2025
Safety of Stimulants Across Patient Populations
Oliva H, Prudente T, Mayerson T, Mignosa M, Oliva I, Potenza M, Jegede O, Angarita G. Safety of Stimulants Across Patient Populations. JAMA Network Open 2025, 8: e259492. PMID: 40343695, PMCID: PMC12065045, DOI: 10.1001/jamanetworkopen.2025.9492.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsHumansLisdexamfetamine DimesylateMethylphenidateRandomized Controlled Trials as TopicConceptsAttention-deficit/hyperactivity disorderRandomized clinical trialsAdverse eventsStimulant medicationData extractionSafety of stimulationRisk ratioIncreased riskMethodological quality assessmentPreferred Reporting ItemsPatient populationClinical conditionsDiverse patient populationsRisk of biasSafety of stimulant medicationsUnclear risk of biasTreatment of attention-deficit/hyperactivity disorderOverall AEsRandom-effects modelWeb of ScienceBinge eating disorderStimulant use disorderComprehensive literature searchMain OutcomesReporting Items
2024
Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes
Olfson E, Farhat L, Liu W, Vitulano L, Zai G, Lima M, Parent J, Polanczyk G, Cappi C, Kennedy J, Fernandez T. Rare de novo damaging DNA variants are enriched in attention-deficit/hyperactivity disorder and implicate risk genes. Nature Communications 2024, 15: 5870. PMID: 38997333, PMCID: PMC11245598, DOI: 10.1038/s41467-024-50247-7.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityCase-Control StudiesChildExome SequencingFemaleGenetic Predisposition to DiseaseHistone DemethylasesHumansMaleMutationRisk FactorsConceptsDNA sequencesRisk genesHigh-confidence risk genesWhole-exome DNA sequencingSequencing of familiesIdentified de novoLysine demethylase 5BDNA variantsTrio cohortBiological pathwaysGenesSequencing cohortGenetic factorsChildhood neurodevelopmental disordersAttention-deficit/hyperactivity disorderSequenceVariantsADHD riskNeurodevelopmental disordersKDM5BDNAMutationsFamilyLysineDiscoveryPolygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence
Ratanatharathorn A, Quan L, Koenen K, Chibnik L, Weisskopf M, Slopen N, Roberts A. Polygenic risk for major depression, attention deficit hyperactivity disorder, neuroticism, and schizophrenia are correlated with experience of intimate partner violence. Translational Psychiatry 2024, 14: 119. PMID: 38409192, PMCID: PMC10897413, DOI: 10.1038/s41398-024-02814-1.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderDepressionDepressive Disorder, MajorFemaleHumansIntimate Partner ViolenceNeuroticismRisk FactorsSchizophreniaConceptsAttention-deficit hyperactivity disorderAutism spectrum disorderMental illnessIntimate partner violenceBipolar disorderHyperactivity disorderGenetic riskAttention deficit hyperactivity disorderGene-environment correlationPartner violenceDeficit hyperactivity disorderDepressive disorderPolygenic risk scoresSpectrum disorderPolygenic riskNeuroticismMDDDisordersIllnessWomen of European ancestryExperience of intimate partner violenceViolenceSchizophreniaAutismDepressionHumanized dopamine D4.7 receptor male mice display risk‐taking behavior and deficits of social recognition and working memory in light/dark‐dependent manner
Alachkar A, Phan A, Dabbous T, Alhassen S, Alhassen W, Reynolds B, Rubinstein M, Ferré S, Civelli O. Humanized dopamine D4.7 receptor male mice display risk‐taking behavior and deficits of social recognition and working memory in light/dark‐dependent manner. Journal Of Neuroscience Research 2024, 102: e25299. PMID: 38361407, PMCID: PMC11503891, DOI: 10.1002/jnr.25299.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAttention Deficit Disorder with HyperactivityDopamineHumansMaleMemory DisordersMemory, Short-TermMiceReceptors, Dopamine D4Risk-TakingConceptsPsychiatric disordersBehavioral phenotypesImpaired social recognition memoryEtiology of psychiatric disordersAttention-deficit hyperactivity disorderDopamine D<sub>4</sub> receptor (DWorking memory deficitsSocial recognition memoryDark phaseRisk-taking behaviorRecognition memoryWorking memoryMemory deficitsR miceIncreased risk behaviorSocial recognitionSpecific behaviorsBehavioral featuresDisordersMale miceDopaminePotential causal relationshipRisk behaviorsLight phaseDeficitsGenetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders
Koller D, Mitjans M, Kouakou M, Friligkou E, Cabrera-Mendoza B, Deak J, Llonga N, Pathak G, Stiltner B, Løkhammer S, Levey D, Zhou H, Hatoum A, Kember R, Kranzler H, Stein M, Corominas R, Demontis D, Artigas M, Ramos-Quiroga J, Gelernter J, Ribasés M, Cormand B, Polimanti R. Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders. Psychiatry Research 2024, 333: 115758. PMID: 38335780, PMCID: PMC11157987, DOI: 10.1016/j.psychres.2024.115758.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismAttention Deficit Disorder with HyperactivityComorbidityGenome-Wide Association StudyHumansOpioid-Related DisordersSubstance-Related DisordersConceptsUse disorderGenome-wide association studiesGenomic structural equation modelingCannabis use disorderAlcohol Use Disorders Identification TestAttention-deficit/hyperactivity disorderAlcohol use disorderProblematic alcohol useSubstance use disordersTwo-sample Mendelian randomization analysisLinkage disequilibrium score regression analysisDisorders Identification TestMendelian randomization analysisAssociated with increased oddsOdds of ADHDOpioid use disorderAttention-deficit/hyperactivityGWAS meta-analysesAlcohol dependenceStructural equation modelingNicotine dependenceInvestigate genetic correlationsADHDPolygenic riskStrength of evidence
2023
Autistic Characteristics in a Nationally Representative Clinical Sample of Adolescents Seeking Medical Gender-Affirming Treatment in Norway
David L, Stenberg N, Diseth T, Helverschou S, Nyquist C, Øien R, Waehre A. Autistic Characteristics in a Nationally Representative Clinical Sample of Adolescents Seeking Medical Gender-Affirming Treatment in Norway. Journal Of Autism And Developmental Disorders 2023, 55: 147-157. PMID: 38055182, PMCID: PMC11802688, DOI: 10.1007/s10803-023-06181-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderAutistic DisorderChildFemaleGender DysphoriaHumansMaleNorwayConceptsSocial Responsiveness ScaleAttention deficit hyperactivity disorderAutism spectrum diagnosisPsychiatric diagnosisAutistic characteristicsHistory of self-harmSocial Motivation subscaleDeficit hyperactivity disorderAnxiety disordersSpectrum diagnosisAwareness subscaleGender incongruenceHyperactivity disorderSuicide attemptsMotivation subscalesSelf-harmTotal scaleClinical populationsSocial motivationResponse scaleASD diagnosisNorm groupClinical rangeNorm populationSubscalesRare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD
Wang S, Wang B, Drury V, Drake S, Sun N, Alkhairo H, Arbelaez J, Duhn C, Bal V, Langley K, Martin J, Hoekstra P, Dietrich A, Xing J, Heiman G, Tischfield J, Fernandez T, Owen M, O’Donovan M, Thapar A, State M, Willsey A. Rare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD. Nature Communications 2023, 14: 8077. PMID: 38057346, PMCID: PMC10700338, DOI: 10.1038/s41467-023-43776-0.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderAutistic DisorderFemaleHumansMaleNeurodevelopmental DisordersTourette SyndromeConceptsDamaging variantsHigh-confidence ASD risk genesExome-wide significanceRare genetic variationASD risk genesRare damaging variantsHemizygous natureWhole-exome sequencing studiesExome sequencing studiesGene discoveryMultiple neurodevelopmental disordersGenetic variationGenetic mechanismsChr XMale sex biasSequencing studiesChromosome XRisk genesTransmission disequilibrium testAttention-deficit/hyperactivity disorderASD probandsAutism spectrum disorderASD familiesSex biasInformative recombinationsCognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial
Bikic A, Dalsgaard S, Pittman B, Leckman J, Wexler B. Cognitive training for children with ADHD: composite cognitive score outcome in a randomized controlled trial. Nordic Journal Of Psychiatry 2023, 78: 87-91. PMID: 37905332, DOI: 10.1080/08039488.2023.2270954.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityChildCognitionCognitive TrainingHumansTreatment OutcomeConceptsAttention-deficit/hyperactivity disorderCognitive trainingDeficit/hyperactivity disorderComposite cognition scoreSessions of trainingCognitive functioningHyperactivity disorderCognitive improvementCognition scoresTraining sessionsMixed resultsFrequency of trainingTrainingChildrenSessionsIntervention groupCognitionInterventionFunctioningPost Hoc AnalysisScore outcomesControl groupPrevious studiesDisordersOutcomes“Dysregulated not deficit”: A qualitative study on symptomatology of ADHD in young adults
Ginapp C, Greenberg N, MacDonald-Gagnon G, Angarita G, Bold K, Potenza M. “Dysregulated not deficit”: A qualitative study on symptomatology of ADHD in young adults. PLOS ONE 2023, 18: e0292721. PMID: 37824501, PMCID: PMC10569543, DOI: 10.1371/journal.pone.0292721.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityCanadaFemaleHumansMaleQualitative ResearchYoung AdultNeurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort
He Q, Keding T, Zhang Q, Miao J, Russell J, Herringa R, Lu Q, Travers B, Li J. Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort. Journal Of Neurodevelopmental Disorders 2023, 15: 30. PMID: 37653373, PMCID: PMC10469494, DOI: 10.1186/s11689-023-09498-6.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityBrainCerebral CortexGray MatterHumansNeurosciencesConceptsADHD polygenic scoresDorsolateral prefrontal cortexADHD outcomesPolygenic scoresIA symptomsHyperactivity-impulsivity symptomsMultiple mediation modelIndirect effectsPhiladelphia Neurodevelopmental CohortBrain volumeInferior temporal lobeBrain-based biomarkersADHD inattentionGray matter volumeADHD symptomsHI symptomsMediation modelAngular gyrusNeurobiological mechanismsNeurodevelopmental CohortADHDPrefrontal cortexInattentionTemporal lobeBrain regionsUsing micro-cognition biomarkers of neurosystem dysfunction to redefine ADHD subtypes: A scalable digital path to diagnosis based on brain function
Wexler B, Kish R. Using micro-cognition biomarkers of neurosystem dysfunction to redefine ADHD subtypes: A scalable digital path to diagnosis based on brain function. Psychiatry Research 2023, 326: 115348. PMID: 37494880, PMCID: PMC10517859, DOI: 10.1016/j.psychres.2023.115348.Peer-Reviewed Original ResearchConceptsPoor response inhibitionResponse inhibitionSymptom-based diagnosisGO/NOGO testMarked performance decrementsNew treatment developmentTD childrenADHD childrenADHD subtypesPerformance decrementsInconsistent attentionAbstract categoriesTreatment developmentNatural categoriesBrain functionADHDDifferent neuropathologiesChildren 6Individual patientsTreatment selectionDepression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses
Als T, Kurki M, Grove J, Voloudakis G, Therrien K, Tasanko E, Nielsen T, Naamanka J, Veerapen K, Levey D, Bendl J, Bybjerg-Grauholm J, Zeng B, Demontis D, Rosengren A, Athanasiadis G, Bækved-Hansen M, Qvist P, Bragi Walters G, Thorgeirsson T, Stefánsson H, Musliner K, Rajagopal V, Farajzadeh L, Thirstrup J, Vilhjálmsson B, McGrath J, Mattheisen M, Meier S, Agerbo E, Stefánsson K, Nordentoft M, Werge T, Hougaard D, Mortensen P, Stein M, Gelernter J, Hovatta I, Roussos P, Daly M, Mors O, Palotie A, Børglum A. Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses. Nature Medicine 2023, 29: 1832-1844. PMID: 37464041, PMCID: PMC10839245, DOI: 10.1038/s41591-023-02352-1.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityBipolar DisorderDepressionFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideSchizophreniaConceptsSingle nucleotide polymorphism heritabilityGenome-wide analysisLikely causal genesFunctional genomics dataRisk variantsWide association studyPolygenic burdenPsychiatric disordersCausal genesPolygenic architectureGenomic dataRisk lociAssociation studiesSubgroups of depressionCause of disabilityDepression genetic riskCommon psychiatric disordersPrecision medicine approachCases of depressionOligodendrocyte lineageGenesLociConsiderable sex differencesGABAergic neuronsPsychiatric comorbidityThe association between polygenic risk scores for mental disorders and social cognition: A scoping review
Fusar-Poli L, Rodolico A, Martinez M, Fichera C, Lin B, Basadonne I, Concerto C, Aguglia E, Guloksuz S, Signorelli M. The association between polygenic risk scores for mental disorders and social cognition: A scoping review. Journal Of Psychiatric Research 2023, 164: 389-401. PMID: 37418886, DOI: 10.1016/j.jpsychires.2023.06.029.Peer-Reviewed Original ResearchMeSH KeywordsAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderHumansPsychotic DisordersRisk FactorsSocial CognitionConceptsAutism spectrum disorderSocial cognitionMental disordersAttention deficit hyperactivity disorderReal-world functioningSC deficitsEmotion recognitionHyperactivity disorderSpectrum disorderPresent impairmentsPolygenic risk scoresCognitionFuture researchMolecular genetic riskSignificant difficultiesSpecific disordersDisordersUnaffected relativesGenetic riskRisk scorePeopleUnderstanding of mechanismsFunctioningEnvironmental risk factorsScoresNetwork analysis of ecological momentary assessment identifies frustration as a central node in irritability
Tseng W, Naim R, Chue A, Shaughnessy S, Meigs J, Pine D, Leibenluft E, Kircanski K, Brotman M. Network analysis of ecological momentary assessment identifies frustration as a central node in irritability. Journal Of Child Psychology And Psychiatry 2023, 64: 1212-1221. PMID: 36977629, PMCID: PMC10615387, DOI: 10.1111/jcpp.13794.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityEcological Momentary AssessmentFemaleFrustrationHumansIrritable MoodMaleMood DisordersConceptsEcological momentary assessmentPolygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample
Sato J, Biazoli C, Bueno A, Caye A, Pan P, Santoro M, Honorato‐Mauer J, Salum G, Hoexter M, Bressan R, Jackowski A, Miguel E, Belangero S, Rohde L. Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample. Genes Brain & Behavior 2023, 22: e12838. PMID: 36811275, PMCID: PMC10067387, DOI: 10.1111/gbb.12838.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAttention Deficit Disorder with HyperactivityBrainChildConnectomeHumansMagnetic Resonance ImagingNeural PathwaysRisk FactorsConceptsCingulo-opercular networkDefault mode networkADHD-PRSAttentional networksFunctional segregationAttention-deficit/hyperactivity disorder (ADHD) symptomsAttention-deficit/hyperactivity disorderLarge-scale brain networksADHD polygenic risk scoresHyperactivity disorder symptomsSegregation of networksFunctional network segregationLongitudinal community-based cohortAttentional processesRs-fMRI dataExecutive functionHyperactivity disorderDisorder symptomsBrain networksCommunity-based sampleProbable ADHDADHDNetwork segregationPolygenic risk scoresDirection of associationAlterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents
Honorato-Mauer J, Xavier G, Ota V, Chehimi S, Mafra F, Cuóco C, Ito L, Ormond R, Asprino P, Oliveira A, Bugiga A, Torrecilhas A, Bressan R, Manfro G, Miguel E, Rohde L, Pan P, Salum G, Pellegrino R, Belangero S, Santoro M. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. Translational Psychiatry 2023, 13: 47. PMID: 36746925, PMCID: PMC9902559, DOI: 10.1038/s41398-023-02326-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxiety DisordersAttention Deficit Disorder with HyperactivityCohort StudiesCross-Sectional StudiesDepressionDepressive Disorder, MajorExtracellular VesiclesGenome-Wide Association StudyHumansMicroRNAsConceptsMental health disordersCross-sectional analysisMajor depressive disorderAttention-deficit/hyperactivity disorderHealth disordersAnxiety disordersExtracellular vesiclesLarge ongoing cohort studiesMiR-432-5pPeripheral extracellular vesiclesTime pointsOngoing cohort studyMiR-328-3pSerum extracellular vesiclesLongitudinal analysisWave 2Deficit/hyperactivity disorderAdolescent participantsTotal extracellular vesiclesAttention-deficit/hyperactivityMiRNA expressionCohort studyDepressive disorderMajor depressionMiR-584-5pExploring mediational roles for self-stigma in associations between types of problematic use of internet and psychological distress in youth with ADHD
Lee K, Chen C, Chen J, Liu C, Chang K, Fung X, Chen J, Kao Y, Potenza M, Pakpour A, Lin C. Exploring mediational roles for self-stigma in associations between types of problematic use of internet and psychological distress in youth with ADHD. Research In Developmental Disabilities 2023, 133: 104410. PMID: 36603311, DOI: 10.1016/j.ridd.2022.104410.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnxietyAnxiety DisordersAttention Deficit Disorder with HyperactivityBehavior, AddictiveChildHumansInternetMalePsychological DistressSocial MediaConceptsAttention deficit hyperactivity disorderProblematic smartphone useProblematic social media usePsychological distressProblematic gamingProblematic useDeficit hyperactivity disorderMediational roleHyperactivity disorderSmartphone useDistressResults of pathAdolescentsSocial media useYouthExtant literaturePsychiatric outpatient clinicMedia useSpecific formAnxietyDifferent formsParticipantsGamingDepressionAssociation
2022
Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study
Chiang H, Tseng W, Tseng W, Tung Y, Hsu Y, Chen C, Gau S. Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study. Asian Journal Of Psychiatry 2022, 79: 103358. PMID: 36481569, DOI: 10.1016/j.ajp.2022.103358.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDiffusion Tensor ImagingHumansLongitudinal StudiesWhite MatterConceptsAttention-deficit/hyperactivity disorderInferior fronto-occipital fasciculusGeneralized fractional anisotropyAttention performanceWhite matter microstructureDevelopmental trajectoriesComputerized continuous performance testAtypical developmental trajectoriesContinuous Performance TestDiffusion spectrum imagingFrontal aslant tractWhite matter tractsInattention symptomsAtypical developmentADHD symptomsHyperactivity disorderSuperior longitudinal fasciculusPrefrontal cortexFrontostriatal tractsImaging studiesArcuate fasciculusDevelopmental changesFronto-occipital fasciculusNeuroplastic processesDiagnosis interactionDisentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathersBehaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters
Stewart A, Mayer F, Gowrishankar R, Davis G, Areal L, Gresch P, Katamish R, Peart R, Stilley S, Spiess K, Rabil M, Diljohn F, Wiggins A, Vaughan R, Hahn M, Blakely R. Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters. Molecular Psychiatry 2022, 27: 4869-4880. PMID: 36117213, DOI: 10.1038/s41380-022-01773-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderCentral Nervous System StimulantsDopamineDopamine Plasma Membrane Transport ProteinsFemaleMaleMiceSignal TransductionConceptsAnomalous DA effluxDA transporterRegulate DA transporterD2R antagonist sulpirideAttention-deficit/hyperactivity disorderSex-dependent behavioursAutism spectrum disorderSex-dependent alterationsResponse to DAPsychostimulant responsesVentral striatumDA autoreceptorsDopamine effluxDA effluxAntagonist sulpirideDA releaseDA signalingSex-biased effectsAttention-deficit/hyperactivityDopamine transporterNeuropsychiatric disordersCognitive performanceDAT proteinDAT traffickingSpectrum disorder
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply