2025
Early Release - Ehrlichia chaffeensis DNA in Haemaphysalis longicornis Ticks, Connecticut, USA - Volume 31, Number 6—June 2025 - Emerging Infectious Diseases journal - CDC
Molaei G, Mohapatra A, Khalil N, Cozens D, Bonilla D. Early Release - Ehrlichia chaffeensis DNA in Haemaphysalis longicornis Ticks, Connecticut, USA - Volume 31, Number 6—June 2025 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2025, 31: 1260-1262. PMID: 40439594, PMCID: PMC12123906, DOI: 10.3201/eid3106.250034.Peer-Reviewed Original ResearchReceipt of addiction treatment after nonfatal opioid overdose and risk of subsequent overdose: A retrospective cohort study
Howell B, Black A, Lin H, Liberatore M, Greene C, D'Onofrio G, Heimer R, Grau L, Hawk K, Fiellin D, Becker W. Receipt of addiction treatment after nonfatal opioid overdose and risk of subsequent overdose: A retrospective cohort study. Drug And Alcohol Dependence 2025, 273: 112679. PMID: 40413965, PMCID: PMC12178112, DOI: 10.1016/j.drugalcdep.2025.112679.Peer-Reviewed Original ResearchConceptsAddiction treatment modalitiesAddiction treatmentInpatient addiction treatmentOpioid overdose survivorsOverdose survivorsOpioid agonist treatmentOpioid overdoseReceipt of methadoneOpioid withdrawalInpatient treatmentBenzodiazepine exposureNon-medicalAddictionAssociated with reduced riskNonfatal opioid overdoseAgonist treatmentNon-fatal opioid overdoseTreatment modalitiesAssociated with increased riskBenzodiazepinesIndividual level dataMethadoneRetrospective cohort studyOpioidBuprenorphineInitiating Injectable Buprenorphine in People Hospitalized With Infections
Seval N, Roth P, Frank C, Di Paola A, Litwin A, Vander Wyk B, Neirinckx V, Schlossberg E, Lawson P, Strong M, Schade M, Nunez J, Levin F, Brady K, Nunes E, Springer S. Initiating Injectable Buprenorphine in People Hospitalized With Infections. JAMA Network Open 2025, 8: e2513000. PMID: 40445619, PMCID: PMC12125644, DOI: 10.1001/jamanetworkopen.2025.13000.Peer-Reviewed Original ResearchConceptsLong-acting buprenorphineOpioid use disorderReceipt of MOUDRandomized clinical trialsTAU armIntent-to-treat outcomesClinical trialsModerate to severe opioid use disorderSevere opioid use disorderProportion of patientsMultisite randomized clinical trialHospital settingStatistically significant differenceNursing case management servicesInfectious diseasesTAU groupMedian ageMedication management interventionCase management servicesInjectable buprenorphineHospitalization periodPrimary outcomeBaseline valuesInitiate MOUDMOUD receiptComputational Phenomapping of Randomized Clinical Trial Participants to Enable Assessment of Their Real-World Representativeness and Personalized Inference
Thangaraj P, Oikonomou E, Dhingra L, Aminorroaya A, Jayaram R, Suchard M, Khera R. Computational Phenomapping of Randomized Clinical Trial Participants to Enable Assessment of Their Real-World Representativeness and Personalized Inference. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011306. PMID: 40261065, PMCID: PMC12203226, DOI: 10.1161/circoutcomes.124.011306.Peer-Reviewed Original ResearchConceptsElectronic health record patientElectronic health recordsDistance metricRandomized clinical trialsElectronic health record dataMachine learning methodsYale New Haven Health SystemElectronic health record cohortRandomized clinical trial participantsLearning methodsHeart failureClinical trial participationTOPCAT participantsReal worldMultidimensional metricRCT participantsHealth recordsTreatment effectsHealth systemCharacteristics of patientsRandomized clinical trial cohortsTrial participantsMetricsUnited StatesNovel statisticCritical Illness, Major Surgery, and Other Hospitalizations and Active and Disabled Life Expectancy
Gill T, Zang E, Leo-Summers L, Gahbauer E, Becher R, Ferrante L, Han L. Critical Illness, Major Surgery, and Other Hospitalizations and Active and Disabled Life Expectancy. JAMA Network Open 2025, 8: e254208. PMID: 40178853, PMCID: PMC11969285, DOI: 10.1001/jamanetworkopen.2025.4208.Peer-Reviewed Original ResearchConceptsActive life expectancyDisabled life expectancyCommunity-living older personsActivities of daily livingFunctional well-beingOlder personsLife expectancyDaily livingEssential activities of daily livingEstimates of active life expectancySurgical admissionsCommunity-living personsCritical illnessMultistate life tablesElective surgical admissionsWell-being of older personsProspective cohort studyMain OutcomesCohort studyWell-beingIllnessLife tablesAge incrementElective surgical proceduresHospitalThe STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis
Yoviene Sykes L, Levine N, Tayfur S, Gibbs-Dean T, Hazan H, Imetovski S, James J, Karmani S, Mathis W, Markovich P, Purushothaman D, Riley S, Tek C, Veillette C, Cahill J, Giard J, Marracino A, Barrette K, Bozak S, Gregory F, McDermott G, Srihari V. The STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis. Schizophrenia Research 2025, 278: 96-108. PMID: 40132282, PMCID: PMC11981821, DOI: 10.1016/j.schres.2025.03.029.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultConnecticutHumansLearning Health SystemPsychotic DisordersSchizophreniaYoung AdultConceptsLearning healthcare systemLearning collaborativeHealthcare systemSchizophrenia spectrum disordersPopulation health outcomesLearning health systemSystems of careCare modelHigh-quality treatmentStage of illnessHealth outcomesHealth systemWorkforce developmentDuration of untreated psychosisStatewide systemEarly stages of illnessEarly psychosisWorkforce readinessStrengthening integrationPolicy advocacyLeverage informaticsCareEpisode psychosisStakeholder engagementUntreated psychosisSpatial associations between alcohol detection in opioid overdose deaths and alcohol outlets
Viera A, Heimer R, Grau L. Spatial associations between alcohol detection in opioid overdose deaths and alcohol outlets. Drug And Alcohol Dependence 2025, 271: 112659. PMID: 40184870, PMCID: PMC12050193, DOI: 10.1016/j.drugalcdep.2025.112659.Peer-Reviewed Original ResearchConceptsOff-premise alcohol outletsNearest alcohol outletAlcohol outletsOpioid overdose deathsSpatial distribution of alcohol outletsSubstance use patternsDistribution of alcohol outletsDensity of alcohol outletsOverdose deathsDepressive effects of opioidsAlcohol outlet densityEffects of opioidsCensus tract levelAssociated with increased oddsOverdose riskCentral nervous systemOutlet densityTract levelCensus tractsDepressant effectCommunity investmentOpioidSocial vulnerabilityAlcoholNervous systemEarly Release - Mycobacterium nebraskense Isolated from Patients in Connecticut and Oregon, USA - Volume 31, Number 3—March 2025 - Emerging Infectious Diseases journal - CDC
Metersky M, Losier A, Fraulino D, Warnock T, Varley C, Le A, Winthrop K, McArdle J, Shakir S, Khare R. Early Release - Mycobacterium nebraskense Isolated from Patients in Connecticut and Oregon, USA - Volume 31, Number 3—March 2025 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2025, 31: 507-515. PMID: 40023800, PMCID: PMC11878316, DOI: 10.3201/eid3103.240608.Peer-Reviewed Original ResearchConceptsNontuberculous mycobacterial pulmonary diseaseMycobacterial pulmonary diseaseAmerican Thoracic Society/Infectious Diseases Society of America criteriaAntimicrobial drug susceptibility testingPulmonary diseaseDrug susceptibility testingRefractory to treatmentClinically significant causeClarithromycin susceptibilitySusceptibility testingConnecticut patientsRespiratory secretionsPatientsNo symptomsOptimum treatmentSignificant causeInfectionHuman casesDiseaseTreatmentCDCClarithromycinCasesClinicM. nebraskenseGambling in Connecticut adolescents: Prevalence, socio-demographic characteristics, trauma exposure, suicidality, and other risk behaviors
Stefanovics E, Zhai Z, Potenza M. Gambling in Connecticut adolescents: Prevalence, socio-demographic characteristics, trauma exposure, suicidality, and other risk behaviors. PLOS ONE 2025, 20: e0290589. PMID: 39908256, PMCID: PMC11798454, DOI: 10.1371/journal.pone.0290589.Peer-Reviewed Original ResearchConceptsSocial supportRisk behaviorsCorrelates of gamblingTraumatic experiencesPoor health outcomesAssociated with traumatic experiencesImplement tailored interventionsReceipt of social supportHealth risk behaviorsConnecticut high school studentsSocio-demographic characteristicsFamily social supportAcademic performanceAssociated with suicideInfluence gambling behaviorPublic health concernTailored interventionsHealth outcomesPast-year gamblingYouth Risk Behavior SurveyPoor academic performanceTrauma exposureRisk Behavior SurveyCurrent prevalenceHigh school studentsObservational pilot using a Data to Care intervention strategy to promote HCV re-engagement and cure for persons with HIV/HCV co-infection who are out of care
Wegener M, Gosselin D, Brooks R, Speers S, Villanueva M. Observational pilot using a Data to Care intervention strategy to promote HCV re-engagement and cure for persons with HIV/HCV co-infection who are out of care. BMC Health Services Research 2025, 25: 140. PMID: 39856760, PMCID: PMC11763122, DOI: 10.1186/s12913-025-12307-6.Peer-Reviewed Original ResearchConceptsDepartment of Public HealthHepatitis C virus treatment initiationHIV/HCV co-infectionHepatitis C virusPublic health strategiesConnecticut Department of Public HealthRe-engagementMethodsIn partnershipOutreach outcomesCare engagementCo-infectionHealth strategiesTreatment initiationHIV/HCV co-infected personsHepatitis C virus cureFollow-up approachHepatitis C virus treatmentCo-infected personsDirect-acting antiviralsIntervention strategiesPublic healthOutreach effortsPersons co-infectedHIVObservational pilotPediatric Behavioral Health Medical-Legal Partnerships: A Novel Approach to Child and Adolescent Psychiatric Care
Kala S, Swallow M, Sicklick J, Poncin Y, Meyer K. Pediatric Behavioral Health Medical-Legal Partnerships: A Novel Approach to Child and Adolescent Psychiatric Care. Academic Pediatrics 2025, 25: 102779. PMID: 39800221, DOI: 10.1016/j.acap.2025.102779.Peer-Reviewed Original ResearchConceptsMedical-legal partnershipPediatric mental healthMental healthHealth-harming legal needsPediatric health care deliveryHealth care deliveryBehavioral health settingsTraditional health careMental health landscapeInterdisciplinary collaborationCare deliveryHealth settingsLegal assistanceLegal representationLegal needsBiopsychosocial natureHealth careLegal factorsHealth landscapeHealthCareReferralYale SchoolUnited StatesConsultation
2024
Accuracy of Electronic Health Record Phenotypes to Detect Recognition of Hypertension in Pediatric Primary Care
Nugent J, Cueto V, Tong C, Sharifi M. Accuracy of Electronic Health Record Phenotypes to Detect Recognition of Hypertension in Pediatric Primary Care. Academic Pediatrics 2024, 25: 102629. PMID: 39732164, PMCID: PMC11893226, DOI: 10.1016/j.acap.2024.102629.Peer-Reviewed Original ResearchConceptsPediatric primary careIncident hypertensionHypertensive BPHypertension recognitionPrimary careRecognition of hypertensionCross-sectional study of children aged 3Diagnosis codesElectronic health record phenotypingClinician recognitionClinician decision supportGuideline-recommended careElectronic health recordsInternational Classification of DiseasesChart reviewDocumentation of hypertensionClassification of DiseasesCross-sectional studyChildren aged 3Problem list entriesWellness visitsHealth recordsEHR phenotypesInternational ClassificationICD-10Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure
Adejumo P, Thangaraj P, Dhingra L, Aminorroaya A, Zhou X, Brandt C, Xu H, Krumholz H, Khera R. Natural Language Processing of Clinical Documentation to Assess Functional Status in Patients With Heart Failure. JAMA Network Open 2024, 7: e2443925. PMID: 39509128, PMCID: PMC11544492, DOI: 10.1001/jamanetworkopen.2024.43925.Peer-Reviewed Original ResearchConceptsFunctional status assessmentArea under the receiver operating characteristic curveClinical documentationElectronic health record dataHF symptomsOptimal care deliveryHealth record dataAssess functional statusStatus assessmentClinical trial participationProcessing of clinical documentsFunctional status groupCare deliveryOutpatient careMain OutcomesMedical notesTrial participantsNew York Heart AssociationFunctional statusQuality improvementRecord dataHeart failureClinical notesDiagnostic studiesStatus groupsEstablishment of Amblyomma maculatum Ticks and Rickettsia parkeri the Northeastern United States - Volume 30, Number 10—October 2024 - Emerging Infectious Diseases journal - CDC
Molaei G, Khalil N, Ramos C, Paddock C. Establishment of Amblyomma maculatum Ticks and Rickettsia parkeri the Northeastern United States - Volume 30, Number 10—October 2024 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2024, 30: 2208-2211. PMID: 39320216, PMCID: PMC11431899, DOI: 10.3201/eid3010.240821.Peer-Reviewed Original ResearchMeSH KeywordsAmblyommaAnimalsAntibodies, BacterialConnecticutFemaleHumansMaleRickettsiaRickettsia InfectionsTick BitesA PrEP decision aid for women survivors of intimate partner violence: Task-shifting implementation to domestic violence service settings
Meyer J, Lazarus E, Phillips K, Watts Z, Duroseau B, Carlson C, Price C, Kershaw T, Willie T. A PrEP decision aid for women survivors of intimate partner violence: Task-shifting implementation to domestic violence service settings. PLOS ONE 2024, 19: e0310837. PMID: 39288155, PMCID: PMC11407614, DOI: 10.1371/journal.pone.0310837.Peer-Reviewed Original ResearchConceptsIntimate partner violence survivorsIntimate partner violenceAgency staffPartner violenceHIV prevention interventionsService agenciesDomestic violence service agenciesSurvivors of intimate partner violenceWomen survivors of intimate partner violenceDomestic violence agenciesFemale IPV survivorsService delivery mechanismsHIV pre-exposure prophylaxisTrauma responseIPV survivorsPre-exposure prophylaxisPreventive health needsWomen survivorsPreventive interventionsQualitative interviewsStructural barriersAid interventionsHealth needsConsolidated Framework for Implementation ResearchAgenciesA Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder
Kiluk B, Benitez B, DeVito E, Frankforter T, LaPaglia D, O’Malley S, Nich C. A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder. JAMA Network Open 2024, 7: e2435205. PMID: 39325452, PMCID: PMC11428014, DOI: 10.1001/jamanetworkopen.2024.35205.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCognitive Behavioral TherapyConnecticutFemaleHumansMaleMiddle AgedTreatment OutcomeConceptsCognitive behavioral therapyDigital cognitive behavioral therapyAlcohol use disorderAlcohol useCBT programUse disorderCognitive behavioral therapy programCurrent alcohol use disorderTreatment-seeking adultsBehavioral therapy programEvidence-based treatmentsBaseline to 6-month follow-upRates of alcohol useReducing alcohol useTreatment periodRandomized clinical trialsBehavioral therapyOutpatient substancePercentage of daysOutpatient treatmentIntention-to-treat analysisIndividual counselingStudy periodFollow-upIntention-to-treatProviders’ knowledge and perception of xylazine in the unregulated drug supply: a sequential explanatory mixed-methods study
Hill K, Minahan-Rowley R, Biegacki E, Heimer R, Sue K. Providers’ knowledge and perception of xylazine in the unregulated drug supply: a sequential explanatory mixed-methods study. Harm Reduction Journal 2024, 21: 148. PMID: 39148036, PMCID: PMC11328386, DOI: 10.1186/s12954-024-01052-4.Peer-Reviewed Original ResearchConceptsSequential explanatory mixed-methods studyExplanatory mixed-methods studyMixed-methods studyHealthcare providersHealthcare providers' experiencesHealthcare providers treating patientsSample of providersProviders treating patientsDrug supplyProvider experienceProvider knowledgeIn-depth interviewsImprove careSense of helplessnessConvenience sampleHealthcare educationThematic analysisInterview transcriptsQualitative phasePurposive samplingProvidersHealthcareOpioid supplyAbsence of literatureResultsSeventy-eightIn-person learning during the pandemic: Student take-up and school-level effects of remote and hybrid instruction on student outcomes
Ross S, Jiang S, Young M, Meyer J, Strambler M. In-person learning during the pandemic: Student take-up and school-level effects of remote and hybrid instruction on student outcomes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2407322121. PMID: 39110729, PMCID: PMC11331081, DOI: 10.1073/pnas.2407322121.Peer-Reviewed Original ResearchConceptsStudent take-upIn-person learningLearning opportunitiesHybrid learningResponse to schoolSchool-level effectsStudent enrollment decisionsEffects of schoolingTake-upIn-personDisadvantaged studentsStudent outcomesSchool yearLearning lossHybrid instructionRemote educationRemote studentsEnrollment decisionsActual enrollmentSchoolStudentsLearningTeachersEnrollmentOpportunitiesConnecticut Implements a Team-Based Approach to Cardiovascular Disease Prevention Using Community Health Workers and Mobile Medical Devices
Griffin A, Ogazi C, Vozzolo C, Davis K, Baker R. Connecticut Implements a Team-Based Approach to Cardiovascular Disease Prevention Using Community Health Workers and Mobile Medical Devices. Journal Of Public Health Management And Practice 2024, 30: s124-s126. PMID: 39041747, DOI: 10.1097/phh.0000000000001939.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesCommunity Health WorkersConnecticutFemaleHumansMass ScreeningMiddle AgedConceptsCommunity health workersRisk reduction counselingHealth workersReduction counselingCervical cancer screening servicesSocial determinants of healthCancer screening servicesDeterminants of healthCardiovascular disease risk assessmentService access barriersHealth Action PlanTeam-based approachDeliver breastHealth coachingScreening servicesHealthcare accessCommunity settingsDisease risk assessmentOutreach sessionsAccess barriersClinical servicesPrevention programsConduct outreachTeam-basedScreening assessmentUsing qualitative system dynamics modeling to understand overdose bystander behavior in the context of Connecticut’s Good Samaritan Laws and identify effective policy options
Thompson R, Sabounchi N, Ali S, Heimer R, D’Onofrio G, Heckmann R. Using qualitative system dynamics modeling to understand overdose bystander behavior in the context of Connecticut’s Good Samaritan Laws and identify effective policy options. Harm Reduction Journal 2024, 21: 124. PMID: 38937759, PMCID: PMC11210010, DOI: 10.1186/s12954-024-00990-3.Peer-Reviewed Original ResearchConceptsSamaritan lawsGood Samaritan lawsBystander behaviorGroup model buildingFear of legal consequencesKnowledge of protectionResponses to opioid overdosesCriminal liabilityDrug arrestsLegal consequencesLaw enforcementNaloxone useLawStakeholder-engaged processOpioid overdoseHealth care providersFatal opioid overdoseSustainable system changeOpioid-related outcomesBystander experiencesSamaritanCare providersHarm reductionPotential bystandersPolicy determination
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