2025
Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study
Yegya-Raman N, Plastaras J, Wright C, Chelius M, Zhang S, Baron J, Hubbeling H, Sim A, Robinson T, Jain M, Imber B, Fregonese B, Yahalom J, Ladbury C, Dandapani S, Pinnix C, Gunther J, Fang P, Wu S, Dabaja B, Yang J, Chew J, Braunstein S, Sinha S, Delinger N, Sun S, Terezakis S, Sakthivel G, Constine L, Chowdhry A, Reagan P, Burke S, Tseng Y, LaRiviere M, Maity A, Schuster S, Chong E, Figura N. Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study. Blood Advances 2025, 9: 3293-3303. PMID: 40203192, DOI: 10.1182/bloodadvances.2025015855.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor T-cell therapyImmune effector cell-associated neurotoxicity syndromeSuperior progression-free survivalProgression-free survivalB-cell lymphomaCytokine release syndromeAssociated with superior progression-free survivalOverall survivalTwo-year progression-free survivalChimeric antigen receptor T cellsLactate dehydrogenaseRelapsed/refractory B-cell lymphomaLactate dehydrogenase normalizationAmerican Society for TransplantationT-cell therapyBaseline lactate dehydrogenaseMedian follow-upRetrospectively reviewed patientsAdvanced-stage diseaseHigh-risk cohortAxicabtagene ciloleucelBrexucabtagene autoleucelSystemic therapyMulticenter studyT cellsCarcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans.
Madrigal J, Fisher J, Pruitt C, Liao L, Graubard B, Ward M, Silverman D, Jones R. Carcinogenic Industrial Air Emissions and Lung Cancer Risk in a Cohort of 440,000 Americans. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 1241-1252. PMID: 40315142, DOI: 10.1164/rccm.202409-1738oc.Peer-Reviewed Original ResearchConceptsLung cancer riskCancer riskAssociated with riskNIH-AARP DietEvaluate lung cancer riskLung carcinogensAssociated with lung cancerCox proportional hazards modelsNIH-AARPHealth StudyProportional hazards modelSquamous cell carcinomaStrong associationsAssociated with benzeneHazards modelIndustrial air emissionsEnrollment residenceCell carcinomaOverall riskLung cancer developmentSmokingAssociationRiskHistological subtypesLung cancerThe distal nephron biomarkers associate with diabetic kidney disease progression
Tamargo C, Coca S, Philbrook H, Hu D, Ix J, Shlipak M, Fried L, Gutierrez O, Waikar S, Schrauben S, Schelling J, Ganz P, Kimmel P, Greenberg J, Deo R, Takakura A, Vasan R, Bonventre J, Parikh C. The distal nephron biomarkers associate with diabetic kidney disease progression. JCI Insight 2025, 10: e186836. PMID: 40548378, DOI: 10.1172/jci.insight.186836.Peer-Reviewed Original ResearchConceptsDiabetic kidney disease progressionUrine albumin-to-creatinine ratioDiabetic kidney diseaseRisk of DKD progressionEpidermal growth factorDKD progressionMedian urine albumin-to-creatinine ratioUrinary epidermal growth factorBiomarker levelsAlbumin-to-creatinine ratioDistal tubule markerPredicting diabetic kidney diseaseMedian follow-upDistal tubular markersKidney disease progressionCox regression modelsBaseline biomarker levelsNational Institute of DiabetesType 2 diabetesEGFR changeTubular markersUrinary biomarkersFollow-upClinical trialsDisease progressionSerotonin Norepinephrine Reuptake Inhibitor Is Associated With Lower Mortality Among Patients Presenting With Takotsubo Cardiomyopathy.
Shamaki G, Anuforo A, Safiriyu I, Corteville D, Sanghavi M, Shah S, Clark K. Serotonin Norepinephrine Reuptake Inhibitor Is Associated With Lower Mortality Among Patients Presenting With Takotsubo Cardiomyopathy. Journal Of The American Heart Association 2025, 14: e037951. PMID: 40551298, DOI: 10.1161/jaha.124.037951.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsDiagnosis of takotsubo cardiomyopathyTakotsubo cardiomyopathyPropensity score matchingReuptake inhibitorsClinical outcomes of patientsNorepinephrine reuptake inhibitorsReuptake of serotoninScore matchingOutcomes of patientsOpioid-related disordersCocaine-related disordersAssociated with lower mortalityLower mortalityTriNetX Research NetworkTreatment of depressionAssociated with lowered mortalityAcute myocardial infarctionNeuropathic painPresynaptic reuptakeClinical outcomesCardiac arrestPrimary outcomeSecondary outcomesVentricular fibrillationPatterns of sialyl-Lewis X expression predict gastric histopathology
Vargas N, Quiroga A, Chaves J, Bolaños H, Nalbantoglu I, Astaiza C, Wu Y, Sáenz J. Patterns of sialyl-Lewis X expression predict gastric histopathology. Diagnostic Pathology 2025, 20: 76. PMID: 40551130, PMCID: PMC12183862, DOI: 10.1186/s13000-025-01673-8.Peer-Reviewed Original ResearchConceptsChronic atrophic gastritisChronic non-atrophic gastritisGastric pathologyAssociated with chronic atrophic gastritisIntestinal metaplasiaProgression to gastric cancerSLex expressionPre-cancerous lesionsNon-atrophic gastritisGastric pre-cancerous lesionsHistological diagnosisPre-cancerous changesGlandular distributionAntrum biopsiesAdult patientsGastric corpusAtrophic gastritisChronic inflammationGastric cancerHistological markersHistological assessmentGastric histopathologyGastric epitheliumIntroductionGastric cancerBiopsyHealth Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study
Savitz S, Stevens M, Nath B, D'Onofrio G, Melnick E, Jeffery M. Health Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study. JMIR Formative Research 2025, 9: e66596. PMID: 40537088, DOI: 10.2196/66596.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosLong-term opioid therapyIn-person careMental illness cohortOpioid use disorderIn-personTelemedicine visitsChronic painPain medicineOpioid therapyEmergency medicineMental healthFamily practiceHealth service usageChronic opioidsPercentage of visitsIn-person visitsIn-person treatmentPoor outcomeAdministrative claims dataUse disorderMedicare Advantage patientsOptumLabs Data WarehouseVulnerable patient populationCare deliveryAmino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum
Goharmanesh F, Masmoie M, Nasiri H, Sadat-Madani S, Namin S, Damizadeh M, Shakeri S, Sodeifian F, Rajabpour-Sanati A, Bahrainian B, Mohammadi Y, Shushtari A, Mayeli M. Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum. Metabolic Brain Disease 2025, 40: 227. PMID: 40531346, DOI: 10.1007/s11011-025-01647-1.Peer-Reviewed Original ResearchConceptsWhite matter integrityMean diffusivityDiffusion tensor imagingFractional anisotropyAlzheimer's Disease Neuroimaging InitiativeAxial diffusivityAA metabolic pathwaysReduced white matter integrityDisease continuumDTI-derived metricsWhite matter integrity measuresWhite matter microstructural integrityAD patientsCross-sectional studyUltra-high performance liquid chromatographyPotential therapeutic targetRadial diffusivityDecreased FAIncreased MDStudy groupEarly diagnosisProgression markersAlzheimer's disease continuumAmino acidsMild cognitive impairmentLatent Health Status Trajectories in Individuals With New or Worsening Claudication Symptoms.
Grubman S, Romain G, Cleman J, Scierka L, Pajarillo C, Kluger J, Mena-Hurtado C, Smolderen K. Latent Health Status Trajectories in Individuals With New or Worsening Claudication Symptoms. Journal Of The American Heart Association 2025, 14: e039455. PMID: 40530482, DOI: 10.1161/jaha.124.039455.Peer-Reviewed Original ResearchConceptsHealth status trajectoriesPeripheral artery disease careStatus trajectoriesDisease careHealth statusClaudication symptomsTrajectory subgroupsPeripheral Artery QuestionnaireVascular specialty clinicsPeripheral artery questionnaire scoresHierarchical multivariable logistic regressionImprove health statusMultivariate logistic regressionClinically meaningful thresholdsRegistry of patientsPsychosocial factorsBiopsychosocial modelDepressive symptomsSpecialty clinicsAlcohol use disorderQuestionnaire scoresRecovery trajectoriesLogistic regressionHealthLatent trajectory modelsImmune Subtyping Identifies Patients With Hormone Receptor–Positive Early-Stage Breast Cancer Who Respond to Neoadjuvant Immunotherapy (IO): Results From Five IO Arms of the I-SPY2 Trial
Wolf D, Yau C, Campbell M, Glas A, Barcaru A, Mittempergher L, Kuilman M, Brown-Swigart L, Hirst G, Basu A, Magbanua M, Sayaman R, Huppert L, Delson A, Investigators I, Symmans W, Borowsky A, Pohlmann P, Rugo H, Clark A, Yee D, DeMichele A, Perlmutter J, Petricoin E, Chien J, Stringer-Reasor E, Shatsky R, Liu M, Han H, Soliman H, Isaacs C, Nanda R, Hylton N, Pusztai L, Esserman L, van ‘t Veer L, Mukhtar R, Melisko M, Wallace A, Yeung K, Albain K, Robinson P, Lo S, Olopade F, Potter D, Beckwith H, Blaes A, Boughey J, Haddad T, Elias A, Isaacs C, Mitri Z, Kemmer K, Lu J, Lang J, Thomas A, Trivedi M, Hershman D, Meisel J, Kalinsky K, Vaklavas C, Williams N, Ellis E, Sanford A, Sanft T, Viscusi R, Arora M, Falkson C, Northfelt D, Murthy R, Haley B, Yung R, Mayer I, Khan Q, Edmiston K. Immune Subtyping Identifies Patients With Hormone Receptor–Positive Early-Stage Breast Cancer Who Respond to Neoadjuvant Immunotherapy (IO): Results From Five IO Arms of the I-SPY2 Trial. JCO Precision Oncology 2025, 9: e2400776. PMID: 40526879, PMCID: PMC12184982, DOI: 10.1200/po-24-00776.Peer-Reviewed Original ResearchConceptsPCR ratePredicting pathologic complete responseTriple-negative breast cancerNeoadjuvant immunotherapyTumor gradeHormone receptor-positive early-stage breast cancerHuman epidermal growth factor receptor 2-negativeBreast cancerEarly-stage triple-negative breast cancerImmune-related adverse eventsControl armEarly-stage breast cancerMammaPrint-high riskHormone receptor-positivePathological complete responseResponse to IOI-SPY2 trialStandard of careER-lowComplete responseNeoadjuvant therapyReceptor-positiveHER2+I-SPY2Adverse eventsTranslation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study
Lee H, Tzuang M, Chow T, Kang Y, Tee B, Li C, Lam E, Gu Y, Lee S, Ho P, Peavy G, Seo E, Kim K, Tran B, Chae W, Nguyen D, Vo N, Dang D, Spat‐Lemus J, Choi Y, Feldman H, Jun G, Wang L, Yu W, Park V, Study T. Translation and cultural adaptation of tools to assess diverse Asian American and Asian Canadian subgroups: The Asian Cohort for Alzheimer's Disease (ACAD) Study. Alzheimer's & Dementia 2025, 21: e70311. PMID: 40528300, PMCID: PMC12173839, DOI: 10.1002/alz.70311.Peer-Reviewed Original ResearchConceptsCultural adaptationWorld Health OrganizationPromote health literacyCanadian older adultsAsian cohortCulturally appropriate translationCognitive assessment toolsLanguage backgroundAsian languagesAppropriate translationAssessment of cognitive functionHealth literacyStudy materialQuality healthcareCanadian adultsAlzheimer's diseaseTranslation processTranslation guidelinesOlder adultsSociocultural backgroundTranslation methodologyCanadian populationLanguage versionsAdaptation of toolsAssessment toolDelineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China
Zhang L, Yu J, Jia X, Su Z, Hu Y, Zhang J, Yang W, Chen X, Hoogendijk E, Huang H, Liu Z. Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China. Journal Of Cachexia Sarcopenia And Muscle 2025, 16: e13862. PMID: 40511588, PMCID: PMC12163542, DOI: 10.1002/jcsm.13862.Peer-Reviewed Original ResearchCost Disparities with Age in the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) in Ontario, Canada
Wang Y, Pond G, Gafni A, Kong C, Ellis P. Cost Disparities with Age in the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) in Ontario, Canada. Current Oncology 2025, 32: 346. PMID: 40558289, PMCID: PMC12191781, DOI: 10.3390/curroncol32060346.Peer-Reviewed Original ResearchConceptsCancer-attributable costsPhase of careNon-small-cell lung cancerAdvanced non-small-cell lung cancerInstitute for Clinical Evaluative SciencesHealthcare costsEnd-of-lifePre-diagnosis costsCost disparityEnd-of-life phaseDiagnosis of advanced non-small-cell lung cancerStage IV non-small-cell lung cancerTreatment of advanced non-small-cell lung cancerIV non-small-cell lung cancerRetrospective cohort studyLung cancerEvaluative SciencesPre-diagnosisCancer diagnosisCohort studyOlder patientsDeceased patientsCareReceiving chemotherapyMedian ageInpatient Outcomes for Patients With Peripheral Artery Disease Hospitalized for Acute Myocardial Infarction.
Gusdorf J, Faridi K, Wang T, Mena-Hurtado C, Smolderen K, Rymer J, Curtis J, Li S, Secemsky E. Inpatient Outcomes for Patients With Peripheral Artery Disease Hospitalized for Acute Myocardial Infarction. Journal Of The American Heart Association 2025, 14: e040526. PMID: 40497502, DOI: 10.1161/jaha.124.040526.Peer-Reviewed Original ResearchConceptsAcute myocardial infarction typesPeripheral arterial diseaseAcute myocardial infarctionIn-hospital mortalityPeripheral artery disease hospitalizationsIn-hospital outcomesAcute myocardial infarction hospitalizationsCardiac arrestHigh-risk populationAssociated with increased ratesLong-term riskRevascularized patientsInpatient outcomesMultivariable adjustmentHeart failureArtery diseasePrimary outcomeAdverse cardiovascular outcomesUS sitesHeightened riskAge groupsSecondary end pointsSubgroup analysisDialysis initiationCoronary artery diseaseOrgan Procurement Organization Approach of ICU Families in Person Versus by Phone for Donation Authorization.
Zhang Q, McKown B, Lau W, Strohm T, Paolillo L, Glazier A, Stinebring J, Hwang D. Organ Procurement Organization Approach of ICU Families in Person Versus by Phone for Donation Authorization. Critical Care Explorations 2025, 7: e1277. PMID: 40505005, DOI: 10.1097/cce.0000000000001277.Peer-Reviewed Original ResearchAcute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021
Koo A, Zhou L, Hameed I, Rivier C, Clocchiatti-Tuozzo S, Kamel H, Falcone G, Ney J, Sharma R, Matouk C, Yaghi S, Sheth K, de Havenon A. Acute Ischemic Stroke Risk Following Cardiac Interventions in the United States From 2016 to 2021. Neurology 2025, 105: e213766. PMID: 40493873, PMCID: PMC12165311, DOI: 10.1212/wnl.0000000000213766.Peer-Reviewed Original ResearchConceptsIntervention hospitalsSurvey weightsNon-Hispanic black ethnicityNIH Stroke ScaleStroke riskIschemic strokeFactors associated with ischemic strokeAssociated with female sexCardiac interventionsIschemic stroke riskIncidence of ischemic strokeVariables associated with riskRate of ischemic strokeNational Inpatient SampleHigh-risk populationDiagnosis-related groupsIntervention patientsCross-sectional cohortUnited StatesAcute ischemic stroke riskIn-hospital deathRisk of strokeSecondary analysisBlack ethnicityInpatient mortalityAssociation Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition
Park J, Van Puyvelde H, Regazzetti L, Clasen J, Heath A, Eussen S, Ueland P, Johansson M, Biessy C, Zamora-Ros R, Huerta J, Sánchez M, Ocke M, Schulze M, Schiborn C, Braaten T, Skeie G, Sacerdote C, Castilla J, Karlsson T, Johansson I, Kyrø C, Tjønneland A, Tong T, Katzke V, Bajracharya R, Lasheras C, Midttun Ø, Vollset S, Vineis P, Masala G, Amiano P, Tumino R, Baldassari I, Weiderpass E, Riboli E, Gunter M, Freisling H, Rinaldi S, Muller D, Huybrechts I, Ferrari P. Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition. Nutrients 2025, 17: 1970. PMID: 40573081, PMCID: PMC12195952, DOI: 10.3390/nu17121970.Peer-Reviewed Original ResearchConceptsEuropean Prospective InvestigationDietary intakeBlood concentrationsProspective InvestigationOne-carbon metabolism-related nutrientsDietary intake of betaineNested case-control studyCancer and NutritionVitamin B6Individual dietary intakeAssociated with folateVitamin B12Vitamin supplement useWeak to moderate associationsCase-control studyCase-control statusIntake of betaineConcentrations of homocysteineSupplement useSmoking statusAssociated with methionineModerate associationBloodFolateIntakeLong-Term Results of External Beam Radiation Therapy with or Without Concurrent Chemotherapy in Differentiated Thyroid Cancer
Choi J, Sherman E, Dee E, Treechairusame T, Zakeri K, Kang J, Yu Y, Chen L, Shamseddine A, McBride S, Riaz N, Ho A, Tuttle R, Fagin J, Sabra M, Cracchiolo J, Shaha A, Wong R, Ghossein R, Katabi N, Lee N. Long-Term Results of External Beam Radiation Therapy with or Without Concurrent Chemotherapy in Differentiated Thyroid Cancer. Thyroid 2025, 35: 633-641. PMID: 40504742, DOI: 10.1089/thy.2025.0052.Peer-Reviewed Original ResearchConceptsTyrosine kinase inhibitorsExternal beam radiation therapyBeam radiation therapyConcurrent chemotherapyRadiation therapyTracheoesophageal fistulaLocoregional controlPercutaneous endoscopic gastrostomyOverall survivalResults of external beam radiation therapyPatients treated with concurrent chemotherapyFollow-upTKI initiationTreated with concurrent chemotherapyTyrosine kinase inhibitor therapyRare group of patientsLong-term follow-upGross residual diseaseTreated with RTRadioactive iodine therapySingle-institution experienceDifferentiated thyroid cancerMedian follow-upKaplan-Meier methodDay of RTCerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease
Mecca A, Ashton N, Chen M, O'Dell R, Toyonaga T, Zhao W, Young J, Salardini E, Bates K, Ra J, Goodcase S, Silva‐Rudberg J, Nabulsi N, Brinkmalm A, Kvartsberg H, Schöll M, Nilsson J, Arnsten A, Huang Y, Hansson O, Zetterberg H, Carson R, Blennow K, van Dyck C. Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease. Alzheimer's & Dementia 2025, 21: e70344. PMID: 40491249, PMCID: PMC12149441, DOI: 10.1002/alz.70344.Peer-Reviewed Original ResearchConceptsSynaptic vesicle glycoprotein 2APositron emission tomographyAlzheimer's diseaseSynaptic densityEnzyme-linked immunosorbent assayC]UCB-J positron emission tomographyPositron emission tomography measurementsEmission tomographyAxonal proteinsCN participantsImmunosorbent assaySymptomatic Alzheimer's diseaseAD groupProteinAssayParticipantsSV2AAlzheimerCerebrospinal fluidBrainInvestigate associationsCerebrospinal fluid assaysSV2A positron emission tomographyCannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients
Mannes Z, Wall M, Alschuler D, Malte C, Olfson M, Livne O, Fink D, Keyhani S, Keyes K, Martins S, Cerdá M, Sacco D, Gutkind S, Maynard C, Sherman S, Saxon A, Hasin D. Cannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients. JAMA Health Forum 2025, 6: e251369. PMID: 40512510, PMCID: PMC12166489, DOI: 10.1001/jamahealthforum.2025.1369.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationVeterans Health Administration patientsMedical cannabis lawsOpioid use disorderPrevalence of opioid use disorderClassification of DiseasesRecreational cannabis lawsChronic painVeterans Health Administration electronic health recordClinical ModificationConsistent with overall findingsState medical cannabis lawsInternational Statistical Classification of DiseasesReceipt of prescription opioidsStatistical Classification of DiseasesElectronic health recordsInternational Classification of DiseasesNon-Hispanic whitesOpioid use disorder diagnosisOpioid use disorder prevalenceInternational Statistical ClassificationDifference-in-differences analysisCannabis lawsUse disorderBurden of opioid use disorderReduced DJ-1-F1Fo ATP synthase association correlates with midbrain dopaminergic neuron vulnerability in idiopathic Parkinson’s disease
Abulimiti A, Bae H, Ali A, Balakrishnan S, Tsujishita M, Gveric D, Tierney T, Jonas E, Smith P, Gentleman S, Alavian K. Reduced DJ-1-F1Fo ATP synthase association correlates with midbrain dopaminergic neuron vulnerability in idiopathic Parkinson’s disease. Science Advances 2025, 11: eads3051. PMID: 40479058, PMCID: PMC12143374, DOI: 10.1126/sciadv.ads3051.Peer-Reviewed Original ResearchConceptsProximity ligation assayVentral tegmental areaF1Fo-ATP synthaseProximity ligation assay signalsMetabolic efficiencyVentral tegmental area neuronsMitochondrial metabolic efficiencyProtein productionLigation assayMitochondrial activityMetabolic homeostasisIntracellular compartmentsMitochondrial efficiencyDistal neuritesParkinson's diseaseControl postmortem brainsImpaired mitochondrial efficiencySubstantia nigra pars compactaDopaminergic neuron vulnerabilityMesDA neuronsMesencephalic dopaminergicNeuronal vulnerabilityTegmental areaNeuronal subpopulationsIdiopathic Parkinson's disease
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