts including Danish and Icelandic adults. Journal Of Mood And Anxiety Disorders 2025, 10: 100112. DOI: 10.1016/j.xjmad.2025.100112.Peer-Reviewed Original ResearchMeasures of psychological resilienceCD-RISC-10Connor-Davidson Resilience ScalePsychometric propertiesCD-RISC-10 scoresPsychological resilienceResilience ScalePopulation-based cohortExploratory factor analysisDepressive disorderDepressive symptomsLongitudinal stabilityInternal consistencyUnidimensional measureConstruct validitySocio-demographic correlatesFactor analysisPhysical healthLower scoresHigher scoresResilient cohortsDanish Blood Donor StudyIcelandic adultsDanish individualsBlood Donor StudyRecommendations for Diagnosing and Quantifying treatment outcomes in clinical trials of compulsive sexual behavior disorder
Engel J, Kraus S, McCurdy L, Potenza M. Recommendations for Diagnosing and Quantifying treatment outcomes in clinical trials of compulsive sexual behavior disorder. Addictive Behaviors Reports 2025, 21: 100610. DOI: 10.1016/j.abrep.2025.100610.Peer-Reviewed Original ResearchCompulsive sexual behaviorCompulsive sexual behavior disorderTreatment of compulsive sexual behaviourSexual behavior disorderTreatment outcome studiesMechanisms of changeNeuropsychological measuresMeasures of quality of lifeParaphilic interestsPrefrontal areasClinical interviewQuantify treatment outcomesProblem behaviorsBehavioral disordersBehavioral engagementReward systemTreatment studiesTreatment trialsOutcome studiesSexual behaviorMoral judgmentTreatment outcomesDiagnostic criteriaDisordersTreatment changesModeration of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate
Kranzler H, Jinwala Z, Davis C, Xu H, Biernacka J, Zhou H, Kember R, Gelernter J, Feinn R. Moderation of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate. Alcohol Clinical And Experimental Research 2025, 49: 1297-1305. PMID: 40445294, PMCID: PMC12173784, DOI: 10.1111/acer.70052.Peer-Reviewed Original ResearchConceptsHeavy drinking daysAlcohol use disorderProblematic alcohol useAlcohol-related problemsPlacebo-controlled trialModerators of treatment outcomePlacebo-controlled trial of topiramateReduce heavy drinking daysTreat alcohol use disorderAlcohol-related traitsTrial of topiramateResponse to topiramateEffects of topiramateTime to relapseGenome-wide association studiesTopiramate's effectsAUD treatmentDrinking daysUse disorderTopiramate groupPolygenic riskHeavy drinkingAlcohol usePharmacogenetic approachShort IndexThe genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.Peer-Reviewed Original ResearchGenomic structural equation modelingCannabis use disorderCannabis usePsychiatric disordersUse disorderStructural equation modelingIncreased rates of psychiatric disordersIncreasing prevalence of cannabis useRates of psychiatric disordersPrevalence of cannabis useThree-factor modelEquation modelingDepressive disorderPsychiatric traitsCannabisLocal genetic correlationDisordersGenetic correlationsMendelian randomization analysisTraitsRandomization analysisSchizophreniaADHDColocalization analysisIncreased riskSex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias
He J, Cabrera‐Mendoza B, Friligkou E, Mecca A, van Dyck C, Pathak G, Polimanti R. Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias. Alzheimer's & Dementia 2025, 21: e70215. PMID: 40421744, PMCID: PMC12107445, DOI: 10.1002/alz.70215.Peer-Reviewed Original ResearchConceptsSocioeconomic factorsFamily historySocioeconomic statusFamily history of Alzheimer's diseaseAssociation of socioeconomic factorsHistory of Alzheimer's diseaseUs Research ProgramCognitive performanceHigher socioeconomic statusSex-specific associationsAlzheimer's disease assessmentSex differencesUK BiobankADRDAlzheimer's diseaseGenetically informed analysesDementiaSample sizeSexGenetic analysisAlzheimerLimited informationStatusConfoundingBiobankAnalysis of associated factors affecting hematoma evacuation rates in spontaneous intracerebral hemorrhage with stereotactic aspiration combined with catheter drainage
Luo X, Song K, Zhuo L, Lin F, Gao Z, He Q, Zheng Y, Lian K, Shangguan H, Luo X, Lin Y, Kang D, Fang W. Analysis of associated factors affecting hematoma evacuation rates in spontaneous intracerebral hemorrhage with stereotactic aspiration combined with catheter drainage. Scientific Reports 2025, 15: 17759. PMID: 40404752, PMCID: PMC12098909, DOI: 10.1038/s41598-025-01754-0.Peer-Reviewed Original ResearchConceptsHematoma evacuationStereotactic aspirationCatheter drainageStereotactic surgeryRisk factorsHE ratesSpontaneous intracerebral hemorrhageHematoma evacuation rateIndependent risk factorBootstrap internal validationMultivariate logistic analysisPredictive scoring modelROC curve analysisPooled individual dataAUC valuesMultivariate logistic regressionBlend signCutoff valueIntracerebral hemorrhageDrainage tubeInternal validityPrimary outcomeHematoma edgeSurgical efficiencyLogistic analysisUnveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study
Xu J, Liu Z, Wu L, Pei F, Jiang H, Cheng C, Yang W, Yuan J, Polimanti R, Yang Y. Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study. Npj Cardiovascular Health 2025, 2: 17. DOI: 10.1038/s44325-025-00054-w.Peer-Reviewed Original ResearchLinkage disequilibrium score regressionGenetic correlationsPleiotropic analysisPleiotropy analysisGut microbiotaGenetic pathwaysMicrobial influenceScore regressionPleiotropic effectsGenetic linkPathwayHeart diseaseButyricicoccusMicrobiotaGenesGutComposite null hypothesisVariantsGastrointestinal disordersCausal effectsLinkageDiseaseIBDAssociations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity – ERRATUM
SooHoo J, Davis C, Han A, Jinwala Z, Gelernter J, Feinn R, Kranzler H. Associations of Childhood Adversity and Polygenic Scores with Substance Use Initiation and Disorder Severity – ERRATUM. Psychological Medicine 2025, 55: e159. PMID: 40400391, PMCID: PMC12115262, DOI: 10.1017/s0033291725100615.Peer-Reviewed Original ResearchCorrection: Sex differences in problematic pornography use among adolescents: a network analysis
Villena-Moya A, Potenza M, Granero R, Paiva Ú, Arrondo G, Chiclana-Actis C, Fernández-Aranda F, Jiménez-Murcia S, Normand E, Ballester L, Mestre-Bach G. Correction: Sex differences in problematic pornography use among adolescents: a network analysis. BMC Psychology 2025, 13: 526. PMID: 40394716, PMCID: PMC12090645, DOI: 10.1186/s40359-025-02878-8.Peer-Reviewed Original ResearchPrescription Pain Medication Misuse with and Without Heroin Use Among Adolescents: relationships with Routine Healthcare, Family Support, Academic Performance, Violence, and Other Risky Behaviors
Jalilian-Khave L, Stefanovics E, Zhai Z, Potenza M. Prescription Pain Medication Misuse with and Without Heroin Use Among Adolescents: relationships with Routine Healthcare, Family Support, Academic Performance, Violence, and Other Risky Behaviors. Substance Use & Misuse 2025, 60: 1400-1410. PMID: 40383936, PMCID: PMC12187537, DOI: 10.1080/10826084.2025.2499945.Peer-Reviewed Original ResearchConceptsPrescription pain medication misusePain medication misuseFamily supportHealthcare participantsRisky behaviorsHeroin useMedication misuseOpioid misuseYouth Risk Behavior Survey dataPrescription pain medicationBehavior Survey dataRoutine healthcareHealthcare utilizationPublic health crisisChi-square analysisHigher oddsSurvey dataOdds ratioPain medicationHigh school respondentsAdjusted modelsAcademic performanceNegative healthOddsHealth crisisCell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs
Ward T, Qu P, Leung L, Zhou B, Muench K, Khechaduri A, Plastini M, Charlton C, Pattni R, Ho S, Ho M, Huang Y, Zhou P, Hallmayer J, Mourrain P, Palmer T, Zhang X, Urban A. Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs. European Journal Of Human Genetics 2025, 1-10. PMID: 40374944, DOI: 10.1038/s41431-025-01856-3.Peer-Reviewed Original ResearchCopy number variantsDNA methylation patternsGlobal reprogrammingMethylation patternsInduced pluripotent stem cellsNeuropsychiatric copy number variantsGene expressionDifferentially expressed genesInduced neuronsCell-type specific alterationsGenome-wideDNA methylomeDuplicate genotypingHuman genomeGene familyLocal genomesDNA methylationInduced pluripotent stem cell lineGenesMolecular etiologyDNAGenomePluripotent stem cellsProtocadherinTranscriptomeUnraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program
Pathak G, Koller D, Cabrera-Mendoza B, Nono Djotsa A, Wendt F, De Lillo A, Friligkou E, He J, Kouakou M, Duong L, Vahey J, Steele L, Quaden R, Harrington K, Ahmed S, Gaziano J, Concato J, Zhao H, Radhakrishnan K, Gelernter J, Gifford E, Aslan M, Helmer D, Hauser E, Polimanti R. Unraveling the genetics of gulf war illness in diverse participants enrolled in the million veteran program. Human Molecular Genetics 2025, ddaf075. PMID: 40366759, DOI: 10.1093/hmg/ddaf075.Peer-Reviewed Original ResearchPolygenic scoresGulf War IllnessGenome-wide dataDepression polygenic scoresPhenome-wide analysisDiverse ancestral backgroundsT2D polygenic scoreAssociated with higher oddsGulf War eraPolygenic architectureAncestral backgroundVeteran ProgramChronic conditionsHigher oddsType 2 diabetesGW veteransVeteransDisease pathogenesisDiverse participantsGulf WarOddsPhysical strengthIllnessComprehensive assessmentAnxietyPolygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms
Han A, Davis C, Jinwala Z, SooHoo J, Gelernter J, Feinn R, Kranzler H. Polygenic risk and childhood adversity as moderators of drug and alcohol withdrawal symptoms. Drug And Alcohol Dependence 2025, 273: 112712. PMID: 40449208, DOI: 10.1016/j.drugalcdep.2025.112712.Peer-Reviewed Original ResearchConceptsAdverse childhood eventsSubstance use disordersPolygenic scoresEUR individualsWithdrawal symptomsWithdrawal severityChildhood adversitySubstance useHigher polygenic scoreAssociated with tobaccoDevelopment of substance use disordersSemi-structured diagnostic instrumentMultivariate regression modelReturn to substance useTobacco withdrawal symptomsPolygenic riskManagement of withdrawal symptomsIndividual withdrawal symptomsStop substance useAlcohol withdrawal severitySecondary analysisAlcohol withdrawal symptomsSevere withdrawal symptomsOpioid withdrawal symptomsChildhood events
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