2021
Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging
Young BD, Moreland H, Oatmen KE, Freeburg LA, Shahab Z, Herzog E, Miller EJ, Spinale FG. Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging. International Heart Journal 2021, 62: 21-164. PMID: 34544982, DOI: 10.1536/ihj.21-164.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCase-Control StudiesCytokinesEvaluation Studies as TopicFemaleFluorodeoxyglucose F18Heart DiseasesHumansImmunosuppressive AgentsInflammationMaleMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesMiddle AgedPositron-Emission TomographyProspective StudiesRadiopharmaceuticalsReceptors, Interleukin-2Receptors, Tumor Necrosis FactorRisk AssessmentSarcoidosisSeverity of Illness IndexTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AConceptsTumor necrosis factorSoluble cytokine receptorsCardiac sarcoidosisCS patientsMatrix metalloproteinasePlasma MMP-9 levelsFluorodeoxyglucose positron emission tomographyPlasma tumor necrosis factorAnti-inflammatory regimensBiopsy-confirmed sarcoidosisReferent control valuesSarcoidosis disease activityVascular endothelial growth factor receptorHeart failure therapySoluble TNF receptorsEndothelial growth factor receptorMMP-9 levelsSpecific inflammatory pathwaysFDG-PET imagingEndogenous MMP inhibitorsCytokine receptorsPositron emission tomographyCytokine receptor profilesGrowth factor receptorSIL-2R
2020
Quantitative volumetric assessment of baseline enhancing tumor volume as an imaging biomarker predicts overall survival in patients with glioblastoma
Auer TA, Della Seta M, Collettini F, Chapiro J, Zschaeck S, Ghadjar P, Badakhshi H, Florange J, Hamm B, Budach V, Kaul D. Quantitative volumetric assessment of baseline enhancing tumor volume as an imaging biomarker predicts overall survival in patients with glioblastoma. Acta Radiologica 2020, 62: 1200-1207. PMID: 32938221, DOI: 10.1177/0284185120953796.Peer-Reviewed Original ResearchConceptsProgression-free survivalOverall survivalTumor volumeGlioblastoma multiformeMagnetic resonance imagingMultivariable analysisCommon malignant primary brain tumorIntracranial progression-free survivalKarnofsky performance status scoreCranial magnetic resonance imagingMalignant primary brain tumorMedian overall survivalPerformance status scoreOS of patientsCox regression modelSignificant prognostic rolePrimary brain tumorsContrast-enhanced MRI sequencesQuantitative volumetric assessmentResection statusPrognostic roleMethyltransferase statusWorse prognosisEntire cohortNon-invasive methodEvaluation of Cancer Care After Medicaid Expansion Under the Affordable Care Act
Salazar MC, Canavan ME, Walters SL, Herrin J, Schwartz JL, Leapman M, Boffa DJ. Evaluation of Cancer Care After Medicaid Expansion Under the Affordable Care Act. JAMA Network Open 2020, 3: e2017544. PMID: 32990734, PMCID: PMC7525361, DOI: 10.1001/jamanetworkopen.2020.17544.Peer-Reviewed Original ResearchProfiling of gastric cancer cell-surface markers to achieve tumour–normal discrimination
Toh J, Hoppe M, Thakur T, Yang H, Tan K, Pang B, Ho S, Roy R, Ho K, Yeoh K, Tan P, Sundar R, Jeyasekharan A. Profiling of gastric cancer cell-surface markers to achieve tumour–normal discrimination. BMJ Open Gastroenterology 2020, 7: e000452. PMID: 32816956, PMCID: PMC7437876, DOI: 10.1136/bmjgast-2020-000452.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAntigens, CDAntigens, Tumor-Associated, CarbohydrateCA-19-9 AntigenCarcinoembryonic AntigenCell Adhesion MoleculesClaudin-4ClaudinsEpithelial Cell Adhesion MoleculeEvaluation Studies as TopicExome SequencingGenomicsGPI-Linked ProteinsHumansImmunohistochemistryMembrane ProteinsROC CurveSensitivity and SpecificitySingaporeStomach NeoplasmsUp-RegulationConceptsWhole-transcriptome sequencingCell surface markersMultispectral immunohistochemistryPutative cell surface proteinGastric cancerNormal tissuesMatched normal samplesCA72-4Cell surface proteinsTumor tissuesLive imaging approachesAnalysis of cell surface markersMolecular profiling of cancersHighest diagnostic validityIdentification of tumor tissueTranscriptome sequencingCancer Genome AtlasProfile of cancerProtein transcriptsCancer cell surface markersCA19-9Genome AtlasDifferentiated tumorsTissue microarrayTCGA dataStudy protocol for the ACT response pilot intervention: development, implementation and evaluation of a systems-based Agitation Code Team (ACT) in the emergency department
Wong AH, Ray JM, Auerbach MA, Venkatesh AK, McVaney C, Burness D, Chmura C, Saxa T, Sevilla M, Flood CT, Patel A, Whitfill T, Dziura JD, Yonkers KA, Ulrich A, Bernstein SL. Study protocol for the ACT response pilot intervention: development, implementation and evaluation of a systems-based Agitation Code Team (ACT) in the emergency department. BMJ Open 2020, 10: e036982. PMID: 32606062, PMCID: PMC7328814, DOI: 10.1136/bmjopen-2020-036982.Peer-Reviewed Original ResearchMeSH KeywordsEmergency Service, HospitalEvaluation Studies as TopicFeasibility StudiesHealth Plan ImplementationHumansPatient Care TeamPilot ProjectsConceptsEmergency departmentRestraint useCode teamControlled interrupted time series designResponse interventionsRate of restraint useInterrupted time series designAcute care settingDe-escalation techniquesTime series designPeer-reviewed publicationsED staffIdentified teamworkPilot interventionCare settingsHealth systemPatient encountersAgitation managementHuman Investigation CommitteeWorkplace violenceEthical approvalStaff safetyPatient agitationReduce harmSeries designCommunity‐Based Caregiver and Family Interventions to Support the Mental Health of Orphans and Vulnerable Children: Review and Future Directions
Penner F, Sharp C, Marais L, Shohet C, Givon D, Boivin M. Community‐Based Caregiver and Family Interventions to Support the Mental Health of Orphans and Vulnerable Children: Review and Future Directions. New Directions For Child And Adolescent Development 2020, 2020: 77-105. PMID: 32618434, DOI: 10.1002/cad.20352.Peer-Reviewed Original ResearchConceptsMental healthFamily interventionsCognitive-behavioral strategiesCaregiver-child relationshipChild mental healthVulnerable childrenCommunity-based caregiversCultural adaptationIntervention scienceQuasi-experimental designIntervention strategiesMajority of interventionsReview of studiesMajority of studiesCommunity participatory methodsFuture directionsInterventionCaregiversChildrenPossible new directionsNew directionsFindingsHealthSaharan AfricaAdaptation
2019
A qualitative analysis of text message conversations in a breastfeeding peer counselling intervention
Martinez‐Brockman J, Harari N, Goeschel L, Bozzi V, Pérez‐Escamilla R. A qualitative analysis of text message conversations in a breastfeeding peer counselling intervention. Maternal And Child Nutrition 2019, 16: e12904. PMID: 31823503, PMCID: PMC7083457, DOI: 10.1111/mcn.12904.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBreast FeedingCounselingEvaluation Studies as TopicFemaleHealth PromotionHumansMalePeer GroupText MessagingYoung AdultConceptsPeer counselorsPostpartum periodSpecial Supplemental Nutrition ProgramTwo-way text messagingTime of enrollmentSupplemental Nutrition ProgramEarly life nutritionLactation AdviceIntervention armBreastfeeding protectionLife nutritionNutrition ProgramPeer counselling programmeBaby nutritionText message exchangesCounselling interventionBreastfeedingSocial supportText messagingNutritionPresent studyInterventionCounselling programmeAdditional themesText messagesQuantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic Encephalopathy.
Ghassemi MM, Amorim E, Alhanai T, Lee JW, Herman ST, Sivaraju A, Gaspard N, Hirsch LJ, Scirica BM, Biswal S, Moura Junior V, Cash SS, Brown EN, Mark RG, Westover MB. Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic Encephalopathy. Critical Care Medicine 2019, 47: 1416-1423. PMID: 31241498, PMCID: PMC6746597, DOI: 10.1097/ccm.0000000000003840.Peer-Reviewed Original ResearchConceptsHypoxic-ischemic encephalopathyNeurologic outcomeElectroencephalogram featuresAcute hypoxic-ischemic encephalopathyAcademic medical centerBetter prognostic predictionReceiver operator curveNeurologic recoveryComatose patientsPrognostic implicationsCardiac arrestMedical CenterPrognostication performancePrognostic predictionOperator curveLogistic regressionSequential logistic regressionSpecificity thresholdEncephalopathyStatistical associationOutcomesEvaluating the addition of bevacizumab to endocrine therapy as first-line treatment for hormone receptor–positive metastatic breast cancer: a pooled analysis from the LEA (GEICAM/2006-11_GBG51) and CALGB 40503 (Alliance) trials
Martín M, Loibl S, Hyslop T, De la Haba-Rodríguez J, Aktas B, Cirrincione CT, Mehta K, Barry WT, Morales S, Carey LA, Garcia-Saenz JA, Partridge A, Martinez-Jañez N, Hahn O, Winer E, Guerrero-Zotano A, Hudis C, Casas M, Rodriguez-Martin C, Furlanetto J, Carrasco E, Dickler MN, Group G, GBG, Oncology A. Evaluating the addition of bevacizumab to endocrine therapy as first-line treatment for hormone receptor–positive metastatic breast cancer: a pooled analysis from the LEA (GEICAM/2006-11_GBG51) and CALGB 40503 (Alliance) trials. European Journal Of Cancer 2019, 117: 91-98. PMID: 31276981, PMCID: PMC6718694, DOI: 10.1016/j.ejca.2019.06.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBevacizumabBone NeoplasmsBreast NeoplasmsEvaluation Studies as TopicFemaleFollow-Up StudiesFulvestrantHumansLetrozoleMiddle AgedNeoplasm Recurrence, LocalPrognosisReceptors, EstrogenReceptors, ProgesteroneSoft Tissue NeoplasmsSurvival RateTamoxifenConceptsProgression-free survivalClinical benefit rateObjective response rateEndocrine therapyMetastatic breast cancerOverall survivalGrade IIIBreast cancerHormone receptor-positive metastatic breast cancerMedian progression-free survivalAddition of BevSignificant additional toxicityStandard endocrine therapyDe novo diseaseAddition of bevacizumabFirst-line treatmentPredictors of efficacyNovo diseaseRecurrent diseaseLiver eventsEndocrine sensitivityBenefit rateAdditional toxicityPatientsResponse rateA 3D quantitative imaging biomarker in pre-treatment MRI predicts overall survival after stereotactic radiation therapy of patients with a singular brain metastasis
Della Seta M, Collettini F, Chapiro J, Angelidis A, Engeling F, Hamm B, Kaul D. A 3D quantitative imaging biomarker in pre-treatment MRI predicts overall survival after stereotactic radiation therapy of patients with a singular brain metastasis. Acta Radiologica 2019, 60: 1496-1503. PMID: 30841703, DOI: 10.1177/0284185119831692.Peer-Reviewed Original ResearchConceptsIntracranial progression-free survivalSingular brain metastasisStereotactic radiation therapyPre-treatment magnetic resonance imagingMagnetic resonance imagingBrain metastasesPrognostic factorsTumor volumeRadiation therapyCranial magnetic resonance imagingContrast-enhanced MRI scansMultivariable Cox regressionProgression-free survivalIntracranial malignant tumorPrediction of survivalOverall survivalMultivariable analysisPrognostic indexCox regressionRetrospective studyMalignant tumorsQuantitative imaging biomarkersMRI scansPatientsRadiomic biomarkers
2018
Factors Influencing Dietary Practices Among Ghanaian Residents and Liberians Living in a Protracted Refugee Situation in Ghana
Mandelbaum J, Pérez-Escamilla R, Sandow A, Gallego-Pérez DF, Lartey A, Hromi-Fiedler A. Factors Influencing Dietary Practices Among Ghanaian Residents and Liberians Living in a Protracted Refugee Situation in Ghana. Journal Of Nutrition Education And Behavior 2018, 51: 567-577. PMID: 30442569, DOI: 10.1016/j.jneb.2018.09.007.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Cultural ComparisonCross-Sectional StudiesDietEvaluation Studies as TopicFemaleGhanaHumansInterviews as TopicLiberiaMiddle AgedRefugeesYoung AdultConceptsLiberian refugeesRefugee settlementRefugee situationsProtracted Refugee SituationsMixed-method cross-sectional studyNational identityHost communitiesDepth interviewsLocal communitiesRefugeesQualitative dataFood accessGhanaian residentsIterative codingGhanaian womenAccess issuesDietary practicesGhanaiansSocial supportSettlementSensitive programsNeighboring villagesPracticeGhanaCommunitySpatially Resolved and Quantitative Analysis of VISTA/PD-1H as a Novel Immunotherapy Target in Human Non–Small Cell Lung Cancer
Villarroel-Espindola F, Yu X, Datar I, Mani N, Sanmamed M, Velcheti V, Syrigos K, Toki M, Zhao H, Chen L, Herbst RS, Schalper KA. Spatially Resolved and Quantitative Analysis of VISTA/PD-1H as a Novel Immunotherapy Target in Human Non–Small Cell Lung Cancer. Clinical Cancer Research 2018, 24: 1562-1573. PMID: 29203588, PMCID: PMC5884702, DOI: 10.1158/1078-0432.ccr-17-2542.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntigens, CDAntigens, Differentiation, MyelomonocyticB7 AntigensB7-H1 AntigenBiomarkers, TumorCarcinoma, Non-Small-Cell LungCD8-Positive T-LymphocytesEvaluation Studies as TopicFemaleGene Expression Regulation, NeoplasticHumansImmunologic FactorsImmunotherapyLung NeoplasmsMaleMembrane ProteinsMutationProgrammed Cell Death 1 ReceptorRetrospective StudiesConceptsNon-small cell lung cancerHuman non-small cell lung cancerT helper cellsCytotoxic T cellsT cellsPD-1Localized expression patternQuantitative immunofluorescenceTumor-infiltrating lymphocytesCell lung cancerLung cancer casesGenomic analysisTissue microarray formatTumor-associated macrophagesPD-L1 proteinCytoplasmic staining patternClin Cancer ResExpression patternsLow mutational burdenTumor epithelial cellsSpecific genomic alterationsVISTA expressionVISTA proteinPD-L1Immunomodulatory role
2017
A qualitative analysis of men's experiences of binge eating
Carey JB, Saules KK, Carr MM. A qualitative analysis of men's experiences of binge eating. Appetite 2017, 116: 184-195. PMID: 28465183, DOI: 10.1016/j.appet.2017.04.030.Peer-Reviewed Original ResearchA Qualitative Analysis of General Emergency Medicine Providers' Perceptions on Pediatric Emergency Telemedicine.
Kim JW, Tiyyagura G, Langhan M. A Qualitative Analysis of General Emergency Medicine Providers' Perceptions on Pediatric Emergency Telemedicine. Pediatric Emergency Care 2017, Publish Ahead of Print: 856-861. PMID: 28225376, DOI: 10.1097/pec.0000000000001067.Peer-Reviewed Original ResearchConceptsED providersLimitations of telemedicineEmergency departmentTelemedicine programProviders' perceptionsPediatric ED providersAdult stroke patientsGeneral emergency departmentsCritical care settingPatient-related outcomesPediatric emergency patientsPediatric emergency careAudio-recorded semistructured interviewsPediatric telemedicineStroke patientsConnecticut hospitalsApplication of telemedicineCare settingsEmergency patientsEmergency careVideo telemedicineTelemedicine's effectMost childrenPediatric resourcesFurther studies
2015
Quantitative variability of 342 plasma proteins in a human twin population
Liu Y, Buil A, Collins BC, Gillet L, Blum LC, Cheng LY, Vitek O, Mouritsen J, Lachance G, Spector TD, Dermitzakis ET, Aebersold R. Quantitative variability of 342 plasma proteins in a human twin population. Molecular Systems Biology 2015, 11: msb145728. PMID: 25652787, PMCID: PMC4358658, DOI: 10.15252/msb.20145728.Peer-Reviewed Original ResearchConceptsQuantitative variabilityUnique plasma proteinsBlood-based biomarker studiesGenetic controlBiological processesDifferent proteinsDifferent traitsPlasma proteinsProteinAbundance variabilityProtein levelsHuman populationMass spectrometry techniquesSpecific plasma proteinsHuman plasma proteinsGenesRelative contributionTraitsHeritabilitySpectrometry techniquesTwin study designDifferent patternsPopulationClinical biomarkersVariability
2014
Designing and Conducting Simulation-Based Research
Cheng A, Auerbach M, Hunt EA, Chang TP, Pusic M, Nadkarni V, Kessler D. Designing and Conducting Simulation-Based Research. 2014, 133: 1091-1101. PMID: 24819576, DOI: 10.1542/peds.2013-3267.Peer-Reviewed Original Research
2013
Lower Hospital Volume Is Associated With Higher In-Hospital Mortality in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction
Kontos MC, Wang Y, Chaudhry SI, Vetrovec GW, Curtis J, Messenger J. Lower Hospital Volume Is Associated With Higher In-Hospital Mortality in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2013, 6: 659-667. PMID: 24192572, DOI: 10.1161/circoutcomes.113.000233.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIHigh-volume hospitalsLow-volume hospitalsPercutaneous coronary interventionBalloon timeCoronary interventionHospital volumeHigher annual hospital volumeHigher In-Hospital MortalityAnnual hospital volumeLow hospital volumeRoutine coronary stentingIn-Hospital MortalityElevation myocardial infarctionMajority of patientsNew pharmacological agentsHospital mortalityCathPCI RegistryMultivariate adjustmentUnadjusted mortalityCoronary stentingMyocardial infarctionCurrent guidelinesPatient visitsQualitative Evaluation of Just-in-Time Simulation-Based Learning
Kamdar G, Kessler DO, Tilt L, Srivastava G, Khanna K, Chang TP, Balmer D, Auerbach M. Qualitative Evaluation of Just-in-Time Simulation-Based Learning. Simulation In Healthcare The Journal Of The Society For Simulation In Healthcare 2013, 8: 43-48. PMID: 23299050, DOI: 10.1097/sih.0b013e31827861e8.Peer-Reviewed Original Research
2011
Professional Challenges of Non-U.S.-Born International Medical Graduates and Recommendations for Support During Residency Training
Chen PG, Curry LA, Bernheim SM, Berg D, Gozu A, Nunez-Smith M. Professional Challenges of Non-U.S.-Born International Medical Graduates and Recommendations for Support During Residency Training. Academic Medicine 2011, 86: 1383-1388. PMID: 21952056, PMCID: PMC3257160, DOI: 10.1097/acm.0b013e31823035e1.Peer-Reviewed Original ResearchConceptsInternational medical graduatesStandardized interview guideDepth interviewsQualitative interviewsProfessional identityQualitative studyPurposeful sampleProfessional challengesInterviewsInterview guideNon-U.S.United StatesLittle researchMedical graduatesParticular challengesKey elementsThemesHighlight challengesLong historySpecific needsVulnerable transitionNew YorkDiverse groupChallengesImmigrantsLong-term safety experience of ustekinumab in patients with moderate-to-severe psoriasis (Part I of II): Results from analyses of general safety parameters from pooled Phase 2 and 3 clinical trials
Lebwohl M, Leonardi C, Griffiths C, Prinz J, Szapary P, Yeilding N, Guzzo C, Li S, Hsu M, Strober B. Long-term safety experience of ustekinumab in patients with moderate-to-severe psoriasis (Part I of II): Results from analyses of general safety parameters from pooled Phase 2 and 3 clinical trials. Journal Of The American Academy Of Dermatology 2011, 66: 731-741. PMID: 21930328, DOI: 10.1016/j.jaad.2011.06.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleDrug-Related Side Effects and Adverse ReactionsEtanerceptEvaluation Studies as TopicFemaleFollow-Up StudiesHumansImmunoglobulin GMaleMiddle AgedPsoriasisReceptors, Tumor Necrosis FactorRisk AssessmentSafety ManagementSeverity of Illness IndexTime FactorsTreatment OutcomeUstekinumabConceptsRate of AEsUstekinumab-treated patientsAdverse eventsSerious AEsSevere psoriasisSafety profileLong-term safety experiencePrevious short-term reportsCumulative safety dataGeneral safety parametersPlacebo-controlled periodSerious adverse eventsYears of treatmentShort-term reportsCases of demyelinationUstekinumab exposureIL-23Clinical trialsOverall infectionSafety dataACCEPT trialPatientsSimilar findingsSafety experienceTrials
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