2025
Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study
Zhong W, Wang X, Song W, Chen H, Xie J, Yan H, Wang J, Lv Y, Li Z, Shi X, Mao C. Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study. Clinical Nutrition 2025, 50: 29-37. PMID: 40367593, DOI: 10.1016/j.clnu.2025.04.033.Peer-Reviewed Original ResearchConceptsRisk of frailtyGenetic riskHealthy lifestyleUnhealthy lifestyleOlder adultsFrailty riskLate-lifeLifestyle changesChinese Longitudinal Healthy Longevity SurveyCommunity-based cohort studyHazard ratioPolygenic risk scoresGenetic risk groupsModerate-to-moderatelyCox proportional hazards regression modelsProportional hazards regression modelsLifestyle scoreHazards regression modelsLongevity SurveyHigh frailty riskPrevent frailtyLifestyle factorsFrailty indexCohort studyLifestyle combinationMulti‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use
Davis C, Jinwala Z, Justice A, Rentsch C, Kranzler H. Multi‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use. Alcohol Clinical And Experimental Research 2025, 49: 1197-1205. PMID: 40322892, PMCID: PMC12174493, DOI: 10.1111/acer.70069.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlcohol DrinkingAlcoholismFemaleGenome-Wide Association StudyHumansMaleMiddle AgedTopiramateConceptsGenome-wide association studiesMillion Veteran ProgramGenome-wide significancePolygenic scoresAlcohol consumptionAssociation studiesAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) scoresGenome-wide association study samplesPhenome-wide association studyAlcohol useElectronic health recordsMeta-analysisGWAS meta-analysisMulti-ancestry genome-wide association studyTopiramate's effectsAlcohol use disorder diagnosisCross-ancestry meta-analysisFrequency of alcohol useCandidate gene studiesHeavy alcohol useHealth recordsVeteran ProgramAlcohol-related liver diseaseCross-ancestryTreatment responseAcute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography
Raval N, Smart K, Angarita G, Miller R, Huang Y, Krystal J, Carson R, Cosgrove K, O'Malley S, Hillmer A. Acute Alcohol‐Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography. Addiction Biology 2025, 30: e70031. PMID: 40309934, PMCID: PMC12044519, DOI: 10.1111/adb.70031.Peer-Reviewed Original ResearchConceptsBlood alcohol levelsAlcohol challengeEffects of acute alcohol consumptionPeak blood alcohol levelsLaboratory alcohol challengeNon-displaceable binding potentialMetabotropic glutamate receptor 5Acute alcohol challengeGlutamate releaseAlcohol-induced changesGlutamate receptor 5Alcohol consumptionAcute alcohol consumptionMGluR5 availabilityPET scansSocial drinkersEthanol doseAlcohol effectsBrain regionsAcute alcoholBinding potentialCortical regionsClinically relevant dosesDrinking occasionsAlcohol levelsWearable Intervention for Alcohol Use Risk and Sleep in Young Adults
Fucito L, Ash G, Wu R, Pittman B, Barnett N, Li C, Redeker N, O’Malley S, DeMartini K. Wearable Intervention for Alcohol Use Risk and Sleep in Young Adults. JAMA Network Open 2025, 8: e2513167. PMID: 40445615, PMCID: PMC12125640, DOI: 10.1001/jamanetworkopen.2025.13167.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlcohol DrinkingFemaleHumansMaleSleepSleep Wake DisordersWearable Electronic DevicesYoung AdultConceptsSleep-related impairmentWorld Health OrganizationSecondary outcomesPrimary outcomeSelf-monitoringSleep-related impairment scoresSleep disturbanceYoung adultsSleep healthWearable feedbackRandomized clinical trialsExploratory outcomesPrevalence of alcohol use disordersAt-risk drinkingIntention-to-treat approachTechnology-based interventionsRisk level reductionMeasures of sleep healthOutcomes of sleep disturbancesSmartphone self-monitoringControl A groupWeek 4Heavy drinking occasionsIntervention groupAlcohol use riskAlcohol Use and Abusive or Neglectful Behaviors Among Family Caregivers of Patients With Dementia
Chilatra J, Browning W, Yildiz M, Yefimova M, Maxwell C, Sullivan T, Pickering C. Alcohol Use and Abusive or Neglectful Behaviors Among Family Caregivers of Patients With Dementia. JAMA Network Open 2025, 8: e256211. PMID: 40261656, PMCID: PMC12015665, DOI: 10.1001/jamanetworkopen.2025.6211.Peer-Reviewed Original ResearchConceptsFamily caregivers of relativesCaregivers of relativesFamily caregiversAssociated with increased oddsCare recipientsHazardous drinkingDaily alcohol consumptionAlcohol useDaily alcohol useSample of family caregiversFamily caregivers of patientsIncreasing prevalence of dementiaAlcohol consumptionAlcohol use patternsCaregivers of patientsPrevalence of dementiaCommunity-dwelling relativeAssociated with higher oddsNeglectful behaviorsAssociated with greater oddsBaseline hazardous drinkingBaseline surveyUnpaid careLinear mixed modelsMain OutcomesSpatial associations between alcohol detection in opioid overdose deaths and alcohol outlets
Viera A, Heimer R, Grau L. Spatial associations between alcohol detection in opioid overdose deaths and alcohol outlets. Drug And Alcohol Dependence 2025, 271: 112659. PMID: 40184870, PMCID: PMC12050193, DOI: 10.1016/j.drugalcdep.2025.112659.Peer-Reviewed Original ResearchConceptsOff-premise alcohol outletsNearest alcohol outletAlcohol outletsOpioid overdose deathsSpatial distribution of alcohol outletsSubstance use patternsDistribution of alcohol outletsDensity of alcohol outletsOverdose deathsDepressive effects of opioidsAlcohol outlet densityEffects of opioidsCensus tract levelAssociated with increased oddsOverdose riskCentral nervous systemOutlet densityTract levelCensus tractsDepressant effectCommunity investmentOpioidSocial vulnerabilityAlcoholNervous systemSex differences in the microglial response to stress and chronic alcohol exposure in mice
Soares A, Garcia-Rivas V, Fai C, Thomas M, Zheng X, Picciotto M, Mineur Y. Sex differences in the microglial response to stress and chronic alcohol exposure in mice. Biology Of Sex Differences 2025, 16: 19. PMID: 40038827, PMCID: PMC11881309, DOI: 10.1186/s13293-025-00701-y.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAmygdalaAnimalsEthanolFemaleHippocampusMaleMiceMice, Inbred C57BLMicrogliaSex CharacteristicsStress, PsychologicalConceptsResponse to stressSex differencesAlcohol exposureStress-induced alcohol drinkingHeightened reactivity to stressInescapable footshock stressDevelopment of AUDReactivity to stressChronic alcohol exposureProminent sex differencesIncreased alcohol intakeCharacterize sex differencesFemale C57BL/6J miceDark paradigmComorbid moodFootshock stressStress disorderLimbic circuitsNeurobiological processesModify drinkingNeuroimmune signalingAdministered alcoholFemale rodentsMicroglial densityAlcohol drinkingBrain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanismsNeural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers
Le T, Hughes F, Oba T, Li C. Neural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers. Addiction Biology 2025, 30: e70020. PMID: 39952897, PMCID: PMC11828665, DOI: 10.1111/adb.70020.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexDrinking motivesAlcohol usePsychological measuresPercentage of heavy drinking daysRisk of alcohol use disorderAlcohol use severityAnterior cingulate cortexHeavy drinking daysAlcohol use disorderPain-related psychological measuresParticipants' alcohol usePromote alcohol usePainful electric shocksLevels of drinkingPain sensitivityAlcohol cravingDrinking severityGo/NoGo taskCingulate cortexNeural correlatesDrinking daysUse disorderAdult drinkersOvert actionsA randomized controlled trial to assess whether a telehealth-based contingency management intervention reduces alcohol use for individuals with alcohol use disorder
Jett J, Tyutyunnyk D, Beck R, Palmer K, Ryan D, Sanchez J, Weeks D, McPherson S, Chaytor N, Kiluk B, Javors M, Ginsburg B, Murphy S, Hill-Kapturczak N, McDonell M. A randomized controlled trial to assess whether a telehealth-based contingency management intervention reduces alcohol use for individuals with alcohol use disorder. Contemporary Clinical Trials 2025, 150: 107807. PMID: 39824379, DOI: 10.1016/j.cct.2025.107807.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol AbstinenceAlcohol DrinkingAlcoholismCognitive Behavioral TherapyFemaleGlycerophospholipidsHumansMaleTelemedicineConceptsAlcohol use disorderContingency managementAlcohol useUse disorderPredictors of intervention outcomeOnline cognitive behavioral therapyCognitive behavioral therapyContingency management interventionAlcohol-related outcomesDecreased alcohol useReducing alcohol useReward contingenciesBehavioral therapyImpact of CMConfirm abstinencePEth resultsCM interventionIntervention outcomesExcessive drinkingCBT4CBTAbstinenceIn-personRewardFollow-upAlcoholDoes semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial)
Klausen M, Kuzey T, Pedersen J, Justesen S, Rasmussen L, Knorr U, Mason G, Ekstrøm C, Holst J, Koob G, Benveniste H, Volkow N, Knudsen G, Vilsbøll T, Fink-Jensen A. Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinical trial (the SEMALCO trial). BMJ Open 2025, 15: e086454. PMID: 39779270, PMCID: PMC11749217, DOI: 10.1136/bmjopen-2024-086454.Peer-Reviewed Original ResearchConceptsAlcohol use disorderUse disorderGamma-aminobutyric acidComorbid obesityAlcohol cue reactivityCognitive behavioral therapyHeavy drinking daysWhite matter tract integrityBrain gamma-aminobutyric acidGlucagon-like peptide-1Alcohol consumptionMental health disordersReduce alcohol consumptionClinical trialsCue reactivityPlacebo-controlled clinical trialBehavioral therapyDrinking daysFunctional connectivityGLP-1 receptor agonist semaglutideWeeks of treatmentDouble-blind clinical trialTract integrityEthics Committee of the Capital Region of DenmarkHealth disordersAssessing Links Between Alcohol Exposure and Firearm Violence: A Scoping Review Update
Matthay E, Gobaud A, Branas C, Keyes K, Roy B, Cerdá M. Assessing Links Between Alcohol Exposure and Firearm Violence: A Scoping Review Update. Alcohol Research 2025, 45: 01. PMID: 39830985, PMCID: PMC11737877, DOI: 10.35946/arcr.v45.1.01.Peer-Reviewed Original ResearchConceptsEffect measure modificationFirearm violenceViolence-related outcomesAlcohol control policiesAlcohol use disorderAlcohol useStudy designFirearm homicideFirearm accessMeasure modificationFirearm suicidesPrevention effortsQuasi-experimental study designSystematic reviewStructured data collection instrumentCross-sectional study designAlcohol exposureComprehensive search of published studiesMeta-Analyses ExtensionDensity of alcohol outletsPositive associationSearch of published studiesModifiable risk factorsFull-text screeningPreferred Reporting Items“Men Take Care of Each Other”: Evaluation of a Community-Based Model for Pre-exposure Prophylaxis Services Among Male Bar Patrons in Rural South Africa
Chen P, Nkosi S, Moll A, Braithwaite R, Ngubane S, Shenoi S. “Men Take Care of Each Other”: Evaluation of a Community-Based Model for Pre-exposure Prophylaxis Services Among Male Bar Patrons in Rural South Africa. AIDS Patient Care And STDs 2025, 39: 3-11. PMID: 39761130, PMCID: PMC11839517, DOI: 10.1089/apc.2024.0154.Peer-Reviewed Original ResearchConceptsMale nursesAlcohol-serving venuesPrEP servicesHIV servicesHIV testingSocial supportHIV service delivery modelsAlcohol useNurse follow-upAlcohol-associated riskAvoidance of stigmaCommunity-based modelRural South AfricaService delivery modelsPre-exposure prophylaxisMale bar patronsPatient ambassadorsCommunity nursesNursing assistantsPrEP disclosurePrEP initiationHome visitsSouth AfricaPost-pilotClinic attendance
2024
Alcohol drinking is attenuated by PDE4 inhibition but partial microglia depletion is not sufficient to block stress-induced escalation of alcohol intake in female mice
Garcia-Rivas V, Soares A, Thomas M, Na J, Smith A, Picciotto M, Mineur Y. Alcohol drinking is attenuated by PDE4 inhibition but partial microglia depletion is not sufficient to block stress-induced escalation of alcohol intake in female mice. Alcohol 2024, 122: 31-42. PMID: 39725336, DOI: 10.1016/j.alcohol.2024.12.004.Peer-Reviewed Original ResearchConceptsAlcohol use disorderEthanol drinkingStress exposureEthanol intakeExposure to foot-shock stressDevelopment of alcohol use disordersTreatment of alcohol use disordersEscalation of alcohol intakeFemale miceReduced ethanol intakeFoot-shock stressIdentified sex differencesInhibitor of phosphodiesterase type 4Alcohol intakeEthanol reinforcementPharmacological depletion of microgliaLimbic circuitsUse disorderChronic ethanolNeuroinflammatory triggerDecreased preferenceC57BL/6J malesPhosphodiesterase type 4Sex differencesBinge drinkingNeural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Le T, Oba T, Couch L, McInerney L, Li C. Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking. Translational Psychiatry 2024, 14: 336. PMID: 39168986, PMCID: PMC11339324, DOI: 10.1038/s41398-024-03039-y.Peer-Reviewed Original ResearchConceptsAvoidance deficitNegative emotionsDrinking motivesAlcohol useNeural correlatesProblem drinkingRight anterior insula activityAssociated with greater alcohol useAnterior insula activityAlcohol use motivesGreater alcohol useProblem drinking groupInfluence alcohol usePhysical painInsula activationDrinking severityGo/NoGo taskNeural underpinningsPutamen responseSocial drinkersBehavioral measuresAvoidance performanceBehavioral resultsFunctional connectivityDrinking behaviorAssociations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging
Qiu L, Liang C, Kochunov P, Hutchison K, Sui J, Jiang R, Zhi D, Vergara V, Yang X, Zhang D, Fu Z, Bustillo J, Qi S, Calhoun V. Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging. Translational Psychiatry 2024, 14: 326. PMID: 39112461, PMCID: PMC11306356, DOI: 10.1038/s41398-024-03035-2.Peer-Reviewed Original ResearchConceptsFronto-limbic networkSalience networkAssociated with cognitionFronto-basal gangliaDevelopmental disordersBrain networksLimbic systemAlcohol useAssociated with alcohol useMultimodal brain networksTobacco useAssociation of alcoholPsychiatric disordersMultimodal neuroimagingDMNBrain featuresCognitionAlcohol/tobacco useDisordersAssociated with tobacco useDepressionSymptomsFunctional abnormalitiesAlcoholBrainAlcohol consumption among Iranian population based on the findings of STEPS survey 2021
Hajebi A, Nasserinejad M, Rezaei N, Azadnajafabad S, Rashidi M, Ahmadi N, Ghasemi E, Farzi Y, Yoosefi M, Djalalinia S, Fattahi N, Rezaei S, Foroutan Mehr E, Kazemi A, Haghshenas R, Rezaee K, Momen Nia Rankohi A, Afsari M, Mahdavihezaveh A, Jamshidi H, Farzadfar F. Alcohol consumption among Iranian population based on the findings of STEPS survey 2021. Scientific Reports 2024, 14: 16819. PMID: 39039151, PMCID: PMC11263364, DOI: 10.1038/s41598-024-66257-w.Peer-Reviewed Original ResearchConceptsAlcohol consumptionAssociation of alcohol consumptionPrevalence of alcohol consumptionAlcohol useModified Persian versionPrevalence of alcohol usePer capita alcohol consumptionAdult populationBehavioral risk factorsPopulation-based surveyRisk factorsMetabolic risk factorsQuantity-frequency methodLifetime alcohol consumptionSTEPS questionnaireSTEPS surveyPersian versionLifestyle variablesLifetime smokersFactor associationsOdds ratioCluster samplingMonthly prevalenceIranian populationPhysical injurySex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake
McGowan C, Krah M, Fogelman N, Seo D, Sinha R. Sex differences in binge drinking-related higher morning cortisol levels and in prospective association with future alcohol intake. Alcohol And Alcoholism 2024, 59: agae047. PMID: 39053499, DOI: 10.1093/alcalc/agae047.Peer-Reviewed Original ResearchConceptsMorning cortisol levelsCortisol levelsHigher morning cortisol levelsHypothalamic-pituitary-adrenal (HPA) axisSex differencesReports of alcohol consumptionProblematic drinking behaviorAlcohol consumptionAverage cortisol levelsBasal cortisol levelsAlcohol intakeHeavy alcohol useChronic alcohol consumptionHPA axisDrinking behaviorNeuroimaging scansPeripheral cortisolAlcohol useStress systemBinge drinkingMorning cortisolStress hormonesMorning plasma cortisolBingeNon-significant relationshipStrategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol.
Savinkina A, Muyindike W, Hahn J, Emenyonu N, Fatch R, Ngabirano C, Adong J, Jacobson K, Linas B. Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 335-342. PMID: 38961548, PMCID: PMC11875055, DOI: 10.5588/ijtld.23.0303.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyTB preventive therapyTuberculin skin testPreventive therapyReport alcohol useAlcohol useHIV-positive patientsTB disease incidenceLiver enzyme monitoringLatent TB infectionTB burden settingsSkin testTB infectionBurden settingsConsuming alcoholTB diseaseTB riskWHO guidanceTherapyEnzyme monitoringPLWHIsoniazidEvaluate hepatotoxicityHepatotoxicity concernsAST/ALTGenome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk.
Ni Z, Kundu P, McKean D, Wheeler W, Albanes D, Andreotti G, Antwi S, Arslan A, Bamlet W, Beane-Freeman L, Berndt S, Bracci P, Brennan P, Buring J, Chanock S, Gallinger S, Gaziano J, Giles G, Giovannucci E, Goggins M, Goodman P, Haiman C, Hassan M, Holly E, Hung R, Katzke V, Kooperberg C, Kraft P, LeMarchand L, Li D, McCullough M, Milne R, Moore S, Neale R, Oberg A, Patel A, Peters U, Rabe K, Risch H, Shu X, Smith-Byrne K, Visvanathan K, Wactawski-Wende J, White E, Wolpin B, Yu H, Zeleniuch-Jacquotte A, Zheng W, Zhong J, Amundadottir L, Stolzenberg-Solomon R, Klein A. Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 1229-1239. PMID: 38869494, PMCID: PMC11928872, DOI: 10.1158/1055-9965.epi-24-0096.Peer-Reviewed Original ResearchConceptsPancreatic cancer riskHeavy alcohol consumptionCancer riskSingle-nucleotide polymorphismsAlcohol consumptionExpression quantitative trait lociQuantitative trait lociAssociated with pancreatic cancer riskGenome-wide interaction analysisGenome-wide significant evidenceEtiology of pancreatic cancerFixed-effect meta-analysesGenomic regionsGenome-wide significant evidence of associationLead single-nucleotide polymorphismsTrait lociGenetic variantsEuropean ancestry populationsEvidence of associationGenome-wide association studiesAnalysis of single-nucleotide polymorphismsCase-control studyPancreatic cancerGenome-wide analysisAncestry populations
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