2025
Development of Evidence-based Guidelines on Assessment and Management of Internal Contamination with Transuranic Actinides
Li C, Kenbayeva Z, Dainiak N, Yepes-Nuñez J, Zeeb H, Gill S, Akashi M, Alves A, Chang A, DiCarlo A, Iddins C, Kazzi Z, Klumpp J, Osamu K, Lopez M, Phan G, Port M, Riddell A, Salame-Alfie A, Sawant P, Tatsuzaki H, Vassilenko V. Development of Evidence-based Guidelines on Assessment and Management of Internal Contamination with Transuranic Actinides. Disaster Medicine And Public Health Preparedness 2025, 19: e156. PMID: 40538032, DOI: 10.1017/dmp.2025.10091.Peer-Reviewed Original ResearchMeSH KeywordsActinoid Series ElementsEvidence-Based MedicineGuidelines as TopicHumansWorld Health OrganizationConceptsGuideline development groupDevelopment of evidence-based guidelinesEvidence-based guidelinesEvidence-based recommendationsWorld Health OrganizationPatient-important health outcomesCare management guidelinesHealth outcomesWorking group meetingsWorld Health Organization protocolSystematic reviewGroup meetingsClinical managementHealth OrganizationContextual factorsManagement guidelinesDevelopment groupQuestion formulationGuidelinesRecommendationsCertainty ratingsResearch question formulationOutcomesEmergency respondersAssessmentACR Appropriateness Criteria® Acute Respiratory Illness in Immunocompetent Patients: 2024 Update
Imaging P, Batra K, Walker C, Little B, Bang T, Bartel T, Brixey A, Christensen J, Cox C, Hanak M, Khurana S, Madan R, Merchant N, Moore W, Pandya S, Sanchez L, Shroff G, Zagurovskaya M, Chung J. ACR Appropriateness Criteria® Acute Respiratory Illness in Immunocompetent Patients: 2024 Update. Journal Of The American College Of Radiology 2025, 22: s14-s35. PMID: 40409874, DOI: 10.1016/j.jacr.2025.02.014.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseEvidence-Based MedicineHumansImmunocompetenceRespiratory Tract InfectionsSocieties, MedicalUnited StatesConceptsAcute respiratory illnessRespiratory illnessManagement of acute respiratory illnessesAmerican College of Radiology Appropriateness CriteriaRAND/UCLA Appropriateness Method User ManualSelf-limiting viral infectionEvidence-based guidelinesEstablished methodology principlesImmunocompetent adult patientsChronic obstructive pulmonary disease exacerbationsAppropriateness of imagingPublic health issuePeer-reviewed journalsFollow-up imagingMultidisciplinary expert panelSuspected pneumonia casesPeer-reviewed literatureGuideline developmentRecommendations AssessmentImmunocompetent patientsOccult malignancyHealth issuesExpert panelAdult patientsAppropriateness CriteriaEvidence-based personalised medicine in critical care: a framework for quantifying and applying individualised treatment effects in patients who are critically ill
Munroe E, Spicer A, Castellvi-Font A, Zalucky A, Dianti J, Linck E, Talisa V, Urner M, Angus D, Baedorf-Kassis E, Blette B, Bos L, Buell K, Casey J, Calfee C, Del Sorbo L, Estenssoro E, Ferguson N, Giblon R, Granholm A, Harhay M, Heath A, Hodgson C, Houle T, Jiang C, Kramer L, Lawler P, Leligdowicz A, Li F, Liu K, Maiga A, Maslove D, McArthur C, McAuley D, Neto A, Oosthuysen C, Perner A, Prescott H, Rochwerg B, Sahetya S, Samoilenko M, Schnitzer M, Seitz K, Shah F, Shankar-Hari M, Sinha P, Slutsky A, Qian E, Webb S, Young P, Zampieri F, Zarychanski R, Fan E, Semler M, Churpek M, Goligher E, investigators P, Group E. Evidence-based personalised medicine in critical care: a framework for quantifying and applying individualised treatment effects in patients who are critically ill. The Lancet Respiratory Medicine 2025, 13: 556-568. PMID: 40250459, DOI: 10.1016/s2213-2600(25)00054-2.Peer-Reviewed Original ResearchMeSH KeywordsCritical CareCritical IllnessEvidence-Based MedicineHumansPrecision MedicineRandomized Controlled Trials as TopicRespiratory Distress SyndromeTreatment OutcomeConceptsAverage treatment effectCritical careHeterogeneity of treatment effectsTreatment decisionsTreatment effectsCritical care syndromesResponse to treatmentClinical careRandomised clinical trialsCareRandomised trialsEffects of treatmentTreatment responseClinical trialsAggregate differencesPatientsOutcomesPersonalised medicineTreatmentEffect ITrialsAssessing Medicare’s Coverage With Evidence Development Program
Mooghali M, Moneer O, Janda G, Dhruva S, Ross J, Ramachandran R. Assessing Medicare’s Coverage With Evidence Development Program. Health Affairs 2025, 44: 32-39. PMID: 39761464, DOI: 10.1377/hlthaff.2024.00814.Peer-Reviewed Original Research
2024
Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence
Sippel L, Hamblen J, Kelmendi B, Alpert J, Carpenter L, Grzenda A, Kraguljac N, McDonald W, Rodriguez C, Widge A, Nemeroff C, Schnurr P, Holtzheimer P, Biomarkers and Treatments T. Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence. American Journal Of Psychiatry 2024, 181: 1045-1058. PMID: 39616450, DOI: 10.1176/appi.ajp.20230950.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderPathophysiology of posttraumatic stress disorderNon-trauma-focused psychotherapyTrauma-focused psychotherapySomatic treatment approachesEvidence-based treatmentsAntidepressant medicationSomatic treatmentsPsychiatric disordersSomatic interventionsTranscranial magnetic stimulationPsychotherapyMagnetic stimulationTreatment approachesDisordersRecommended first-line treatmentAdultsFirst-line treatmentMedicationMechanism of actionMonotherapy strategySalienceSpecific treatmentEvidenceEvidence-based guideline: premature ovarian insufficiency†‡
ASRM C, Panay N, Anderson R, Bennie A, Cedars M, Davies M, Ee C, Gravholt C, Kalantaridou S, Kallen A, Kim K, Misrahi M, Mousa A, Nappi R, Rocca W, Ruan X, Teede H, Vermeulen N, Vogt E, Vincent A. Evidence-based guideline: premature ovarian insufficiency†‡. Climacteric 2024, 27: 510-520. PMID: 39647506, DOI: 10.1080/13697137.2024.2423213.Peer-Reviewed Original ResearchMeSH KeywordsEvidence-Based MedicineFemaleHumansPractice Guidelines as TopicPrimary Ovarian InsufficiencyQuality of LifeConceptsProvision of careGuideline development groupAnti-Mullerian hormoneFollicle stimulating hormoneHealthcare professionalsHormone therapyScoping surveyClinical questionsSurvey of womenElevated follicle stimulating hormoneFollicle stimulating hormone measurementsEuropean Society of Human Reproduction and Embryology (ESHREDevelopment groupQuality of lifeRandomized controlled trialsCombined oral contraceptivesPractice careGeneral well-beingAnti-Mullerian hormone testCognitive healthIntegrative reviewNon-hormonal treatmentsESHRE Executive CommitteeWomen's healthMuscle healthEvidence-based nutrition for the very preterm infant in 2024
Taylor S. Evidence-based nutrition for the very preterm infant in 2024. Jornal De Pediatria 2024, 100: 559-561. PMID: 39218032, PMCID: PMC11662738, DOI: 10.1016/j.jped.2024.08.002.Peer-Reviewed Original ResearchACR Appropriateness Criteria® Female Breast Cancer Screening: 2023 Update
Imaging P, Niell B, Jochelson M, Amir T, Brown A, Adamson M, Baron P, Bennett D, Chetlen A, Dayaratna S, Freer P, Ivansco L, Klein K, Malak S, Mehta T, Moy L, Neal C, Newell M, Richman I, Schonberg M, Small W, Ulaner G, Slanetz P. ACR Appropriateness Criteria® Female Breast Cancer Screening: 2023 Update. Journal Of The American College Of Radiology 2024, 21: s126-s143. PMID: 38823941, DOI: 10.1016/j.jacr.2024.02.019.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsEarly Detection of CancerEvidence-Based MedicineFemaleHumansMammographyMass ScreeningRisk AssessmentSocieties, MedicalUnited StatesConceptsReduce breast cancer mortalityRecommendation of mammographyBreast cancerBreast cancer mortalityBreast cancer riskBreast cancer screeningDigital breast tomosynthesisEvidence-based guidelinesAmerican College of Radiology Appropriateness CriteriaPeer-reviewed journalsMultidisciplinary expert panelRAND/UCLA Appropriateness Method User ManualMultiple different imaging modalitiesPeer-reviewed literatureScreening recommendationsCancer screeningCancer mortalityCancer riskGuideline developmentAppropriateness of imagingRecommendations AssessmentBreast tomosynthesisEstablished methodology principlesExpert panelAmerican CollegePragmatic randomized controlled trials: strengthening the concept through a robust international collaborative network: PRIME-9—Pragmatic Research and Innovation through Multinational Experimentation
Omerovic E, Petrie M, Redfors B, Fremes S, Murphy G, Marquis-Gravel G, Lansky A, Velazquez E, Perera D, Reid C, Smith J, van der Meer P, Lipsic E, Juni P, McMurray J, Bauersachs J, Køber L, Rouleau J, Doenst T. Pragmatic randomized controlled trials: strengthening the concept through a robust international collaborative network: PRIME-9—Pragmatic Research and Innovation through Multinational Experimentation. Trials 2024, 25: 80. PMID: 38263138, PMCID: PMC10807265, DOI: 10.1186/s13063-024-07935-y.Peer-Reviewed Original ResearchMeSH KeywordsAdministrative PersonnelEvidence-Based MedicineHumansRandomized Controlled Trials as TopicResearch DesignSample SizeConceptsRandomized controlled trialsValue-based health careHealth policy decision-makingResearch priority settingQuality of healthcareHealthcare delivery systemValue-based healthcareDiverse practice settingsEffectiveness of interventionsPragmatic clinical trialsDiverse patient populationsPublic health impactEvidence-based medicineHealthcare qualityHealth outcomesHealth careHealthcare settingsDecision-making questionsPractice settingsPriority settingDecision-makingAlternative interventionsHealthcareStudy designPRCTs
2023
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
Tobias D, Merino J, Ahmad A, Aiken C, Benham J, Bodhini D, Clark A, Colclough K, Corcoy R, Cromer S, Duan D, Felton J, Francis E, Gillard P, Gingras V, Gaillard R, Haider E, Hughes A, Ikle J, Jacobsen L, Kahkoska A, Kettunen J, Kreienkamp R, Lim L, Männistö J, Massey R, Mclennan N, Miller R, Morieri M, Most J, Naylor R, Ozkan B, Patel K, Pilla S, Prystupa K, Raghavan S, Rooney M, Schön M, Semnani-Azad Z, Sevilla-Gonzalez M, Svalastoga P, Takele W, Tam C, Thuesen A, Tosur M, Wallace A, Wang C, Wong J, Yamamoto J, Young K, Amouyal C, Andersen M, Bonham M, Chen M, Cheng F, Chikowore T, Chivers S, Clemmensen C, Dabelea D, Dawed A, Deutsch A, Dickens L, DiMeglio L, Dudenhöffer-Pfeifer M, Evans-Molina C, Fernández-Balsells M, Fitipaldi H, Fitzpatrick S, Gitelman S, Goodarzi M, Grieger J, Guasch-Ferré M, Habibi N, Hansen T, Huang C, Harris-Kawano A, Ismail H, Hoag B, Johnson R, Jones A, Koivula R, Leong A, Leung G, Libman I, Liu K, Long S, Lowe W, Morton R, Motala A, Onengut-Gumuscu S, Pankow J, Pathirana M, Pazmino S, Perez D, Petrie J, Powe C, Quinteros A, Jain R, Ray D, Ried-Larsen M, Saeed Z, Santhakumar V, Kanbour S, Sarkar S, Monaco G, Scholtens D, Selvin E, Sheu W, Speake C, Stanislawski M, Steenackers N, Steck A, Stefan N, Støy J, Taylor R, Tye S, Ukke G, Urazbayeva M, Van der Schueren B, Vatier C, Wentworth J, Hannah W, White S, Yu G, Zhang Y, Zhou S, Beltrand J, Polak M, Aukrust I, de Franco E, Flanagan S, Maloney K, McGovern A, Molnes J, Nakabuye M, Njølstad P, Pomares-Millan H, Provenzano M, Saint-Martin C, Zhang C, Zhu Y, Auh S, de Souza R, Fawcett A, Gruber C, Mekonnen E, Mixter E, Sherifali D, Eckel R, Nolan J, Philipson L, Brown R, Billings L, Boyle K, Costacou T, Dennis J, Florez J, Gloyn A, Gomez M, Gottlieb P, Greeley S, Griffin K, Hattersley A, Hirsch I, Hivert M, Hood K, Josefson J, Kwak S, Laffel L, Lim S, Loos R, Ma R, Mathieu C, Mathioudakis N, Meigs J, Misra S, Mohan V, Murphy R, Oram R, Owen K, Ozanne S, Pearson E, Perng W, Pollin T, Pop-Busui R, Pratley R, Redman L, Redondo M, Reynolds R, Semple R, Sherr J, Sims E, Sweeting A, Tuomi T, Udler M, Vesco K, Vilsbøll T, Wagner R, Rich S, Franks P. Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine. Nature Medicine 2023, 29: 2438-2457. PMID: 37794253, PMCID: PMC10735053, DOI: 10.1038/s41591-023-02502-5.Peer-Reviewed Original ResearchConceptsDiabetes medicinesInternational Consensus ReportPrecision diabetes medicineContemporary evidence-based medicineSystematic evidence reviewEvidence-based medicineHealth equityConsensus reportHealth recommendationsPrecision medicine researchEvidence reviewPrecision medicineClinical readinessLife-threatening complicationsPillars of precision medicineRisk of complicationsMedical decisionsClinically relevant evidenceRelevant evidenceClinical presentationMedicine researchHealthRevealed opportunitiesOptimal outcomesDiabetes
2022
Incorporating sex- and gender-based medicine into journal club
Jarman AF, Safdar B, Madsen TE, Kane BG, McGregor AJ. Incorporating sex- and gender-based medicine into journal club. European Journal Of Emergency Medicine 2022, 29: 393-394. PMID: 36222813, PMCID: PMC10008087, DOI: 10.1097/mej.0000000000000973.Peer-Reviewed Original ResearchEvidence-Based Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease
Beldhuis IE, Lam CSP, Testani JM, Voors AA, Van Spall HGC, Maaten J, Damman K. Evidence-Based Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease. Circulation 2022, 145: 693-712. PMID: 35226558, PMCID: PMC9074837, DOI: 10.1161/circulationaha.121.052792.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsDisease-Free SurvivalEvidence-Based MedicineHeart FailureHumansRandomized Controlled Trials as TopicRenal Insufficiency, ChronicSurvival RateConceptsChronic kidney diseasePresence of CKDSevere chronic kidney diseaseHeart failure hospitalizationReduced ejection fractionHFrEF therapyHeart failureFailure hospitalizationEjection fractionMedical therapyKidney diseaseDrug classesSodium-glucose cotransporter 2 inhibitorsEvidence-based medical therapyGlucose cotransporter 2 inhibitorsStrong independent risk factorEnd pointCKD stage 3bPoor cardiovascular outcomesCKD stage 5Combined end pointCotransporter 2 inhibitorsIndependent risk factorSevere heart failureGlomerular filtration rateThe Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data
You SC, Krumholz HM. The Evolution of Evidence-Based Medicine: When the Magic of the Randomized Clinical Trial Meets Real-World Data. Circulation 2022, 145: 107-109. PMID: 35007161, DOI: 10.1161/circulationaha.121.057931.Peer-Reviewed Original ResearchWhat Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding
Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Network A. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e1-e13. PMID: 34989701, PMCID: PMC8769352, DOI: 10.1097/pcc.0000000000002854.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaBlood Component TransfusionChildCritical CareCritical IllnessErythrocyte TransfusionEvidence-Based MedicineHemorrhageHumansPlasmaPlatelet TransfusionConceptsAnemia EXpertise Initiative-Control/AvoidanceIll pediatric patientsIll childrenPlasma transfusionPediatric patientsPlatelet transfusionsConsensus statementSystematic reviewLos Angeles Appropriateness MethodPhysiologic triggerExpert-based statementsCritically Ill ChildrenDevelopment/UniversityExpert consensus statementCochrane Library databasesBleeding expertsRecommendations AssessmentTransfusion managementAppropriateness MethodBlood productsLaboratory testingTransfusionLibrary databasesConsensus conferenceExpert consensusPlasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding
Lieberman L, Karam O, Stanworth SJ, Goobie SM, Crighton G, Goel R, Lacroix J, Nellis ME, Parker RI, Steffen K, Stricker P, Valentine SL, Steiner ME, Network A. Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e37-e49. PMID: 34989704, PMCID: PMC8769367, DOI: 10.1097/pcc.0000000000002857.Peer-Reviewed Original ResearchConceptsAnemia EXpertise Initiative-Control/AvoidanceAcute liver diseaseLiver transplantationExpert consensus statementLiver diseaseIntravascular coagulationIll neonatesPlatelet transfusionsIll childrenConsensus statementSystematic reviewLos Angeles Appropriateness MethodExpert-based statementsAcute liver failurePlatelet transfusion strategyDevelopment/UniversityCochrane Library databasesBleeding expertsRecommendations AssessmentTransfusion strategyLiver failureTransfusion managementAppropriateness MethodTransfusionSepsisExecutive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB)
Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Network A. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB). Pediatric Critical Care Medicine 2022, 23: 34-51. PMID: 34989711, PMCID: PMC8820267, DOI: 10.1097/pcc.0000000000002851.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaChildCritical CareCritical IllnessErythrocyte TransfusionEvidence-Based MedicineHumansInfantPlatelet TransfusionConceptsIll pediatric patientsPlatelet transfusionsPediatric patientsIll childrenAnemia EXpertise Initiative-Control/AvoidanceSystematic reviewExpert-based consensusMultidisciplinary international expertsPlatelet transfusion practicesGrading of RecommendationsRisk of bleedingAdministration of plasmaConsensus-based statementsCochrane Library databasesEvidence-based recommendationsBest practice statementsClinical decision treeSubject Headings termsCritical illnessIll infantsTransfusion practicePediatric intensivistsConsensus statementTransfusionLibrary databasesPediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.
Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yehya N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. 2022, 149: s1-s12. PMID: 34970673, PMCID: PMC9599725, DOI: 10.1542/peds.2021-052888b.Peer-Reviewed Original ResearchMeSH KeywordsChildCritical CareCritical IllnessEvidence-Based MedicineHumansMultiple Organ FailureOrgan Dysfunction ScoresConceptsMultiple organ dysfunctionOrgan dysfunctionIll childrenElectronic data extraction formSingle organ dysfunctionPrognosis Studies toolRisk of biasImmune system dysfunctionMedical Subject Headings termsEvidence-based criteriaData extraction formSubject Headings termsAcute liverSystem dysfunctionClinical assessmentElectronic searchDysfunctionExtraction formSystematic reviewAvailable evidenceExpert panelMeaningful outcomesStudy identificationChildrenStudy tool
2021
Evidence-Based Minireview: In young children with severe sickle cell disease, do the benefits of HLA-identical sibling donor HCT outweigh the risks?
Shah N, Krishnamurti L. Evidence-Based Minireview: In young children with severe sickle cell disease, do the benefits of HLA-identical sibling donor HCT outweigh the risks? Hematology 2021, 2021: 190-195. PMID: 34889371, PMCID: PMC8791135, DOI: 10.1182/hematology.2021000322.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantVaso-occlusive pain episodesSickle cell diseaseCell diseaseDonor hematopoietic stem cell transplantAllogeneic hematopoietic stem cell transplantHuman leukocyte antigen identicalSevere sickle cell diseaseBenefits of HLAAcute chest syndromeHLA-identical siblingsStem cell transplantYears of ageAge-appropriate activitiesChest syndromePain crisisPain episodesFebrile episodesCell transplantMedical conditionsMale childrenFemale childrenPatientsCase 2Case 1Cilostazol for Secondary Stroke Prevention
de Havenon A, Sheth KN, Madsen TE, Johnston KC, Turan TN, Toyoda K, Elm JJ, Wardlaw JM, Johnston SC, Williams OA, Shoamanesh A, Lansberg MG. Cilostazol for Secondary Stroke Prevention. Stroke 2021, 52: e635-e645. PMID: 34517768, PMCID: PMC8478840, DOI: 10.1161/strokeaha.121.035002.Peer-Reviewed Original ResearchMeSH KeywordsCilostazolEvidence-Based MedicineHumansIschemic StrokePhosphodiesterase 3 InhibitorsSecondary PreventionStrokeConceptsSecondary stroke preventionStroke preventionDouble-blind placebo-controlled randomized trialLargest secondary stroke prevention trialSecondary stroke prevention trialsPlacebo-controlled randomized trialStroke Prevention TrialTreatment of claudicationOpen-label designNoncardioembolic ischemic strokePeripheral arterial diseaseLong-term treatmentOnset of benefitDays of treatmentEuropean Medicines AgencyCognitive outcome dataMillions of patientsPremature trial terminationDrug discontinuationMajor bleedingGastrointestinal symptomsStroke recurrenceIschemic strokeNoncardioembolic strokeSecondary preventionEvidence‐to‐Practice Gap for Preventing Procedure‐Related Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention
Shoji S, Sawano M, Sandhu A, Heidenreich P, Shiraishi Y, Noma S, Suzuki M, Numasawa Y, Fukuda K, Kohsaka S. Evidence‐to‐Practice Gap for Preventing Procedure‐Related Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention. Journal Of The American Heart Association 2021, 10: e020047. PMID: 34310187, PMCID: PMC8475676, DOI: 10.1161/jaha.120.020047.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overClinical Decision-MakingContrast MediaDatabases, FactualEvidence-Based MedicineFemaleHumansIncidenceJapanKidneyKidney Function TestsMaleMiddle AgedPercutaneous Coronary InterventionProfessional Practice GapsProtective FactorsQuality ImprovementQuality Indicators, Health CareRadiography, InterventionalRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeConceptsAcute kidney injuryPercutaneous coronary interventionAKI risk scoreBaseline renal functionContrast volumeCoronary interventionRisk scoreAKI riskKidney injuryRenal functionAcute coronary syndrome presentationBackground Acute kidney injuryIntra-aortic balloon pumpMultivariable linear regression analysisContrast volume usagePreprocedural risk assessmentChronic kidney diseaseAvailable risk scoresCommon complicationBalloon pumpHeart failureSusceptible patientsOverall incidenceSyndrome presentationKidney disease
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