2025
Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial
Schreiber A, Subirà C, Sklar M, Santos M, Ko M, Panelli A, Schaller S, Theodore D, Rowley D, Watson D, Bonde P, Baedorf Kassis E, Talmor D, Ranieri M, Goligher E, Slutsky A, Brochard L. Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial. Trials 2025, 26: 202. PMID: 40500715, PMCID: PMC12153206, DOI: 10.1186/s13063-025-08838-2.Peer-Reviewed Original ResearchConceptsVentilator-induced diaphragmatic dysfunctionPhrenic nerve stimulationMechanically ventilated patientsIntensive care unitNerve stimulationMechanical ventilationClinical trialsProcedure-related adverse eventsMagnetic phrenic nerve stimulationProlonged ventilatory dependencySevere chronic pulmonary diseaseRandomized multi-center studyDiaphragm thicknessMuscle thicknessMaximal inspiratory pressureMulti-center randomized clinical trialChronic pulmonary diseaseRandomized clinical trialsMeasure diaphragm thicknessMulti-center studyRandomized superiority clinical trialInvasive electrical stimulationVentilatory dependenceDiaphragmatic dysfunctionSuperiority clinical trialPeer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial
Nath B, Desai R, Cook J, Dziura J, Davis-Plourde K, Youins R, Guy K, Pavlo A, Smith E, Smith D, Kangas K, Heckmann R, Hart L, Powsner S, Sevilla M, Evans M, Kumar A, Faustino I, Hu Y, Bellamy C, Wong A. Peer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial. BMJ Open 2025, 15: e103775. PMID: 40484432, PMCID: PMC12161358, DOI: 10.1136/bmjopen-2025-103775.Peer-Reviewed Original ResearchMeSH KeywordsCrisis InterventionEmergency Service, HospitalHumansMental DisordersPeer GroupRandomized Controlled Trials as TopicRestraint, PhysicalSocial SupportConceptsCluster randomised controlled trialEmergency departmentPeer supportDelivery of trauma-informed careStepped-wedge cluster randomised controlled trialExperience of mental illnessPhysical restraintRate of physical restraintBehavioral crisesPeer support workersReduce restraint useSecondary outcomesFollow-up data collectionResponse teamPatient-centred approachPositive patient outcomesTrauma-informed carePeer-reviewed journalsCrisis response teamsUsual careStepped-wedgeIntervention readinessPeer deliveryRestraint useED settingThe efficacy of lithium in the treatment of suicidal ideation, behavior and suicide: An updated systematic review and meta-analysis of randomized controlled trials
Wang J, Le G, Wong S, Teopiz K, Kwan A, Rosenblat J, Rhee T, Ho R, Lo H, Goldberg J, Vinberg M, Grande I, Mansur R, Meyer J, McIntyre R. The efficacy of lithium in the treatment of suicidal ideation, behavior and suicide: An updated systematic review and meta-analysis of randomized controlled trials. Journal Of Affective Disorders 2025, 387: 119487. PMID: 40441661, DOI: 10.1016/j.jad.2025.119487.Peer-Reviewed Original ResearchMeSH KeywordsAntimanic AgentsBipolar DisorderHumansLithiumLithium CompoundsRandomized Controlled Trials as TopicSuicidal IdeationSuicideSuicide PreventionSuicide, AttemptedConceptsSuicidal ideationBipolar disorderSuicide attemptsCompleted suicideTreatment of suicidal ideationTreating acute maniaRate of completed suicideAnti-suicidal effectsEfficacy of lithiumAcute maniaDiagnostic heterogeneityBD-I.Randomized controlled trialsTreatment fidelitySuicide measuresLithium effectsSuicideIdeationLithium levelsMethodological limitationsAssociated with nonsignificant reductionsMeta-analysis of randomized controlled trialsControlled trialsFirst-line treatmentMeta-analysisCombining Rule-based NLP-lite with Rapid Iterative Chart Adjudication for Creation of a Large, Accurately Curated Cohort from EHR data: A Case Study in the Context of a Clinical Trial Emulation.
Mutalik P, Cheung K, Green J, Buelt-Gebhardt M, Anderson K, Jeanpaul V, McDonald L, Wininger M, Li Y, Rajeevan N, Jessel P, Moore H, Adabag S, Raitt M, Aslan M. Combining Rule-based NLP-lite with Rapid Iterative Chart Adjudication for Creation of a Large, Accurately Curated Cohort from EHR data: A Case Study in the Context of a Clinical Trial Emulation. AMIA Annual Symposium Proceedings 2025, 2024: 847-856. PMID: 40417550, PMCID: PMC12099393.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCohort StudiesElectronic Health RecordsHumansInformation Storage and RetrievalNatural Language ProcessingRandomized Controlled Trials as TopicUnited StatesConceptsCorporate data warehouseNon-expertsClinical AI applicationsData warehouseAI applicationsVirtual emulationEHR dataClinical decision criteriaExtract informationCurated datasetComputational algorithmDecision criteriaTraining toolEmulationClinical notesStructural dataCase studyAlgorithmEHRDatasetWarehouseComputerInclusion/exclusion decisionsAt-home Breast Oncology care Delivered with EHealth solutions (ABODE) study protocol: a randomised controlled trial
Mac A, Kalia M, Reel E, Amir E, Isenberg A, Kim R, Kennedy E, Koch C, Li M, McCready D, Metcalfe K, Okrainec A, Papadakos J, Rotstein S, Rodin G, Xu W, Zhong T, Cleland J, Forbes R, Easson A, Escallon J, Haykal S, Jarvis S, Leong W, McCuaig J, Santa Mina D, Peck L, Reedijk M, Sarvanantham S, Schaffer D, Thain E, Walimohamed F, Cil T. At-home Breast Oncology care Delivered with EHealth solutions (ABODE) study protocol: a randomised controlled trial. BMJ Open 2025, 15: e091579. PMID: 40345693, PMCID: PMC12067776, DOI: 10.1136/bmjopen-2024-091579.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCOVID-19FemaleFitness TrackersHumansMobile ApplicationsOntarioPatient ParticipationPatient Reported Outcome MeasuresQuality of LifeRandomized Controlled Trials as TopicSARS-CoV-2TelemedicineConceptsRandomised controlled trialsPatient activationStandard careEHealth solutionsCancer care continuumPatient-reported outcome measuresHealth service outcomesBreast cancerMeasuring patient activationControlled trialsAmbulatory care servicesTertiary care cancer centreMonths post-diagnosisIn-person servicesPatient-reported outcomesMeasured waiting timePeer-reviewed journalsQuality of lifeCare continuumCare servicesIntervention groupHealthcare deliveryRemote carePatient programmeIndividualised supportSedation for moderate‐to‐severe traumatic brain injury in adults
Williamson D, Dryden L, Cheng W, Hutton B, Skidmore B, Mehta S, Golan E, Turgeon A, Adhikari N, Rose L, Burry L. Sedation for moderate‐to‐severe traumatic brain injury in adults. Cochrane Database Of Systematic Reviews 2025, 2025: cd012639. PMID: 40326601, PMCID: PMC12053465, DOI: 10.1002/14651858.cd012639.pub2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesicsAnestheticsBrain Injuries, TraumaticConscious SedationHumansHypnotics and SedativesRandomized Controlled Trials as TopicSystematic Reviews as TopicHigh- vs low-dose oxytocin protocols for labor induction: a systematic review and meta-analysis
Grasch J, Costantine M, Cahill A, Subramaniam A, Son M, Raghuraman N, Grobman W, Frey H. High- vs low-dose oxytocin protocols for labor induction: a systematic review and meta-analysis. American Journal Of Obstetrics & Gynecology MFM 2025, 7: 101691. PMID: 40334983, DOI: 10.1016/j.ajogmf.2025.101691.Peer-Reviewed Original ResearchMeSH KeywordsCesarean SectionDose-Response Relationship, DrugFemaleHumansLabor, InducedOxytocicsOxytocinPregnancyPregnancy OutcomeRandomized Controlled Trials as TopicConceptsLow-dose oxytocin protocolsOxytocin protocolInduction of laborLabor inductionCesarean deliveryLow-dose protocolVaginal deliveryNeonatal outcome of inductionFrequency of postpartum hemorrhageRisk of cesarean deliveryLikelihood of cesarean deliveryDuration of labor inductionFrequency of cesarean deliveryHigh-dose oxytocin protocolRelative riskCochrane risk of bias assessment toolSystematic reviewRisk of bias assessment toolOxytocin infusion protocolOperative vaginal deliveryHigh-dose oxytocinConfidence intervalsDuration of laborOutcome of inductionHigh risk of biasSafety of Stimulants Across Patient Populations
Oliva H, Prudente T, Mayerson T, Mignosa M, Oliva I, Potenza M, Jegede O, Angarita G. Safety of Stimulants Across Patient Populations. JAMA Network Open 2025, 8: e259492. PMID: 40343695, PMCID: PMC12065045, DOI: 10.1001/jamanetworkopen.2025.9492.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsHumansLisdexamfetamine DimesylateMethylphenidateRandomized Controlled Trials as TopicConceptsAttention-deficit/hyperactivity disorderRandomized clinical trialsAdverse eventsStimulant medicationData extractionSafety of stimulationRisk ratioIncreased riskMethodological quality assessmentPreferred Reporting ItemsPatient populationClinical conditionsDiverse patient populationsRisk of biasSafety of stimulant medicationsUnclear risk of biasTreatment of attention-deficit/hyperactivity disorderOverall AEsRandom-effects modelWeb of ScienceBinge eating disorderStimulant use disorderComprehensive literature searchMain OutcomesReporting ItemsHow Should Parallel Cluster Randomized Trials With a Baseline Period be Analyzed?—A Survey of Estimands and Common Estimators
Lee K, Li F. How Should Parallel Cluster Randomized Trials With a Baseline Period be Analyzed?—A Survey of Estimands and Common Estimators. Biometrical Journal 2025, 67: e70052. PMID: 40302411, PMCID: PMC12041842, DOI: 10.1002/bimj.70052.Peer-Reviewed Original ResearchConceptsInformative cluster sizeIndependence estimating equationsCluster-period sizesParallel cluster randomized trialsTreatment effect estimatesCluster randomized trialInconsistent estimatesSimulation studyEstimandsEstimating equationsCluster sizeContinuous outcomesEstimationTreatment effectsEffect estimatesImprove mental healthRandomized trialsConvergenceEquationsRural eastern IndiaMental healthMixed-effects modelsYouth teamsEfficacy of enhanced recovery programmes for cardiac surgery: a systematic review and meta-analysis
Hoogma D, Meeusen I, Coppens S, Verbrugghe P, van den Eynde J, Engelman D, Grant M, Stoppe C, Rex S. Efficacy of enhanced recovery programmes for cardiac surgery: a systematic review and meta-analysis. British Journal Of Anaesthesia 2025, 135: 31-39. PMID: 40287362, DOI: 10.1016/j.bja.2025.03.019.Peer-Reviewed Original ResearchMeSH KeywordsCardiac Surgical ProceduresEnhanced Recovery After SurgeryHumansLength of StayPerioperative CareRandomized Controlled Trials as TopicConceptsHospital length of stayLength of stayCardiac surgeryFast-track cardiac anesthesiaFast-track (FTICU length of stayMeta-analysisAssessed risk of biasRandom-effects modelAdditive valueRisk of biasPerioperative strategiesEfficacy outcomesVentilation timeFT programmesVentilatory timeHospital lengthPostoperative interventionsCardiac anesthesiaComparative efficacySurgeryWeb of ScienceRandomised trialsPRISMA guidelinesEnhanced recoveryBrief verbal intervention to address inappropriate prescriptions of chinese patent medicines among western practitioners in primary health care (BRAVERY): a study protocol for an unannounced standardized patient experiment with a factorial design randomized controlled trial in China
Zhao Q, Lin L, Kwan A, Hu H, Wu L, Chen Y, Shi Z, Li B, Xiao J, Tong G, He W, Luo H, Li Q, Wang R, Zhong D, Liu S, Xie Y, Li J, Zhang L, Huang Z, Zhu X, Wan Y, Chen X, Huang W, Tian Y, Li X, Zhou Y, Cai Y, Xu D. Brief verbal intervention to address inappropriate prescriptions of chinese patent medicines among western practitioners in primary health care (BRAVERY): a study protocol for an unannounced standardized patient experiment with a factorial design randomized controlled trial in China. BMC Complementary Medicine And Therapies 2025, 25: 150. PMID: 40269893, PMCID: PMC12020188, DOI: 10.1186/s12906-025-04870-6.Peer-Reviewed Original ResearchMeSH KeywordsChinaDrugs, Chinese HerbalHumansInappropriate PrescribingMedicine, Chinese TraditionalNonprescription DrugsPractice Patterns, Physicians'Primary Health CareRandomized Controlled Trials as TopicConceptsUnannounced standardized patientsRandomized controlled trialsPrimary healthcareGeneralized linear mixed modelsWestern medicine practitionersPrimary health careControlled trialsFactorial design randomized controlled trialStudy protocolDesign randomized controlled trialChinese patent medicineVerbal interventionsChina Clinical Trial RegistryPatent medicineClinical Trials RegistryPrimary outcome evaluationStandardized patientsHealth careLinear mixed modelsMedical encountersControl providersTargeted policy interventionsIntervention researchPatient expectationsAppropriateness of antibiotic prescriptionsComputational Phenomapping of Randomized Clinical Trial Participants to Enable Assessment of Their Real-World Representativeness and Personalized Inference
Thangaraj P, Oikonomou E, Dhingra L, Aminorroaya A, Jayaram R, Suchard M, Khera R. Computational Phenomapping of Randomized Clinical Trial Participants to Enable Assessment of Their Real-World Representativeness and Personalized Inference. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011306. PMID: 40261065, PMCID: PMC12203226, DOI: 10.1161/circoutcomes.124.011306.Peer-Reviewed Original ResearchConceptsElectronic health record patientElectronic health recordsDistance metricRandomized clinical trialsElectronic health record dataMachine learning methodsYale New Haven Health SystemElectronic health record cohortRandomized clinical trial participantsLearning methodsHeart failureClinical trial participationTOPCAT participantsReal worldMultidimensional metricRCT participantsHealth recordsTreatment effectsHealth systemCharacteristics of patientsRandomized clinical trial cohortsTrial participantsMetricsUnited StatesNovel statisticEvidence-based personalised medicine in critical care: a framework for quantifying and applying individualised treatment effects in patients who are critically ill
Munroe E, Spicer A, Castellvi-Font A, Zalucky A, Dianti J, Linck E, Talisa V, Urner M, Angus D, Baedorf-Kassis E, Blette B, Bos L, Buell K, Casey J, Calfee C, Del Sorbo L, Estenssoro E, Ferguson N, Giblon R, Granholm A, Harhay M, Heath A, Hodgson C, Houle T, Jiang C, Kramer L, Lawler P, Leligdowicz A, Li F, Liu K, Maiga A, Maslove D, McArthur C, McAuley D, Neto A, Oosthuysen C, Perner A, Prescott H, Rochwerg B, Sahetya S, Samoilenko M, Schnitzer M, Seitz K, Shah F, Shankar-Hari M, Sinha P, Slutsky A, Qian E, Webb S, Young P, Zampieri F, Zarychanski R, Fan E, Semler M, Churpek M, Goligher E, investigators P, Group E. Evidence-based personalised medicine in critical care: a framework for quantifying and applying individualised treatment effects in patients who are critically ill. The Lancet Respiratory Medicine 2025, 13: 556-568. PMID: 40250459, DOI: 10.1016/s2213-2600(25)00054-2.Peer-Reviewed Original ResearchMeSH KeywordsCritical CareCritical IllnessEvidence-Based MedicineHumansPrecision MedicineRandomized Controlled Trials as TopicRespiratory Distress SyndromeTreatment OutcomeConceptsAverage treatment effectCritical careHeterogeneity of treatment effectsTreatment decisionsTreatment effectsCritical care syndromesResponse to treatmentClinical careRandomised clinical trialsCareRandomised trialsEffects of treatmentTreatment responseClinical trialsAggregate differencesPatientsOutcomesPersonalised medicineTreatmentEffect ITrialsEfficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials
Tanriverdi L, Barrett A, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Efficacy of beta-blocker agents on clinical outcomes in patients with thoracic aortic aneurysm: A systematic review and meta-analysis of randomized controlled trials. Vascular Pharmacology 2025, 159: 107494. PMID: 40204023, DOI: 10.1016/j.vph.2025.107494.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAdultAortic Aneurysm, ThoracicFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeYoung AdultConceptsThoracic aortic aneurysmRandomized controlled trialsPooled risk ratioB-blockersAortic dissectionClinical outcomesAortic aneurysmRisk ratioRisk of aortic dissectionMeta-analysis of randomized controlled trialsControlled trialsB-blocker treatmentCompared to placeboBeta-blocking agentsCochrane Risk of Bias 2 toolRisk of Bias 2 toolRobust randomized controlled trialsInverse variance-weighted random-effects modelRisk of bias assessmentRandom-effects modelEvidence of benefitSystematic literature searchAortic eventsEvidence-based recommendationsFollow-upPower calculation for cross-sectional stepped wedge cluster randomized trials with a time-to-event endpoint
Baumann M, Esserman D, Taljaard M, Li F. Power calculation for cross-sectional stepped wedge cluster randomized trials with a time-to-event endpoint. Biometrics 2025, 81: ujaf074. PMID: 40557765, PMCID: PMC12188223, DOI: 10.1093/biomtc/ujaf074.Peer-Reviewed Original ResearchMeSH KeywordsBiometryCluster AnalysisComputer SimulationCross-Sectional StudiesEndpoint DeterminationHumansProportional Hazards ModelsRandomized Controlled Trials as TopicConceptsSW-CRTsCluster randomized trialStepped wedge cluster randomized trialTime-to-event endpointsTime-to-event outcomesRobust sandwich varianceMarginal Cox modelSandwich varianceWithin-periodElectronic reminder systemSW-CRTRandomized trialsBinary outcomesPower calculationsPower formulaReminder systemR Shiny applicationHospital settingCorrelation parametersSample sizePlanned trialsCox modelWaldFormulaTrialsEffects of Tirzepatide in Type 2 Diabetes Individual Variation and Relationship to Cardiometabolic Outcomes
Aminorroaya A, Oikonomou E, Biswas D, Jastreboff A, Khera R. Effects of Tirzepatide in Type 2 Diabetes Individual Variation and Relationship to Cardiometabolic Outcomes. Journal Of The American College Of Cardiology 2025, 85: 1858-1872. PMID: 40368575, PMCID: PMC12186526, DOI: 10.1016/j.jacc.2025.03.516.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiometabolic Risk FactorsDiabetes Mellitus, Type 2FemaleHumansHypoglycemic AgentsMaleMetabolic SyndromeMiddle AgedRandomized Controlled Trials as TopicTirzepatideTreatment OutcomeConceptsElevated body mass indexCardiometabolic abnormalitiesBody mass indexOdds of elevated body mass indexType 2 diabetesIndividual participant data meta-analysisMass indexParticipant data meta-analysisOdds of MetSCardiometabolic risk factorsComponents of metabolic syndromeData meta-analysisHigh-density lipoprotein cholesterolCardiometabolic healthStudy design differencesMixed-effects modelsBaseline usePhase 3 randomized clinical trialSodium-glucose cotransporter 2 inhibitorsOddsStudy outcomesEffects of tirzepatideMeta-analysisRisk factorsClinical subpopulationsOptical Coherence Tomography Versus Angiography Alone to Guide PCI for Complex Lesions: A Meta-Analysis of Randomized Controlled Trials
Ezenna C, Krishna M, Joseph M, Ibrahim S, Pereira V, Jenil-Franco A, Nanna M, Bangalore S, Goldsweig A. Optical Coherence Tomography Versus Angiography Alone to Guide PCI for Complex Lesions: A Meta-Analysis of Randomized Controlled Trials. Circulation Cardiovascular Interventions 2025, 18: e015141. PMID: 40159113, DOI: 10.1161/circinterventions.125.015141.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse cardiovascular eventsRandomized controlled trialsOptical coherence tomographyMyocardial infarctionControlled trialsCardiac deathCardiovascular eventsComplex lesionsRisk ratioMeta-analysis of randomized controlled trialsOCT-guided percutaneous coronary interventionHigh-resolution intracoronary imagingMajor adverse cardiovascular eventsAssociated with lower major adverse cardiovascular eventsMedian follow-upTarget vessel revascularizationPeriprocedural myocardial infarctionRandom-effects modelClinical outcomesCoherence tomographyFollow-upCochrane DatabaseCoronary interventionStent thrombosisCardiovascular and Kidney Outcomes and Mortality With Long-Acting Injectable and Oral Glucagon-Like Peptide 1 Receptor Agonists in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Trials.
Lee M, Sattar N, Pop-Busui R, Deanfield J, Emerson S, Inzucchi S, Mann J, Marx N, Mulvagh S, Poulter N, Badve S, Pratley R, Perkovic V, Buse J, McGuire D. Cardiovascular and Kidney Outcomes and Mortality With Long-Acting Injectable and Oral Glucagon-Like Peptide 1 Receptor Agonists in Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Trials. Diabetes Care 2025, 48: 846-859. PMID: 40156846, DOI: 10.2337/dc25-0241.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralCardiovascular DiseasesDiabetes Mellitus, Type 2Glucagon-Like Peptide 1Glucagon-Like Peptide-1 Receptor AgonistsGlucagon-Like PeptidesHumansHypoglycemic AgentsRandomized Controlled Trials as TopicConceptsGlucagon-like peptide 1 receptor agonistsPeptide 1 receptor agonistsComposite kidney outcomeGLP-1RAAll-cause mortalityType 2 diabetesKidney outcomesLong-actingOral formulationOutcome trialsHazard ratioReduced incidence of MACEIncidence rates of MACEIncreased risk of severe hypoglycemiaMeta-analysis of randomized trialsLong-acting GLP-1RASystematic review of PubMedWorsening kidney functionRisk of severe hypoglycemiaIncidence of MACERate of MACEEvaluate renal functionAdverse cardiovascular eventsCardiovascular outcome trialsReview of PubMedTreatment of Substance Use Disorders With a Mobile Phone App Within Rural Collaborative Care Management (Senyo Health): Protocol for a Mixed Methods Randomized Controlled Trial
Oesterle T, Bormann N, Paul M, Breitinger S, Lai B, Smith J, Stoppel C, Arndt S, Williams M. Treatment of Substance Use Disorders With a Mobile Phone App Within Rural Collaborative Care Management (Senyo Health): Protocol for a Mixed Methods Randomized Controlled Trial. JMIR Research Protocols 2025, 14: e65693. PMID: 40138685, PMCID: PMC11982759, DOI: 10.2196/65693.Peer-Reviewed Original ResearchMeSH KeywordsCOVID-19HumansMobile ApplicationsPrimary Health CareRandomized Controlled Trials as TopicReferral and ConsultationRural Health ServicesRural PopulationSARS-CoV-2Substance-Related DisordersTelemedicineConceptsINTERNATIONAL REGISTERED REPORT IDENTIFIERPrimary care settingCollaborative care managementPrimary careSubstance use disordersRandomized controlled trialsCare settingsCare managementRural primary care clinicsMethods Randomized controlled trialsPrimary care clinicsPrimary care providersControlled trialsSpecialty addictions treatmentReferral to treatmentImplementation research methodsMental health treatmentWaitlist-controlled trialWaitlist control groupEvidenced-based strategiesUse disorderMobile appsCare clinicsBrief interventionCare providersSystematic Review for the Follow-up of Curatively Treated Patients With Lung Cancer
Shargall Y, Vella E, Del Giudice M, Dennie C, Ellis P, Kulkarni S, MacRae R, Ung Y. Systematic Review for the Follow-up of Curatively Treated Patients With Lung Cancer. Clinical Lung Cancer 2025, 26: e327-e341. PMID: 40240202, DOI: 10.1016/j.cllc.2025.03.003.Peer-Reviewed Original ResearchMeSH KeywordsFollow-Up StudiesHumansLung NeoplasmsPatient Reported Outcome MeasuresQuality of LifeRandomized Controlled Trials as TopicSmoking CessationConceptsSmoking cessation interventionsPatient-reported outcome toolsPatient-reported outcomesRandomized controlled trialsCessation interventionsSystematic reviewOntario Health (Cancer Care OntarioNurse-led interventionRisk factorsClinical practice guidelinesQuality of lifeExercise trainingFollow-upManagement of signsCurative-intent treatmentPractice guidelinesControlled trialsTarget populationCochrane LibraryFollow-up strategiesInterventionLung cancerSymptoms of recurrencePatient populationFollow-up of patients
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