2025
Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanisms
2024
Tobacco smoking, smoking cessation and life expectancy among people with HIV on antiretroviral therapy in South Africa: a simulation modelling study
Thielking A, Fitzmaurice K, Sewpaul R, Chrysanthopoulou S, Dike L, Levy D, Rigotti N, Siedner M, Wood R, Paltiel A, Freedberg K, Hyle E, Reddy K. Tobacco smoking, smoking cessation and life expectancy among people with HIV on antiretroviral therapy in South Africa: a simulation modelling study. Journal Of The International AIDS Society 2024, 27: e26315. PMID: 38924347, PMCID: PMC11197963, DOI: 10.1002/jia2.26315.Peer-Reviewed Original ResearchMeSH KeywordsAdultComputer SimulationFemaleHIV InfectionsHumansLife ExpectancyMaleMiddle AgedSmoking CessationSouth AfricaTobacco SmokingConceptsMortality hazard ratioSmoking cessationLife yearsNever smoking statusLife expectancyVirologically suppressed PWHSmoking statusTobacco smokeIntegrate tobacco cessation interventionsMortality riskHazard ratioTobacco cessation interventionsSmoking cessation increasesTobacco-related illnessesImpact of tobacco smokingAntiretroviral therapyMortality risk increaseProportion of deathsChronic respiratory conditionsImpact of smokingCohort of PWHVirological non-suppressionCessation interventionsVirologic suppressionHIV care
2023
The smoking and vaping model, A user-friendly model for examining the country-specific impact of nicotine VAPING product use: application to Germany
Sánchez-Romero L, Liber A, Li Y, Yuan Z, Tam J, Travis N, Jeon J, Issabakhsh M, Meza R, Levy D. The smoking and vaping model, A user-friendly model for examining the country-specific impact of nicotine VAPING product use: application to Germany. BMC Public Health 2023, 23: 2299. PMID: 37990171, PMCID: PMC10662637, DOI: 10.1186/s12889-023-17152-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultElectronic Nicotine Delivery SystemsHumansNicotineSmokingSmoking CessationTobacco SmokingVapingConceptsNicotine vaping productsMortality riskNVP usePopulation health effectsPublic health interventionsPublic health impactAdults ages 18Smoking prevalenceSmokingHealth interventionsAge 18Tobacco controlDeath rateHealth effectsVaping productsLife expectancyProduct useHealth impactsSVaDPrevalenceLYLSame periodRiskSmokersPopulationHow do smoking, vaping, and nicotine affect people with epilepsy and seizures? A scoping review protocol
Narrett J, Khan W, Funaro M, Moeller J. How do smoking, vaping, and nicotine affect people with epilepsy and seizures? A scoping review protocol. PLOS ONE 2023, 18: e0288120. PMID: 37418386, PMCID: PMC10328254, DOI: 10.1371/journal.pone.0288120.Peer-Reviewed Original ResearchConceptsSmoking cessationTobacco useReview protocolBurden of comorbiditiesType of epilepsyJoanna Briggs Institute ManualPopulation of personsPeer-reviewed journalsSeizure frequencyNicotine replacementControl seizuresPreventable deathsSide effectsSmokingEthical approvalEpilepsyHealth outcomesPrevalent diseaseSeizuresPersonalized careDirect further researchEvidence synthesisMajor causeSystematic screeningAPA PsycInfoSummary and Concluding Remarks: Patterns of Birth Cohort‒Specific Smoking Histories
Levy D, Tam J, Jeon J, Holford T, Fleischer N, Meza R. Summary and Concluding Remarks: Patterns of Birth Cohort‒Specific Smoking Histories. American Journal Of Preventive Medicine 2023, 64: s72-s79. PMID: 36935130, PMCID: PMC11193149, DOI: 10.1016/j.amepre.2022.12.007.Peer-Reviewed Original ResearchConceptsRace/ethnicitySmoking patternsCohort methodologyTobacco control strategiesMortality RRSmoking historyMiddle-income countriesWorking GroupSmoking trendsHealth disparitiesCancer interventionTobacco controlCohort approachPublic healthEducation groupFamily incomeGroupEthnicitySociodemographic analysisSmokingEducational attainmentUsing the Past to Understand the Future of U.S. and Global Smoking Disparities: A Birth Cohort Perspective
Tam J, Levy D, Feuer E, Jeon J, Holford T, Meza R. Using the Past to Understand the Future of U.S. and Global Smoking Disparities: A Birth Cohort Perspective. American Journal Of Preventive Medicine 2023, 64: s1-s10. PMID: 36781373, PMCID: PMC10033336, DOI: 10.1016/j.amepre.2022.12.003.Peer-Reviewed Original ResearchBirth Cohort‒Specific Smoking Patterns by Family Income in the U.S.
Jeon J, Cao P, Fleischer N, Levy D, Holford T, Meza R, Tam J. Birth Cohort‒Specific Smoking Patterns by Family Income in the U.S. American Journal Of Preventive Medicine 2023, 64: s32-s41. PMID: 36653231, PMCID: PMC11186479, DOI: 10.1016/j.amepre.2022.07.019.Peer-Reviewed Original ResearchConceptsFederal poverty levelBirth cohortSmoking patternsSmoking prevalenceFamily incomeRecent cohortsRecent birth cohortsHigh-income groupsCessation probabilitiesLower cessationPoverty levelCohortMore recent cohortsSmoking disparitiesPrevalenceIncome groupsIntervention strategiesCohort modelOlder cohortGreater declineLevel groupLow-income individualsCessationCohort differencesFuture studiesSmoking Disparities by Level of Educational Attainment and Birth Cohort in the U.S.
Cao P, Jeon J, Tam J, Fleischer N, Levy D, Holford T, Meza R. Smoking Disparities by Level of Educational Attainment and Birth Cohort in the U.S. American Journal Of Preventive Medicine 2023, 64: s22-s31. PMID: 36935129, PMCID: PMC10177656, DOI: 10.1016/j.amepre.2022.06.021.Peer-Reviewed Original ResearchConceptsBirth cohortSmoking patternsRecent cohortsEducation groupCurrent smoking prevalenceEducation levelGrade educationCessation probabilitiesSmoking prevalenceTobacco useLow prevalenceCohortSmoking disparitiesDemographic characteristicsPrevalenceCohort modelCollege degreeCalendar yearDemographic factorsCessationGroupSpecial considerationDisparitiesIndividualsImportant differences
2022
Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial
Lang A, de Havenon A, Mac Grory B, Henninger N, Shu L, Furie K, Easton J, Kim A, Johnston S, Yaghi S. Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial. European Stroke Journal 2022, 8: 328-333. PMID: 37021190, PMCID: PMC10069178, DOI: 10.1177/23969873221148224.Peer-Reviewed Original ResearchConceptsSubsequent ischemic strokeEffect of clopidogrelSubsequent stroke riskIschemic strokeMajor hemorrhagePoint trialStroke riskSmoking statusMinor Ischemic Stroke (POINT) trialSubgroup interaction analysesMultivariable Cox regressionMinor ischemic strokeIschemic stroke trialsEffect of smokingNon-significant trendNew TIACurrent smokersStroke trialsTobacco smokingCox regressionIndex eventSmokersSecondary analysisClopidogrelStroke
2021
Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk
De Angelis F, Wendt FR, Pathak GA, Tylee DS, Goswami A, Gelernter J, Polimanti R. Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk. Translational Psychiatry 2021, 11: 586. PMID: 34775470, PMCID: PMC8590689, DOI: 10.1038/s41398-021-01713-z.Peer-Reviewed Original ResearchConceptsSubstance useYoung adultsBehavioral traitsPhiladelphia Neurodevelopmental CohortRemoval of participantsAnxiety-related traitsRisk-taking behaviorVerbal reasoningCognitive performancePolygenic risk scoresSocial competenciesNeurobiological processesNeurodevelopmental CohortPsychiatric genetic riskDrinking behaviorParent educationPRS associationsPolygenic riskPsychopathologyGenetic overlapPsychotic symptomsAdverse health outcomesHazardous behaviorEducational attainmentTobacco smokingUS Smoking Trends Among Young Adults with Serious Psychological Distress: 1997–2018
Friedman AS, Tam J, Busch SH. US Smoking Trends Among Young Adults with Serious Psychological Distress: 1997–2018. Journal Of General Internal Medicine 2021, 37: 2110-2112. PMID: 34378116, PMCID: PMC9198120, DOI: 10.1007/s11606-021-07013-y.Peer-Reviewed Original ResearchExploring the interactions between Helicobacter pylori (Hp) infection and other risk factors of gastric cancer: A pooled analysis in the Stomach cancer Pooling (StoP) Project
Collatuzzo G, Pelucchi C, Negri E, López‐Carrillo L, Tsugane S, Hidaka A, Hamada G, Hernández‐Ramírez R, López‐Cervantes M, Malekzadeh R, Pourfarzi F, Mu L, Zhang Z, Lunet N, La Vecchia C, Boffetta P. Exploring the interactions between Helicobacter pylori (Hp) infection and other risk factors of gastric cancer: A pooled analysis in the Stomach cancer Pooling (StoP) Project. International Journal Of Cancer 2021, 149: 1228-1238. PMID: 33990950, DOI: 10.1002/ijc.33678.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStomach cancer Pooling (StoP) ProjectHP infectionRisk factorsGastric cancerSocioeconomic statusCigarette smokingPooled analysisAlcohol drinkingOdds ratioPooling ProjectMultivariate unconditional logistic regressionDietary salt intakeModifiable risk factorsHelicobacter pylori infectionUnconditional logistic regressionGastric cancer preventionConfidence intervalsCase-control studySummary odds ratiosLifestyle modificationHP eradicationSalt intakeTobacco smokingDietary saltHistologic typeThe relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system
Satre DD, Levine-Hall T, Sterling SA, Young-Wolff KC, Lam JO, Alexeeff S, Hojilla JC, Williams A, Justice AC, Sterne J, Cavassini M, Bryant KJ, Williams EC, Horberg MA, Volberding P, Weisner C, Silverberg MJ. The relationship of smoking and unhealthy alcohol use to the HIV care continuum among people with HIV in an integrated health care system. Drug And Alcohol Dependence 2021, 219: 108481. PMID: 33429295, PMCID: PMC7869693, DOI: 10.1016/j.drugalcdep.2020.108481.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useHIV care continuum outcomesIntegrated health care systemCare continuum outcomesAlcohol useHealth care systemContinuum outcomesCare continuumOdds ratioHigher oddsKaiser Permanente Northern CaliforniaCare systemHIV RNA controlPrimary care screeningHIV care continuumRelationship of smokingAdjusted odds ratioSeparate logistic regression modelsLogistic regression modelsRace/ethnicityHIV careHIV RNASmoking statusMean ageCare screening
2020
Modeling smoking-attributable mortality among adults with major depression in the United States
Tam J, Taylor GMJ, Zivin K, Warner KE, Meza R. Modeling smoking-attributable mortality among adults with major depression in the United States. Preventive Medicine 2020, 140: 106241. PMID: 32860820, PMCID: PMC7680404, DOI: 10.1016/j.ypmed.2020.106241.Peer-Reviewed Original ResearchMeSH KeywordsAdultDepressionDepressive Disorder, MajorFemaleHumansMalePrevalenceSmokingSmoking PreventionTobacco SmokingUnited StatesConceptsCurrent major depressionSmoking-attributable mortalityMajor depressionGeneral populationComorbid mental health conditionsSmoking-attributable deathsUS adult populationMental health statusTobacco-related health disparitiesPublic health effortsMental health conditionsTobacco control effortsPrevalence ratiosSmoking prevalenceAbsence of interventionMD onsetDifferent intervention strategiesHealth effortsMD increaseDrug useHealth statusLife yearsMD comorbidityAdult populationPremature deathComparing participant estimated demand intensity on the cigarette Purchase Task to consumption when usual-brand cigarettes were provided free
Nighbor T, Barrows A, Bunn J, DeSarno M, Oliver A, Coleman S, Davis D, Streck J, Reed E, Reed D, Higgins S. Comparing participant estimated demand intensity on the cigarette Purchase Task to consumption when usual-brand cigarettes were provided free. Preventive Medicine 2020, 140: 106221. PMID: 32717262, PMCID: PMC7680356, DOI: 10.1016/j.ypmed.2020.106221.Peer-Reviewed Original ResearchConceptsUsual brand cigarettesSmoking ratesCigarette purchase taskSmoking riskFree cigarettesCo-morbid psychiatric conditionsAdult smokersGreater cigarettesInteractive voice response systemPsychiatric conditionsVoice response systemCigarettesOlder adultsAddiction potentialSocioeconomic disadvantageGroup differencesHypothetical cigarette purchase taskGreater educational attainmentPresent studyPurchase taskParticipantsDaysRiskSmokersEducational attainmentAssociations of Flavored e-Cigarette Uptake With Subsequent Smoking Initiation and Cessation
Friedman AS, Xu S. Associations of Flavored e-Cigarette Uptake With Subsequent Smoking Initiation and Cessation. JAMA Network Open 2020, 3: e203826. PMID: 32501490, PMCID: PMC7275248, DOI: 10.1001/jamanetworkopen.2020.3826.Peer-Reviewed Original ResearchConceptsSmoking initiationE-cigarettesFlavored e-cigarettesSubsequent smoking initiationHealth StudyAdult smoking cessationE-cigarette uptakeE-cigarette useUnflavored e-cigarettesWave 1Cohort studySmoking statusSmoking cessationYouth smoking initiationSecondary data analysisMAIN OUTCOMEE-cigarette flavorsPrime-age adultsSmokingNew uptakeBaselineAnalytic sampleCessationWhite individualsPopulation AssessmentPredictors of prenatal smoking among US women veterans
Coleman JN, DeRycke EC, Bastian LA, Calhoun PS, Beckham JC, Kroll-Desrosiers AR, Haskell SG, Mattocks K, Brandt CA, Wilson SM. Predictors of prenatal smoking among US women veterans. Journal Of Health Psychology 2020, 26: 2648-2655. PMID: 32255376, DOI: 10.1177/1359105320913100.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesCross-Sectional StudiesFemaleHumansPregnancySmokingTobacco SmokingVeteransConceptsUS women veteransPrenatal smokingWomen veteransVeterans Health Administration primary careMultivariable logistic regressionSubstance use disordersLikelihood of smokingPosttraumatic stress disorderPerinatal smokingCohort studyCurrent smokersFormer smokersPrimary careWhite raceUse disordersSmokingLogistic regressionStress disorderMental healthSubstance useCross-sectional dataSmokersVeteransDisordersOfficer rankSmoking and HIV associated with subclinical tuberculosis: analysis of a population-based prevalence survey
Gunasekera K, Cohen T, Gao W, Ayles H, Godfrey-Faussett P, Claassens M. Smoking and HIV associated with subclinical tuberculosis: analysis of a population-based prevalence survey. The International Journal Of Tuberculosis And Lung Disease 2020, 24: 340-346. PMID: 32228765, DOI: 10.5588/ijtld.19.0387.Peer-Reviewed Original ResearchConceptsActive TBPrevalence surveyPopulation-based prevalence surveyCurrent tobacco smokingTypical symptomsHIV-positive statusTuberculosis prevalence surveyPrevalence survey dataSubclinical tuberculosisPositive TBCrude prevalenceTobacco smokingEpidemiological burdenPrevalent casesReduction TrialSubclinical TBMedical variablesSecondary analysisEstimate associationsSouth African communitySymptomsHIVSmokingTuberculosisDiseaseTobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study
Hillmer AT, Matuskey D, Huang Y, Nabulsi N, Ropchan J, Carson RE, O'Malley SS, Cosgrove KP. Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study. Journal Of Nuclear Medicine 2020, 61: 1200-1204. PMID: 32005773, PMCID: PMC7413239, DOI: 10.2967/jnumed.119.237735.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansMaleMiddle AgedPositron-Emission TomographyReceptors, GABATobacco SmokingYoung AdultConceptsTobacco smokingTobacco smokersTSPO levelsImmune systemPET studiesBrain immune systemBrain TSPO levelsPrimary immunocompetent cellsPrevious PET studiesTranslocator proteinTranslocator protein (TSPO) levelsInflammatory effectsImmunocompetent cellsArterial bloodTobacco smokePET scansNonsmokersSmokersRadiotracer concentrationMedium effect sizeSmokingPET imagingBrainProtein levelsSignificant differencesDifferential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers
Jensen KP, Valentine G, Gueorguieva R, Sofuoglu M. Differential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers. Psychopharmacology 2020, 237: 1359-1369. PMID: 31996940, PMCID: PMC7386792, DOI: 10.1007/s00213-020-05463-6.Peer-Reviewed Original ResearchConceptsSubjective drug effectsBlood pressureHeart rateDrug effectsSmoking urgesDifferential effectsBlood pressure increaseBody weight doseEffects of nicotineDelivery rateGreater heart rateAmount of nicotineWeight doseFemale smokersTobacco smokersAbstinence symptomsNicotine doseSaline infusionInfusion protocolNon-treatment seekingTobacco cigarettesHuman studiesInfusionTobacco productsNicotine
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