2025
Neurocognitive effects of psilocybin: A systematic and comprehensive review of neuroimaging studies in humans
Berkovitch L, Fauvel B, Preller K, Gaillard R. Neurocognitive effects of psilocybin: A systematic and comprehensive review of neuroimaging studies in humans. Neuroscience & Biobehavioral Reviews 2025, 175: 106239. PMID: 40456393, DOI: 10.1016/j.neubiorev.2025.106239.Peer-Reviewed Original ResearchConceptsEffects of psilocybinPsilocybin effectsNeuroimaging studiesBrain changesNeuroimaging techniquesTherapeutic effects of psilocybinTreat various psychiatric disordersFunctional brain changesSamples of healthy volunteersSerotonergic compoundsEmotional processingNeurobiological mechanismsMode networkPsychiatric disordersCognitive tasksPsychoactive effectsBrain activityNeuroimaging dataPsilocybinSelf-experienceAssociated with acute alterationsSocial functioningTherapeutic effectBrainNeuronal networksSex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias
He J, Cabrera‐Mendoza B, Friligkou E, Mecca A, van Dyck C, Pathak G, Polimanti R. Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias. Alzheimer's & Dementia 2025, 21: e70215. PMID: 40421744, PMCID: PMC12107445, DOI: 10.1002/alz.70215.Peer-Reviewed Original ResearchConceptsSocioeconomic factorsFamily historySocioeconomic statusFamily history of Alzheimer's diseaseAssociation of socioeconomic factorsHistory of Alzheimer's diseaseUs Research ProgramCognitive performanceHigher socioeconomic statusSex-specific associationsAlzheimer's disease assessmentSex differencesUK BiobankADRDAlzheimer's diseaseGenetically informed analysesDementiaSample sizeSexGenetic analysisAlzheimerLimited informationStatusConfoundingBiobankDevelopment and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults.
Nanna M, Wojdyla D, Peterson E, Navar A, Williamson J, Colantonio L, Wang S, Jamil Y, Bertoni A, Nahid M, Damluji A, Goyal P, Chaudhry S, Gill T, Alexander K. Development and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults. Journal Of The American Heart Association 2025, 14: e038949. PMID: 40401627, DOI: 10.1161/jaha.124.038949.Peer-Reviewed Original ResearchConceptsRisk of cognitive impairmentAtherosclerotic cardiovascular disease eventsAtherosclerotic cardiovascular diseaseRisk prediction modelCognitive impairmentOlder adultsMeasures of healthIncident cognitive impairmentOlder person's riskPooled Cohort EquationsCardiovascular diseaseRisk of deathCohort EquationsFramingham OffspringOlder personsExternal validationFunctional statusPersonal riskIncidence riskValidation cohortYoung adultsInternal validityFraminghamCohortTreatment decisionsLongitudinal and Geographic Trends in Perceived Racial Discrimination Among Adolescents in the United States: The Adolescent Brain Cognitive Development Study
Fields C, Black C, Calhoun A, Rosenblatt M, Rodriguez R, Aina J, Thind J, Grayson J, Khalifa F, Assari S, Zhou X, Nagata J, Gee D. Longitudinal and Geographic Trends in Perceived Racial Discrimination Among Adolescents in the United States: The Adolescent Brain Cognitive Development Study. Journal Of Adolescent Health 2025, 77: 118-127. PMID: 40382724, DOI: 10.1016/j.jadohealth.2025.03.014.Peer-Reviewed Original ResearchConceptsNon-Hispanic youthPerceived discriminationDevelopment studiesHigher levels of perceived discriminationAmerican Community SurveyAnti-Black biasLevels of perceived discriminationPacific IslandersPerceived Discrimination ScaleWhite non-Hispanic youthNeighborhood segregationBlack householdsBlack youthContext-specific approachImmigrant backgroundPerceived racial discriminationRacial discriminationCommunity SurveyRacial biasYouthGeographic variationStructural contextAdolescent Brain Cognitive Development StudyNational representativesRacial/ethnic groupsIncreased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity
Gogniat M, Khan O, Li J, Park C, Robb W, Zhang P, Sun Y, Moore E, Houston M, Pechman K, Shashikumar N, Davis L, Liu D, Landman B, Cole K, Bolton C, Gifford K, Hohman T, Full K, Jefferson A. Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity. Alzheimer's & Dementia 2025, 21: e70157. PMID: 40357887, PMCID: PMC12070248, DOI: 10.1002/alz.70157.Peer-Reviewed Original ResearchConceptsSedentary behaviorSedentary timeOlder adultsLevels of physical activityAPOE-e4 carrier statusReduce sedentary timeBrain structuresIncreased sedentary behaviorAPOE-e4 statusRisk factorsModifiable risk factorsLongitudinal linear regressionAlzheimer's diseaseHippocampal volume reductionPhysical activityEffect modificationAPOE-e4E4 statusEpisodic memoryNeuropsychological assessmentApolipoprotein EWorse cognitionAging adultsGenetic riskCognitive changes[Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China].
Xu H, Wu Y, Chen C, Meng X, Chen J, Zhang Z, Zhong Z, Yang J, Fu X, Chen S, Chen Y, Li Z, Ye L, Shi X, Lyu Y. [Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China]. Chinese Journal Of Epidemiology 2025, 46: 753-760. PMID: 40494781, DOI: 10.3760/cma.j.cn112338-20250124-00060.Peer-Reviewed Original ResearchConceptsLevels of physical activityPhysical activityOlder adultsCognitive impairmentIntensity levels of physical activityIntensity of physical activityPhysical Activity ScaleChronic disease historyWork-related activitiesMultifactorial logistic regression modelsLogistic regression modelsMini-MentalBiomarkers Cohort StudyChinese versionActivity ScaleActive leisureCohort studyLongevity areasDemographic characteristicsHealthy agingDisease historyHousehold activitiesRegression modelsCognitive functionNegative associationRegional disparities in cognitive life expectancy: The role of birth and current residence in the United States
Wong J, Zang E. Regional disparities in cognitive life expectancy: The role of birth and current residence in the United States. Health & Place 2025, 94: 103475. PMID: 40311376, DOI: 10.1016/j.healthplace.2025.103475.Peer-Reviewed Original ResearchConceptsCognitive impairment riskCurrent residenceLife expectancyCognitive impairmentMultistate life table approachHealth and Retirement StudyRegional disparitiesHealthy life expectancyImpairment riskImpact of birthLong-term healthLife table approachPercentage of lifeRetirement StudyImpaired life expectancyEstimate yearsBirth regionDementiaPolicy implicationsCombination of birthCognitive declineResidentsHealthDisparitiesBirthEffects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study
Baker L, Pa J, Katula J, Aslanyan V, Salmon D, Jacobs D, Chmelo E, Hodge H, Morrison R, Matthews G, Brewer J, Jung Y, Rissman R, Taylor C, Léger G, Messer K, Evans A, Okonkwo O, Shadyab A, Zou J, Jin S, Thomas R, Zhang J, La Croix A, Cotman C, Feldman H, Group F. Effects of exercise on cognition and Alzheimer's biomarkers in a randomized controlled trial of adults with mild cognitive impairment: The EXERT study. Alzheimer's & Dementia 2025, 21: e14586. PMID: 40271888, PMCID: PMC12019696, DOI: 10.1002/alz.14586.Peer-Reviewed Original ResearchConceptsSedentary older adultsAmnestic mild cognitive impairmentIntensity aerobic trainingMild cognitive impairmentEffects of exerciseRandomized controlled trialsIntervention deliveryAerobic trainingOlder adultsMonths of supervised exerciseCognitive impairmentMultisite randomized controlled trialCognitive trajectoriesLower-intensity exerciseMeasure of global cognitive functionRandomized controlled trials of adultsTests of executive functionIntervention group differencesMeasures of brain healthAssess intervention efficacyGlobal cognitive functionGlobal cognitive compositeMild cognitive impairment groupSupervised exerciseMild memory problemsImpact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition
Le G, Kwan A, Guo Z, Dev D, Wong S, Badulescu S, Ceban F, Teopiz K, Johnson D, Gill H, Di Vincenzo J, Meshkat S, Rhee T, Ho R, Phan L, Rosenblat J, Mansur R, Subramaniapillai M, McIntyre R. Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition. Clinical Nursing Research 2025, 34: 143-152. PMID: 40231351, DOI: 10.1177/10547738251329412.Peer-Reviewed Original ResearchConceptsDigit Symbol Substitution TestFatigue Severity ScaleTMT-A/BCognitive deficitsAssociated with cognitive deficitsTrail Making Test Part APost-COVID-19 conditionNeurobiological substratesDigit SymbolObjective cognitionSubstitution TestCognitive functionCognitionSeverity ScalePart AImpact of fatigueDeficitsPersonsMultiple lines of evidenceSecondary analysisGeneral populationLines of evidenceDebilitating conditionEffects of fatigueGeneralized linear modelWhole-brain white matter variation across childhood environments
Carozza S, Kletenik I, Astle D, Schwamm L, Dhand A. Whole-brain white matter variation across childhood environments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2409985122. PMID: 40193606, PMCID: PMC12012481, DOI: 10.1073/pnas.2409985122.Peer-Reviewed Original ResearchConceptsAdolescent Brain Cognitive DevelopmentAssociated with later difficultiesFractional anisotropyWhite matter fractional anisotropyWhite matter FAGray matter maturationWhite matter differencesEffects of adversityLower white matter fractional anisotropyLowest values of FACourse of childhoodExperience-dependent mannerInterpersonal adversityGray matter regionsReceptive languageCognitive effectsDevelopmental theoryEarly environmentCognitive outcomesCognitive developmentNeighborhood adversityChildhood environmentCross-sectional associationsMatter regionsAdversityCOVID-19 Pandemic–Related Exposures and Cognitive Function in Middle-Aged Women
Wang S, Menor A, Chibnik L, Kang J, Vyas C, Blacker D, Kubzansky L, Koenen K, Roberts A. COVID-19 Pandemic–Related Exposures and Cognitive Function in Middle-Aged Women. JAMA Network Open 2025, 8: e255532. PMID: 40244583, PMCID: PMC12006873, DOI: 10.1001/jamanetworkopen.2025.5532.Peer-Reviewed Original ResearchConceptsMiddle-aged womenCognitive AssessmentStudy of registered nursesNurses' Health Study IICognitive functionCohort study analyzed dataCOVID-19 pandemicAssociated with cognitive functionCognitive declineCogstate Brief BatteryPost-COVID-19 conditionAssociated with cognitive declineAssociated with risk factorsStudy analyzed dataPandemic-related eventsComposite cognitive scoreCognitive test batteryReduced cognitive functionMain OutcomesEducation levelTest practice effectsCohort studyCOVID-19Brief batteryStudy IIAssociations Between Internalized HIV Stigma and Cognitive Function Among Older Women With HIV
Vu T, Wise J, Jones D, Wingood G, Diaz M, Chandran A, Cohen M, Weiser S, Spence A, Wilson T, Norcini-Pala A, Sharma A, Rubin L, Turan B, Turan J, Monin J. Associations Between Internalized HIV Stigma and Cognitive Function Among Older Women With HIV. The Journals Of Gerontology Series B 2025, 80: gbaf058. PMID: 40123355, PMCID: PMC12067073, DOI: 10.1093/geronb/gbaf058.Peer-Reviewed Original ResearchMeSH KeywordsAgedCognitionCognitive DysfunctionFemaleHIV InfectionsHumansMiddle AgedSelf ConceptSocial StigmaConceptsInternalized HIV stigmaHIV stigmaAssociated with poorer global cognitive functionCognitive functionHIV Stigma ScalePoorer global cognitive functionStigma reduction interventionsAnnual incomeBenefit cognitive functionDomain-specific scoresFine motor functionGlobal cognitive scoreNonprescription drug useGlobal cognitive functionWomen's Interagency HIV StudyStigma ScaleMental healthReduction interventionsDepressive symptomsLinear regression modelsOlder WomenWomen ageStigmaCognitive AssessmentAlcohol useQuantifying associations between socio-spatial factors and cognitive development in the ABCD cohort
Osayande N, Marotta J, Aggarwal S, Kopal J, Holmes A, Yip S, Bzdok D. Quantifying associations between socio-spatial factors and cognitive development in the ABCD cohort. Nature Computational Science 2025, 5: 221-233. PMID: 40114020, DOI: 10.1038/s43588-025-00774-0.Peer-Reviewed Original ResearchConceptsAdolescent Brain Cognitive Development StudyCognitive developmentUS Census dataCognitive Development StudyBayesian multilevel regressionPost-stratificationSocio-spatial factorsSociodemographic disparitiesSocioeconomic statusABCD cohortSociodemographic variablesBayesian multilevel modelsQuantify associationsInter-individual differencesMultilevel regressionPublic healthMultilevel modelsCensus dataInterpretation of model predictionsDemographic groupsDevelopment studiesHolistic explanationHomogeneous representationModeling frameworkMounting demandEpigenetic Clocks Relate to 4 Age-related Health Outcomes Similarly Across 3 Countries
Crimmins E, Hernandez B, Potter C, Kim J, Higgins-Chen A, Kenny R, O’Halloran A, McGuinness B, Smyth L, Hill C, Fiorito G, Faul J, McKnight A, McCrory C. Epigenetic Clocks Relate to 4 Age-related Health Outcomes Similarly Across 3 Countries. The Journals Of Gerontology Series A 2025, 80: glaf036. PMID: 40091605, PMCID: PMC12168442, DOI: 10.1093/gerona/glaf036.Peer-Reviewed Original ResearchConceptsHealth outcomesIrish Longitudinal Study on AgeingLongitudinal Study on AgingHealth and Retirement StudyLongitudinal Study of AgingAge-related health outcomesEpigenetic ageMeasures of epigenetic agingStudy of AgingNationally representative dataUnited StatesRepublic of IrelandNorthern Ireland CohortRetirement StudyEpigenetic clocksNorthern IrelandOlder populationPopulation agingLife circumstancesRepresentative dataHealthSurvey questionsIreland CohortPopulation characteristicsLongitudinal studyWhite Matter, Cognition, and Electrophysiological Variables in Bipolar Disorder: Using Multimodal Integration of Biomarker Variables Associated With Bipolar Disorder to Elucidate Deficits
Berardi A, Brown J, Jackson B, Huang L, Trotti R, Parker D, Hill S, Ivleva E, Pearlson G, Tamminga C, Keshavan M, Keedy S, Gershon E, Sweeney J, Clementz B, McDowell J. White Matter, Cognition, and Electrophysiological Variables in Bipolar Disorder: Using Multimodal Integration of Biomarker Variables Associated With Bipolar Disorder to Elucidate Deficits. Bipolar Disorders 2025, 27: 205-216. PMID: 40084552, PMCID: PMC12169086, DOI: 10.1111/bdi.70010.Peer-Reviewed Original ResearchConceptsEvent-related potentialsStop signal taskBipolar disorderBrief Assessment of CognitionLongitudinal fasciculusFractional anisotropyBrain electrophysiological measuresRight inferior longitudinal fasciculusIntermediate Phenotypes consortiumMeasures of white matter microstructureBilateral superior longitudinal fasciculusAssessment of CognitionAuditory event-related potentialsBilateral anterior thalamic radiationIntrinsic brain activitySuperior longitudinal fasciculusWhite matter integrityInferior longitudinal fasciculusCingulum cingulate gyrusWhite matter microstructureAnterior thalamic radiationRadial diffusivityWhite matter variabilitySignal taskBrief AssessmentCurrent interpretations of the I-PACE model of behavioral addictions
Brand M, Müller A, Wegmann E, Antons S, Brandtner A, Müller S, Stark R, Steins-Loeber S, Potenza M. Current interpretations of the I-PACE model of behavioral addictions. Journal Of Behavioral Addictions 2025, 14: 1-17. PMID: 40063161, PMCID: PMC11974429, DOI: 10.1556/2006.2025.00020.Peer-Reviewed Original ResearchConceptsI-PACE modelI-PACEBehavioral addictionsInteraction of Person-Affect-Cognition-ExecutionBehavioral addiction researchCue-reactivityDesire thinkingCompulsive behaviorsExecutive functionAddictive behaviorsNegative reinforcementAddiction researchPermissive beliefsAddiction theoryAddiction fieldSelf-controlAddictionCravingEmpirical findingsTheory buildingClinical careStimulate researchGratificationBehaviorContext of changesDeep learning to quantify the pace of brain aging in relation to neurocognitive changes
Yin C, Imms P, Chowdhury N, Chaudhari N, Ping H, Wang H, Bogdan P, Irimia A, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Landau S, Rivera-Mindt M, Okonkwo O, Shaw L, Lee E, Toga A, Beckett L, Harvey D, Green R, Saykin A, Nho K, Perrin R, Tosun D, Sachdev P, Green R, Drake E, Montine T, Conti C, Weiner M, Nosheny R, Truran Sacrey D, Fockler J, Miller M, Conti C, Kwang W, Jin C, Diaz A, Ashford M, Flenniken D, Kormos A, Petersen R, Aisen P, Rafii M, Raman R, Jimenez G, Donohue M, Salazar J, Fidell A, Boatwright V, Robison J, Zimmerman C, Cabrera Y, Walter S, Clanton T, Shaffer E, Webb C, Hergesheimer L, Smith S, Ogwang S, Adegoke O, Mahboubi P, Pizzola J, Jenkins C, Beckett L, Harvey D, Donohue M, Saito N, Diaz A, Hussen K, Okonkwo O, Rivera-Mindt M, Amaza H, Thao M, Parkins S, Ayo O, Glittenberg M, Hoang I, Germano K, Strong J, Weisensel T, Magana F, Thomas L, Guzman V, Ajayi A, Di Benedetto J, Talavera S, Jack C, Felmlee J, Fox N, Thompson P, DeCarli C, Forghanian-Arani A, Borowski B, Reyes C, Hedberg C, Ward C, Schwarz C, Reyes D, Gunter J, Moore-Weiss J, Kantarci K, Matoush L, Senjem M, Vemuri P, Reid R, Malone I, Thomopoulos S, Nir T, Jahanshad N, Knaack A, Fletcher E, Harvey D, Tosun-Turgut D, Rossi Chen S, Choe M, Crawford K, Yushkevich P, Das S, Jagust W, Landau S, Koeppe R, Rabinovici G, Villemagne V, LoPresti B, Perrin R, Morris J, Franklin E, Bernhardt H, Cairns N, Taylor-Reinwald L, Shaw L, Lee E, Lee V, Korecka M, Brylska M, Wan Y, Trojanowki J, Toga A, Crawford K, Neu S, Saykin A, Nho K, Foroud T, Jo T, Risacher S, Craft H, Apostolova L, Nudelman K, Faber K, Potter Z, Lacy K, Kaddurah-Daouk R, Shen L, Karlawish J, Erickson C, Grill J, Largent E, Harkins K, Weiner M, Thal L, Kachaturian Z, Frank R, Snyder P, Buckholtz N, Hsiao J, Ryan L, Molchan S, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Okonkwo O, Perrin R, Ryan L, Silverberg N, Silbert L, Kaye J, White S, Pierce A, Thomas A, Clay T, Schwartz D, Devereux G, Taylor J, Ryan J, Nguyen M, DeCapo M, Shang Y, Schneider L, Munoz C, Ferman D, Conant C, Martin K, Oleary K, Pawluczyk S, Trejo E, Dagerman K, Teodoro L, Becerra M, Fairooz M, Garrison S, Boudreau J, Avila Y, Brewer J, Jacobson A, Gama A, Kim C, Little E, Frascino J, Ferng N, Trujillo S, Heidebrink J, Koeppe R, MacDonald S, Malyarenko D, Ziolkowski J, O’Connor J, Robert N, Lowe S, Rogers V, Petersen R, Hackenmiller B, Boeve B, Albers C, Kreuger C, Jones D, Knopman D, Botha H, Magnuson J, Graff-Radford J, Crawley K, Schumacher M, McKinzie S, Smith S, Helland T, Lowe V, Ramanan V, Pavlik V, Faircloth J, Bishop J, Nath J, Chaudhary M, Kataki M, Yu M, Pacini N, Barker R, Brooks R, Aggarwal R, Honig L, Stern Y, Mintz A, Cordona J, Hernandez M, Long J, Arnold A, Groves A, Middleton A, Vogler B, McCurry C, Mayo C, Raji C, Amtashar F, Klemp H, Elmore H, Ruszkiewicz J, Kusuran J, Stewart J, Horenkamp J, Greeson J, Wever K, Vo K, Larkin K, Rao L, Schoolcraft L, Gallagher L, Paczynski M, McMillan M, Holt M, Gagliano N, Henson R, LaBarge R, Swarm R, Munie S, Cepeda S, Winterton S, Hegedus S, Wilson T, Harte T, Bonacorsi Z, Geldmacher D, Watkins A, Barger B, Smelser B, Bates C, Stover C, McKinley E, Ikner G, Hendrix H, Cooper H, Mahaffey J, Booth Robbins L, Brown Ashley L, Natelson-Love M, Carter P, Solomon V, Grossman H, Groome A, Ardolino A, Kaplan A, Sheppard F, Burgos-Rivera G, Garcia-Camilo G, Lim J, Neugroschl J, Jackson K, Evans K, Soleimani L, Sano M, Ghesani N, Binder S, Apuango X, Sood A, Troutman A, Blanchard K, Richards A, Nelson G, Hendrickson K, Yurko E, Plenge J, Rufo V, Shah R, Duara R, Lynch B, Chirinos C, Dittrich C, Campbell D, Mejia D, Perez G, Colvee H, Gonzalez J, Gondrez J, Knaack J, Acevedo M, Cereijo M, Greig-Custo M, Villar M, Wishnia M, Detling S, Barker W, Albert M, Moghekar A, Rodzon B, Demsky C, Pontone G, Pekar J, Farrington L, Pomper M, Johnson N, Alo T, Sadowski M, Ulysse A, Masurkar A, Marti B, Mossa D, Geesey E, Petrocca E, Schulze E, Wong J, Boonsiri J, Kenowsky S, Martinez T, Briglall V, Doraiswamy P, Nwosu A, Adhikari A, Hellegers C, Petrella J, James O, Wong T, Hawk T, Vaishnavi S, McCoubrey H, Nasrallah I, Rovere R, Maneval J, Robinson E, Rivera F, Uffelman J, Combs M, O’Donnell P, Manning S, King R, Nieto A, Glueck A, Mandal A, Swain A, Gamble B, Meacham B, Forenback D, Ross D, Cheatham E, Hartman E, Cornell G, Harp J, Ashe L, Goins L, Watts L, Yazell M, Mandal P, Buckler R, Vincent S, Rudd T, Lopez O, Malia A, Chiado C, Zik C, Ruszkiewicz J, Savage K, Fenice L, Oakley M, Tacey P, Berman S, Bowser S, Hegedus S, Saganis X, Porsteinsson A, Mathewson A, Widman A, Holvey B, Clark E, Morales E, Young I, Ruszkiewicz J, Hopkins K, Martin K, Kowalski N, Hunt R, Calzavara R, Kurvach R, D’Ambrosio S, Thai G, Vides B, Lieb B, McAdams-Ortiz C, Toso C, Mares I, Moorlach K, Liu L, Corona M, Nguyen M, Tallakson M, McDonnell M, Rangel M, Basheer N, Place P, Romero R, Tam S, Nguyen T, Thomas A, Frolov A, Khera A, Browning A, Kelley B, Dawson C, Mathews D, Most E, Phillips E, Nguyen L, Nunez M, Miller M, Jones M, Martinez N, Logan R, McColl R, Pham S, Fox T, Moore T, Levey A, Brown A, Kippels A, Ellison A, Lyons C, Hales C, Parry C, Williams C, McCorkle E, Harris G, Rose H, Jooma I, Al-Amin J, Lah J, Webster J, Swiniarski J, Chapman L, Donnelly L, Mariotti L, Locke M, Vaughn P, Penn R, Carpentier S, Yeboah S, Basadre S, Malakauskas S, Lyron S, Villinger T, Burney T, Burns J, Abusalim A, Dahlgren A, Montero A, Arthur A, Dooly H, Kreszyn K, Berner K, Gillen L, Scanlan M, Madison M, Mathis N, Switzer P, Townley R, Fikru S, Sullivan S, Wright E, Beigi M, Daley A, Ko A, Luong B, Nyborg G, Morales J, Durbin K, Garcia L, Parand L, Macias L, Monserratt L, Farchi M, Wu P, Hernandez R, Rodriguez T, Graff-Radford N, Marolt A, Thomas A, Aloszka D, Moncayo E, Westerhold E, Day G, Chrestensen K, Imhansiemhonehi M, McKinzie S, Stephens S, Grant S, Brosch J, Perkins A, Saunders A, Kovac D, Polson H, Mwaura I, Mejia K, Britt K, King K, Nichols K, Lawrence K, Rankin L, Farlow M, Wiesenauer P, Bryant R, Herring S, Lynch S, Wilson S, Day T, Korst W, van Dyck C, Mecca A, Miller A, Brennan A, Khan A, Ruan A, Gunnoud C, Mendonca C, Raynes-Goldfinger D, Salardini E, Hidalgo E, Cooper E, Singh E, Murphy E, May J, Stanhope J, Lam J, Waszak J, Nelsen K, Sacaza K, Hasbani M, Donahue M, Chen M, Barcelos N, Eigenberger P, Bonomi R, O’Dell R, Jefferson S, Khasnavis S, Smilowitz S, DeStefano S, Good S, Camarro T, Clayton V, Cavrel Y, Lu Y, Chertkow H, Bergman H, Hosein C, Black S, Kapadia A, Bhan A, Lam B, Scott C, Gabriel G, Bray J, Zotovic L, Gutierrez M, Masellis M, Farshadi M, Gui M, Mitchell M, Taylor R, Endre R, Taghi-Zada Z, Hsiung R, English C, Kim E, Yau E, Tong H, Barlow L, Jennings L, Assaly M, Nunes P, Marian T, Kertesz A, Rogers J, Trost D, Wint D, Bernick C, Munic D, Grant I, Korkoyah A, Raja A, Lapins A, Ryan C, Pejic J, Basham K, Lukose L, Haddad L, Quinlan L, Houghtaling N, Sadowsky C, Martinez W, Villena T, Reynolds B, Forero A, Ward C, Brennan E, Figueroa E, Esposito G, Mallory J, Johnson K, Turner K, Seidenberg K, McCann K, Bassett M, Chadwick M, Turner R, Bean R, Sharma S, Marshall G, Haviari A, Pietras A, Wallace B, Munro C, Rivera-Delpin G, Hustead H, Levesque I, Ramirez J, Nolan K, Glennon K, Palou M, Erkkinen M, DaSilva N, Friedman P, Silver R, Salazar R, Polleys R, McGinnis S, Gale S, Hall T, Luu T, Chao S, Lin E, Coleman J, Epperson K, Vasanawala M, Atri A, Rangel A, Evans B, Monarrez C, Cline C, Liebsack C, Bandy D, Goldfarb D, Intorcia D, Olgin J, Clark K, King K, York K, Reade M, Callan M, Glass M, Johnson M, Gutierrez M, Goddard M, Trncic N, Choudhury P, Reyes P, Lowery S, Hall S, Olgin S, de Santiago S, Alosco M, Ton A, Jimenez A, Ellison A, Tran A, Anderson B, Carter D, Veronelli D, Lenio S, Steinberg E, Mez J, Weller J, Johns J, Mez J, Harkins J, Puleio A, Hoti I, Mwicigi J, Puleio A, Alosco M, Schultz O, Lauture M, Steinberg E, Denis R, Killiany R, Singh S, Lenio S, Qiu W, Devis Y, Obisesan T, Stone A, Ordor D, Udodong I, Okonkwo I, Khan J, Turner J, Hughes K, Kadiri O, Duffy C, Moss A, Stapleton K, Toth M, Sanders M, Ayres M, Hamski M, Fatica P, Ogrocki P, Ash S, Pot S, Chen D, Soto A, Tanase C, Bissig D, Vanya H, Russell H, Patel H, Zhang H, Wallace K, Ayers K, Gallegos M, Forloines M, Sinn M, Kahulugan Q, Isip R, Calderon S, Hamm T, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Perrin A, Tariot P, Fleisher A, Reeder S, Capote H, Emborsky A, Mattle A, Ajtai B, Wagner B, Myers B, Slazyk D, Fragale D, Fransen E, Macnamara H, Falletta J, Hirtreiter J, Mechtler L, King M, Asbach M, Rainka M, Zawislak R, Wisniewski S, O’Malley S, Jimenez-Knight T, Peehler T, Aladeen T, Bates V, Wenner V, Elmalik W, Scharre D, Ramamurthy A, Bouchachi S, Kataki M, Tarawneh R, Kelley B, Celmins D, Leader A, Figueroa C, Bauerle H, Patterson K, Reposa M, Presto S, Ahmed T, Stewart W, Pearlson G, Blank K, 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Deep learning to quantify the pace of brain aging in relation to neurocognitive changes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2413442122. PMID: 39993207, PMCID: PMC11912385, DOI: 10.1073/pnas.2413442122.Peer-Reviewed Original ResearchConceptsCN adultsBrain agingNeuroanatomical agingLongitudinal modelAdverse cognitive changesChronological ageAlzheimer's diseaseNeurocognitive agingCognitive changesNeurocognitive changesCognitive functionNeurocognitive statusAssociated with changesAge trendsLongitudinal MRIAdultsBrainQuantify DNA methylationAD risk assessmentBlood-brain barrierProfile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study
Wei X, Li C, Liu D, Chen J, Ju Y, Liu J, Liu B, Zhang Y. Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study. BMC Public Health 2025, 25: 420. PMID: 39894807, PMCID: PMC11789399, DOI: 10.1186/s12889-025-21479-z.Peer-Reviewed Original ResearchConceptsPhysical health indicatorsHealth indicatorsMild cognitive impairmentOlder adultsChina HealthCognitive performanceRight grip strengthChinese older adultsScreening of cognitive declineCognitive domainsLongitudinal cohort designCognitive performance domainsSubgroup analysisDomains of cognitive performancePhysical functionBackgroundExisting studiesGrip strengthCohort designLinear regression modelsMultiple linear regression modelStandardised interviewMethodsThe present studyResultsPulmonary functionSex-specific factorsGeneral cognitionCare Recipients’ Cognitive Trajectories and Caregivers’ Depressive Symptoms: The Mediating Role of Caregiving Burden
Lou Y, Gong J, Zang E. Care Recipients’ Cognitive Trajectories and Caregivers’ Depressive Symptoms: The Mediating Role of Caregiving Burden. The Gerontologist 2025, 65: gnaf024. PMID: 39873410, PMCID: PMC11934274, DOI: 10.1093/geront/gnaf024.Peer-Reviewed Original ResearchConceptsCaregiver depressive symptomsCare recipientsCaregiver burdenDepressive symptomsCognitive trajectoriesCaregiving burdenNational Health and Aging Trends StudyNational Study of CaregivingFinancial caregiving burdensCaregiver mental healthStudy of CaregivingStress process modelLongitudinal cognitive courseGroup-based trajectoryCaregiving difficultiesCaregiving experienceTrajectory group membershipEmotional burdenTrends StudyMental healthCaregiversCareTrajectory groupsNational studyCognitive functionEarly-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study
Roberts A, Qiu X, McAlaine K, Germine L, Rotem R, Weisskopf M. Early-life cognitively stimulating activities and late-life cognitive function in the St. Louis Baby Tooth Later Life Health Study. Scientific Reports 2025, 15: 2105. PMID: 39814743, PMCID: PMC11736041, DOI: 10.1038/s41598-024-79083-x.Peer-Reviewed Original ResearchConceptsCognitively stimulating activitiesVisual short-term memoryCognitive functionWorking memoryShort-term memoryProcessing speedTests of crystallized intelligenceAssociated with specific cognitive domainsSpecific cognitive domainsVisual working memoryAssociated with higher cognitive functionOverall cognitive functionHigher cognitive functionsAssociated with overall cognitionLate-life cognitive functionAssociated with higher cognitive scoresCognitive controlEpisodic memoryVerbal reasoningCognitive domainsHigher cognitive scoresSustained attentionAssociated with activationOverall cognitionCognitive tests
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