2025
Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China
Zhang L, Yu J, Jia X, Su Z, Hu Y, Zhang J, Yang W, Chen X, Hoogendijk E, Huang H, Liu Z. Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China. Journal Of Cachexia Sarcopenia And Muscle 2025, 16: e13862. PMID: 40511588, PMCID: PMC12163542, DOI: 10.1002/jcsm.13862.Peer-Reviewed Original ResearchThe Brain Care Score and its associations with cardiovascular disease and cancer
Senff J, Rivier C, Tack R, Tan B, Kimball T, Brouwers H, Newhouse A, Fricchione G, Tanzi R, Yechoor N, Chemali Z, Anderson C, Rosand J, Falcone G, Singh S. The Brain Care Score and its associations with cardiovascular disease and cancer. Family Practice 2025, 42: cmaf034. PMID: 40464807, DOI: 10.1093/fampra/cmaf034.Peer-Reviewed Original ResearchConceptsLate-life depressionIncidence of cardiovascular diseaseCare scoresCardiovascular diseaseUK Biobank (UKBCases of cardiovascular diseaseRisk of dementiaHealth-related behaviorsIncident cardiovascular diseaseModifiable risk factorsCases of cancerCancer typesUKB participantsCox proportional hazards regression analysisProportional hazards regression analysisHazards regression analysisHealthy agingRisk factorsUKBDementiaRegression analysisFollow-upParticipantsAge-related brain diseasesBaselineSex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias
He J, Cabrera‐Mendoza B, Friligkou E, Mecca A, van Dyck C, Pathak G, Polimanti R. Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias. Alzheimer's & Dementia 2025, 21: e70215. PMID: 40421744, PMCID: PMC12107445, DOI: 10.1002/alz.70215.Peer-Reviewed Original ResearchConceptsSocioeconomic factorsFamily historySocioeconomic statusFamily history of Alzheimer's diseaseAssociation of socioeconomic factorsHistory of Alzheimer's diseaseUs Research ProgramCognitive performanceHigher socioeconomic statusSex-specific associationsAlzheimer's disease assessmentSex differencesUK BiobankADRDAlzheimer's diseaseGenetically informed analysesDementiaSample sizeSexGenetic analysisAlzheimerLimited informationStatusConfoundingBiobankThe United Kingdom Hand and Upper Limb Transplantation Service: A report on the first twelve years of a single-center, single-protocol clinical cohort
Leonard D, Natalwala I, Taplin S, Burdon J, Clarke E, Seitz A, Merchant W, Wilks D, Clark B, Bellew M, Baker R, Bourke G, Kay S. The United Kingdom Hand and Upper Limb Transplantation Service: A report on the first twelve years of a single-center, single-protocol clinical cohort. Journal Of Plastic Reconstructive & Aesthetic Surgery 2025, 106: 331-341. PMID: 40472654, DOI: 10.1016/j.bjps.2025.05.001.Peer-Reviewed Original ResearchConceptsDonor-specific antibodiesFollow-upSingle-centerYears of follow-upSemmes-Weinstein monofilament testBox & Block TestHistory of dialysisLevel of amputationComposite functional scoresPatient satisfaction questionnaireWorld's first caseFunctional outcome measuresUpper limb transplantationMycophenolate mofetilRenal impairmentClinically significant improvementPsychological follow-upImmunosuppression monitoringGraft survivalRejection monitoringSecondary surgeryImmunological evaluationSurgical techniqueMonofilament testSF-36Socioeconomic area deprivation and its relationship with dementia, Parkinson's Disease and all-cause mortality among UK older adults: a multistate modeling approach
Beydoun M, Georgescu M, Weiss J, Noren Hooten N, Beydoun H, Tsai J, Maino Vieytes C, Evans M, Zonderman A. Socioeconomic area deprivation and its relationship with dementia, Parkinson's Disease and all-cause mortality among UK older adults: a multistate modeling approach. Social Science & Medicine 2025, 379: 118137. PMID: 40388863, DOI: 10.1016/j.socscimed.2025.118137.Peer-Reviewed Original ResearchConceptsArea-level deprivationTownsend deprivation indexSocioeconomic statusCardiovascular healthArea-level socioeconomic statusUK older adultsAll-cause mortalityDementia deathsArea deprivationDeprivation indexUK BiobankCox proportional hazardsOlder adultsDementiaParkinson's diseasePD dementiaPotential mediatorsZ-scoreProportional hazardsMultistate modeling approachHealthMortalityMultistate modelWeibull regressionMultistate approachAssociation between endometriosis and type and age of menopause: a pooled analysis of 279 948 women from five cohort studies
Chung H, Hayashi K, Dobson A, Sandin S, Ideno Y, Hardy R, Weiderpass E, Mishra G. Association between endometriosis and type and age of menopause: a pooled analysis of 279 948 women from five cohort studies. Human Reproduction 2025, 40: 1210-1219. PMID: 40304605, PMCID: PMC12127511, DOI: 10.1093/humrep/deaf068.Peer-Reviewed Original ResearchConceptsPremature ovarian insufficiencySpontaneous premature ovarian insufficiencySurgical menopauseNatural menopauseAge of menopauseBilateral oophorectomyOvarian reserveEarly menopauseMenopausal ageCohort studyHazard ratioIncreased riskMenopause typeOdds ratioInternational Agency for Research on CancerImpact ovarian reservePremature surgical menopauseMenopausal hormone therapyStages of endometriosisPremenopausal bilateral oophorectomyManagement of endometriosisMonitoring of womenOvarian preservationPremenopausal hysterectomyFine-Gray subdistribution hazard modelEstimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort
Lin C, Liu R, Sutton C, DeWan A, Forastiere L, Chen K. Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort. Environmental Health Perspectives 2025, 133: 047007. PMID: 40062909, PMCID: PMC12010936, DOI: 10.1289/ehp14723.Peer-Reviewed Original ResearchConceptsRisk of dementiaParametric g-formulaUK Biobank cohortG-formulaBiobank cohortLate lifeFree of dementiaUK Biobank participantsModifiable risk factorsParticulate matterAerodynamic diameter <Annual average standardBiobank participantsHypothetical interventionAmbient particulate matterNo interventionDementiaRisk differenceInterventionRisk factorsHealth benefitsPotential health benefitsCohortRiskParticipantsPolypharmacy and its association with dementia, Parkinson’s disease, and mortality risk in UK adults: a multistate modeling approach
Weiss J, Beydoun M, Georgescu M, Maldonado A, Beydoun H, Noren Hooten N, Tsai J, Song M, Nieva A, Evans M, Zonderman A. Polypharmacy and its association with dementia, Parkinson’s disease, and mortality risk in UK adults: a multistate modeling approach. GeroScience 2025, 47: 4349-4367. PMID: 40080299, PMCID: PMC12181516, DOI: 10.1007/s11357-025-01586-w.Peer-Reviewed Original ResearchConceptsHealth transitionOlder adultsCardiovascular healthLatent class analysisUK Biobank participantsRisks associated with polypharmacyHealth statesAssociated with dementiaPopulation-based cohortAssociated with higher riskYears of follow-upMedication combinationsClass analysisBiobank participantsHealth outcomesPolypharmacy statusPolypharmacy prevalenceSocioeconomic statusUK adultsMortality riskDementiaParkinson's diseasePolypharmacyHealthAdverse outcomesIdentification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities
Loesch D, Garg M, Matelska D, Vitsios D, Jiang X, Ritchie S, Sun B, Runz H, Whelan C, Holman R, Mentz R, Moura F, Wiviott S, Sabatine M, Udler M, Gause-Nilsson I, Petrovski S, Oscarsson J, Nag A, Paul D, Inouye M. Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities. Nature Communications 2025, 16: 2124. PMID: 40032831, PMCID: PMC11876343, DOI: 10.1038/s41467-025-56695-z.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCardiovascular DiseasesComorbidityDiabetes Mellitus, Type 2Extracellular Matrix ProteinsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInsulin-Like Growth Factor Binding Protein 2MaleMiddle AgedMultifactorial InheritanceProteomicsRisk FactorsUnited KingdomConceptsPolygenic scoresNon-coding variantsEtiology of type 2 diabetesMolecular dataVariant effectsPathway enrichmentPlasma proteomic markersPotential therapeutic targetType 2 diabetesProteinDisease biologyPolygenic riskUK BiobankProteomic markersTherapeutic targetPathwayCirculating proteinsGenomeRisk of type 2 diabetesCardiometabolic scoreBiologyInteractive portalVariantsEnrichmentDiabetes comorbiditiesSex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data
Hu Y, Che M, Zhang H. Sex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data. Genetic Epidemiology 2025, 49: e70004. PMID: 40007508, PMCID: PMC11924109, DOI: 10.1002/gepi.70004.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSingle-nucleotide polymorphismsAssociation studiesAlpha geneEstrogen receptor alpha geneGenetic risk factorsRisk lociGenomic associationsMajor depressive disorderMDD phenotypesGenetic studiesGenetic associationRisk factors of MDDGenesESR1 geneUK BiobankESR1Participant genotypesPolymorphismSex-specificSex-specific associationsDepressive disorderRacial/ethnic disparitiesFindings lack consistencyLength of lifeProtective role of parenthood on age-related brain function in mid- to late-life
Orchard E, Chopra S, Ooi L, Chen P, An L, Jamadar S, Yeo B, Rutherford H, Holmes A. Protective role of parenthood on age-related brain function in mid- to late-life. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2411245122. PMID: 39999172, PMCID: PMC11892684, DOI: 10.1073/pnas.2411245122.Peer-Reviewed Original ResearchConceptsBrain functionFunctional connectivityPatterns of brain functionAssociated with higher connectivityConsistent with animal modelsBrain structuresCaregiving environmentAssociated with patternsAge-related alterationsBrain healthAging trajectoriesLate-lifeSpatial topographyAdult brainImpact of caregivingBrainPreliminary findingsHuman parentingImpact of ageCaregiving experienceChildrenCaregiversHigher connectivityEffect of parenthoodOne-bodyBrain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanismsMapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants
Arias-Magnasco A, Lin B, Pries L, Guloksuz S. Mapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants. Psychological Medicine 2025, 55: e16. PMID: 39917825, PMCID: PMC11968124, DOI: 10.1017/s0033291724003015.Peer-Reviewed Original ResearchConceptsMental health phenotypesMental health outcomesExposome-wide association studySymptom dimensionsDiagnostic domainsCommon psychiatric disordersHealth phenotypesHealth outcomesEarly life experiencesMental Health SurveyImproving mental well-beingMental health frameworkAssociation studiesUK Biobank participantsCannabis usePsychiatric disordersEating disordersChildhood adversityPublic health policiesTraumatic eventsMental well-beingMultivariate modelDifferential associationsNeurodevelopmental disordersMental healthA systematic review of military-to-civilian transition, The role of gender
Smith A, Rafferty L, Croak B, Greenberg N, Khan R, Langston V, Sharp M, Stagg A, Fear N, Stevelink S. A systematic review of military-to-civilian transition, The role of gender. PLOS ONE 2025, 20: e0316448. PMID: 39899533, PMCID: PMC11790093, DOI: 10.1371/journal.pone.0316448.Peer-Reviewed Original ResearchConceptsMilitary-to-civilian transitionJoanna Briggs InstituteFemale veteransQualitative studyLoss of military identitySystematic reviewAssessment of study qualityFramework analysis approachCritical Appraisal ChecklistFull-text reviewMilitary serviceEx-service personnelOpen Science FrameworkRemoval of duplicatesMulti-database searchPeer-reviewed literatureSynthesised findingsAppraisal checklistVeteran cultureLeaving serviceStudy qualityProvision of servicesService membersScience FrameworkEligibility criteriaA systemic approach to identifying sustainable community-based interventions for improving adolescent mental health: a participatory group model building and design protocol
Keenan M, Freeman L, Santana de Lima E, Potter K, Hobbs T, Ballard E, Fonagy P. A systemic approach to identifying sustainable community-based interventions for improving adolescent mental health: a participatory group model building and design protocol. Health Research Policy And Systems 2025, 23: 9. PMID: 39806346, PMCID: PMC11727203, DOI: 10.1186/s12961-024-01247-y.Peer-Reviewed Original ResearchConceptsParticipatory group model buildingAdolescent mental healthImprove adolescent mental healthMental healthGroup model buildingMental health of childrenCo-designed interventionsCommunity-based participatoryPerceived mental healthCommunity-based interventionsWell-beingYoung peopleWell-being of young peopleHealth of childrenHealth determinantsSocial determinantsCommunity settingsParticipants' needsCo-designPost-deliveryFidelity evaluationLocal young peopleHealthDesign protocolsCommunity membersUsing Quantitative Bias Analysis to Adjust for Misclassification of COVID‐19 Outcomes: An Applied Example of Inhaled Corticosteroids and COVID‐19 Outcomes
Bokern M, Rentsch C, Quint J, Hunnicutt J, Douglas I, Schultze A. Using Quantitative Bias Analysis to Adjust for Misclassification of COVID‐19 Outcomes: An Applied Example of Inhaled Corticosteroids and COVID‐19 Outcomes. Pharmacoepidemiology And Drug Safety 2025, 34: e70086. PMID: 39776023, PMCID: PMC11706700, DOI: 10.1002/pds.70086.Peer-Reviewed Original ResearchConceptsProbabilistic bias analysisRisk of COVID-19 hospitalisationCOVID-19 hospitalisationChronic obstructive pulmonary diseaseOutcome misclassificationInhaled corticosteroid usersCOVID-19 outcomesIncreased risk of COVID-19 hospitalisationClinical Practice Research Datalink AurumInhaled corticosteroidsLogistic regressionQuantitative bias analysisBias analysisTriple therapySummary-levelObstructive pulmonary diseaseImpact treatment effect estimatesBenzodiazepine and z-drug prescribing in critical care survivors and the risk of rehospitalisation or death due to falls/trauma and due to any cause: a retrospective matched cohort study using the UK Clinical Practice Research Datalink
Mansi E, Rentsch C, Bourne R, Jeffery A, Guthrie B, Lone N. Benzodiazepine and z-drug prescribing in critical care survivors and the risk of rehospitalisation or death due to falls/trauma and due to any cause: a retrospective matched cohort study using the UK Clinical Practice Research Datalink. Intensive Care Medicine 2025, 51: 125-136. PMID: 39774867, DOI: 10.1007/s00134-024-07762-4.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsAcetamidesAdultAgedAged, 80 and overAzabicyclo CompoundsBenzodiazepinesCohort StudiesCritical CareFemaleHumansHypnotics and SedativesMaleMiddle AgedPatient ReadmissionPiperazinesProportional Hazards ModelsPyrimidinesRetrospective StudiesSurvivorsUnited KingdomWounds and InjuriesConceptsCritical care survivorsUK Clinical Practice Research DatalinkClinical Practice Research DatalinkZ-drug prescribingAssociated with increased riskPalliative careZ-drugsAssociated with increased risk of all-causeRisk of all-causeCohort studyConfidence intervalsBenzodiazepines/Z-drugsMental health problemsRisk of rehospitalisationMatched cohort studyVulnerable patient groupRetrospective matched cohort studyTreatment naive individualsAll-causeMethodsRetrospective cohort studyHazard ratioHealth problemsPrescribed benzodiazepinesPrescribingHighest prevalence
2024
Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design
Barron D, Saltoun K, Kiesow H, Fu M, Cohen-Tanugi J, Geha P, Scheinost D, Isaac Z, Silbersweig D, Bzdok D. Pain can’t be carved at the joints: defining function-based pain profiles and their relevance to chronic disease management in healthcare delivery design. BMC Medicine 2024, 22: 594. PMID: 39696368, PMCID: PMC11656997, DOI: 10.1186/s12916-024-03807-z.Peer-Reviewed Original ResearchConceptsChronic diseasesPain ProfileChronic conditionsPatient functionPain conditionsManagement of chronic diseasesChronic disease managementContinuum of careHealthcare delivery systemImprove quality of lifeQuality of lifePainful body partPain interferenceAssociated with clinical variablesUK BiobankWhole-body perspectiveHealth strategiesTreatment of individual patientsPain intensityClinically relevant differencesPatient wellbeingPain managementTreat painful conditionsICD codesMedical specialtiesPatient Characteristics and Practice Variation Associated With New Community Prescription of Benzodiazepine and z‐Drug Hypnotics After Critical Illness: A Retrospective Cohort Study Using the UK Clinical Practice Research Datalink
Mansi E, Rentsch C, Bourne R, Guthrie B, Lone N. Patient Characteristics and Practice Variation Associated With New Community Prescription of Benzodiazepine and z‐Drug Hypnotics After Critical Illness: A Retrospective Cohort Study Using the UK Clinical Practice Research Datalink. Pharmacoepidemiology And Drug Safety 2024, 33: e70056. PMID: 39603606, PMCID: PMC11602247, DOI: 10.1002/pds.70056.Peer-Reviewed Original ResearchConceptsCommunity prescriptionsZ-drugsIllness survivorsRetrospective cohort studyClinical Practice Research Datalink dataPractice variationUK Clinical Practice Research DatalinkClinical Practice Research DatalinkWorsening mental health conditionsCohort studyMultilevel multivariable logistic regressionSurvivors of critical illnessZ-drug prescribingCritical care survivorsPrimary care practicesCritical illnessMental health conditionsZ-drug prescriptionsCritical illness survivorsMultivariate logistic regressionPrescription opioid useCare practicesRisk of adverse eventsHealth conditionsHistory of insomniaInvestigating social orienting in children with Phelan-McDermid syndrome and ‘idiopathic’ autism
San José Cáceres A, Wilkinson E, Cooke J, Baskett V, Blackmore C, Crawley D, Durkin A, Halpern D, Núñez M, Siper P, Murphy D, Foss-Feig J, Kolevzon A, Loth E. Investigating social orienting in children with Phelan-McDermid syndrome and ‘idiopathic’ autism. Journal Of Neurodevelopmental Disorders 2024, 16: 64. PMID: 39563223, PMCID: PMC11575217, DOI: 10.1186/s11689-024-09564-7.Peer-Reviewed Original ResearchConceptsNon-social stimuliPhelan-McDermid syndromeNeurotypical childrenIdiopathic autismAutistic featuresClinical groupsOrienting responseSocial orientationBackgroundPhelan-McDermid syndromeMental ageAutism groupSocial stimuliStimulus typeMotivational difficultiesAutismDevelopmental delay/intellectual disabilityDelayed speechSocial interactionStimuliPMS groupConclusionsThese findingsGroup levelSocial learningChildrenAtypicality
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