2025
Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report
Yang Y, Matuskey D, Benjamin C, Fesharaki-Zadeh A. Self-Inflicted Head Injury in Behavioral Variant Frontotemporal Dementia with Compulsive Behaviors: A Case Report. Cognitive And Behavioral Neurology 2025, 38: 66-72. PMID: 40298273, DOI: 10.1097/wnn.0000000000000392.Peer-Reviewed Original ResearchConceptsBehavioral variant frontotemporal dementiaDiagnosis of behavioural variant frontotemporal dementiaFrontotemporal dementiaEpisodic memory lossLoss of empathyCompulsive behaviorsExecutive functionProgressive behavioral deficitsPsychiatric diagnosisPsychiatric disordersBehavioral deficitsRight hippocampusRight hemisphereBehavioral agitationPersonality changesNeuroimaging findingsInstrumental activities of daily livingMemory lossRight lateral ventricleSevere hypometabolismLateral ventricleParenchymal volume lossClinician's abilityInstrumental activitiesVolume lossCurrent interpretations of the I-PACE model of behavioral addictions
Brand M, Müller A, Wegmann E, Antons S, Brandtner A, Müller S, Stark R, Steins-Loeber S, Potenza M. Current interpretations of the I-PACE model of behavioral addictions. Journal Of Behavioral Addictions 2025, 14: 1-17. PMID: 40063161, PMCID: PMC11974429, DOI: 10.1556/2006.2025.00020.Peer-Reviewed Original ResearchMeSH KeywordsBehavior, AddictiveCognitionCompulsive BehaviorExecutive FunctionHumansImpulsive BehaviorModels, PsychologicalReinforcement, PsychologySelf-ControlConceptsI-PACE modelI-PACEBehavioral addictionsInteraction of Person-Affect-Cognition-ExecutionBehavioral addiction researchCue-reactivityDesire thinkingCompulsive behaviorsExecutive functionAddictive behaviorsNegative reinforcementAddiction researchPermissive beliefsAddiction theoryAddiction fieldSelf-controlAddictionCravingEmpirical findingsTheory buildingClinical careStimulate researchGratificationBehaviorContext of changes
2024
A meta‐analysis assessing reliability of the Yale Food Addiction Scale: Implications for compulsive eating and obesity
Jahrami H, Husain W, Trabelsi K, Ammar A, Pandi‐Perumal S, Saif Z, Potenza M, Lin C, Pakpour A. A meta‐analysis assessing reliability of the Yale Food Addiction Scale: Implications for compulsive eating and obesity. Obesity Reviews 2024, 26: e13881. PMID: 39715731, PMCID: PMC11884959, DOI: 10.1111/obr.13881.Peer-Reviewed Original ResearchMeSH KeywordsCompulsive BehaviorFeeding and Eating DisordersFood AddictionHumansObesityPsychometricsReproducibility of ResultsConceptsYale Food Addiction ScaleRandom-effects meta-analysisReliability generalization meta-analysisMeta-analysisFood addictionTest-retest correlation coefficientTest-retest reliabilityComprehensive systematic reviewSixty-five studiesIntraclass coefficientSystematic reviewAddiction ScaleDisordered eatingCompulsive eatingObesitySample sizeEatingCorrelation coefficientEating disordersIntraclassReliability measuresReliabilityParticipantsScaleInceptionCurrent Understanding of Compulsive Sexual Behavior Disorder and Co-occurring Conditions: What Clinicians Should Know about Pharmacological Options
Mestre-Bach G, Potenza M. Current Understanding of Compulsive Sexual Behavior Disorder and Co-occurring Conditions: What Clinicians Should Know about Pharmacological Options. CNS Drugs 2024, 38: 255-265. PMID: 38485889, DOI: 10.1007/s40263-024-01075-2.Peer-Reviewed Original ResearchMeSH KeywordsCompulsive BehaviorFluoxetineHumansParoxetineSelective Serotonin Reuptake InhibitorsSertralineConceptsCompulsive sexual behavior disorderSexual behavior disorderReuptake inhibitorsBehavioral disordersPornography usePharmacological treatmentCo-occurring disordersEmpirical supportSerotonin reuptake inhibitorsCo-occurring conditionsMood stabilizersPsychiatric disordersPsychological therapiesTricyclic antidepressantsGeneralizability of resultsOpioid antagonistSerotonin antagonistsDisordersSerotoninPharmacological optionsPharmacological approachesAntagonistPharmacological therapyNarrative reviewNefazodoneDebates on Compulsive Sexual Behavior Disorder: A Call for Global and Interdisciplinary Perspectives
Bőthe B, Potenza M, Demetrovics Z. Debates on Compulsive Sexual Behavior Disorder: A Call for Global and Interdisciplinary Perspectives. Archives Of Sexual Behavior 2024, 53: 1215-1220. PMID: 38418717, DOI: 10.1007/s10508-024-02836-2.Peer-Reviewed Original Research
2023
Behavioral addictions in the ICD-11: An important debate that is anticipated to continue for some time
Brand M, Potenza M. Behavioral addictions in the ICD-11: An important debate that is anticipated to continue for some time. Journal Of Behavioral Addictions 2023, 12: 585-589. PMID: 37682725, PMCID: PMC10562818, DOI: 10.1556/2006.2023.00042.Commentaries, Editorials and LettersCompulsive sexual behavior disorder in 42 countries: Insights from the International Sex Survey and introduction of standardized assessment tools
Bőthe B, Koós M, Nagy L, Kraus S, Demetrovics Z, Potenza M, Michaud A, Ballester-Arnal R, Batthyány D, Bergeron S, Billieux J, Briken P, Burkauskas J, Cárdenas-López G, Carvalho J, Castro-Calvo J, Chen L, Ciocca G, Corazza O, Csako R, Fernandez D, Fernandez E, Fournier L, Fujiwara H, Fuss J, Gabrhelík R, Gewirtz-Meydan A, Gjoneska B, Gola M, Grubbs J, Hashim H, Islam S, Ismail M, Jiménez-Martínez M, Jurin T, Kalina O, Klein V, Költő A, Lee C, Lee S, Lewczuk K, Lin C, team L, Lochner C, López-Alvarado S, Lukavská K, Mayta-Tristán P, Milea I, Miller D, Orosová O, Orosz G, team S, Ponce F, Quintana G, Garzola G, Ramos-Diaz J, Rigaud K, Rousseau A, De Tubino Scanavino M, Schulmeyer M, Sharan P, Shibata M, Shoib, Leirós V, Sniewski L, Spasovski O, Steibliene V, Stein D, Strizek J, Štulhofer A, Ünsal B, Vaillancourt-Morel M. Compulsive sexual behavior disorder in 42 countries: Insights from the International Sex Survey and introduction of standardized assessment tools. Journal Of Behavioral Addictions 2023, 12: 393-407. PMID: 37352095, PMCID: PMC10316175, DOI: 10.1556/2006.2023.00028.Peer-Reviewed Original Research
2022
Obsessive-compulsive, harm-avoidance and persistence tendencies in patients with gambling, gaming, compulsive sexual behavior and compulsive buying-shopping disorders/concerns
Mestre-Bach G, Granero R, Fernández-Aranda F, Potenza M, Jiménez-Murcia S. Obsessive-compulsive, harm-avoidance and persistence tendencies in patients with gambling, gaming, compulsive sexual behavior and compulsive buying-shopping disorders/concerns. Addictive Behaviors 2022, 139: 107591. PMID: 36587418, DOI: 10.1016/j.addbeh.2022.107591.Peer-Reviewed Original ResearchMeSH KeywordsBehavior, AddictiveCompulsive BehaviorGamblingHumansObsessive-Compulsive DisorderSexual BehaviorVideo GamesConceptsObsessive-compulsive featuresTreatment-seeking patientsObsessive-compulsive subscaleBehavioral addictionsDifferent behavioural addictionsHarm avoidanceDifferent addictionsSymptom ChecklistObsessive-compulsive measuresLower scoresBuying-shopping disorderInternet gaming disorderCompulsive sexual behavior disorderCompulsive sexual behaviorSexual behavior disorderCharacter Inventory-RevisedGambling disorderGaming disorderCharacter InventoryClinical populationsInventory-RevisedPersonality profilesBehavior disorderHigher scoresEmpirical groupMale DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes
Stewart A, Davis G, Areal L, Rabil M, Tran V, Mayer F, Blakely R. Male DAT Val559 Mice Exhibit Compulsive Behavior under Devalued Reward Conditions Accompanied by Cellular and Pharmacological Changes. Cells 2022, 11: 4059. PMID: 36552823, PMCID: PMC9777203, DOI: 10.3390/cells11244059.Peer-Reviewed Original ResearchConceptsDAT Val559 miceAnomalous DA effluxDorsal medial striatumCompulsive behaviorsFormation of goal-directedLever-pressing paradigmDA agonist apomorphineDevaluation of rewardPairwise discrimination taskGoal-directed behaviorDendritic spine densityDAT Val559Habitual rewardAgonist apomorphineDA neurotransmissionDA effluxReward conditionCognitive flexibilityReinforcement scheduleReward motivationStriatal circuitryChecking behaviorMedial striatumPsychiatric disordersDiscrimination taskThe World Federation of Societies of Biological Psychiatry guidelines on the assessment and pharmacological treatment of compulsive sexual behaviour disorder
Turner D, Briken P, Grubbs J, Malandain L, Mestre-Bach G, Potenza M, Thibaut F. The World Federation of Societies of Biological Psychiatry guidelines on the assessment and pharmacological treatment of compulsive sexual behaviour disorder. Dialogues In Clinical Neuroscience 2022, 24: 10-69. PMID: 37522807, PMCID: PMC10408697, DOI: 10.1080/19585969.2022.2134739.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultBiological PsychiatryCompulsive BehaviorHumansParaphilic DisordersSexual BehaviorSexual Dysfunctions, PsychologicalConceptsPharmacological treatmentCompulsive sexual behavior disorderBehavior disorderBiological Psychiatry (WFSBP) GuidelinesRelevant pharmacological treatmentFirst-choice treatmentTreatment of adultsType of medicationTreatment of patientsSexual behavior disorderParaphilic disordersStrength of evidenceChemsex behavioursHormonal agentsTreatment recommendationsCurrent guidelinesPsychiatric disordersPharmacological agentsClinical practiceExtensive literature searchLiterature searchPatientsGoogle ScholarDisordersWorld FederationCo-Occurring Obsessive–Compulsive Disorder and Compulsive Sexual Behavior: Clinical Features and Psychiatric Comorbidities
Snaychuk L, Ferrão Y, Fontenelle L, Miguel E, de Mathis M, Scanavino M, Kim H. Co-Occurring Obsessive–Compulsive Disorder and Compulsive Sexual Behavior: Clinical Features and Psychiatric Comorbidities. Archives Of Sexual Behavior 2022, 51: 4111-4123. PMID: 36066680, DOI: 10.1007/s10508-022-02412-6.Peer-Reviewed Original ResearchMeSH KeywordsComorbidityCompulsive BehaviorFemaleHumansMaleObsessive-Compulsive DisorderSexual BehaviorSexual Dysfunctions, PsychologicalConceptsCo-occurring obsessive-compulsive disorderObsessive-compulsive disorderPsychiatric comorbidityCompulsive sexual behaviorBinary logistic regression analysisComorbid obsessive-compulsive disorderGreater psychiatric comorbidityLogistic regression analysisComplex treatment needsSexual behaviorClinical characteristicsClinical factorsClinical featuresStandardized self-report measuresComorbiditiesControl disordersTreatment needsPsychiatric conditionsDisordersRegression analysisPreliminary evidenceSelf-report measuresCurrent studySemi-structured interviewsParticipantsNeurocircuit models of obsessive-compulsive disorder: limitations and future directions for research
Shephard E, Batistuzzo M, Hoexter M, Stern E, Zuccolo P, Ogawa C, Silva R, Brunoni A, Costa D, Doretto V, Saraiva L, Cappi C, Shavitt R, Simpson H, van den Heuvel O, Miguel E. Neurocircuit models of obsessive-compulsive disorder: limitations and future directions for research. Brazilian Journal Of Psychiatry 2022, 44: 187-200. PMID: 35617698, PMCID: PMC9041967, DOI: 10.1590/1516-4446-2020-1709.Peer-Reviewed Original ResearchMeSH KeywordsCognitionCompulsive BehaviorHumansNeuroimagingObsessive BehaviorObsessive-Compulsive DisorderConceptsObsessive-compulsive disorderCourse of OCDCognitive mechanismsCommon psychiatric conditionsSpecific neurocircuitsCognitive functionNeurocognitive functionPsychiatric conditionsFuture researchComplexity of brainFuture directionsDisordersCurrent reviewNeuroscienceNeurocircuitsCompulsionResearchSymptomatologyObsessionExperiences of patientsExperienceImportant limitationsPresentationBetter understandingBrainClinical characteristics of transformation obsessions in obsessive-compulsive disorder: A psychopathological study
Bettess Z, Albertella L, Destree L, Rosário M, Ferrão Y, Miguel E, Fontenelle L. Clinical characteristics of transformation obsessions in obsessive-compulsive disorder: A psychopathological study. Australian & New Zealand Journal Of Psychiatry 2022, 57: 130-139. PMID: 35303769, DOI: 10.1177/00048674221084241.Peer-Reviewed Original ResearchMeSH KeywordsCompulsive BehaviorHumansObsessive BehaviorObsessive-Compulsive DisorderPsychopathologySuicidal Ideation
2021
Assigning the right credit to the wrong action: compulsivity in the general population is associated with augmented outcome-irrelevant value-based learning
Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Kiddle B, Polek E, Fearon P, Suckling J, van Harmelen A, Kievit R, Chamberlain S. Assigning the right credit to the wrong action: compulsivity in the general population is associated with augmented outcome-irrelevant value-based learning. Translational Psychiatry 2021, 11: 564. PMID: 34741013, PMCID: PMC8571313, DOI: 10.1038/s41398-021-01642-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnxiety DisordersCompulsive BehaviorHumansMotivationObsessive-Compulsive DisorderReinforcement, PsychologyConceptsCompulsive behaviorsCompulsive tendenciesValue-based learningSelf-reported compulsivityReinforcement learning tasksSchizotypal tendenciesStimulus locationCompulsivityFuture eventsWrong actionsLearning processFuture researchPositive relationshipSpecific actsCurrent studyTaskLearningIndividualsGeneral populationCausal relationshipHealthy individualsAnxietyTendencyBehaviorBeliefsImpulsivity and compulsivity in binge eating disorder: A systematic review of behavioral studies
Carr MM, Wiedemann AA, Macdonald-Gagnon G, Potenza MN. Impulsivity and compulsivity in binge eating disorder: A systematic review of behavioral studies. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2021, 110: 110318. PMID: 33794320, PMCID: PMC8222068, DOI: 10.1016/j.pnpbp.2021.110318.Peer-Reviewed Original ResearchMeSH KeywordsBinge-Eating DisorderCase-Control StudiesCompulsive BehaviorFeeding BehaviorHumansImpulsive BehaviorNeuropsychological TestsObesityConceptsRapid-response impulsivityResponse impulsivityChoice impulsivityTask methodologyBehavioral studiesMultiple psychiatric disordersImpulsivityCompulsive behaviorsSpecific facetsCompulsivityGroup differencesFuture researchSample characteristicsPsychiatric disordersUnique sampleIndividualsDisordersMore researchBingeResearchOverweight/obesityBehavior
2020
Validation of a Brief Pornography Screen across multiple samples
Kraus SW, Gola M, Grubbs JB, Kowalewska E, Hoff RA, Lew-Starowicz M, Martino S, Shirk SD, Potenza MN. Validation of a Brief Pornography Screen across multiple samples. Journal Of Behavioral Addictions 2020, 9: 259-271. PMID: 32644937, PMCID: PMC8939429, DOI: 10.1556/2006.2020.00038.Peer-Reviewed Original ResearchConceptsCompulsive sexual behavior disorderMale patientsU.S. representative sampleU.S. veteransBehavior disorderHigh internal consistencyReceiver Operating Characteristic (ROC) curveCharacteristic curveOne-factor solutionFactor structureOperating Characteristic curveFive-itemPolish adultsSexual behavior disorderInternal consistencyPsychometric propertiesRepresentative sampleDiscriminant validityProblematic pornography useScoresItem endorsementStudy 1PatientsIndependent samplesCurrent gapsSubacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation
Bey AL, Gorman MP, Gallentine W, Kohlenberg TM, Frankovich J, Jiang YH, Van Haren K. Subacute Neuropsychiatric Syndrome in Girls With SHANK3 Mutations Responds to Immunomodulation. 2020, 145: e20191490. PMID: 32015180, PMCID: PMC7802010, DOI: 10.1542/peds.2019-1490.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionAntipsychotic AgentsAnxietyAutism Spectrum DisorderCatatoniaChildCompulsive BehaviorCryingDevelopmental DisabilitiesFemaleFrameshift MutationHallucinationsHumansImmunoglobulins, IntravenousImmunosuppressive AgentsImmunotherapyIrritable MoodMethylprednisoloneMutismNerve Tissue ProteinsNeuroprotective AgentsObsessive-Compulsive DisorderRecurrenceSelf CareSleep Initiation and Maintenance DisordersStereotyped BehaviorSyndromeUrinary IncontinenceUrinary RetentionConceptsClinical observationsChronic relapsing coursePeriod of treatmentYears of ageImmunomodulatory treatmentUrinary retentionRelapsing courseNeurologic regressionCase seriesAntipsychotic medicationNeuropsychiatric syndromeMood disordersImmune functionObsessive-compulsive behaviorRare monogenic disordersNeurobehavioral syndromeTranslational investigationsPremorbid levelSHANK3 mutationsPatientsHormonal stimuliMonogenic disordersResponsive phenotypeDevelopmental disabilitiesSyndrome
2019
Btbd3 expression regulates compulsive-like and exploratory behaviors in mice
Thompson SL, Welch AC, Ho EV, Bessa JM, Portugal-Nunes C, Morais M, Young JW, Knowles JA, Dulawa SC. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Translational Psychiatry 2019, 9: 222. PMID: 31501410, PMCID: PMC6733800, DOI: 10.1038/s41398-019-0558-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderKnockout miceCompulsive-like behaviorLimbic cortico-striatoExploratory behaviorThalamo-cortical circuitsMarble-burying testPrimary sensory cortexNeural circuit formationDendritic morphologyImpaired goal-directed behaviorAnterior cingulate cortexGoal-directed behaviorChronic treatmentSpine densityCortico-striatoMediodorsal thalamusDendritic pruningSensory cortexNeonatal developmentAnterior cingulateCingulate cortexCircuit formationPotential risk genesMice
2018
Manifesto for a European research network into Problematic Usage of the Internet
Fineberg N, Demetrovics Z, Stein D, Ioannidis K, Potenza M, Grünblatt E, Brand M, Billieux J, Carmi L, King D, Grant J, Yücel M, Dell'Osso B, Rumpf H, Hall N, Hollander E, Goudriaan A, Menchon J, Zohar J, Burkauskas J, Martinotti G, Van Ameringen M, Corazza O, Pallanti S, Network C, Chamberlain. Manifesto for a European research network into Problematic Usage of the Internet. European Neuropsychopharmacology 2018, 28: 1232-1246. PMID: 30509450, PMCID: PMC6276981, DOI: 10.1016/j.euroneuro.2018.08.004.Peer-Reviewed Original ResearchDual diagnosis of obsessive compulsive and compulsive buying disorders: Demographic, clinical, and psychiatric correlates
Kim H, Hodgins D, Torres A, Fontenelle L, do Rosário M, de Mathis M, Ferrão Y, Miguel E, Tavares H. Dual diagnosis of obsessive compulsive and compulsive buying disorders: Demographic, clinical, and psychiatric correlates. Comprehensive Psychiatry 2018, 86: 67-73. PMID: 30081209, DOI: 10.1016/j.comppsych.2018.07.013.Peer-Reviewed Original ResearchConceptsCompulsive buying disorderObsessive-compulsive disorderBuying disorderComorbid obsessive-compulsive disorderDual diagnosisUnique clinical populationInternet use disordersDual diagnosis populationPsychiatric correlatesPsychiatric disordersPsychological mechanismsSocial phobiaOCD symptomsStructured Clinical InterviewClinical populationsSound measureLarge multi-centre studyClinical InterviewProtective factorsMulti-center studyUse disordersPresent researchTreatment utilityBinary logistic regressionCorrelates
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