2025
Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis
Zhang X, Zhang H, Shao Y, Li Y, Zhang F, Zhang H. Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis. Translational Psychiatry 2025, 15: 190. PMID: 40467551, PMCID: PMC12137653, DOI: 10.1038/s41398-025-03396-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexSuperior frontal gyrusMedian cingulate gyrusInferior frontal gyrusResting-state functional connectivityBrain reward circuitsReward circuitSUD patientsPrefrontal cortexFamily-wise errorFrontal gyrusUse disorderCortical-striatal-thalamic-cortical circuitWhole-brain rs-fMRI studiesReduced resting-state functional connectivityDorsal anterior cingulate cortexResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsPatterns of substance use disordersAssociated with impulsivityStages of addictionSubstance use disordersRs-fMRI studiesBackgroundSubstance use disordersGambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome?
Mestre-Bach G, Potenza M, Granero R, Håkansson A, Gómez-Peña M, Perales I, Vicó À, Uríszar J, Fernández-Aranda F, Sánchez I, Jiménez-Murcia S. Gambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome? Journal Of Behavioral Addictions 2025, 14: 465-479. PMID: 40116860, PMCID: PMC11974433, DOI: 10.1556/2006.2025.00023.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyGambling disorderPornography useEmotion regulationGD severityTreatment outcomesCognitive-behavioral therapy approachCognitive-behavioral therapy sessionsTreatment outcomes of individualsCo-occurrence of GDCo-occurrenceMental health concernsImprove treatment adherenceBehavioral addictionsTreatment dropoutOutcomes of individualsWeekly sessionsTreatment adherencePsychopathologyGamblingSessionsDisordersAssociated with higher likelihoodRelapseImpulseCurrent interpretations of the I-PACE model of behavioral addictions
Brand M, Müller A, Wegmann E, Antons S, Brandtner A, Müller S, Stark R, Steins-Loeber S, Potenza M. Current interpretations of the I-PACE model of behavioral addictions. Journal Of Behavioral Addictions 2025, 14: 1-17. PMID: 40063161, PMCID: PMC11974429, DOI: 10.1556/2006.2025.00020.Peer-Reviewed Original ResearchConceptsI-PACE modelI-PACEBehavioral addictionsInteraction of Person-Affect-Cognition-ExecutionBehavioral addiction researchCue-reactivityDesire thinkingCompulsive behaviorsExecutive functionAddictive behaviorsNegative reinforcementAddiction researchPermissive beliefsAddiction theoryAddiction fieldSelf-controlAddictionCravingEmpirical findingsTheory buildingClinical careStimulate researchGratificationBehaviorContext of changesKleptomania on the impulsive–compulsive spectrum. Clinical and therapeutic considerations for women
Munguía L, Baenas-Soto I, Granero R, Fábregas-Balcells M, Gaspar-Pérez A, Rosinska M, Potenza M, Cuquerella Á, Tapia-Martínez J, Cabús-Grange R, Taranilla-Castro A, Macharé-Alberni M, Talón-Navarro M, Fernández-Aranda F, Jiménez-Murcia S. Kleptomania on the impulsive–compulsive spectrum. Clinical and therapeutic considerations for women. Scientific Reports 2025, 15: 7886. PMID: 40050325, PMCID: PMC11885670, DOI: 10.1038/s41598-025-85705-9.Peer-Reviewed Original ResearchConceptsImpulsive-compulsive spectrumDSM-5 criteriaClinical groupsDSM-5Personality featuresSemi-structured clinical interviewTreatment outcomesHarm avoidance scoresCognitive behavioral treatmentHealthy control individualsSample of female patientsImpact treatment outcomesPoor treatment outcomesCompulsive featuresBehavioral treatmentHigher impulsivityAvoidance scoresClinical interviewKleptomaniaInvestigate treatment outcomesCharacteristics of peopleFemale participantsPsychopathologyClinical samplesTreatment approaches
2024
Differential Mapping of Psychopathic Traits and General Psychopathology in a Large Young Adult Sample.
Carlisi C, Fielder J, Knodt A, Romer A, Hariri A, Viding E. Differential Mapping of Psychopathic Traits and General Psychopathology in a Large Young Adult Sample. Journal Of Personality Disorders 2024, 38: 535-558. PMID: 39705101, DOI: 10.1521/pedi.2024.38.6.535.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntisocial Personality DisorderFemaleHumansImpulsive BehaviorLife StyleMaleMental DisordersPsychopathologyStudentsYoung AdultConceptsPsychopathic traitsAntisocial facet of psychopathyBehavioral features of psychopathyFacets of psychopathyFeatures of psychopathySample of young adultsYoung adult sampleMental health problemsU.S. undergraduate studentsAntisocial facetPersonality disorderLifestyle facetGeneral psychopathologyAffective facetsAntisocial behaviorExternalizing behaviorsAdult samplesPsychopathologyPsychopathyInternalizing behaviorsBehavioral featuresUndergraduate studentsYoung adultsLifestyle traitsDifferential mappingDistinct patterns of hippocampal subfield volumes predict coping strategies, emotion regulation, and impulsivity in healthy adults
Fallahi M, Sahebekhtiari K, Hosseini H, Aliasin M, Noroozi M, Moghadam Fard A, Aarabi M, Gulisashvili D, Shafie M, Mayeli M. Distinct patterns of hippocampal subfield volumes predict coping strategies, emotion regulation, and impulsivity in healthy adults. Brain Imaging And Behavior 2024, 18: 1100-1120. PMID: 39103671, DOI: 10.1007/s11682-024-00904-8.Peer-Reviewed Original Research
2023
On the impulsivity path: Examining the unique and conjoint relations between emotion‐ and non‐emotion‐related impulsivity, internalizing symptoms, alcohol use, and physical health parameters
Javelle F, Schlagheck M, Broos H, Timpano K, Joormann J, Zimmer P, Johnson S. On the impulsivity path: Examining the unique and conjoint relations between emotion‐ and non‐emotion‐related impulsivity, internalizing symptoms, alcohol use, and physical health parameters. Journal Of Clinical Psychology 2023, 80: 339-354. PMID: 37883120, PMCID: PMC11170548, DOI: 10.1002/jclp.23608.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingCognitive DysfunctionEmotionsFemaleHumansImpulsive BehaviorMalePsychopathologyConceptsPhysical health parametersPoor sleep qualityPhysical activitySleep qualityHealth parametersAlcohol useAim 1Feelings Trigger ActionPsychopathology symptomsPotential treatment targetLack of followAssociation of ERIFollow-ThroughInternalizing symptomsCombined associationsTreatment targetsSymptomsAim 2Physical healthModerate associationMeasures of impulsivityAssociationControl comparisonSeparate path modelsImpulsivityPlasma concentration of leptin is related to food addiction in gambling disorder: Clinical and neuropsychological implications
Etxandi M, Baenas I, Mora-Maltas B, Granero R, Fernández-Aranda F, Tovar S, Solé-Morata N, Lucas I, Casado S, Gómez-Peña M, Moragas L, del Pino-Gutiérrez A, Tapia J, Valenciano-Mendoza E, Potenza M, Gearhardt A, Diéguez C, Jiménez-Murcia S. Plasma concentration of leptin is related to food addiction in gambling disorder: Clinical and neuropsychological implications. Journal Of Behavioral Addictions 2023, 12: 1019-1031. PMID: 38141066, PMCID: PMC10786224, DOI: 10.1556/2006.2023.00051.Peer-Reviewed Original ResearchConceptsBody mass indexLeptin concentrationsFood addictionPlasma concentrationsHigher body mass indexAppetite-regulating hormonesYale Food Addiction Scale 2.0Gambling disorderSemi-structured clinical interviewLiver-expressed antimicrobial peptide 2Clinical featuresMass indexAppetite regulationHormonal variablesBlood samplesLifetime diagnosisPatientsAntimicrobial peptide 2Clinical InterviewNeuropsychological featuresPoor inhibitory controlAnthropometric variablesEndocrine measuresHormonal concentrationsLeptinInflamed but not impulsive: Acute inflammatory cytokine response does not impact prepotent response inhibition
Madison A, Andridge R, Renna M, Sheridan J, Lustberg M, Ramaswamy B, Wesolowski R, Williams N, Sardesai S, Noonan A, Reinbolt R, Cherian M, Malarkey W, Kiecolt-Glaser J. Inflamed but not impulsive: Acute inflammatory cytokine response does not impact prepotent response inhibition. Journal Of Affective Disorders 2023, 342: 1-9. PMID: 37683942, PMCID: PMC10591975, DOI: 10.1016/j.jad.2023.09.008.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesCytokinesFemaleHumansImpulsive BehaviorInflammationInhibition, PsychologicalTyphoid-Paratyphoid VaccinesConceptsInflammatory cytokine responseCytokine responsesCancer survivorsTyphoid vaccineConners' Continuous Performance TestPostmenopausal breast cancer survivorsInterleukin-1 receptor antagonistResponse inhibitionBreast cancer survivorsInterleukin-6 responseSaline placebo injectionsOutcomes of interestPolysaccharide vaccinationPlacebo injectionsCrossover trialReceptor antagonistSeparate visitsContinuous Performance TestSecondary analysisAspects of impulsivityPlaceboNon-significant resultsPrepotent response inhibitionVaccineInjectionResting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals
Dong X, Zhornitsky S, Wang W, Le T, Chen Y, Chaudhary S, Li C, Zhang S. Resting-State Functional Connectivity of the Dorsal and Ventral Striatum, Impulsivity, and Severity of Use in Recently Abstinent Cocaine-Dependent Individuals. The International Journal Of Neuropsychopharmacology 2023, 26: 627-638. PMID: 37579016, PMCID: PMC10519818, DOI: 10.1093/ijnp/pyac019.Peer-Reviewed Original ResearchMeSH KeywordsCocaineCocaine-Related DisordersHumansImpulsive BehaviorMagnetic Resonance ImagingPrefrontal CortexVentral StriatumConceptsResting-state functional connectivityInferior frontal cortexCocaine-dependent individualsHealthy controlsVentral striatumCocaine useDorsal striatumAbstinent cocaine-dependent individualsCocaine misuseFunctional connectivityYears of drinkingLeft orbitofrontal cortexBIS-11 scoresRecent cocaine useLeft inferior frontal cortexDopaminergic deficitCortex connectivityFrontal cortexSeparate cohortHuman studiesSeverity of useAnimal studiesSecond cohortOrbitofrontal cortexBarratt Impulsivity ScaleDistinct neurocognitive fingerprints reflect differential associations with risky and impulsive behavior in a neurotypical sample
Ruiz S, Brazil I, Baskin-Sommers A. Distinct neurocognitive fingerprints reflect differential associations with risky and impulsive behavior in a neurotypical sample. Scientific Reports 2023, 13: 11782. PMID: 37479846, PMCID: PMC10362008, DOI: 10.1038/s41598-023-38991-0.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremEmotionsHumansImpulsive BehaviorMemory DisordersNeurocognitive DisordersRisk-TakingConceptsImpulsive behaviorNathan Kline Institute-Rockland SampleNeurotypical sampleEpisodic memoryPositive urgencyNegative urgencyEmotion featuresAttention featuresNeurocognitive functionNeurocognitionDifferential associationsIndividual-specific profilesSubstance useNormative rangeExternalizingSubtle variabilityIndian buffet processImpulsivitySubfunctionsMemoryBehaviorLatent featuresDeficitsEngagementIndividualsClinical Correlates of Sports Betting: A Systematic Review
Valenciano-Mendoza E, Mora-Maltas B, Mestre-Bach G, Munguía L, Richard J, Derevensky J, Potenza M, Jiménez-Murcia S. Clinical Correlates of Sports Betting: A Systematic Review. Journal Of Gambling Studies 2023, 39: 579-624. PMID: 37004597, PMCID: PMC10066997, DOI: 10.1007/s10899-023-10196-0.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSystematic reviewMultiple sociodemographic variablesGambling disorderNCBI/PubMedSelf-administered instrumentAPA PsycINFO databasesClinical correlatesCo-occurring psychopathologyGeneral populationPRISMA guidelinesPrevention strategiesClinical diagnosisPsycINFO databasesSubstance useSociodemographic variablesAddictive disordersRelevant studiesVulnerable individualsHigh impulsivityDisordersCertain pathologiesImpulsive malesGambling-related variablesAddictive behaviorsGroups of participantsRelationships Between Impulsivity, Methamphetamine use Disorder and Gambling Disorder
Wang Y, Zuo J, Hao W, Wu L, Liu F, Wang Q, He L, Peng P, Zhou Y, Li M, Yang Q, Wang X, Liu T, Potenza M. Relationships Between Impulsivity, Methamphetamine use Disorder and Gambling Disorder. Journal Of Gambling Studies 2023, 39: 1635-1650. PMID: 36973505, DOI: 10.1007/s10899-023-10201-6.Peer-Reviewed Original ResearchConceptsMethamphetamine use disorderUse disordersMethamphetamine usePotential risk factorsDrug use characteristicsGambling disorderFirst sexual activityClinical characteristicsClinical featuresDrug rehabilitation centersRisk factorsHigh prevalenceDichotomous logistic regressionIndependent sample t-testRehabilitation centerCompulsory drug rehabilitation centerNon-planning impulsivityLogistic regressionSample t-testPrevalenceDisordersSexual activityBarratt Impulsiveness Scale-11T-testFamily members
2022
Are Signals Regulating Energy Homeostasis Related to Neuropsychological and Clinical Features of Gambling Disorder? A Case–Control Study
Etxandi M, Baenas I, Mora-Maltas B, Granero R, Fernández-Aranda F, Tovar S, Solé-Morata N, Lucas I, Casado S, Gómez-Peña M, Moragas L, del Pino-Gutiérrez A, Codina E, Valenciano-Mendoza E, Potenza M, Diéguez C, Jiménez-Murcia S. Are Signals Regulating Energy Homeostasis Related to Neuropsychological and Clinical Features of Gambling Disorder? A Case–Control Study. Nutrients 2022, 14: 5084. PMID: 36501114, PMCID: PMC9736671, DOI: 10.3390/nu14235084.Peer-Reviewed Original ResearchConceptsGambling disorderSemi-structured clinical interviewHigher impulsivity levelsBad psychological stateDysfunctional personality profileHigher cognitive impairmentGd presenceCognitive flexibilityNeuropsychological factorsSubstance use disordersDecision-making strategiesCognitive dimensionsImpulsivity levelsPsychological statePsychometric batteryVulnerability pathwaysHealthy controlsPersonality profilesBody mass indexCognitive impairmentClinical InterviewUse disordersGD groupPresent studyEnergy homeostasisDifficulties in impulse control in adolescents with problematic use of the internet and self-injurious behaviors
Greenberg N, Zhai Z, Hoff R, Krishnan-Sarin S, Potenza M. Difficulties in impulse control in adolescents with problematic use of the internet and self-injurious behaviors. Psychiatry Research 2022, 317: 114919. PMID: 37732862, DOI: 10.1016/j.psychres.2022.114919.Peer-Reviewed Original ResearchGray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability
Chen Y, Ide JS, Li CS, Chaudhary S, Le TM, Wang W, Zhornitsky S, Zhang S, Li C. Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability. Human Brain Mapping 2022, 43: 2634-2652. PMID: 35212098, PMCID: PMC9057091, DOI: 10.1002/hbm.25810.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainChildFemaleGray MatterHumansImpulsive BehaviorMagnetic Resonance ImagingMaleSex CharacteristicsConceptsGray matter volumeImpulsivity traitsPositive urgencyVolumetric correlatesSensation seekingHigher positive urgencyMid-cingulate cortexSex differencesVoxel-based morphometry analysisSmaller gray matter volumeImpulsivity dimensionsSubsample of twinsDistinct correlatesCingulate cortexPrecentral gyrusSubcortical gray matter volumesMatter volumeTotal intracranial volumeSeekingImpulsivityMorphometry analysisPrevious researchInsulaCorrelatesGirlsRethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features
Drachman R, Colic L, Sankar A, Spencer L, Goldman DA, Villa LM, Kim JA, Oquendo MA, Pittman B, Blumberg HP. Rethinking “aggression” and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features. Journal Of Affective Disorders 2022, 303: 331-339. PMID: 35181384, PMCID: PMC9109470, DOI: 10.1016/j.jad.2022.02.047.Peer-Reviewed Original ResearchMeSH KeywordsAdultAggressionBipolar DisorderBrainFemaleGray MatterHumansImpulsive BehaviorMaleSubstance-Related DisordersConceptsSubstance use disordersChildhood Trauma QuestionnaireChildhood maltreatmentBarratt Impulsiveness Scale scoresBipolar disorderAnterior cingulate cortexEmotional childhood maltreatmentElevated mood statesBIS total scoreBilateral orbitofrontal cortexMotor impulsivenessSuicide attemptsOrbitofrontal cortexImpulsiveness scoresMood statesBehavioral dyscontrolCingulate cortexBehavioral constructsTrauma QuestionnaireBrain circuitrySocial behaviorElevated aggressionModest sample sizeBrain regionsSuicide ideationThe steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting
Floris G, Scheggi S, Pes R, Bortolato M. The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting. Brain Research Bulletin 2022, 181: 157-166. PMID: 35122898, PMCID: PMC9012661, DOI: 10.1016/j.brainresbull.2022.01.020.Peer-Reviewed Original ResearchConceptsProbability discountingNucleus accumbensMonoamine-depleting agent reserpinePathological gambling severityImpulse-control disordersEffects of reserpineHighest dose of finasterideRisk of pathological gamblingParkinson's diseaseLever pressPathological gamblingDopamine receptorsGambling severityDoses of finasteridePramipexole treatmentRat's propensityAccumbensPramipexoleRestless legs syndromeImpact of finasterideReceptor upregulationNormalizing effectPD patientsReserpineReceptor expressionClinical and behavior characteristics of individuals who used ketamine
Lee TS, Liu YH, Huang YJ, Tang WK, Wang Y, Hu S, Lin CP, Li CR, Hung CC. Clinical and behavior characteristics of individuals who used ketamine. Scientific Reports 2022, 12: 801. PMID: 35039593, PMCID: PMC8764021, DOI: 10.1038/s41598-022-04832-9.Peer-Reviewed Original ResearchConceptsMemory testLower urinary tract symptomsN-back memory testShort-term recallShort-term memoryDrug-using participantsCigarette smokersImpulsivity measuresTerm recallBehavioral dispositionsPolydrug usersKetamine usersGroup of individualsSex-related behaviorsUrinary tract symptomsPolydrug useDrug-related problemsCross-sectional interviewMemoryRisk behaviorsKetamine useTract symptomsClinical characteristicsParticipantsHIV serostatus
2021
Change in impulsivity is prospectively associated with treatment outcomes for binge-eating disorder
Boswell RG, Gueorguieva R, Grilo CM. Change in impulsivity is prospectively associated with treatment outcomes for binge-eating disorder. Psychological Medicine 2021, 53: 2789-2797. PMID: 34812713, PMCID: PMC9124732, DOI: 10.1017/s003329172100475x.Peer-Reviewed Original ResearchMeSH KeywordsBinge-Eating DisorderCognitive Behavioral TherapyHumansImpulsive BehaviorObesityTreatment OutcomeConceptsEating-disorder psychopathologyCognitive behavioral therapyTreatment outcomesDepression scoresPharmacological treatmentRandomized placebo-controlled clinical trialPlacebo-controlled clinical trialEfficacy of CBTBinge-eating disorderBaseline impulsivityAssociation of rapidClinical trialsTreatment groupsOverall changeDisorder psychopathologyMixed effects modelsOutcomesTreatmentBMIPatientsMeasures of impulsivityScoresPsychopathologyGeneral outcomeImpulsivity
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