2025
Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum
Goharmanesh F, Masmoie M, Nasiri H, Sadat-Madani S, Namin S, Damizadeh M, Shakeri S, Sodeifian F, Rajabpour-Sanati A, Bahrainian B, Mohammadi Y, Shushtari A, Mayeli M. Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum. Metabolic Brain Disease 2025, 40: 227. PMID: 40531346, DOI: 10.1007/s11011-025-01647-1.Peer-Reviewed Original ResearchConceptsWhite matter integrityMean diffusivityDiffusion tensor imagingFractional anisotropyAlzheimer's Disease Neuroimaging InitiativeAxial diffusivityAA metabolic pathwaysReduced white matter integrityDisease continuumDTI-derived metricsWhite matter integrity measuresWhite matter microstructural integrityAD patientsCross-sectional studyUltra-high performance liquid chromatographyPotential therapeutic targetRadial diffusivityDecreased FAIncreased MDStudy groupEarly diagnosisProgression markersAlzheimer's disease continuumAmino acidsMild cognitive impairmentGreater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolenzius J, Team A. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 104: e213591. PMID: 40327828, PMCID: PMC12060792, DOI: 10.1212/wnl.0000000000213591.Peer-Reviewed Original ResearchConceptsAcute HIV infectionAntiretroviral therapyWhite matter hyperintensitiesWMH changeViral suppressionHIV infectionBaseline CD4<sup>+</sup> T-cell countVascular comorbiditiesCD4<sup>+</sup> T-cell countIncreased rate of ischemic strokeUndetectable plasma viral loadT2-fluid-attenuated inversion recovery sequencesPlasma viral loadT-cell countsAntiretroviral therapy initiationEarly ART initiationFluid-attenuated inversion recovery sequencesBrain white matter hyperintensityHistory of psychiatric disordersFollow-up periodRate of ischemic strokeRepeated-measures ANOVAIncreased risk of strokeTwo-year follow-upExposure to HIVLifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI
Zhu A, Nir T, Javid S, Villalón-Reina J, Rodrigue A, Strike L, de Zubicaray G, McMahon K, Wright M, Medland S, Blangero J, Glahn D, Kochunov P, Williamson D, Håberg A, Thompson P, Jahanshad N. Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI. Scientific Data 2025, 12: 748. PMID: 40328780, PMCID: PMC12056076, DOI: 10.1038/s41597-025-05028-2.Peer-Reviewed Original ResearchHow does SES influence the brain circuitry for literacy? Modeling the association between SES, oral language, white matter integrity, and reading
Villa M, Koirala N, Perdue M, Branum-Martin L, Landi N. How does SES influence the brain circuitry for literacy? Modeling the association between SES, oral language, white matter integrity, and reading. Developmental Cognitive Neuroscience 2025, 73: 101561. PMID: 40319671, PMCID: PMC12099765, DOI: 10.1016/j.dcn.2025.101561.Peer-Reviewed Original ResearchConceptsWhite matter integrityOral languageSocioeconomic statusOral language skillsWhite matter tractsEffect of socioeconomic statusNeurobiological factorsBrain circuitryContribution of socioeconomic statusStructural equation modelingLanguage skillsInfluence readingEducational objectivesLanguageOccupational successParental educationSkill variationReadingEquation modelingContribution of environmental factorsNeurobiologyLiteracyEducationIndirect contributionSkillsWhole-brain white matter variation across childhood environments
Carozza S, Kletenik I, Astle D, Schwamm L, Dhand A. Whole-brain white matter variation across childhood environments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2409985122. PMID: 40193606, PMCID: PMC12012481, DOI: 10.1073/pnas.2409985122.Peer-Reviewed Original ResearchConceptsAdolescent Brain Cognitive DevelopmentAssociated with later difficultiesFractional anisotropyWhite matter fractional anisotropyWhite matter FAGray matter maturationWhite matter differencesEffects of adversityLower white matter fractional anisotropyLowest values of FACourse of childhoodExperience-dependent mannerInterpersonal adversityGray matter regionsReceptive languageCognitive effectsDevelopmental theoryEarly environmentCognitive outcomesCognitive developmentNeighborhood adversityChildhood environmentCross-sectional associationsMatter regionsAdversityMicroglial regulation of white matter development and its disruption in autism spectrum disorder
Canada K, Evans T, Pelphrey K. Microglial regulation of white matter development and its disruption in autism spectrum disorder. Cerebral Cortex 2025, 35: bhaf109. PMID: 40302613, DOI: 10.1093/cercor/bhaf109.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMaternal immune activationWhite matter developmentSpectrum disorderPresentation of autism spectrum disorderService of perceptionCortical brain regionsBrain-resident immune cellsWhite matterResident immune cellsSocial cognitionCore symptomsWhite matter abnormalitiesBrain regionsBrain functionNeurodevelopmental disordersOL lineage cellsImmune dysregulationEfficient neuronal signalingImmune activationImmune cellsCytokine releaseMicroglial reactivityHuman brainLineage cellsWhite Matter, Cognition, and Electrophysiological Variables in Bipolar Disorder: Using Multimodal Integration of Biomarker Variables Associated With Bipolar Disorder to Elucidate Deficits
Berardi A, Brown J, Jackson B, Huang L, Trotti R, Parker D, Hill S, Ivleva E, Pearlson G, Tamminga C, Keshavan M, Keedy S, Gershon E, Sweeney J, Clementz B, McDowell J. White Matter, Cognition, and Electrophysiological Variables in Bipolar Disorder: Using Multimodal Integration of Biomarker Variables Associated With Bipolar Disorder to Elucidate Deficits. Bipolar Disorders 2025, 27: 205-216. PMID: 40084552, PMCID: PMC12169086, DOI: 10.1111/bdi.70010.Peer-Reviewed Original ResearchConceptsEvent-related potentialsStop signal taskBipolar disorderBrief Assessment of CognitionLongitudinal fasciculusFractional anisotropyBrain electrophysiological measuresRight inferior longitudinal fasciculusIntermediate Phenotypes consortiumMeasures of white matter microstructureBilateral superior longitudinal fasciculusAssessment of CognitionAuditory event-related potentialsBilateral anterior thalamic radiationIntrinsic brain activitySuperior longitudinal fasciculusWhite matter integrityInferior longitudinal fasciculusCingulum cingulate gyrusWhite matter microstructureAnterior thalamic radiationRadial diffusivityWhite matter variabilitySignal taskBrief AssessmentBrain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease
Ramsingh N, Lin H, Ouyang Y, Ravona‐Springer R, Livny A, Soleimani L, Bendlin B, Matatov A, Niv T, Shamir T, Ganmore I, Heymann A, Sano M, Azuri J, Beeri M. Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70060. PMID: 40050014, DOI: 10.1002/gps.70060.Peer-Reviewed Original ResearchConceptsSuperior longitudinal fasciculusCortical volumeCortical brain volumesWhite matterAlzheimer's Prevention studyEarly cognitive declineBrain signaturesBrain regionsCognitive changesWM microstructureMiddle-aged adultsBrain volumeLongitudinal fasciculusCognitive declinePreclinical cognitive changesOffspring of peopleBrain tractsPatient's offspringTarget individualsEarly interventionCorpus callosumParental historyBrainAlzheimer's diseaseLinear regression modelsOuter radial glia promotes white matter regeneration after neonatal brain injury
Jinnou H, Rosko L, Yamashita S, Henmi S, Prasad J, Lam V, Agaronyan A, Tu T, Imamura Y, Kuboyama K, Sawamoto K, Hashimoto-Torii K, Ishibashi N, Gallo V. Outer radial glia promotes white matter regeneration after neonatal brain injury. Cell Reports Medicine 2025, 6: 101986. PMID: 40023165, PMCID: PMC11970391, DOI: 10.1016/j.xcrm.2025.101986.Peer-Reviewed Original ResearchConceptsOuter radial gliaActivating transcription factor 5Oligodendrocyte precursor cellsTreating white matter injuryNeonatal brain injuryWhite matter injuryPeriventricular white matterWhite matter regenerationImprove functional recoveryPopulation of neural stem cellsNeural stem cellsBrain injuryOuter subventricular zoneSubventricular zoneProliferative capacityPostnatal developmentVentricular zoneFunctional recoveryPrecursor cellsStem cellsWhite matterRadial gliaTherapeutic targetNeonatal pigletsInjuryAssociations between diffusion tensor imaging patterns and cerebrospinal fluid markers in mild cognitive impairment
Niknam N, Khaefi S, Heidarpour H, Sadeghi M, Jafari N, Mohammadi S, Ahmadi Z, Ahangar-Sirous R, Mayeli M, Seyedmirzaei H, Initiative A. Associations between diffusion tensor imaging patterns and cerebrospinal fluid markers in mild cognitive impairment. Journal Of Clinical Neuroscience 2025, 135: 111141. PMID: 40010169, DOI: 10.1016/j.jocn.2025.111141.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentDiffusion tensor imagingWhite matter tractsDiffusion tensor imaging metricsAlzheimer's Disease Neuroimaging InitiativeCognitive impairmentLeft uncinate fasciculusMild cognitive impairment groupDiffusion tensor imaging markersBrain changesUncinate fasciculusCerebrospinal fluidDTI patternsTensor imagingCerebrospinal fluid biomarkersStudy groupImpairmentIncreased water diffusionCerebrospinal fluid markersStatistically significant associationStatistically significant differenceBrain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanismsGenetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water
Rodrigue A, Knowles E, Mollon J, Mathias S, Peralta J, Leandro A, Fox P, Kochunov P, Olvera R, Almasy L, Curran J, Blangero J, Glahn D. Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water. Human Brain Mapping 2025, 46: e70101. PMID: 39757975, PMCID: PMC11702472, DOI: 10.1002/hbm.70101.Peer-Reviewed Original ResearchConceptsGenetic correlationsDiffusion tensor imagingCirculating cytokine levelsPeripheral inflammatory responseWhite matter architectureFA measurementsCytokine levelsCytokine measurementsWhite matter integrityProinflammatory cytokinesSingle-compartment modelIL-8Inflammatory processInflammatory responseFree water volumeFree waterGenetic relationshipsWhite matterWhite matter microstructureExtracellular free waterGenetic association
2024
Associations of blood pressure with white matter hyperintensities later in life; influence of short-term menopausal hormone therapy
Kara F, Tosakulwong N, Lesnick T, Fought A, Kendell-Thomas J, Kapoor E, Faubion L, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek-Ahmadi M, Cedars M, Naftolin F, Santoro N, Miller V, Harman S, Dowling N, Gleason C, Kantarci K. Associations of blood pressure with white matter hyperintensities later in life; influence of short-term menopausal hormone therapy. Menopause The Journal Of The North American Menopause Society 2024, 32: 12-22. PMID: 39729067, PMCID: PMC11896108, DOI: 10.1097/gme.0000000000002481.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyMenopausal hormone therapyBaseline blood pressureWhite matter hyperintensityBlood pressureHormone therapySD age of participantsPeriventricular white matter hyperintensityLower CVD riskDiastolic blood pressureCVD risk factorsObservational follow-upAssociation of blood pressureRisk of white matter hyperintensityWMH volumeAssociation of systolicAssociated with greater WMH volumeDouble-blindPostmenopausal womenGreater WMH volumeSD ageAge of participantsFollow-upMenopausal womenElevated BPRobust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy
Barisano G, Iv M, Choupan J, Hayden-Gephart M, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Shaw L, Liu E, Montine T, Thomas R, Donohue M, Walter S, Gessert D, Sather T, Jiminez G, Harvey D, Donohue M, Bernstein M, Fox N, Thompson P, Schuff N, DeCarli C, Borowski B, Gunter J, Senjem M, Vemuri P, Jones D, Kantarci K, Ward C, Koeppe R, Foster N, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Reinwald L, Lee V, Korecka M, Figurski M, Crawford K, Neu S, Foroud T, Potkin S, Shen L, Kelley F, Kim S, Nho K, Kachaturian Z, Frank R, Snyder P, Molchan S, Kaye J, Quinn J, Lind B, Carter R, Dolen S, Schneider L, Pawluczyk S, Beccera M, Teodoro L, Spann B, Brewer J, Vanderswag H, Fleisher A, Heidebrink J, Lord J, Petersen R, Mason S, Albers C, Knopman D, Johnson K, Doody R, Meyer J, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Bell K, Ances B, Morris J, Carroll M, Leon S, Householder E, Mintun M, Schneider S, Oliver A, Marson D, Griffith R, Clark D, Geld-macher D, Brockington J, Roberson E, Grossman H, Mitsis E, deToledo-Morrell L, Shah R, Duara R, Varon D, Greig M, Roberts P, Albert M, Onyike C, D’Agostino D, Kielb S, Galvin J, Pogorelec D, Cerbone B, Michel C, Rusinek H, de Leon M, Glodzik L, De Santi S, Doraiswamy P, Petrella J, Wong T, Arnold S, Karlawish J, Wolk D, Smith C, Jicha G, Hardy P, Sinha P, Oates E, Conrad G, Lopez O, Oakley M, Simpson D, Porsteinsson A, Goldstein B, Martin K, Makino K, Ismail M, Brand C, Mulnard R, Thai G, Mc Adams Ortiz C, Womack K, Mathews D, Quiceno M, Arrastia R, King R, Weiner M, Cook K, DeVous M, Levey A, Lah J, Cellar J, Burns J, Anderson H, Swerdlow R, Apostolova L, Tingus K, Woo E, Silverman D, Lu P, Bartzokis G, Radford N, Parfitt F, Kendall T, Johnson H, Farlow M, Hake A, Matthews B, Herring S, Hunt C, van Dyck C, Carson R, MacAvoy M, Chertkow H, Bergman H, Hosein C, Black S, Stefanovic B, Caldwell C, Hsiung G, Feldman H, Mudge B, Assaly M, Kertesz A, Rogers J, Trost D, Bernick C, Munic D, Kerwin D, Mesulam M, Lipowski K, Wu C, Johnson N, Sadowsky C, Martinez W, Villena T, Turner R, Johnson K, Reynolds B, Sperling R, Johnson K, Marshall G, Frey M, Yesavage J, Taylor J, Lane B, Rosen A, Tinklenberg J, Sabbagh M, Belden C, Jacobson S, Sirrel S, Kowall N, Killiany R, Budson A, Norbash A, Johnson P, Obisesan T, Wolday S, Allard J, Lerner A, Ogrocki P, Hudson L, Fletcher E, Carmichael O, Olichney J, DeCarli C, Kittur S, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Potkin S, Preda A, Nguyen D, Tariot P, Fleisher A, Reeder S, Bates V, Capote H, Rainka M, Scharre D, Kataki M, Adeli A, Zimmerman E, Celmins D, Brown A, Pearlson G, Blank K, Anderson K, Santulli R, Kitzmiller T, Schwartz E, Sink K, Williamson J, Garg P, Watkins F, Ott B, Querfurth H, Tremont G, Salloway S, Malloy P, Correia S, Rosen H, Miller B, Mintzer J, Spicer K, Bachman D, Finger E, Pasternak S, Rachinsky I, Rogers J, Kertesz A, Drost D, Pomara N, Hernando R, Sarrael A, Schultz S, Ponto L, Shim H, Smith K, Relkin N, Chaing G, Raudin L, Smith A, Fargher K, Raj B. Robust, fully-automated assessment of cerebral perivascular spaces and white matter lesions: a multicentre MRI longitudinal study of their evolution and association with risk of dementia and accelerated brain atrophy. EBioMedicine 2024, 111: 105523. PMID: 39721217, PMCID: PMC11732520, DOI: 10.1016/j.ebiom.2024.105523.Peer-Reviewed Original ResearchConceptsRisk of dementiaDementia riskAccelerated brain atrophyLower risk of dementiaMeasures of cognitive functionLongitudinal studyUS National Institutes of HealthNational Institutes of HealthCombat dementiaInstitutes of HealthPerivascular spaces countAlzheimer's disease biomarkersUS National InstitutesClinical measures of cognitive functioningDementiaBrain healthMixed-effects modelsScreening toolClinical measuresConfounding factorsObservational studyCognitive declineLongitudinal trajectoriesParticipantsBrain atrophyNeuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children
Acosta-Rodriguez H, Yuan C, Bobba P, Stephan A, Zeevi T, Malhotra A, Tran A, Kaltenhauser S, Payabvash S. Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children. Journal Of Integrative Neuroscience 2024, 23: 217. PMID: 39735971, PMCID: PMC11851640, DOI: 10.31083/j.jin2312217.Peer-Reviewed Original ResearchConceptsCognitive composite scoreAdolescent Brain Cognitive DevelopmentFluid cognition composite scoresStructural magnetic resonance imagingComposite scoreDiffusion tensor imagingNeuroimaging correlatesCognitive functionRs-fMRINational Institutes of Health (NIH) Toolbox Cognition BatteryCognitive scoresMicrostructural integrityResting-state functional connectivityCrystallized cognition composite scoreCortical surface areaTotal cognitive scoreWM microstructural integrityCognitive batteryCrystallized cognitionNeuroanatomical correlatesWhite matterCognitive performanceNeuroimaging metricsFunctional connectivityNeuroimaging dataPortable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease
Sorby-Adams A, Guo J, Laso P, Kirsch J, Zabinska J, Garcia Guarniz A, Schaefer P, Payabvash S, de Havenon A, Rosen M, Sheth K, Gomez-Isla T, Iglesias J, Kimberly W. Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease. Nature Communications 2024, 15: 10488. PMID: 39622805, PMCID: PMC11612292, DOI: 10.1038/s41467-024-54972-x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMachine learning pipelineMild cognitive impairmentAlzheimer's diseaseWhite matter hyperintensities volumeLearning pipelineAssessment of patientsIncrease accessCognitive impairmentEvaluation of Alzheimer's diseaseDementiaLF-MRIPoint-of-care assessmentMagnetic resonance imagingHippocampal volumeResonance imagingImage qualityDiseaseReduce costsAnisotropic counterpartIncreasing availabilityManual segmentationAssociation between cannabis use and brain structure and function: an observational and Mendelian randomisation study
Ishrat S, Levey D, Gelernter J, Ebmeier K, Topiwala A. Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study. BMJ Mental Health 2024, 27: e301065. PMID: 39477366, PMCID: PMC11529520, DOI: 10.1136/bmjment-2024-301065.Peer-Reviewed Original ResearchConceptsCannabis useBrain structuresFunctional connectivityHistory of cannabis useResting-state functional connectivityMeasures of brain structureLifetime cannabis useCentral executive networkLifetime cannabis usersWhite matter integrityGenu of the corpus callosumMendelian randomisation analysisAssociated with multiple measuresPoorer white matter integrityInvestigate potential causal relationshipsCannabis usersExecutive networkBrain regionsImaging-derived phenotypesBrain healthCannabisRandomisation analysesTwo-sample Mendelian randomisation analysisFractional anisotropyYoung adulthoodInvestigating the association between the GAP-43 concentration with diffusion tensor imaging indices in Alzheimer’s dementia continuum
Ariaei A, Ghorbani A, Habibzadeh E, Moghaddam N, Chegeni Nezhad N, Abdoli A, Mazinanian S, Sadeghi M, Mayeli M. Investigating the association between the GAP-43 concentration with diffusion tensor imaging indices in Alzheimer’s dementia continuum. BMC Neurology 2024, 24: 397. PMID: 39420261, PMCID: PMC11484424, DOI: 10.1186/s12883-024-03904-9.Peer-Reviewed Original ResearchConceptsDiffusion tensor imaging valuesDiffusion tensor imagingLevels of GAP-43Cerebrospinal fluidGAP-43 levelsGAP-43MethodsA total numberMonitoring treatment efficacySuperior fronto-occipital fasciculusGrowth-associated protein 43Diffusion tensor imaging indicesSuperior corona radiateCerebrospinal fluid levelsDementia continuumFronto-occipital fasciculusFollow-upWhite matter microstructural changesTreatment efficacyCorona radiateMapping the structure-function relationship along macroscale gradients in the human brain
Collins E, Chishti O, Obaid S, McGrath H, King A, Shen X, Arora J, Papademetris X, Constable R, Spencer D, Zaveri H. Mapping the structure-function relationship along macroscale gradients in the human brain. Nature Communications 2024, 15: 7063. PMID: 39152127, PMCID: PMC11329792, DOI: 10.1038/s41467-024-51395-6.Peer-Reviewed Original ResearchConceptsStructure-function correspondenceBrain regionsMacroscale gradientWhite matter connectivityHuman brain regionsStructure-function couplingNeural network propertiesAssociation cortexCognitive functionBridging neuroscienceFunctional coactivationOrganizational axisCortical thicknessHuman brainMotor cortexLanguage processingBrainCortexMotor functionNatural language processingNetwork propertiesMotorNeuroscienceNatural languageData repositoriesThe White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure
Zhang F, Li Y, Chen R, Shen P, Wang X, Meng H, Du J, Yang G, Liu B, Niu Q, Zhang H, Tan Y. The White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure. ENeuro 2024, 11: eneuro.0128-24.2024. PMID: 39142823, PMCID: PMC11360986, DOI: 10.1523/eneuro.0128-24.2024.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentFunctional connectivityCognitive impairmentNeural mechanismsRight inferior frontal gyrusResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingInferior frontal gyrusRight anterior cingulateRight temporal poleFunctional connectivity differencesWhite matter integrityRight sagittal stratumFractional anisotropy valuesAnterior cingulateFrontal gyrusDiffusion tensor imagingMontreal Cognitive AssessmentTemporal poleWhite matterWM integrityPlasma Al concentrationParacingulate gyriCognitive AssessmentSagittal stratum
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