2025
Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
Dribin T, Sampson H, Zhang Y, Boyd S, Zhang N, Michelson K, Neuman M, Brousseau D, Mistry R, Freedman S, Aronson P, Bergmann K, Boswell B, Chinta S, Chua W, Cohen A, Cohen J, Daggett A, Davis J, Freeman J, Khanna K, Knoles C, Kwan K, Larsen C, Lee J, Lubell T, Metcalf A, Moake M, Nesiama J, Ngo T, Pulcini C, Russo C, Singh N, Srivastava G, Strutt J, Thapar V, Vander Wyst C, Walsh P, Wolnerman Y, Schnadower D, Academy of Pediatrics P, Kanngiesser A, McGarghan F, Dulchavsky A, Costalez J, DesPain A, Armanious M, Haghnazarian E, Brown-Whitehorn T, Weigert R, Dayan P, Meltzer J, Chowdhury N, Benedetti J, Sinziana C, Handorf A, Ruthford M, Devens M, Mecham C, Holland J, Casas T, Brown J, Panda P, Morrow A, Maready M, Nathani Y, Stevens M, Abraham G, Yen K, Cooper-Sood J, Woolf S. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 484-496. PMID: 40506197, DOI: 10.1016/s2352-4642(25)00139-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnaphylaxisCanadaChildChild, PreschoolEmergency Service, HospitalEpinephrineFemaleHumansInfantMaleRetrospective StudiesTime FactorsUnited StatesConceptsElectronic medical recordsEmergency departmentRetrospective cohort studyCohort studyMedical recordsDocumentation of symptomsCardiovascular involvementHealth-care facilitiesEpinephrine doseAcute allergic reactionsNational Institutes of HealthCumulative incidenceNational Center for Advancing Translational SciencesInstitutes of HealthChildren aged 6 monthsClinical ModificationHospital wardsIncidence rateICD-10Observation periodPrimary outcomeAllergic reactionsSecondary to medicationsInitiation to discontinuationKaplan-Meier analysisRisk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study
Ramgopal S, Aronson P, Lorenz D, Rogers A, Cruz A. Risk Factors for Serious Bacterial Infections Among Young Infants With Hypothermia: Protocol for a Multicenter, Retrospective Case-Control Study. JMIR Research Protocols 2025, 14: e66722. PMID: 40536806, DOI: 10.2196/66722.Peer-Reviewed Original ResearchConceptsEpidemiology of SBIHerpes simplex virusCase-control studyEmergency departmentYoung infantsMultivariable prediction modelRetrospective nested case-control studyBacterial infectionsRetrospective case-control studyManagement of young infantsNested case-control studyUrinary tract infectionOptimal cutoff valueSerious bacterial infectionsSoft tissue infectionsOutcome measuresPediatric Emergency Medicine Collaborative Research CommitteeReceiver operating characteristic curvePediatric emergency departmentOperating characteristics curveUS children's hospitalsMixed effects logistic regressionHSV-positiveBlood culturesPredicting SBIRisk of Bacterial Infections in Febrile Infants 61 to 90 Days Old With Respiratory Viruses.
Aronson P, Mahajan P, Nielsen B, Olsen C, Meeks H, Grundmeier R, Kuppermann N. Risk of Bacterial Infections in Febrile Infants 61 to 90 Days Old With Respiratory Viruses. 2025, 156 PMID: 40506050, DOI: 10.1542/peds.2025-070617.Peer-Reviewed Original ResearchConceptsPrevalence of urinary tract infectionUrinary tract infectionPediatric Emergency Care Applied Research NetworkRespiratory viral testingRespiratory viral infectionsFebrile infantsBacterial meningitisRespiratory virusesSARS-CoV-2Viral testingViral infectionSARS-CoV-2-positive infantsBacterial infectionsRisk of bacterial infectionPrevalence of bacteremiaPrevalence of bacterial infectionRespiratory syncytial virusBlood culturesTract infectionsPositive infantsSyncytial virusNegative infantsBacteremiaMeningitisInfantsSocial Determinants of Health and Healthcare Utilization in Infants With Bronchopulmonary Dysplasia
Urbach H, Ostfeld‐Johns S, McCollum S, Weiss P, Kandil S, Brumer E. Social Determinants of Health and Healthcare Utilization in Infants With Bronchopulmonary Dysplasia. Pediatric Pulmonology 2025, 60: e71153. PMID: 40504047, DOI: 10.1002/ppul.71153.Peer-Reviewed Original ResearchConceptsSocial determinants of healthChildhood Opportunity IndexArea Deprivation IndexHealthcare utilizationED visitsImpact of social determinants of healthSocial determinants of health variablesInfluence of social determinants of healthEmergency departmentAssociated with fewer ED visitsAssociated with increased ED visitsHigh-deprivation neighborhoodsDeterminants of healthBronchopulmonary dysplasiaAdverse health outcomesMediation analysisDeprivation indexHealthcare useSocial determinantsNo significant associationHealth outcomesFollow-upHospital utilizationNeighborhood disadvantageRacial/ethnic differencesPeer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial
Nath B, Desai R, Cook J, Dziura J, Davis-Plourde K, Youins R, Guy K, Pavlo A, Smith E, Smith D, Kangas K, Heckmann R, Hart L, Powsner S, Sevilla M, Evans M, Kumar A, Faustino I, Hu Y, Bellamy C, Wong A. Peer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial. BMJ Open 2025, 15: e103775. PMID: 40484432, PMCID: PMC12161358, DOI: 10.1136/bmjopen-2025-103775.Peer-Reviewed Original ResearchMeSH KeywordsCrisis InterventionEmergency Service, HospitalHumansMental DisordersPeer GroupRandomized Controlled Trials as TopicRestraint, PhysicalSocial SupportConceptsCluster randomised controlled trialEmergency departmentPeer supportDelivery of trauma-informed careStepped-wedge cluster randomised controlled trialExperience of mental illnessPhysical restraintRate of physical restraintBehavioral crisesPeer support workersReduce restraint useSecondary outcomesFollow-up data collectionResponse teamPatient-centred approachPositive patient outcomesTrauma-informed carePeer-reviewed journalsCrisis response teamsUsual careStepped-wedgeIntervention readinessPeer deliveryRestraint useED settingDetection of emergency department patients at risk of dementia through artificial intelligence
Cohen I, Taylor R, Xue H, Faustino I, Festa N, Brandt C, Gao E, Han L, Khasnavis S, Lai J, Mecca A, Sapre A, Young J, Zanchelli M, Hwang U. Detection of emergency department patients at risk of dementia through artificial intelligence. Alzheimer's & Dementia 2025, 21: e70334. PMID: 40457744, PMCID: PMC12130574, DOI: 10.1002/alz.70334.Peer-Reviewed Original ResearchConceptsElectronic health record dataHealth record dataEmergency departmentDetect dementiaDementia detectionYale New Haven HealthRecord dataRisk of dementiaEmergency department patientsBalance detection accuracyDementia algorithmsImprove patient outcomesCare coordinationCare transitionsDementia diagnosisReal-time applicationsClinical decision-makingClinician supportED usePatient safetyProbable dementiaMachine learning algorithmsED workflowED visitsED encountersNovel algorithms & blood‐based biomarkers: Dementia detection and care transitions for persons living with dementia in the emergency department
Saxena S, Carpenter C, Floden D, Meldon S, Taylor R, Hwang U. Novel algorithms & blood‐based biomarkers: Dementia detection and care transitions for persons living with dementia in the emergency department. Alzheimer's & Dementia 2025, 21: e70287. PMID: 40390207, PMCID: PMC12089069, DOI: 10.1002/alz.70287.Peer-Reviewed Original ResearchConceptsElectronic health recordsGeriatric emergency departmentCare partnersEmergency departmentImprove careLeveraging electronic health recordsRisk of dementiaHigh emergency departmentRisk stratification algorithmCare transitionsCoordinated careED environmentDeliver careED settingHealth recordsDementia detectionHealthcare systemHigh acuityCareOutpatient settingStratification algorithmDementiaEmergency cliniciansBlood-based biomarkersPLWDPredicting Agitation Events in the Emergency Department Through Artificial Intelligence
Wong A, Sapre A, Wang K, Nath B, Shah D, Kumar A, Faustino I, Desai R, Hu Y, Robinson L, Meng C, Tong G, Bernstein S, Yonkers K, Melnick E, Dziura J, Taylor R. Predicting Agitation Events in the Emergency Department Through Artificial Intelligence. JAMA Network Open 2025, 8: e258927. PMID: 40332935, PMCID: PMC12059975, DOI: 10.1001/jamanetworkopen.2025.8927.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedArtificial IntelligenceCohort StudiesEmergency Service, HospitalFemaleHumansMaleMiddle AgedPsychomotor AgitationRisk AssessmentRisk FactorsConceptsED visitsEmergency departmentAgitation eventsElectronic health record dataArea under the receiver operating characteristic curvePatient-centered careHealth service utilizationPrimary outcomeHealth record dataUrban health systemED visit dataMode of arrivalPrevention of agitationOutcome of agitationDiverse patient populationsRestraint ordersCross-sectional cohortService utilizationVital signsED sitesHealth systemMain OutcomesRestraint eventsRange of predicted probabilitiesVisit dataA cohort study of predictors of short-term nonfatal suicidal and self-harm events among individuals with mental health disorders treated in the emergency department
Marcus S, Cullen S, Schmutte T, Xie M, Liu T, Ungar L, Cardamone N, Williams N, Olfson M. A cohort study of predictors of short-term nonfatal suicidal and self-harm events among individuals with mental health disorders treated in the emergency department. Journal Of Psychiatric Research 2025, 186: 458-468. PMID: 40318538, DOI: 10.1016/j.jpsychires.2025.04.035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCohort StudiesElectronic Health RecordsEmergency Service, HospitalFemaleHumansMaleMental DisordersMiddle AgedSelf-Injurious BehaviorSuicidal IdeationSuicideYoung AdultConceptsSelf-harm eventsMental health disordersED visitsHealth disordersBulimia nervosaEmergency departmentNonfatal suicideDiagnosis of bulimia nervosaElectronic health record dataSuicidal self-harmEmergency mental healthcareSuicide-related eventsLogistic regressionHealth record dataMental health diagnosesEmergency department visitsMental health problemsVisits of individualsSuicidal symptomsMental healthcareED episodesHealth recordsSelf-harmShort-term riskHealth diagnosisDetection and differentiation of undiagnosed dementia in the emergency department: A pilot referral pathway
Gettel C, Galske J, Araujo K, Dresden S, Dussetschleger J, Iannone L, Lai J, Martin P, Mignosa B, Muschong K, Safdar B, Weintraub S, Hwang U. Detection and differentiation of undiagnosed dementia in the emergency department: A pilot referral pathway. Alzheimer's & Dementia 2025, 21: e70189. PMID: 40257011, PMCID: PMC12010273, DOI: 10.1002/alz.70189.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCognitive DysfunctionDementiaEmergency Service, HospitalFeasibility StudiesFemaleHumansMaleMiddle AgedNeuropsychological TestsPilot ProjectsReferral and ConsultationConceptsEmergency departmentClinician referralED cliniciansOutpatient referralsCognitive impairmentOutpatient evaluationCognitive evaluationOlder adult patientsUndiagnosed dementiaReferral pathwaysReporting such issuesEmergency careFollow-upReferral ratesCI screeningCognitive screeningOutpatient follow-upTelephone interviewsED patientsReferral statusReferralFollow-up challengesDementiaChart reviewOlder patientsThe perils of pickleball: A two decade analysis of upper and lower extremity injuries from America’s fastest growing sport
Boroumand S, Park N, Katsnelson B, Qian E, Norman M, Joo P, Diatta F, Noel O, Moran J, Jimenez A. The perils of pickleball: A two decade analysis of upper and lower extremity injuries from America’s fastest growing sport. Journal Of Sports Sciences 2025, 43: 1378-1385. PMID: 40254855, DOI: 10.1080/02640414.2025.2496089.Peer-Reviewed Original ResearchConceptsLower extremity injuriesExtremity injuriesUS emergency departmentsAge groupsTwo-proportion z-testInjury trendsGeriatric age groupPickleball injuriesEmergency departmentUpper/lower extremitiesBonferroni correctionPediatric patientsEpidemiological analysisClinical variablesZ-testPatientsAdultsInjuryPickleballExtremitiesOccupational injury severity among healthcare workers: a retrospective study
Khairallah G, Al-Hajj S, Mowafi H, Rahme D, Sakr C. Occupational injury severity among healthcare workers: a retrospective study. BMC Public Health 2025, 25: 1447. PMID: 40247310, PMCID: PMC12004751, DOI: 10.1186/s12889-025-22727-y.Peer-Reviewed Original ResearchConceptsInjury severityDeterminants of injury severityOccupant injury severityRisk of sustaining injuriesExposure to harmful substancesAssociated with more severe injuriesMore severe injuriesInjury reportsTransport injuriesModified workComprehensive safetyEmergency departmentOpening hoursWellness programsClinic opening hoursIncident reportsSevere injuriesMethodsThis retrospective cross-sectional studyCross-sectional studyWorkersRetrospective cross-sectional studyTertiary care hospitalED visitsAssociated with ageBackgroundHealthcare workersUse of broad-spectrum antibiotics in adult cancer patients presenting to emergency department with non-neutropenic fever and/or suspected infection
Li Y, Al Maqrashi Z, Zhan L, Siddiqui Z, Jin E, Ellis P. Use of broad-spectrum antibiotics in adult cancer patients presenting to emergency department with non-neutropenic fever and/or suspected infection. Supportive Care In Cancer 2025, 33: 383. PMID: 40237926, DOI: 10.1007/s00520-025-09419-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnti-Bacterial AgentsCohort StudiesEmergency Service, HospitalFemaleFeverHumansMaleMiddle AgedNeoplasmsPractice Patterns, Physicians'Retrospective StudiesConceptsNon-neutropenic feverBroad-spectrum antibioticsBroad-spectrum intravenous antibioticsBroad-spectrum antibiotic useCancer patientsSuspected infectionAdult cancer patientsAntibiotic useIntravenous antibioticsEmergency departmentAntibiotics prescribed to patientsMethodsA retrospective cohort studySingle-center studyProportion of patientsRetrospective cohort studyStage IV cancerMultivariate logistic regressionImprove antibiotic stewardshipSystemic treatmentSolid malignanciesGenitourinary cancersAdult patientsAntibiotic stewardshipIV cancerCohort studyLongitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men
Ellis R, Webber T, Noble N, Linnstaedt S, Hinrichs R, Wiltshire C, Reda M, Davie W, House S, Beaudoin F, An X, Neylan T, Clifford G, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Punches B, Pascual J, Seamon M, Datner E, Pearson C, Peak D, Domeier R, Rathlev N, O'Neil B, Sergot P, Sanchez L, Bruce S, Joormann J, Kessler R, Ressler K, Koenen K, McLean S, Stevens J, Jovanovic T, Seligowski A. Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men. Stress And Health 2025, 41: e3522. PMID: 40119846, PMCID: PMC11991665, DOI: 10.1002/smi.3522.Peer-Reviewed Original ResearchConceptsFear-potentiated startleSkin conductancePotentiated startlePTSD severityFear conditioningTrauma exposureTrauma recallAutonomic functionLongitudinal associationsPTSDAURORA studyEmergency departmentHigh oestradiol levelsFearEffect of oestradiolOestradiol levelsAssociated with autonomic dysfunctionStartleTraumaED-SCNegative correlationAutonomic dysfunctionRecallWomenOestradiolDisparities in use of physical restraint and chemical sedation in the emergency department by patient housing status
Robinson L, Ryus C, Nath B, Kumar A, Desai R, Shah D, Faustino I, Wong A. Disparities in use of physical restraint and chemical sedation in the emergency department by patient housing status. PLOS ONE 2025, 20: e0319286. PMID: 40080507, PMCID: PMC11906057, DOI: 10.1371/journal.pone.0319286.Peer-Reviewed Original ResearchConceptsPatient's housing statusEmergency departmentHousing statusPhysical restraintSedative usePsychiatric emergency careAdverse health outcomesCross-sectional studyLogistic regression modelsRestraint ordersEmergency careHealth outcomesED visitsPatient raceYears of ageDescriptive statisticsHealthcare networkRegional healthcare networkChemical sedationHoused patientsDemographic factorsMarginalized populationsRegression modelsCareChief complaintCannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients
Fink D, Samples H, Malte C, Olfson M, Wall M, Alschuler D, Simpson T, Mannes Z, Saxon A, Hasin D. Cannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients. International Journal Of Drug Policy 2025, 138: 104765. PMID: 40058102, PMCID: PMC11967342, DOI: 10.1016/j.drugpo.2025.104765.Peer-Reviewed Original ResearchConceptsUrine drug screensCannabis use disorderMedical cannabis lawsVeterans Health AdministrationCannabis useRecreational cannabis lawsRates of cannabis use disordersCannabis lawsEmergency departmentIndicators of cannabis useUrine toxicology testsIncreased cannabis useDifference-in-differences analysisLegalized cannabis useEmergency room patientsSelf-reported dataBinomial regression modelsED visitsED patientsHealth AdministrationCannabis involvementPatient samplesPatientsUse disorderCannabisUnderstanding oncologic emergencies and related emergency department visits and hospitalizations: a systematic review
Yilmaz S, Aryal K, King J, Bischof J, Hong A, Wood N, Gould Rothberg B, Hudson M, Heinert S, Wattana M, Coyne C, Reyes-Gibby C, Todd K, Lyman G, Klotz A, Abar B, Grudzen C, Bastani A, Baugh C, Henning D, Bernstein S, Rico J, Ryan R, Yeung S, Qdaisat A, Padela A, Madsen T, Liu R, Adler D. Understanding oncologic emergencies and related emergency department visits and hospitalizations: a systematic review. BMC Emergency Medicine 2025, 25: 40. PMID: 40045233, PMCID: PMC11883922, DOI: 10.1186/s12873-025-01183-2.Peer-Reviewed Original ResearchConceptsEmergency departmentEmergency visitsPredictors of ED usePeer-reviewed original research studiesSystematic reviewOncologic emergencyCancer incidence ratesCare delivery pathwaysGeriatric oncology researchManagement of oncologic emergenciesEmergency department visitsResultsThe search strategyTreatment side effectsOriginal research studiesCancer patientsVulnerable patient populationAcute careSingle-site studyWeb of ScienceCare venuesED useDepartment visitsHealth systemED visitsED presentationsUsing Radiology as a Screening Tool to Identify Intimate Partner Violence
Lenehan P, Tang A, Watane G, Gujrathi R, Park H, Gosangi B, Thomas R, Franco F, Patel K, Warsofsky I, Rosner B, Khurana B. Using Radiology as a Screening Tool to Identify Intimate Partner Violence. Journal Of The American College Of Radiology 2025, 22: 395-404. PMID: 40044319, PMCID: PMC11887577, DOI: 10.1016/j.jacr.2025.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesEmergency Service, HospitalFemaleHumansIncidenceIntimate Partner ViolenceMass ScreeningMiddle AgedRetrospective StudiesConceptsAdjusted incidence rate ratiosEmergency departmentRetrospective case-control studyImaging utilization patternsEvident injuriesCox proportional hazards regressionRace-matched controlsCase-control studyTime-to-event analysisProportional hazards regressionImaging utilizationIncidence rate ratiosCumulative incidenceAnatomical sitesScreening mammogramsHazards regressionOdds ratioImaging studiesIntimate partner violencePatientsInjury patternsLogistic regressionInjuryOrgan systemsPoisson regressionAdaptive decision support for addiction treatment to implement initiation of buprenorphine for opioid use disorder in the emergency department: protocol for the ADAPT Multiphase Optimization Strategy trial
Iscoe M, Hooper C, Levy D, Buchanan L, Dziura J, Meeker D, Taylor R, D’Onofrio G, Oladele C, Sarpong D, Paek H, Wilson F, Heagerty P, Delgado M, Hoppe J, Melnick E. Adaptive decision support for addiction treatment to implement initiation of buprenorphine for opioid use disorder in the emergency department: protocol for the ADAPT Multiphase Optimization Strategy trial. BMJ Open 2025, 15: e098072. PMID: 39979056, PMCID: PMC11842997, DOI: 10.1136/bmjopen-2024-098072.Peer-Reviewed Original ResearchConceptsClinical decision supportMultiphase optimization strategyOpioid use disorderEmergency departmentInitiation of buprenorphineClinical decision support usePlan-Do-Study-Act cyclesLearning health system approachPlan-Do-Study-ActClinical decision support toolHealth system approachAdaptive decision supportUse disorderDecision supportAddiction treatmentPeer-reviewed journalsBuprenorphine initiationOpioid use disorder treatment initiationOpioid-related mortalityIntervention componentsED settingClinician feedbackInstitute Institutional Review BoardTreatment of opioid use disorderParticipating sitesPalliative Care Initiated in the Emergency Department
Grudzen C, Siman N, Cuthel A, Adeyemi O, Yamarik R, Goldfeld K, Abella B, Bellolio F, Bourenane S, Brody A, Cameron-Comasco L, Chodosh J, Cooper J, Deutsch A, Elie M, Elsayem A, Fernandez R, Fleischer-Black J, Gang M, Genes N, Goett R, Heaton H, Hill J, Horwitz L, Isaacs E, Jubanyik K, Lamba S, Lawrence K, Lin M, Loprinzi-Brauer C, Madsen T, Miller J, Modrek A, Otero R, Ouchi K, Richardson C, Richardson L, Ryan M, Schoenfeld E, Shaw M, Shreves A, Southerland L, Tan A, Uspal J, Venkat A, Walker L, Wittman I, Zimny E. Palliative Care Initiated in the Emergency Department. JAMA 2025, 333: 599-608. PMID: 39813042, PMCID: PMC11836764, DOI: 10.1001/jama.2024.23696.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overDecision Support Systems, ClinicalEmergency Service, HospitalFemaleHospitalizationHumansMalePalliative CareConceptsInitiate palliative careLife-limiting illnessHealth care usePalliative carePostintervention periodPreintervention periodMulticomponent interventionCare useEmergency departmentOlder adultsHospital admissionRates of hospice useShort-term mortalitySecondary outcomesRate of hospital admissionsED clinical staffHome health useClinical decision supportNursing home patientsSimulation-based workshopGagne comorbidity scoreRate of admissionRisk of short-term mortalityHospice useIllness communication
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