2025
The Five-Item Modified Frailty Index Predicts Adverse Surgical Outcomes in Patients Undergoing Mastectomy
Chiarella L, Huelsboemer L, Diatta F, Klimitz F, Kammien A, Kochen A, Boroumand S, Allam O, Kauke-Navarro M, Pomahac B. The Five-Item Modified Frailty Index Predicts Adverse Surgical Outcomes in Patients Undergoing Mastectomy. Annals Of Surgical Oncology 2025, 32: 4829-4837. PMID: 40342005, DOI: 10.1245/s10434-025-17105-2.Peer-Reviewed Original ResearchConceptsHigh-risk patientsMFI-5Surgical complicationsFrail patientsPredicting adverse surgical outcomesNational Surgical Quality Improvement Program dataIncreased risk of complicationsQuality Improvement Program dataMethodsThis retrospective cohort studyPredicting surgical complicationsDependent functional statusHigher body mass indexAdverse surgical outcomesOdds of complicationsRetrospective cohort studyAcute kidney failureRisk of complicationsAdult female patientsCongestive heart failurePostoperative complication riskAdjusted multivariable logistic regressionBody mass indexChronic obstructive pulmonary diseaseHigh-risk groupMultivariate logistic regressionIntegrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology
Davis C, Khan Y, Toikumo S, Jinwala Z, Boomsma D, Levey D, Gelernter J, Kember R, Kranzler H. Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology. Psychological Medicine 2025, 55: e138. PMID: 40336358, PMCID: PMC12094639, DOI: 10.1017/s0033291725000856.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMultivariate genome-wide association studyGenetic architectureComorbid forms of psychopathologyHierarchical Taxonomy of PsychopathologyBivariate causal mixture modelResearch Domain CriteriaTaxonomy of PsychopathologyPsychiatric classification systemsConfirmatory factor modelsInternalizing psychopathologyComorbid formsGenetic liabilityPsychopathologyTwo-factorHierarchical taxonomyModerate genetic correlationLatent factorsAssociation studiesBiological basisHiTOPReference panelGenetic underpinningsFactor modelGenetic variantsPerformance of the Charlson and Elixhauser Comorbidity Index Varies With the Type of Minimally Invasive Thoracic Surgery
Kim A, Ding L, Udelsman B, Atay S, Wightman S, Harano T, Rosenberg G, Blasberg J, Boffa D, Kim A. Performance of the Charlson and Elixhauser Comorbidity Index Varies With the Type of Minimally Invasive Thoracic Surgery. World Journal Of Surgery 2025, 49: 1418-1431. PMID: 40261152, DOI: 10.1002/wjs.12599.Peer-Reviewed Original ResearchConceptsMinimally invasive pulmonary lobectomyMinimally invasive Ivor Lewis esophagectomyArea under the receiver operating characteristic curveThoracic surgeryPredicting mortalityMinimally invasive thoracic surgeryPredicting short-term outcomesUtilization Project National Readmission DatabasePredicting long-term outcomesInvasive thoracic surgeryIvor Lewis esophagectomyMultivariate logistic regression modelReceiver operating characteristic curveShort-term outcomesLong-term outcomesNational Readmission DatabasePulmonary lobectomyInternational Classification of DiseasesSurgery typeClinical prognosisLogistic regression modelsComorbidity indexNonroutine dischargeICD-10 codesSurgeryRole of Serum Brain‐Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults
Ortolá R, Sotos‐Prieto M, Carballo A, Cabello‐Plan S, Koni A, Mustieles V, García‐Segura L, Artalejo A, Rodríguez‐Artalejo F, García‐Esquinas E. Role of Serum Brain‐Derived Neurotrophic Factor as a Biomarker of Chronic Pain in Older Adults. European Journal Of Pain 2025, 29: e70014. PMID: 40222813, PMCID: PMC11994381, DOI: 10.1002/ejp.70014.Peer-Reviewed Original ResearchConceptsSerum brain-derived neurotrophic factorBrain-derived neurotrophic factorChronic painBrain-derived neurotrophic factor concentrationsDepression statusCommunity-dwelling individualsMental health differencesControl of confoundingChronic pain diagnosesElectronic medical recordsSpanish general populationBiomarkers of chronic painNeurotrophic factorNon-depressed participantsHealth differencesMusculoskeletal painInterference painOlder AdultsPain surveyPain diagnosisPain severityGeneral populationDepressed womenPain subtypesCP evaluationComparing major comorbidity indices as predictors of all-cause mortality in the Veterans Affairs health care system
Beydoun H, Szymkowiak D, Beydoun M, Nixdorff N, Brunner R, Tsai J. Comparing major comorbidity indices as predictors of all-cause mortality in the Veterans Affairs health care system. Journal Of Clinical Epidemiology 2025, 182: 111778. PMID: 40185292, PMCID: PMC12146076, DOI: 10.1016/j.jclinepi.2025.111778.Peer-Reviewed Original ResearchConceptsFunctional Comorbidity IndexUS Department of Veterans AffairsDepartment of Veterans AffairsFunctional Comorbidity Index scoresElixhauser Comorbidity IndexMeasures of comorbidityVeterans AffairsCharlson Comorbidity IndexHarrell's concordance statisticMortality riskNonhomeless veteransVeterans Affairs health care systemComorbidity indexHomeless individualsHigh-risk patient populationVA healthcare servicesHigh riskClinical measuresHealth care servicesHealth care systemLow riskAll-cause mortalityPatient populationAssociated with homelessnessPredictor of all-cause mortalityThe inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression
Jiang R, Geha P, Rosenblatt M, Wang Y, Fu Z, Foster M, Dai W, Calhoun V, Sui J, Spann M, Scheinost D. The inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression. Science Advances 2025, 11: eadt1083. PMID: 40173244, PMCID: PMC11964001, DOI: 10.1126/sciadv.adt1083.Peer-Reviewed Original ResearchConceptsDepression riskChronic pain conditionsPain conditionsPrevalence of comorbid depressionPain scoresUK Biobank participantsPain-free individualsComposite pain scoresHigh-risk individualsPain screeningMendelian randomizationBiobank participantsPain sitesDepression incidenceComorbid depressionIncreased riskBody sitesDepressionC-reactive proteinPainCausal inferenceFollow-upScoresRiskInflammatory markersLong-term mortality from imaging-diagnosed pulmonary embolism in women and men
Sosner E, Mathai B, Bordon A, Ye K, Moadel R, Haramati L, Lazarus M. Long-term mortality from imaging-diagnosed pulmonary embolism in women and men. Clinical Imaging 2025, 122: 110469. PMID: 40273669, DOI: 10.1016/j.clinimag.2025.110469.Peer-Reviewed Original ResearchConceptsElectronic health recordsOne-year mortalityIncreased one-year mortalityCox proportional hazards modelsCharlson Comorbidity IndexProportional hazards modelLong-term mortalityUrban academic medical centerNational Death IndexMortality of womenHazards modelAcademic medical centerStudy of adultsHigher hazard ratioHealth recordsDeath IndexHealth statusInclusion of ageImpact of PEHazard ratioRetrospective study of adultsMedical CenterRisk factorsComorbidity indexPulmonary embolismGambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome?
Mestre-Bach G, Potenza M, Granero R, Håkansson A, Gómez-Peña M, Perales I, Vicó À, Uríszar J, Fernández-Aranda F, Sánchez I, Jiménez-Murcia S. Gambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome? Journal Of Behavioral Addictions 2025, 14: 465-479. PMID: 40116860, PMCID: PMC11974433, DOI: 10.1556/2006.2025.00023.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyGambling disorderPornography useEmotion regulationGD severityTreatment outcomesCognitive-behavioral therapy approachCognitive-behavioral therapy sessionsTreatment outcomes of individualsCo-occurrence of GDCo-occurrenceMental health concernsImprove treatment adherenceBehavioral addictionsTreatment dropoutOutcomes of individualsWeekly sessionsTreatment adherencePsychopathologyGamblingSessionsDisordersAssociated with higher likelihoodRelapseImpulseIncidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure
Barbano R, Jabbari B, Sadeghi M, Ukah A, Yue E, Ifantides K, Huang N, Swope D. Incidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure. Toxins 2025, 17: 148. PMID: 40137921, PMCID: PMC11945862, DOI: 10.3390/toxins17030148.Peer-Reviewed Original ResearchConceptsIncidence of dysphagiaCervical dystoniaComorbid conditionsContinuous health plan enrollmentCohort entry dateRate of dysphagiaRetrospective cohort studyPre-existing dysphagiaHealth plan enrollmentRisk factors of dysphagiaFactors of dysphagiaReal-world studyPotential adverse eventsPotential risk factorsPatient-level dataReal-world analysisAdverse eventsCD patientsCohort studyComorbid neurological conditionsLongitudinal patient-level dataCD diagnosisDysphagiaDysphagia riskPatientsUric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial
Patel R, Kumskova M, Kodali H, Budnik I, Kuznetsov V, Jain A, Jha A, Thedens D, Dhanesha N, Sutariya B, Nagarkatti K, Lamb J, Kamat P, Shi Y, Avery B, Imai T, Jin X, Chauhan A, Boisserand L, Khan M, Dhandapani K, Sanganahalli B, Sansing L, Hess D, Koehler R, McCullough L, Aronowski J, Ayata C, Diniz M, Lyden P, Planas A, Chamorro A, Chauhan A, Leira E, Investigators O. Uric Acid Stroke Cerebroprotection Transcended Sex, Age, and Comorbidities in a Multicenter Preclinical Trial. Stroke 2025, 56: 965-973. PMID: 40091742, PMCID: PMC11932773, DOI: 10.1161/strokeaha.124.048748.Peer-Reviewed Original ResearchConceptsUA-treated animalsPrimary functional outcomeFunctional outcomesMiddle cerebral artery filament occlusionModified intention-to-treat populationIntention-to-treat populationUric acidHuman clinical trialsImprove functional outcomesStudy drugIntravenous salineEffects of UARelevant to patientsClinical trialsPrimary outcomeSaline controlsSecondary outcomesPreclinical trialsDay 2Survival rateDay 7Filament occlusionGroups of animalsComorbiditiesDiverse comorbiditiesPhysical health correlates of co-occurring chronic pain and PTSD Among U.S. Veterans: Results from a nationally representative study
Reed D, Fischer I, Williams R, Na P, Engel C, Pietrzak R. Physical health correlates of co-occurring chronic pain and PTSD Among U.S. Veterans: Results from a nationally representative study. Psychiatry Research 2025, 348: 116440. PMID: 40088518, DOI: 10.1016/j.psychres.2025.116440.Peer-Reviewed Original ResearchConceptsPhysical health conditionsCo-occurring chronic painPosttraumatic stress disorderHealth conditionsChronic painU.S. veteransNational Health and ResilienceNon-Hispanic whitesMental health concernsPhysical health correlatesPosttraumatic Stress Disorder ChecklistPosttraumatic stress disorder diagnosisU.S. veteran populationNationally representative samplePhysical functionLogistic regression analysisPsychosocial burdenVeterans StudyVeteran populationSelf-reportDSM-5Representative sampleStress disorderVeteransHealth concernIdentification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities
Loesch D, Garg M, Matelska D, Vitsios D, Jiang X, Ritchie S, Sun B, Runz H, Whelan C, Holman R, Mentz R, Moura F, Wiviott S, Sabatine M, Udler M, Gause-Nilsson I, Petrovski S, Oscarsson J, Nag A, Paul D, Inouye M. Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities. Nature Communications 2025, 16: 2124. PMID: 40032831, PMCID: PMC11876343, DOI: 10.1038/s41467-025-56695-z.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCardiovascular DiseasesComorbidityDiabetes Mellitus, Type 2Extracellular Matrix ProteinsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInsulin-Like Growth Factor Binding Protein 2MaleMiddle AgedMultifactorial InheritanceProteomicsRisk FactorsUnited KingdomConceptsPolygenic scoresNon-coding variantsEtiology of type 2 diabetesMolecular dataVariant effectsPathway enrichmentPlasma proteomic markersPotential therapeutic targetType 2 diabetesProteinDisease biologyPolygenic riskUK BiobankProteomic markersTherapeutic targetPathwayCirculating proteinsGenomeRisk of type 2 diabetesCardiometabolic scoreBiologyInteractive portalVariantsEnrichmentDiabetes comorbiditiesImpact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis
Sumsuzzman D, Ye Y, Wang Z, Pandey A, Langley J, Galvani A, Moghadas S. Impact of disease severity, age, sex, comorbidity, and vaccination on secondary attack rates of SARS-CoV-2: a global systematic review and meta-analysis. BMC Infectious Diseases 2025, 25: 215. PMID: 39948450, PMCID: PMC11827239, DOI: 10.1186/s12879-025-10610-5.Peer-Reviewed Original ResearchConceptsPopulation settingEffective public health strategiesConfidence intervalsImpact of disease severityModified Newcastle-Ottawa ScalePublic health strategiesHigher secondary attack rateRisk of biasNewcastle-Ottawa ScalePandemic responseGlobal systematic reviewRandom-effects modelFreeman-Tukey double arcsine transformationWeb of ScienceNo significant associationDrivers of SARS-CoV-2 transmissionHealth strategiesSecondary attack rateSARS-CoV-2Disease severityEffective pandemic responseTargeted interventionsDouble arcsine transformationOvid MEDLINESystematic reviewThe Challenging Problems of Cancer and Serious Mental Illness
Grassi L, McFarland D, Riba M, Ferrara M, Zaffarami G, Belvederi Murri M, Cruciata M, Caruso R. The Challenging Problems of Cancer and Serious Mental Illness. Current Psychiatry Reports 2025, 27: 41-57. PMID: 39786658, PMCID: PMC11724792, DOI: 10.1007/s11920-024-01570-9.Peer-Reviewed Original ResearchConceptsSerious mental illnessProblem of cancerMental illnessGeneral populationPhysical health careRates of screeningMental health servicesHealth-care systemMedication side effectsHealth servicesOncology settingUnhealthy lifestyleHealth careCancer preventionStandard cancer treatmentHigher mortalitySomatic disordersCareVulnerable segmentsNegative outcomesIllnessOncologyCancer treatmentDelayed treatmentCancerLGBTQ+ status and sex of record in Veterans with post-traumatic stress disorder: demographics, comorbidities, and outpatient encounters
Workman T, Goulet J, Brandt C, Skanderson M, O’Leary J, Gordon K, Treitler-Zeng Q. LGBTQ+ status and sex of record in Veterans with post-traumatic stress disorder: demographics, comorbidities, and outpatient encounters. Frontiers In Public Health 2025, 12: 1487866. PMID: 39835315, PMCID: PMC11743380, DOI: 10.3389/fpubh.2024.1487866.Peer-Reviewed Original ResearchConceptsMilitary sexual traumaLGBTQ+ individualsMedical care usagePost-traumatic stress disorderTransgenderSexual traumaMarital statusSubstance use disorder diagnosisMental healthStress disorderContext of post-traumatic stress disorderQueerLGBTQ+CrimeVeterans with post-traumatic stress disorderMaltreatmentVeteransOutpatient encountersPolicySexStatusIncreased riskDemographicsChi-squareDisorder diagnosis
2024
Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss - A Comorbidity Lens.
Leder Macek A, Wang R, Cottrell J, Kay-Rivest E, McMenomey S, Roland J, Ross F. Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss - A Comorbidity Lens. Undersea And Hyperbaric Medicine 2024, 51: 393-402. PMID: 39821768, DOI: 10.22462/730.Peer-Reviewed Original ResearchConceptsSudden sensorineural hearing lossSensorineural hearing lossHearing loss onsetHearing lossHyperbaric oxygen therapyWord discrimination scoresSpeech perception outcomesIntratympanic steroid injectionOxygen therapyOral steroid coursesPerception outcomesTone averageSiegel's criteriaClinical improvementPhysician visitsPatient comorbiditiesRheumatologic disordersDiscrimination scoresAssociated with patient outcomesTreated with hyperbaric oxygen therapyCharlson Comorbidity IndexImpact of patient comorbiditiesTertiary referral centerOutcomes of patientsAdjunct to steroidsCannabis Use and Cannabis Use Disorder Among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013
Hasin D, Mannes Z, Livne O, Fink D, Martins S, Stohl M, Olfson M, Cerdá M, Keyes K, Keyhani S, Wisell C, Bujno J, Saxon A. Cannabis Use and Cannabis Use Disorder Among U.S. Adults with Psychiatric Disorders: 2001-2002 and 2012-2013. Substance Use & Misuse 2024, 60: 285-292. PMID: 39533528, PMCID: PMC11710973, DOI: 10.1080/10826084.2024.2423374.Peer-Reviewed Original ResearchConceptsCannabis use disorderPsychiatric disordersCannabis useNon-medical cannabis useCannabis outcomesUse disorderDSM-IV cannabis use disorderRates of cannabis use disordersRates of cannabis useCannabis use disorder prevalenceAntisocial personality disorderU.S. adultsPersonality disorderDSM-IVVeterans AdministrationPatient samplesNon-medical useDisordersPrevalence differencesU.S. general populationNationally representative sampleCannabisVA patientsAdultsDisproportionate increasePrevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans.
Fischer I, Na P, Harpaz-Rotem I, Marx B, Pietrzak R. Prevalence, Correlates, and Burden of Subthreshold PTSD in US Veterans. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39480145, DOI: 10.4088/jcp.24m15465.Peer-Reviewed Original ResearchConceptsSubthreshold posttraumatic stress disorderPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersLifetime psychiatric disordersUS veteransUS military veteransSymptom-related distressStress disorderPsychiatric disordersSymptom clustersTreating veteransCriterion AMilitary veteransTraumatic eventsCognitive functionWorking case definitionMental healthCriterion FFunctional impairmentVeteransNationally representative sampleFunctional correlatesDisordersElevated oddsGreater oddsTreatment for Co-Occurring Stimulant and Opioid Use Disorders
Howell B, Lin L, Coughlin L. Treatment for Co-Occurring Stimulant and Opioid Use Disorders. JAMA Psychiatry 2024, 81: 853-854. PMID: 38985457, DOI: 10.1001/jamapsychiatry.2024.1775.Peer-Reviewed Original ResearchExternal Validation of an Electronic Phenotyping Algorithm Detecting Attention to High Body Mass Index in Pediatric Primary Care
Barron A, Fenick A, Maciejewski K, Turer C, Sharifi M. External Validation of an Electronic Phenotyping Algorithm Detecting Attention to High Body Mass Index in Pediatric Primary Care. Applied Clinical Informatics 2024, 15: 700-708. PMID: 39197473, PMCID: PMC11387092, DOI: 10.1055/s-0044-1787975.Peer-Reviewed Original ResearchConceptsElectronic health recordsBody mass indexPediatric primary careElevated body mass indexWeight-related comorbiditiesPrimary carePediatric primary care practicesElectronic health record dataBody mass index categoriesMass indexImprove obesity managementPrimary care practicesWell-child visitsHigher body mass indexChart reviewLikelihood of classificationElectronic phenotyping algorithmsFree-text componentsClinician typeCare practicesHealth recordsClinician behaviorLaboratory ordersProgress notesObesity management
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