2025
Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study
Yegya-Raman N, Plastaras J, Wright C, Chelius M, Zhang S, Baron J, Hubbeling H, Sim A, Robinson T, Jain M, Imber B, Fregonese B, Yahalom J, Ladbury C, Dandapani S, Pinnix C, Gunther J, Fang P, Wu S, Dabaja B, Yang J, Chew J, Braunstein S, Sinha S, Delinger N, Sun S, Terezakis S, Sakthivel G, Constine L, Chowdhry A, Reagan P, Burke S, Tseng Y, LaRiviere M, Maity A, Schuster S, Chong E, Figura N. Bridging Radiotherapy Prior to Chimeric Antigen Receptor T-Cells for B-Cell Lymphomas: An ILROG Multicenter Study. Blood Advances 2025, 9: 3293-3303. PMID: 40203192, DOI: 10.1182/bloodadvances.2025015855.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor T-cell therapyImmune effector cell-associated neurotoxicity syndromeSuperior progression-free survivalProgression-free survivalB-cell lymphomaCytokine release syndromeAssociated with superior progression-free survivalOverall survivalTwo-year progression-free survivalChimeric antigen receptor T cellsLactate dehydrogenaseRelapsed/refractory B-cell lymphomaLactate dehydrogenase normalizationAmerican Society for TransplantationT-cell therapyBaseline lactate dehydrogenaseMedian follow-upRetrospectively reviewed patientsAdvanced-stage diseaseHigh-risk cohortAxicabtagene ciloleucelBrexucabtagene autoleucelSystemic therapyMulticenter studyT cellsSulopenem versus Amoxicillin/Clavulanate for the Treatment of Uncomplicated Urinary Tract Infection.
Puttagunta S, Aronin S, Gupta J, Das A, Gupta K, Dunne M. Sulopenem versus Amoxicillin/Clavulanate for the Treatment of Uncomplicated Urinary Tract Infection. NEJM Evidence 2025, 4: evidoa2400414. PMID: 40552968, DOI: 10.1056/evidoa2400414.Peer-Reviewed Original ResearchConceptsUrinary tract infectionUncomplicated urinary tract infectionsIntent-to-treat populationSusceptible to amoxicillin/clavulanateTract infectionsUrine cultureAdverse eventsTreatment of uncomplicated urinary tract infectionsCombined population of patientsPatients treated with amoxicillin/clavulanateTreatment-emergent adverse eventsBaseline urine culturePositive urine cultureMild adverse eventsPopulation of patientsTreatment of adult womenClasses of antibioticsMicrobiological eradicationBaseline pathogensClinical cureDouble-blindMedian ageTrial medicationAmoxicillin/clavulanateAntimicrobial resistanceMulti-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial
Schreiber A, Subirà C, Sklar M, Santos M, Ko M, Panelli A, Schaller S, Theodore D, Rowley D, Watson D, Bonde P, Baedorf Kassis E, Talmor D, Ranieri M, Goligher E, Slutsky A, Brochard L. Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial. Trials 2025, 26: 202. PMID: 40500715, PMCID: PMC12153206, DOI: 10.1186/s13063-025-08838-2.Peer-Reviewed Original ResearchConceptsVentilator-induced diaphragmatic dysfunctionPhrenic nerve stimulationMechanically ventilated patientsIntensive care unitNerve stimulationMechanical ventilationClinical trialsProcedure-related adverse eventsMagnetic phrenic nerve stimulationProlonged ventilatory dependencySevere chronic pulmonary diseaseRandomized multi-center studyDiaphragm thicknessMuscle thicknessMaximal inspiratory pressureMulti-center randomized clinical trialChronic pulmonary diseaseRandomized clinical trialsMeasure diaphragm thicknessMulti-center studyRandomized superiority clinical trialInvasive electrical stimulationVentilatory dependenceDiaphragmatic dysfunctionSuperiority clinical trialLong-Term Results of External Beam Radiation Therapy with or Without Concurrent Chemotherapy in Differentiated Thyroid Cancer
Choi J, Sherman E, Dee E, Treechairusame T, Zakeri K, Kang J, Yu Y, Chen L, Shamseddine A, McBride S, Riaz N, Ho A, Tuttle R, Fagin J, Sabra M, Cracchiolo J, Shaha A, Wong R, Ghossein R, Katabi N, Lee N. Long-Term Results of External Beam Radiation Therapy with or Without Concurrent Chemotherapy in Differentiated Thyroid Cancer. Thyroid 2025, 35: 633-641. PMID: 40504742, DOI: 10.1089/thy.2025.0052.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedChemoradiotherapyFemaleHumansMaleMiddle AgedRetrospective StudiesThyroid NeoplasmsTreatment OutcomeConceptsTyrosine kinase inhibitorsExternal beam radiation therapyBeam radiation therapyConcurrent chemotherapyRadiation therapyTracheoesophageal fistulaLocoregional controlPercutaneous endoscopic gastrostomyOverall survivalResults of external beam radiation therapyPatients treated with concurrent chemotherapyFollow-upTKI initiationTreated with concurrent chemotherapyTyrosine kinase inhibitor therapyRare group of patientsLong-term follow-upGross residual diseaseTreated with RTRadioactive iodine therapySingle-institution experienceDifferentiated thyroid cancerMedian follow-upKaplan-Meier methodDay of RTPrior Expectations of Volatility Following Psychotherapy for Delusions
Sheffield J, Sloan A, Corlett P, Rogers B, Vandekar S, Liu J, Beals K, Hall L, Gautier T, Moussa-Tooks A, Torregrossa L, Achee M, Armstrong K, Woodward N, Belt K, Freeman D, Isham L, Diamond R, Brinen A, Heckers S. Prior Expectations of Volatility Following Psychotherapy for Delusions. JAMA Network Open 2025, 8: e2517132. PMID: 40553472, PMCID: PMC12188364, DOI: 10.1001/jamanetworkopen.2025.17132.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCognitive Behavioral TherapyDelusionsFemaleHumansMaleMiddle AgedTreatment OutcomeYoung AdultConceptsDelusion severityPersecutory delusionsPrefrontal cortexBrain activityStandard careProbabilistic reversal learning taskPsychotic Symptom Rating ScalesCommunity mental health centerBlood oxygenation level-dependent signal changesFunctional magnetic resonance imagingRandomized clinical trialsReversal learning taskCognitive behavioral therapyModels of delusionsMental health centerBelief update taskSymptom Rating ScaleIntention-to-treat analysisCaudate activationAntipsychotic medicationAssociated with clinical improvementDelusional disorderSchizophrenia spectrumBehavioral therapyHealth centersBetting on Change: An Analysis of Cognitive Motivational Behavior Therapy Versus Referral to Gamblers Anonymous for Gambling Disorder
Wulfert E, Wemm S, Broussard J. Betting on Change: An Analysis of Cognitive Motivational Behavior Therapy Versus Referral to Gamblers Anonymous for Gambling Disorder. Psychology Of Addictive Behaviors 2025, 39: 375-388. PMID: 40111861, PMCID: PMC12140906, DOI: 10.1037/adb0001063.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyFemaleGamblingHumansMaleMiddle AgedMotivationReferral and ConsultationSelf-Help GroupsTreatment OutcomeConceptsGambling disorderGamblers AnonymousSeverity of problem gamblingSecondary moderation analysisBehavioral therapyModeration analysisLess moneyEfficacy literatureGambling problemsAnchor participantsProblem gamblingGamblingPeriod relative to baselineLow readinessDisordersTreatment sessionsSessionsParticipantsAmount of moneyIncrease adherenceIndividualsCognitionReadinessSymptomsTreatmentEstimated Theoretical Benefit of Aggressive LDL Lowering in Patients With Symptomatic Intracranial Atherosclerosis
Siegler J, Badillo Goicoechea E, Yaghi S, Morsi R, Arevalo A, Smith M, Kothari S, Desai H, Sehgal N, Rana R, Kellogg C, Jhaveri A, de Havenon A, Dunne T, Cameron K, Chaturvedi S, Ghannam M, Prabhakaran S, Coleman E, Brorson J, Mehendale R, Kass-Hout T. Estimated Theoretical Benefit of Aggressive LDL Lowering in Patients With Symptomatic Intracranial Atherosclerosis. Neurology 2025, 105: e213768. PMID: 40446174, DOI: 10.1212/wnl.0000000000213768.Peer-Reviewed Original ResearchConceptsProprotein convertase subtilisin/kexin type 9 inhibitorsIntracranial atherosclerotic diseasePrimary outcomeMyocardial infarctionStroke due to intracranial stenosisRecurrent strokeIntracranial stenosisPCSK9 inhibitor useClass IV evidenceCox proportional hazards regressionRecurrent cerebral infarctionSymptomatic intracranial atherosclerosisAggressive medical managementAssociated with lower ratesLow-density lipoprotein (LDLInterventional clinical trialsAtherosclerotic vascular eventsProportional hazards regressionSecondary analysisLDL improvementLipoprotein (LDLPreventing recurrent strokeIncidence rate differenceLDL reductionIV evidenceModeration of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate
Kranzler H, Jinwala Z, Davis C, Xu H, Biernacka J, Zhou H, Kember R, Gelernter J, Feinn R. Moderation of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate. Alcohol Clinical And Experimental Research 2025, 49: 1297-1305. PMID: 40445294, PMCID: PMC12173784, DOI: 10.1111/acer.70052.Peer-Reviewed Original ResearchConceptsHeavy drinking daysAlcohol use disorderProblematic alcohol useAlcohol-related problemsPlacebo-controlled trialModerators of treatment outcomePlacebo-controlled trial of topiramateReduce heavy drinking daysTreat alcohol use disorderAlcohol-related traitsTrial of topiramateResponse to topiramateEffects of topiramateTime to relapseGenome-wide association studiesTopiramate's effectsAUD treatmentDrinking daysUse disorderTopiramate groupPolygenic riskHeavy drinkingAlcohol usePharmacogenetic approachShort IndexReduced sociodemographic disparities in surgical outcomes after spine surgery for spinal epidural abscess
Elsamadicy A, Ghanekar S, Serrato P, Mitre L, Kolb L, Lo S, Sciubba D. Reduced sociodemographic disparities in surgical outcomes after spine surgery for spinal epidural abscess. Journal Of Clinical Neuroscience 2025, 137: 111351. PMID: 40446558, DOI: 10.1016/j.jocn.2025.111351.Peer-Reviewed Original ResearchConceptsNon-Hispanic blacksNon-Hispanic whitesAmerican College of SurgeonsLength of stayNational Surgical Quality Improvement ProgramNon-routine dischargeRacial disparitiesSpinal epidural abscessSpine surgeryReduce racial disparitiesHispanic (HISHighest proportion of individualsQuality Improvement ProgramSurgical Quality Improvement ProgramHealth disparitiesMultivariate logistic regression analysisEpidural abscessSociodemographic disparitiesHealth outcomesLogistic regression analysisProportion of individualsRetrospective cohort studyAdverse eventsCollege of SurgeonsSpinal epidural abscess patientsDifferences in In-Hospital and Post-Discharge Ischemic Stroke Care According to Prestroke Functional Status.
Wechsler P, Mistry E, Sucharew H, Robinson D, Stanton R, de Los Rios La Rosa F, Mackey J, Ferioli S, Demel S, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Haverbusch M, Alwell K, Woo D, Kleindorfer D, Kissela B. Differences in In-Hospital and Post-Discharge Ischemic Stroke Care According to Prestroke Functional Status. Journal Of The American Heart Association 2025, 14: e040499. PMID: 40417811, DOI: 10.1161/jaha.124.040499.Peer-Reviewed Original ResearchConceptsIschemic stroke carePrestroke disabilityStroke careIn-hospitalGreater Cincinnati/Northern Kentucky populationAssociated with lower oddsPopulation-based dataSecondary stroke prevention treatmentPrestroke functional statusMedical decision-makingCare continuumStroke prevention treatmentRehabilitation therapyLower oddsIschemic stroke patientsFunctional statusStroke reperfusion therapyStroke patientsLogistic regressionCareDisabilityKentucky populationAcute ischemic strokeReperfusion therapyPrestrokeContemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation.
Park D, McLean B, Akman Z, Li D, Babapour G, Nanna M. Contemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation. Journal Of The American Heart Association 2025, 14: e038589. PMID: 40401606, DOI: 10.1161/jaha.124.038589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsAspirinAtrial FibrillationClinical RelevanceDrug Therapy, CombinationDual Anti-Platelet TherapyFemaleHemorrhageHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsRetrospective StudiesTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionST-segment elevation myocardial infarctionDouble therapyTriple therapyClinical adverse eventsIn-hospital mortalityAtrial fibrillationPost-PCIMyocardial infarctionIntracranial hemorrhageAdverse eventsCourse of triple therapyCoronary interventionStent thrombosisInverse probability of treatment weightingProbability of treatment weightingHigh-risk subgroupsMultivariate logistic regressionAssociated with higher oddsRandomized trial evidenceNo significant differenceVizient Clinical DatabaseClinical significancePrescribing patternsCompare outcomesAnalysis of associated factors affecting hematoma evacuation rates in spontaneous intracerebral hemorrhage with stereotactic aspiration combined with catheter drainage
Luo X, Song K, Zhuo L, Lin F, Gao Z, He Q, Zheng Y, Lian K, Shangguan H, Luo X, Lin Y, Kang D, Fang W. Analysis of associated factors affecting hematoma evacuation rates in spontaneous intracerebral hemorrhage with stereotactic aspiration combined with catheter drainage. Scientific Reports 2025, 15: 17759. PMID: 40404752, PMCID: PMC12098909, DOI: 10.1038/s41598-025-01754-0.Peer-Reviewed Original ResearchConceptsHematoma evacuationStereotactic aspirationCatheter drainageStereotactic surgeryRisk factorsHE ratesSpontaneous intracerebral hemorrhageHematoma evacuation rateIndependent risk factorBootstrap internal validationMultivariate logistic analysisPredictive scoring modelROC curve analysisPooled individual dataAUC valuesMultivariate logistic regressionBlend signCutoff valueIntracerebral hemorrhageDrainage tubeInternal validityPrimary outcomeHematoma edgeSurgical efficiencyLogistic analysisAutosomal Dominant Polycystic Kidney Disease
Chebib F, Hanna C, Harris P, Torres V, Dahl N. Autosomal Dominant Polycystic Kidney Disease. JAMA 2025, 333: 1708-1719. PMID: 40126492, DOI: 10.1001/jama.2025.0310.Peer-Reviewed Original ResearchMeSH KeywordsAdultAneurysm, RupturedAntidiuretic Hormone Receptor AntagonistsDisease ProgressionGlomerular Filtration RateHumansHypertensionIntracranial AneurysmKidneyPolycystic Kidney, Autosomal DominantRenal Insufficiency, ChronicRenal Replacement TherapySeverity of Illness IndexTolvaptanTreatment OutcomeTRPP Cation ChannelsConceptsAutosomal dominant polycystic kidney diseaseMayo imaging classificationRate of eGFR declineKidney replacement therapyEGFR declineDevelopment of kidney cystsKidney diseaseKidney failureReplacement therapyMm HgVasopressin type 2 receptor antagonist tolvaptanProgression to kidney replacement therapyAnnual rate of eGFR declineAdequate hydrationIntracranial aneurysmsManagement of Autosomal Dominant Polycystic Kidney DiseaseWeight managementProgression to kidney failureDietary sodium restrictionFirst-line treatmentKidney cystsSeverity of kidney diseaseTotal kidney volumeDominant polycystic kidney diseaseDe novo diseaseImpact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device‐Supported High‐Risk Percutaneous Coronary Intervention: The PROTECT III Study
Bonnet G, Rommel K, Falah B, Lansky A, Zhang Y, Schonning M, Redfors B, Burkhoff D, Cohen D, Basir M, O'Neill W, Granada J. Impact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device‐Supported High‐Risk Percutaneous Coronary Intervention: The PROTECT III Study. Journal Of The American Heart Association 2025, 14: e036367. PMID: 40371603, PMCID: PMC12184586, DOI: 10.1161/jaha.124.036367.Peer-Reviewed Original ResearchConceptsIn-hospital outcomesBP categoriesPercutaneous coronary interventionHigh-risk percutaneous coronary interventionMean blood pressureBaseline BP levelsCoronary interventionIn-hospital deathAssociated with higher ratesVentricular assist device supportStroke/transient ischemic attackLeft ventricular assist device supportCerebrovascular eventsAssist device supportPercutaneous left ventricular assist device supportHistory of heart failureIn-hospitalInterventionHemodynamic profileAdverse outcomesBP levelsPrevent hypotensionPercutaneous left ventricular assist deviceMyocardial infarctionBlood pressurePerioperative nivolumab and chemotherapy in locally advanced squamous cell carcinoma of the oesophagus: a randomized multicentre phase 2 study with circulating tumor DNA dynamics monitoring
Jiao H, Lin S, Gu J, Jiang D, Cui P, Huang Z, Fang Y, Wang H, Lin M, Tang H, Jiang T, Lin G, Zhang S, Yin H, Liang F, Wang J, Fan X, Qiu F, Yang Y, Li Z, Li B, Xiang J, Leng X, Han Y, Li C, Ai L, Hou Y, Wang G, Zhang Z, Cai S, Liu T, Yin J, Tan L. Perioperative nivolumab and chemotherapy in locally advanced squamous cell carcinoma of the oesophagus: a randomized multicentre phase 2 study with circulating tumor DNA dynamics monitoring. Molecular Cancer 2025, 24: 143. PMID: 40375301, PMCID: PMC12079821, DOI: 10.1186/s12943-025-02332-8.Peer-Reviewed Original ResearchConceptsCirculating tumor DNAOesophageal squamous cell carcinomaPathological complete responseResectable oesophageal squamous cell carcinomaPathologic complete response rateR0 resection ratePhase 2 studySquamous cell carcinomaNivolumab groupResection rateCell carcinomaLocally advanced squamous cell carcinomaTreating oesophageal squamous cell carcinomaTwo-year overall survival ratesCirculating tumor DNA dynamicsMulticenter phase 2 studyMulticentre phase 2 studyAdvanced squamous cell carcinomaCirculating tumor DNA levelsEvent-free survival rateMedian follow-up durationEffect of adjuvant therapyLong-term survival dataMonitoring minimal residual diseaseIntention-to-treat populationThe United Kingdom Hand and Upper Limb Transplantation Service: A report on the first twelve years of a single-center, single-protocol clinical cohort
Leonard D, Natalwala I, Taplin S, Burdon J, Clarke E, Seitz A, Merchant W, Wilks D, Clark B, Bellew M, Baker R, Bourke G, Kay S. The United Kingdom Hand and Upper Limb Transplantation Service: A report on the first twelve years of a single-center, single-protocol clinical cohort. Journal Of Plastic Reconstructive & Aesthetic Surgery 2025, 106: 331-341. PMID: 40472654, DOI: 10.1016/j.bjps.2025.05.001.Peer-Reviewed Original ResearchConceptsDonor-specific antibodiesFollow-upSingle-centerYears of follow-upSemmes-Weinstein monofilament testBox & Block TestHistory of dialysisLevel of amputationComposite functional scoresPatient satisfaction questionnaireWorld's first caseFunctional outcome measuresUpper limb transplantationMycophenolate mofetilRenal impairmentClinically significant improvementPsychological follow-upImmunosuppression monitoringGraft survivalRejection monitoringSecondary surgeryImmunological evaluationSurgical techniqueMonofilament testSF-36Clinical Evidence of Mesenchymal Stromal Cells for Cerebral Palsy: Scoping Review with Meta-Analysis of Efficacy in Gross Motor Outcomes
Paton M, Griffin A, Blatch-Williams R, Webb A, Verter F, Couto P, Bersenev A, Dale R, Popat H, Novak I, Finch-Edmondson M. Clinical Evidence of Mesenchymal Stromal Cells for Cerebral Palsy: Scoping Review with Meta-Analysis of Efficacy in Gross Motor Outcomes. Cells 2025, 14: 700. PMID: 40422203, PMCID: PMC12110704, DOI: 10.3390/cells14100700.Peer-Reviewed Original ResearchMeSH KeywordsCerebral PalsyHumansMesenchymal Stem Cell TransplantationMesenchymal Stem CellsTreatment OutcomeConceptsGross Motor Function MeasureCerebral palsyIPD meta-analysisTreatment of cerebral palsyMeta-analysisMotor Function MeasureGross motor outcomesData meta-analysisScoping reviewWell-designed trialsStudy heterogeneityMeta-analysesEffect sizeMotor outcomeFunction measurementsParticipation variablesSubgroup analysisMeta-analysis of efficacyRegistered trialsPalsyOutcomesVariable reportingReports of efficacyTrialsPublished reportsThe implementation of artificial intelligence in serial monitoring of post gamma knife vestibular schwannomas: A pilot study
Singh M, Jester N, Lorr S, Briano A, Schwartz N, Mahajan A, Chiang V, Tommasini S, Wiznia D, Buono F. The implementation of artificial intelligence in serial monitoring of post gamma knife vestibular schwannomas: A pilot study. Clinical Imaging 2025, 123: 110495. PMID: 40388858, DOI: 10.1016/j.clinimag.2025.110495.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryVestibular schwannomaPost-GKSTumor growthVS volumeHalting tumor growthRetrospective cohort studyAssess treatment efficacyManual segmentationHearing lossBenign tumorsPaired t-testT1-weighted MRI scansAssess statistical significanceCohort studyDice similarity coefficientNeurological functionTreatment efficacyClinical monitoringMRI scansStatistical significancePercentage changeSchwannomaSpatial overlapTumorSleep tracking and sleep hygiene counseling improve fatigue in pediatric patients with inflammatory bowel disease
Kuzoian S, Jerson B, Brimacombe M, Schneeberg L, Hyams J. Sleep tracking and sleep hygiene counseling improve fatigue in pediatric patients with inflammatory bowel disease. Journal Of Pediatric Gastroenterology And Nutrition 2025, 81: 62-68. PMID: 40341610, DOI: 10.1002/jpn3.70066.Peer-Reviewed Original ResearchConceptsSleep hygiene counselingIntervention groupFatigue scoresSleep behaviour changeHygiene counselingSleep logsBehavioral changesSleep improvement interventionsInflammatory bowel diseasePresence of fatigueRandomized controlled trialsSleep/rest fatigueIntervention implementationAssessed 2 weeksPediatric QualityFatigue ScaleImprovement interventionsSleep counselingReduce fatigueSleep trackingImprove fatigueIn-personImprove sleepInadequate sleepCounselingA Sticky Situation: Case Series of Successful Treatment of Glue Ear With Dupilumab
Kallenberger E, Kaur S, Everist B, Ator G, Gierer S, D’Mello A. A Sticky Situation: Case Series of Successful Treatment of Glue Ear With Dupilumab. Otology & Neurotology 2025, 46: e210-e214. PMID: 40360240, DOI: 10.1097/mao.0000000000004501.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, Monoclonal, HumanizedChronic DiseaseHearing LossHumansOtitis Media with EffusionRetrospective StudiesTreatment OutcomeConceptsChronic otitis mediaGlue earOtitis mediaTreatment of glue earPatient-reported incidencePatient-reported symptomsPresence of eosinophilic inflammationTreating chronic otitis mediaAudiometric dataInjection of dupilumabCase 2Efficacy of dupilumabHearing lossInterruption of treatmentNonsurgical treatment optionsEar painDupilumab therapyEar drainageEar infectionsSurgical treatmentEosinophilic inflammationCase seriesDupilumabAtopic conditionsTreatment options
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