2025
Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study
Yegya-Raman N, Plastaras J, Wright C, Chelius M, Zhang S, Baron J, Hubbeling H, Sim A, Robinson T, Jain M, Imber B, Fregonese B, Yahalom J, Ladbury C, Dandapani S, Pinnix C, Gunther J, Fang P, Wu S, Dabaja B, Yang J, Chew J, Braunstein S, Sinha S, Delinger N, Sun S, Terezakis S, Sakthivel G, Constine L, Chowdhry A, Reagan P, Burke S, Tseng Y, LaRiviere M, Maity A, Schuster S, Chong E, Figura N. Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study. Blood Advances 2025, 9: 3293-3303. PMID: 40203192, DOI: 10.1182/bloodadvances.2025015855.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor T-cell therapyImmune effector cell-associated neurotoxicity syndromeSuperior progression-free survivalProgression-free survivalB-cell lymphomaCytokine release syndromeAssociated with superior progression-free survivalOverall survivalTwo-year progression-free survivalChimeric antigen receptor T cellsLactate dehydrogenaseRelapsed/refractory B-cell lymphomaLactate dehydrogenase normalizationAmerican Society for TransplantationT-cell therapyBaseline lactate dehydrogenaseMedian follow-upRetrospectively reviewed patientsAdvanced-stage diseaseHigh-risk cohortAxicabtagene ciloleucelBrexucabtagene autoleucelSystemic therapyMulticenter studyT cellsFunctional Correlates of Atypical Visuoperceptual Organization in a Multisite Clinical High-Risk Sample
Pokorny V, Tran T, Williams T, Kenney J, Silverstein S, Gold J, Waltz J, Schiffman J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Corlett P, Mittal V. Functional Correlates of Atypical Visuoperceptual Organization in a Multisite Clinical High-Risk Sample. Journal Of Psychopathology And Clinical Science 2025, 134: 527-539. PMID: 40193439, PMCID: PMC12162206, DOI: 10.1037/abn0000992.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFacial RecognitionFemaleHumansMalePattern Recognition, VisualPsychotic DisordersYoung AdultConceptsClinical high riskPsychotic-like Experiences groupClinical high-risk statusClinical high-risk samplesMeasures of cognitive abilityClinical high-risk groupHigh-risk sampleMeasuring perceptual organizationFaces taskPsychotic disordersPerceptual priorsCognitive abilitiesCognitive functionClinical groupsPerceptual organizationHealthy control groupContext-sensitiveSocial functioningTwo-tone imagesTarget circleSymbolic codeEbbinghausFunctional correlatesTaskParticipantsA Vaccine to Block Plasmodium falciparum Transmission.
Healy S, Sagara I, Assadou M, Katile A, Kone M, Imeru A, Kwan J, Swihart B, Fintzi J, Potter G, Zeguimé A, Dolo A, Diarra B, Narum D, Rausch K, MacDonald N, Zhu D, Mohan R, Thera I, Morrison R, Zaidi I, Doritchamou J, Sylla D, Hume J, Coulibaly M, Morelle D, Lievens M, Doumbo O, Duffy P. A Vaccine to Block Plasmodium falciparum Transmission. NEJM Evidence 2025, 4: evidoa2400188. PMID: 40552966, DOI: 10.1056/evidoa2400188.Peer-Reviewed Original ResearchConceptsStandard membrane feeding assayPfs230D1-EPASafety trialsAntibody responseEnd pointsSkin feeding assaysTransmission-reducing activityWeeks of follow-upMembrane feeding assaysAs-treated populationPrimary efficacy analysisSecondary end pointsPrimary end pointInfected mosquitoesEnzyme-linked immunosorbent assayMalian adultsMalaria vaccineComparator-controlledDouble-blindProportion of infected mosquitoesDosing regimensEfficacy analysisThird doseYears postvaccinationBlock disease transmissionCollege Community–Based Physical Activity Support at a Public University During the COVID-19 Pandemic: Retrospective Longitudinal Analysis of Intra- Versus Interpersonal Components for Uptake and Outcome Association
Ash G, Mak S, Haughton A, Augustine M, Bodurtha P, Axtell R, Borsari B, Liu J, Lou S, Xin X, Fucito L, Jeon S, Stults-Kolehmainen M, Gerstein M. College Community–Based Physical Activity Support at a Public University During the COVID-19 Pandemic: Retrospective Longitudinal Analysis of Intra- Versus Interpersonal Components for Uptake and Outcome Association. JMIR MHealth And UHealth 2025, 13: e51707. PMID: 40523272, PMCID: PMC12209730, DOI: 10.2196/51707.Peer-Reviewed Original ResearchConceptsPA promotion programsPhysical activityPromotion programsPhysical activity supportLow physical activityCollege studentsInterpersonal componentsEngagement frequencyRetrospective longitudinal analysisPA interventionsPA outcomesPA supportCOVID-19 pandemicIntervention componentsApp engagementUndergraduate studentsApp useInterpersonal supportAssociated with longer retentionImplementation strategiesStaff membersLong-term trajectoriesOutcome associationsLongitudinal analysisStaffCost Efficiency of fMRI Studies Using Resting‐State Vs. Task‐Based Functional Connectivity
Zhang X, Hulvershorn L, Constable T, Zhao Y, Wang S. Cost Efficiency of fMRI Studies Using Resting‐State Vs. Task‐Based Functional Connectivity. Human Brain Mapping 2025, 46: e70260. PMID: 40543060, PMCID: PMC12182254, DOI: 10.1002/hbm.70260.Peer-Reviewed Original ResearchConceptsNeuroimaging studiesNeuropsychological outcomesFMRI conditionsGradual-onset continuous performance taskCognitive control outcomesN-back memory taskContinuous performance taskNegative emotional outcomesFMRI taskMemory taskFMRI studyPerformance tasksTask conditionsEmotional outcomesFMRITaskFunctional fingerprintsPower differentialsSociabilityOutcomesControl outcomesValidation of a food security experience scale among indigenous populations in Brazil
Segall-Corrêa A, Luz V, do Amaral Azevedo M, Ferreira B, Emperaire L, Gruppi D, Marín-Leon L, Licio J, Pérez-Escamilla R. Validation of a food security experience scale among indigenous populations in Brazil. International Journal For Equity In Health 2025, 24: 175. PMID: 40517230, PMCID: PMC12167585, DOI: 10.1186/s12939-025-02515-1.Peer-Reviewed Original ResearchConceptsSevere food insecurityFood insecurityIndigenous populationGood/very good healthPoor health statusIndigenous householdsPsychometrically valid scaleIndigenous organizationsIndigenous peoplesNutrition insecurityHealth statusRural communitiesGood healthHouseholdsBivariate analysisInsecurityNutrition securityLinguistic diversityRasch modelUrban areasIncomeMeasurement scaleExperiences ScaleMethodsA totalMitigate foodDelineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China
Zhang L, Yu J, Jia X, Su Z, Hu Y, Zhang J, Yang W, Chen X, Hoogendijk E, Huang H, Liu Z. Delineating Life‐Course Percentile Curves and Normative Values of Multi‐Systemic Ageing Metrics in the United Kingdom, the United States, and China. Journal Of Cachexia Sarcopenia And Muscle 2025, 16: e13862. PMID: 40511588, PMCID: PMC12163542, DOI: 10.1002/jcsm.13862.Peer-Reviewed Original ResearchA large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing
Klöbl M, Murgaš M, Reed M, Silberbauer L, Hartmann A, Godbersen G, Gryglewski G, Nics L, Hahn A, Rujescu D, Hacker M, Lanzenberger R. A large-scale multimodal investigation of the interplay between the serotonergic system and emotion processing. Translational Psychiatry 2025, 15: 196. PMID: 40500269, PMCID: PMC12159172, DOI: 10.1038/s41398-025-03407-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortex activationAnterior cingulate cortexMajor depressive disorderFunctional magnetic resonance imagingSerotonin transporter availabilitySerotonin transporterEmotional processingSerotonergic systemDiagnosis of major depressive disorderAnxiolytic effect of citalopramFacial emotion processing taskMonths of antidepressant treatmentViewing fearful facesAcute anxiolytic effectsEmotion processing taskEffect of citalopramReduced fMRI activationSuperior frontal sulcusSERT availabilityFearful facesHappy facesAntidepressant treatmentFear processingNeutral facesDepressive disorderHousehold practices and infrastructure associated with high Plasmodium falciparum infection rates among children under five years old in Northern Uganda
Echodu R, Ajolorwot S, Aryemo F, Nyeko C, Okot J, Iwiru T, Nakiwu V, Bei A, DeBlasio M, Turyasingura N, Zhang E, Parikh S. Household practices and infrastructure associated with high Plasmodium falciparum infection rates among children under five years old in Northern Uganda. Malaria Journal 2025, 24: 181. PMID: 40484941, PMCID: PMC12145591, DOI: 10.1186/s12936-025-05288-8.Peer-Reviewed Original ResearchConceptsIndoor residual sprayingArtemisinin-based combination therapyMalaria prevalenceCoverage of indoor residual sprayingPlasmodium falciparum infection rateIndoor residual spraying coverageEffective malaria preventionHighest malaria prevalenceInsecticide-treated netsConclusionA high prevalenceReduce malaria prevalenceHealth-seeking behaviorYears of ageMalaria preventionCombination therapyInsecticidal netsPlasmodium falciparumGovernment health centersBed netsMethodsA cross-sectional surveyPositive prevalenceResidual sprayingUntreated netsPre-tested questionnaireMosquito netsCannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients
Mannes Z, Wall M, Alschuler D, Malte C, Olfson M, Livne O, Fink D, Keyhani S, Keyes K, Martins S, Cerdá M, Sacco D, Gutkind S, Maynard C, Sherman S, Saxon A, Hasin D. Cannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients. JAMA Health Forum 2025, 6: e251369. PMID: 40512510, PMCID: PMC12166489, DOI: 10.1001/jamahealthforum.2025.1369.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationVeterans Health Administration patientsMedical cannabis lawsOpioid use disorderPrevalence of opioid use disorderClassification of DiseasesRecreational cannabis lawsChronic painVeterans Health Administration electronic health recordClinical ModificationConsistent with overall findingsState medical cannabis lawsInternational Statistical Classification of DiseasesReceipt of prescription opioidsStatistical Classification of DiseasesElectronic health recordsInternational Classification of DiseasesNon-Hispanic whitesOpioid use disorder diagnosisOpioid use disorder prevalenceInternational Statistical ClassificationDifference-in-differences analysisCannabis lawsUse disorderBurden of opioid use disorderPrior Expectations of Volatility Following Psychotherapy for Delusions
Sheffield J, Sloan A, Corlett P, Rogers B, Vandekar S, Liu J, Beals K, Hall L, Gautier T, Moussa-Tooks A, Torregrossa L, Achee M, Armstrong K, Woodward N, Belt K, Freeman D, Isham L, Diamond R, Brinen A, Heckers S. Prior Expectations of Volatility Following Psychotherapy for Delusions. JAMA Network Open 2025, 8: e2517132. PMID: 40553472, PMCID: PMC12188364, DOI: 10.1001/jamanetworkopen.2025.17132.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCognitive Behavioral TherapyDelusionsFemaleHumansMaleMiddle AgedTreatment OutcomeYoung AdultConceptsDelusion severityPersecutory delusionsPrefrontal cortexBrain activityStandard careProbabilistic reversal learning taskPsychotic Symptom Rating ScalesCommunity mental health centerBlood oxygenation level-dependent signal changesFunctional magnetic resonance imagingRandomized clinical trialsReversal learning taskCognitive behavioral therapyModels of delusionsMental health centerBelief update taskSymptom Rating ScaleIntention-to-treat analysisCaudate activationAntipsychotic medicationAssociated with clinical improvementDelusional disorderSchizophrenia spectrumBehavioral therapyHealth centersTrends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores
Yang H, Huang C, Sawano M, Herrin J, Faridi K, Li Z, Spatz E, Krumholz H, Lu Y. Trends and Key Factors Associated With Racial and Ethnic Differences in Life’s Essential 8 Scores. JAMA Network Open 2025, 8: e2516663. PMID: 40531529, PMCID: PMC12177675, DOI: 10.1001/jamanetworkopen.2025.16663.Peer-Reviewed Original ResearchConceptsLife's Essential 8 scoreLife's Essential 8Cross-sectional studyWhite differencesEthnic differencesNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveySleep health scoreNutrition Examination SurveyGroup-specific interventionsPrimary positive factorPhysical activityExamination SurveyHealth scoresBlack adultsWhite adultsMain OutcomesAsian adultsOverall scoreEvaluate trendsNicotine exposureEssential 8Blood lipidsAdultsEthnic groupsThe Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry
Chopra S, Cocuzza C, Lawhead C, Ricard J, Labache L, Patrick L, Kumar P, Rubenstein A, Moses J, Chen L, Blankenbaker C, Gillis B, Germine L, Harpaz-Rotem I, Yeo B, Baker J, Holmes A. The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry. Scientific Data 2025, 12: 923. PMID: 40456751, PMCID: PMC12130183, DOI: 10.1038/s41597-025-04895-z.Peer-Reviewed Original ResearchConceptsTask-based functional MRIHigh-resolution anatomical scansBrain-behavior relationshipsHealthy comparison groupFeatures of brain functionFunctional network organizationClinically relevant symptomsPsychiatric illnessFunctional MRINeuroimaging dataResting-stateBrain functionClinical neuroscienceCognitive AssessmentBehavioral dataConnectome ProjectAnatomical scansComparison groupDiagnostic criteriaNetwork organizationRelevant symptomsPsychiatryActivating effectIndividualsTransdiagnosticLatent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes
Lledó-Delgado A, Preston-Hurlburt P, Higdon L, Hu A, James E, Lim N, Long S, McNamara J, Nguyen H, Serti E, Sumida T, Herold K. Latent EBV enhances the efficacy of anti-CD3 mAb in Type 1 diabetes. Nature Communications 2025, 16: 5033. PMID: 40447640, PMCID: PMC12125364, DOI: 10.1038/s41467-025-60276-5.Peer-Reviewed Original ResearchConceptsCD8+ T cellsEBV-seropositive individualsType 1 diabetesT cellsImmune cellsAntigen-specific CD8+ T cellsDiagnosis of type 1 diabetesEBV-seronegative patientsEBV-seropositive patientsT cell activation pathwaysRegulatory T cellsAnti-CD3 mAbInnate immune cellsPeripheral blood cellsT cell receptorProgression of diseaseContext of type 1 diabetesImpaired signaling pathwaysTeplizumabClinical trialsLatent EBVBlood cellsSingle cell transcriptomicsModulate progressionMTOR signalingSoil‐Transmitted Helminths and the Intricacies of Immunoregulation: Evidence From Amazonian Ecuador for the Importance of Considering Species‐Specific Effects Within the Old Friends Hypothesis
Cepon‐Robins T, Gildner T, Urlacher S, Liebert M, Madimenos F, Bribiescas R, Eick G, Harrington C, Sugiyama L, Snodgrass J. Soil‐Transmitted Helminths and the Intricacies of Immunoregulation: Evidence From Amazonian Ecuador for the Importance of Considering Species‐Specific Effects Within the Old Friends Hypothesis. American Journal Of Human Biology 2025, 37: e70076. PMID: 40444920, PMCID: PMC12175971, DOI: 10.1002/ajhb.70076.Peer-Reviewed Original ResearchConceptsSystemic inflammationImmune biomarkersIL-6Infection statusSpecies-specific relationshipsOld Friends hypothesesSpecies-specific effectsExacerbated systemic inflammationSoil-Transmitted HelminthsFinger-prick blood samplesLevels of CRPLow CRP levelsHelminth speciesCoinfected participantsAmazonian EcuadorHigh IgECRP levelsUninfected participantsPerinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer
Deziel N, Wang R, Warren J, Dinauer C, Ogilvie J, Clark C, Zhong C, Wiemels J, Morimoto L, Metayer C, Ma X. Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer. Environmental Health Perspectives 2025, 133: 057026. PMID: 40209106, PMCID: PMC12121722, DOI: 10.1289/ehp14849.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAir PollutantsCaliforniaCarcinoma, PapillaryCase-Control StudiesChildChild, PreschoolEnvironmental ExposureFemaleHumansInfantInfant, NewbornLightingMaleParticulate MatterPregnancyPrenatal Exposure Delayed EffectsRisk FactorsThyroid Cancer, PapillaryThyroid NeoplasmsYoung AdultConceptsThyroid cancer riskOutdoor artificial lightAmbient fine particulate matterCancer riskOdds ratioAge groupsConfidence intervalsExposure to ambient fine particulate matterIndividual-level exposuresAssociated with thyroid cancerPediatric thyroid cancer incidenceControls frequency-matchedPapillary thyroid cancer riskThyroid cancer incidenceFine particulate matterCalifornia birth cohortOutdoor air pollutionAerodynamic diameter <Case-control studyHypothesized risk factorsStatistically significant associationCancer incidenceThyroid cancerExposure tertilesFrequency-matchedAmbient air pollution in critical windows of exposure and spontaneous miscarriage in a preconception cohort
Jukic A, Konrad K, Buller I, Jahnke J, Rosen Vollmar A, McConnaughey D, Keil A, Steiner A. Ambient air pollution in critical windows of exposure and spontaneous miscarriage in a preconception cohort. Environmental Research 2025, 281: 121965. PMID: 40447021, DOI: 10.1016/j.envres.2025.121965.Peer-Reviewed Original ResearchConceptsAir pollutionExposure to PM<sub>10</sub>Increased air pollution exposureAir pollution risksAmbient air pollutionAir pollution exposureConfidence intervalsInterquartile range increaseCritical windows of exposureLow vitamin DSelf-reported pregnancy lossChemical transport modelHazard ratioQuantile-based g-computationWindows of exposurePollutant concentrationsPollution riskProspective time-to-pregnancy studyMiscarriage riskPollution exposureAssociated with small increasesRange increaseCox proportional hazards modelsPollutionPublic health implicationsFunctional connectome-based predictive modeling of suicidal ideation
Averill L, Tamman A, Fouda S, Averill C, Nemati S, Ragnhildstveit A, Gosnell S, Akiki T, Salas R, Abdallah C. Functional connectome-based predictive modeling of suicidal ideation. Journal Of Affective Disorders 2025, 387: 119518. PMID: 40441623, DOI: 10.1016/j.jad.2025.119518.Peer-Reviewed Original ResearchConceptsSuicidal ideationAssociated with increased suicidal ideationRecurrent major depressive disorderConnectome-based predictive modelingResting-state functional magnetic resonance imagingMechanisms of suicidal behaviorAssociated with suicidal ideationFunctional magnetic resonance imagingMajor depressive disorderDorsal salience networkIncreased suicidal ideationIncreased network integrationIncreased suicide riskThe Menninger ClinicNetwork integrationReduced network integrationRelative to controlsCentral executiveDepressive disorderDepressive episodeSalience networkNeural alterationsSuicidal behaviorSuicide riskBrain networksCost-effective pricing of long-acting injectable HIV pre-exposure prophylaxis for adolescent girls and young women in South Africa: a model-based analysis
Jin E, Ahmed A, Bekker L, Rousseau E, Dugdale C, Flanagan C, Wallace M, Freedberg K, Orrell C, Reddy K, Paltiel A, Ciaranello A, Neilan A. Cost-effective pricing of long-acting injectable HIV pre-exposure prophylaxis for adolescent girls and young women in South Africa: a model-based analysis. The Lancet Global Health 2025, 13: e1230-e1239. PMID: 40441175, DOI: 10.1016/s2214-109x(25)00119-6.Peer-Reviewed Original ResearchConceptsHIV pre-exposure prophylaxisPre-exposure prophylaxisLife yearsIncremental cost-effectiveness ratioTDF-FTCCAB-LAAdolescent girlsYoung womenHIV-related careHealth-care sector perspectiveDaily oral tenofovir disoproxil fumarateIncrease life-yearsDaily oral TDF-FTCOral tenofovir disoproxil fumaratePrEP programmesCumulative HIV-transmissionHIV incidencePrEP persistenceTenofovir disoproxil fumarateCost-effectiveness ratioHIV transmissionCost-effectiveModel-projected outcomesSouth AfricaPrEP drugsInvestigating the familiality of trichotillomania and excoriation disorder
Chen D, Farhat L, Lebowitz E, Silverman W, Bloch M, Fernandez T, Olfson E. Investigating the familiality of trichotillomania and excoriation disorder. Psychiatry Research 2025, 350: 116560. PMID: 40449230, PMCID: PMC12179820, DOI: 10.1016/j.psychres.2025.116560.Peer-Reviewed Original ResearchConceptsFamily history of mental health disordersFirst-degreeHistory of mental health disordersSelf-reported family historyExcoriation disorderFamily history of individualsMental health historyMental health disordersFamily history of anxietyHistory of anxietyCross-sectional survey responsesFirst-degree relativesHealth historyHealth disordersFamily historySurvey responsesAged 4Etiological underpinningsTrichotillomaniaAnxietyDepressionIndividualsHistory of individualsDisordersEnvironmental factors
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