2025
Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum
Goharmanesh F, Masmoie M, Nasiri H, Sadat-Madani S, Namin S, Damizadeh M, Shakeri S, Sodeifian F, Rajabpour-Sanati A, Bahrainian B, Mohammadi Y, Shushtari A, Mayeli M. Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum. Metabolic Brain Disease 2025, 40: 227. PMID: 40531346, DOI: 10.1007/s11011-025-01647-1.Peer-Reviewed Original ResearchCost Efficiency of fMRI Studies Using Resting‐State Vs. Task‐Based Functional Connectivity
Zhang X, Hulvershorn L, Constable T, Zhao Y, Wang S. Cost Efficiency of fMRI Studies Using Resting‐State Vs. Task‐Based Functional Connectivity. Human Brain Mapping 2025, 46: e70260. PMID: 40543060, PMCID: PMC12182254, DOI: 10.1002/hbm.70260.Peer-Reviewed Original ResearchConceptsNeuroimaging studiesNeuropsychological outcomesFMRI conditionsGradual-onset continuous performance taskCognitive control outcomesN-back memory taskContinuous performance taskNegative emotional outcomesFMRI taskMemory taskFMRI studyPerformance tasksTask conditionsEmotional outcomesFMRITaskFunctional fingerprintsPower differentialsSociabilityOutcomesControl outcomesOrchestrating Neural Development Through mRNA Translation Regulation
Rodrigue B, Sajish M, Salmaso N, Aguilar‐Valles A. Orchestrating Neural Development Through mRNA Translation Regulation. Journal Of Neurochemistry 2025, 169: e70128. PMID: 40509688, PMCID: PMC12163303, DOI: 10.1111/jnc.70128.Peer-Reviewed Original ResearchConceptsMRNA translation regulationRegulation of mRNA translationMammalian/mechanistic target of rapamycin complex 1MRNA translationTranslational regulationFragile X Messenger Ribonucleoprotein 1Neural developmentGene expressionRegulation of gene expressionCell fate decisionsControlling gene expressionControl of brain developmentTarget of rapamycin complex 1Integrated stress responseNeuronal growth conesDysregulation of mRNA translationRapamycin complex 1Fate decisionsSubcellular compartmentsTranscriptional controlSignaling cascadesFragile X syndromeAxon guidanceMammalian/mechanistic targetStem cell proliferationElectrophysiological indices of reading intervention response: A systematic review
Lee B, Landi N. Electrophysiological indices of reading intervention response: A systematic review. Advances In Child Development And Behavior 2025, 68: 105-131. PMID: 40581393, DOI: 10.1016/bs.acdb.2025.03.001.Peer-Reviewed Original ResearchConceptsEvent-related potentialsReading disabilityNeural systemsEvent-related potential componentRegional activity changesNeural functionPre-post intervention changesCognitive neuroscience toolsPre- to post-interventionMagnetic resonance imagingIntervention-associated changesBrain basisRD readersTD readersReading interventionReading improvementTemporal dynamicsIntervention changesActivity changesNeuroscience toolsReview of studiesPost-interventionNeural signalsSystematic review of studiesSystematic reviewCerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease
Mecca A, Ashton N, Chen M, O'Dell R, Toyonaga T, Zhao W, Young J, Salardini E, Bates K, Ra J, Goodcase S, Silva‐Rudberg J, Nabulsi N, Brinkmalm A, Kvartsberg H, Schöll M, Nilsson J, Arnsten A, Huang Y, Hansson O, Zetterberg H, Carson R, Blennow K, van Dyck C. Cerebrospinal fluid and brain positron emission tomography measures of synaptic vesicle glycoprotein 2A: Biomarkers of synaptic density in Alzheimer's disease. Alzheimer's & Dementia 2025, 21: e70344. PMID: 40491249, PMCID: PMC12149441, DOI: 10.1002/alz.70344.Peer-Reviewed Original ResearchConceptsSynaptic vesicle glycoprotein 2APositron emission tomographyAlzheimer's diseaseSynaptic densityEnzyme-linked immunosorbent assayC]UCB-J positron emission tomographyPositron emission tomography measurementsEmission tomographyAxonal proteinsCN participantsImmunosorbent assaySymptomatic Alzheimer's diseaseAD groupProteinAssayParticipantsSV2AAlzheimerCerebrospinal fluidBrainInvestigate associationsCerebrospinal fluid assaysSV2A positron emission tomographyA Bird's‐Eye View of Glycolytic Upregulation in Activated Brain: The Major Fate of Lactate Is Release From Activated Tissue, Not Shuttling to Nearby Neurons
Dienel G, Rothman D, Mangia S. A Bird's‐Eye View of Glycolytic Upregulation in Activated Brain: The Major Fate of Lactate Is Release From Activated Tissue, Not Shuttling to Nearby Neurons. Journal Of Neurochemistry 2025, 169: e70111. PMID: 40476345, PMCID: PMC12142580, DOI: 10.1111/jnc.70111.Peer-Reviewed Original ResearchConceptsNeuron-astrocyte interactionsCerebral blood flowMetabolic brain imagingMetabolite of glucoseMetabolic mismatchBlood-borne glucoseActive neuronsAdequate oxygenationNearby neuronsActive tissuesLactate transportBlood flowAerobic glycolysisGlycolytic metabolismIntense sensory stimulationAstrocytesNeuronsTissue pHBrain cellsAstrocytic glycogenBrainSensory stimulationTissueGlycolysisRate of glucoseMolecular hallmarks of hydrocephalus
Hale A, Zhou B, Rajan A, Duy P, Goolam M, Alper S, Lehtinen M, Lancaster M, Fame R, Kahle K. Molecular hallmarks of hydrocephalus. Science Translational Medicine 2025, 17: eadq1810. PMID: 40465691, DOI: 10.1126/scitranslmed.adq1810.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidBrain-CSF interfacePluripotent stem cell-derived cerebral organoidsStem cell dysfunctionAssociated with dilatationDisrupts synaptogenesisNeural stem cell dysfunctionMolecular classificationPharmacological treatmentCell dysfunctionImpaired neurogenesisBiomechanical instabilityHC subtypesGenome-widePleiotropic mechanismsCSF dynamicsNeural circuitryHydrocephalusEnvironmental insultsCerebral organoidsNeurodevelopmental comorbiditiesCommon neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis
Zhang X, Zhang H, Shao Y, Li Y, Zhang F, Zhang H. Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis. Translational Psychiatry 2025, 15: 190. PMID: 40467551, PMCID: PMC12137653, DOI: 10.1038/s41398-025-03396-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexSuperior frontal gyrusMedian cingulate gyrusInferior frontal gyrusResting-state functional connectivityBrain reward circuitsReward circuitSUD patientsPrefrontal cortexFamily-wise errorFrontal gyrusUse disorderCortical-striatal-thalamic-cortical circuitWhole-brain rs-fMRI studiesReduced resting-state functional connectivityDorsal anterior cingulate cortexResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsPatterns of substance use disordersAssociated with impulsivityStages of addictionSubstance use disordersRs-fMRI studiesBackgroundSubstance use disordersThe Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry
Chopra S, Cocuzza C, Lawhead C, Ricard J, Labache L, Patrick L, Kumar P, Rubenstein A, Moses J, Chen L, Blankenbaker C, Gillis B, Germine L, Harpaz-Rotem I, Yeo B, Baker J, Holmes A. The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry. Scientific Data 2025, 12: 923. PMID: 40456751, PMCID: PMC12130183, DOI: 10.1038/s41597-025-04895-z.Peer-Reviewed Original ResearchConceptsTask-based functional MRIHigh-resolution anatomical scansBrain-behavior relationshipsHealthy comparison groupFeatures of brain functionFunctional network organizationClinically relevant symptomsPsychiatric illnessFunctional MRINeuroimaging dataResting-stateBrain functionClinical neuroscienceCognitive AssessmentBehavioral dataConnectome ProjectAnatomical scansComparison groupDiagnostic criteriaNetwork organizationRelevant symptomsPsychiatryActivating effectIndividualsTransdiagnosticNeurocognitive effects of psilocybin: A systematic and comprehensive review of neuroimaging studies in humans
Berkovitch L, Fauvel B, Preller K, Gaillard R. Neurocognitive effects of psilocybin: A systematic and comprehensive review of neuroimaging studies in humans. Neuroscience & Biobehavioral Reviews 2025, 175: 106239. PMID: 40456393, DOI: 10.1016/j.neubiorev.2025.106239.Peer-Reviewed Original ResearchConceptsEffects of psilocybinPsilocybin effectsNeuroimaging studiesBrain changesNeuroimaging techniquesTherapeutic effects of psilocybinTreat various psychiatric disordersFunctional brain changesSamples of healthy volunteersSerotonergic compoundsEmotional processingNeurobiological mechanismsMode networkPsychiatric disordersCognitive tasksPsychoactive effectsBrain activityNeuroimaging dataPsilocybinSelf-experienceAssociated with acute alterationsSocial functioningTherapeutic effectBrainNeuronal networksFunctional connectome-based predictive modeling of suicidal ideation
Averill L, Tamman A, Fouda S, Averill C, Nemati S, Ragnhildstveit A, Gosnell S, Akiki T, Salas R, Abdallah C. Functional connectome-based predictive modeling of suicidal ideation. Journal Of Affective Disorders 2025, 387: 119518. PMID: 40441623, DOI: 10.1016/j.jad.2025.119518.Peer-Reviewed Original ResearchConceptsSuicidal ideationAssociated with increased suicidal ideationRecurrent major depressive disorderConnectome-based predictive modelingResting-state functional magnetic resonance imagingMechanisms of suicidal behaviorAssociated with suicidal ideationFunctional magnetic resonance imagingMajor depressive disorderDorsal salience networkIncreased suicidal ideationIncreased network integrationIncreased suicide riskThe Menninger ClinicNetwork integrationReduced network integrationRelative to controlsCentral executiveDepressive disorderDepressive episodeSalience networkNeural alterationsSuicidal behaviorSuicide riskBrain networksPrediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers
Wang J, Huang Q, Chen X, You Z, He K, Mao X, Huang Y, Franzmeier N, Schöll M, Guo T, Zhao J, Guan Y, Ni R, Li B, Xie F. Prediction of longitudinal synaptic loss in Alzheimer's disease using tau PET and plasma biomarkers. Alzheimer's & Dementia 2025, 21: e70333. PMID: 40432308, PMCID: PMC12117192, DOI: 10.1002/alz.70333.Peer-Reviewed Original ResearchConceptsAssociated with longitudinal cognitive declineLongitudinal cognitive declineSynaptic lossCognitive declineSynapse lossPositron emission tomographyTau depositionTau positron emission tomographyTau burdenHealthy controlsAlzheimer's diseaseSynaptic densityMedial temporal lobePlasma glial fibrillary acidic proteinIncreased tau burdenPhosphorylated tau181Longitudinal changesCognitively impaired individualsAcidic proteinTau pathologyTemporal lobeAmyloid positron emission tomographyGlial fibrillary acidic proteinPlasma phosphorylated tau181CI groupMicroRNA Signatures Predict Brain Amyloidosis and Neurodegeneration in Alzheimer’s Disease: Insights from [18F] AV45 and FDG PET Imaging
saberian P, Darvishi A, khezragha D, Forouzandegan M, Farhadieh M, Khorshidi S, Nejad M, Sedighi S, Barati R, Safavi S, Sadeghi M, Gulisashvili D, Mayeli M, Shakeri S. MicroRNA Signatures Predict Brain Amyloidosis and Neurodegeneration in Alzheimer’s Disease: Insights from [18F] AV45 and FDG PET Imaging. Brain And Behavior 2025, 15: e70572. PMID: 40418688, PMCID: PMC12105656, DOI: 10.1002/brb3.70572.Peer-Reviewed Original ResearchFilter bank common spatial pattern and envelope-based features in multimodal EEG-fTCD brain-computer interfaces
Essam A, Ibrahim A, Al-Nasr A, El-Saqa M, Mohamed S, Anwar A, Eldeib A, Akcakaya M, Khalaf A. Filter bank common spatial pattern and envelope-based features in multimodal EEG-fTCD brain-computer interfaces. PLOS ONE 2025, 20: e0311075. PMID: 40403087, PMCID: PMC12097611, DOI: 10.1371/journal.pone.0311075.Peer-Reviewed Original ResearchConceptsFilter Bank Common Spatial PatternBrain-computer interfaceMultimodal brain-computer interfaceCommon Spatial PatternClassification accuracyEEG-fNIRS brain-computer interfaceMI paradigmMotor imageryPerformance of brain-computer interfacesImproving classification performanceBayesian fusion frameworkBinary classification problemTime series featuresUser intentionClassification problemFusion frameworkClassification performanceBrain-computerAccuracy improvementAssistive technologySystem performanceImagery tasksAccuracyAnalysis approachAdvanced analysis approachesElevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum
Nasiri H, Azargoonjahromi A, Nouri Z, Azimi S, Zand H, Shourideh A, Heydari S, Mahmoudvand B, Barabadi S, Samadpour N, Mohamadhosseini A, Khodadadi A, Shakeri S, Mayeli M, Initiative F. Elevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum. Neuroscience 2025, 577: 47-53. PMID: 40348165, DOI: 10.1016/j.neuroscience.2025.05.013.Peer-Reviewed Original ResearchIncreased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity
Gogniat M, Khan O, Li J, Park C, Robb W, Zhang P, Sun Y, Moore E, Houston M, Pechman K, Shashikumar N, Davis L, Liu D, Landman B, Cole K, Bolton C, Gifford K, Hohman T, Full K, Jefferson A. Increased sedentary behavior is associated with neurodegeneration and worse cognition in older adults over a 7‐year period despite high levels of physical activity. Alzheimer's & Dementia 2025, 21: e70157. PMID: 40357887, PMCID: PMC12070248, DOI: 10.1002/alz.70157.Peer-Reviewed Original ResearchConceptsSedentary behaviorSedentary timeOlder adultsLevels of physical activityAPOE-e4 carrier statusReduce sedentary timeBrain structuresIncreased sedentary behaviorAPOE-e4 statusRisk factorsModifiable risk factorsLongitudinal linear regressionAlzheimer's diseaseHippocampal volume reductionPhysical activityEffect modificationAPOE-e4E4 statusEpisodic memoryNeuropsychological assessmentApolipoprotein EWorse cognitionAging adultsGenetic riskCognitive changesIntegrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology
Davis C, Khan Y, Toikumo S, Jinwala Z, Boomsma D, Levey D, Gelernter J, Kember R, Kranzler H. Integrating HiTOP and RDoC frameworks part II: shared and distinct biological mechanisms of externalizing and internalizing psychopathology. Psychological Medicine 2025, 55: e137. PMID: 40340892, PMCID: PMC12094665, DOI: 10.1017/s0033291725000819.Peer-Reviewed Original ResearchConceptsDrug repurposing analysisAssociated with reduced gray matter volumeHierarchical Taxonomy of PsychopathologyGenome-wide association studiesTaxonomy of PsychopathologyResearch Domain CriteriaTissue-specific expression patternsAspects of psychopathologyGray matter volumeSingle-cell RNA sequencing dataGene identification methodsMagnetic resonance imaging dataMulti-omics approachRNA sequencing dataBrain cell typesHiTOP frameworkInternalizing psychopathologyPhysical health conditionsPsychopathological spectrumSubcallosal cortexGene annotationMatter volumeGenomic insightsSequence dataGenetic liabilityAltered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity
Mason A, Palmer W, Cao H, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Mathalon D, Walker E, Woods S, Cannon T. Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity. Schizophrenia Research 2025, 281: 115-121. PMID: 40328092, DOI: 10.1016/j.schres.2025.04.034.Peer-Reviewed Original ResearchConceptsInferior parietal lobe activityPsychotic symptom severityParietal lobe activityDevelopmental traumaDelusion severityHallucination severityMemory taskNeurocognitive measuresMemory processesMemory performanceSymptom severityScale of Psychosis-risk SymptomsNorth American Prodrome Longitudinal StudyPoorer episodic memory performanceRisk of psychotic symptomsPaired-associate memory taskAssociated with memory processingMemory-associated regionsTrauma-exposed individualsEpisodic memory processesEpisodic memory tasksPsychosis-risk symptomsClinical high riskEpisodic memory performanceSubclinical delusionsLifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI
Zhu A, Nir T, Javid S, Villalón-Reina J, Rodrigue A, Strike L, de Zubicaray G, McMahon K, Wright M, Medland S, Blangero J, Glahn D, Kochunov P, Williamson D, Håberg A, Thompson P, Jahanshad N. Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI. Scientific Data 2025, 12: 748. PMID: 40328780, PMCID: PMC12056076, DOI: 10.1038/s41597-025-05028-2.Peer-Reviewed Original ResearchDecoding human brain evolution: Insights from genomics
Liu Y, Li M, Segal A, Zhang M, Sestan N. Decoding human brain evolution: Insights from genomics. Current Opinion In Neurobiology 2025, 92: 103033. PMID: 40334295, DOI: 10.1016/j.conb.2025.103033.Peer-Reviewed Original ResearchConceptsHuman brain evolutionNonhuman primatesBrain evolutionHigh-throughput functional screeningSingle-cell resolutionAdvanced cognitive abilitiesGenetic basisCognitive abilitiesFunctional screeningGenetic changesGenetic underpinningsBrain featuresLiving relativesHuman-specific featuresComprehensive atlasGenomic profilingHuman brainFunctional specializationMolecular level
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