2025
Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolenzius J, Team A. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 104: e213591. PMID: 40327828, PMCID: PMC12060792, DOI: 10.1212/wnl.0000000000213591.Peer-Reviewed Original ResearchConceptsAcute HIV infectionAntiretroviral therapyWhite matter hyperintensitiesWMH changeViral suppressionHIV infectionBaseline CD4<sup>+</sup> T-cell countVascular comorbiditiesCD4<sup>+</sup> T-cell countIncreased rate of ischemic strokeUndetectable plasma viral loadT2-fluid-attenuated inversion recovery sequencesPlasma viral loadT-cell countsAntiretroviral therapy initiationEarly ART initiationFluid-attenuated inversion recovery sequencesBrain white matter hyperintensityHistory of psychiatric disordersFollow-up periodRate of ischemic strokeRepeated-measures ANOVAIncreased risk of strokeTwo-year follow-upExposure to HIVPredicting White Matter Hyperintensity: Leveraging Portable Magnetic Resonance Imaging for Accessible Brain Health Screening.
Johnson I, Brigger H, Smith J, Peasley E, Champagne A, Littig L, Lalwani D, Sze G, Payabvash S, Safdar B, D'Onofrio G, Wira C, Iglesias J, Rosen M, Sorby-Adams A, Kimberly W, Sheth K, de Havenon A. Predicting White Matter Hyperintensity: Leveraging Portable Magnetic Resonance Imaging for Accessible Brain Health Screening. American Journal Of Neuroradiology 2025, ajnr.a8734. PMID: 40081846, DOI: 10.3174/ajnr.a8734.Peer-Reviewed Original ResearchWhite matter hyperintensitiesWMH measuresMagnetic resonance imagingConventional MRIScreening pilot programRisk factorsValidation cohortHigh-risk individualsAcute neurologic pathologyVascular risk factorsTertiary care hospitalSystolic blood pressure >Resonance imagingDevelopment cohortWhite matter hyperintensities burdensHealth screeningTobacco useBlood pressure >Emergency departmentCare hospitalPortable MRIRisk scoreScreening toolPilot programPrimary outcomeBrain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanisms
2024
Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease
Sorby-Adams A, Guo J, Laso P, Kirsch J, Zabinska J, Garcia Guarniz A, Schaefer P, Payabvash S, de Havenon A, Rosen M, Sheth K, Gomez-Isla T, Iglesias J, Kimberly W. Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease. Nature Communications 2024, 15: 10488. PMID: 39622805, PMCID: PMC11612292, DOI: 10.1038/s41467-024-54972-x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMachine learning pipelineMild cognitive impairmentAlzheimer's diseaseWhite matter hyperintensities volumeLearning pipelineAssessment of patientsIncrease accessCognitive impairmentEvaluation of Alzheimer's diseaseDementiaLF-MRIPoint-of-care assessmentMagnetic resonance imagingHippocampal volumeResonance imagingImage qualityDiseaseReduce costsAnisotropic counterpartIncreasing availabilityManual segmentationRecent advances in portable, low-field magnetic resonance imaging in cerebrovascular disease
Zabinska J, de Havenon A, Sheth K. Recent advances in portable, low-field magnetic resonance imaging in cerebrovascular disease. Current Opinion In Neurology 2024, 38: 35-39. PMID: 39624032, DOI: 10.1097/wco.0000000000001338.Peer-Reviewed Original ResearchConceptsCerebrovascular diseaseWhite matter hyperintensityHealthcare settingsHemorrhage managementAlzheimer's dementiaClinical timepointsStages of cerebrovascular diseaseHemorrhagic strokeEmergency settingWhite matter hyperintensitiesIntracerebral hemorrhage managementCardiovascular intensive careThrombolytic administrationPatient populationCerebrovascular disease progressionIntensive careMagnetic resonance imagingStrokeEndovascular reperfusionCerebrovascularCost-effectiveDisease progressionResonance imagingChronic stageCareAssociation Between Cumulative Anticholinergic Use and White Matter Hyperintensity Burden
Li K, Krakauer C, Nelson J, Crane P, Andre J, Curl P, Yuh E, Ralston J, Gray S, MacDonald C. Association Between Cumulative Anticholinergic Use and White Matter Hyperintensity Burden. Alzheimer's & Dementia 2024, 20: e084407. PMCID: PMC11714981, DOI: 10.1002/alz.084407.Peer-Reviewed Original ResearchMagnetic resonance imagingDose-response relationshipWhite matter hyperintensitiesAssociated with higher dementia riskAssociated with greater WMH burdenAnticholinergic useCumulative anticholinergic useKaiser Permanente WashingtonMagnetic resonance imaging scansThought (ACTAnticholinergic medication useProspective cohort studyWhite matter hyperintensity burdenDementia riskAdult ChangesWhite matter hyperintensities burdensOlder adultsAnticholinergic medicationsClinical indicationsAnticholinergic burdenCohort studyLinear regression modelsTSDDsMedication useResonance imagingEnhancing cognitive performance prediction by white matter hyperintensity connectivity assessment
Petersen M, Coenen M, DeCarli C, De Luca A, van der Lelij E, Weiner M, Aisen P, Petersen R, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Landau S, Rivera-Mindt M, Okonkwo O, Shaw L, Lee E, Toga A, Beckett L, Harvey D, Green R, Saykin A, Nho K, Perrin R, Tosun D, Sachdev P, Green R, Drake E, Montine T, Conti C, Weiner M, Nosheny R, Sacrey D, Fockler J, Miller M, Conti C, Kwang W, Jin C, Diaz A, Ashford M, Flenniken D, Petersen R, Aisen P, Rafii M, Raman R, Jimenez G, Donohue M, Salazar J, Fidell A, Boatwright V, Robison J, Zimmerman C, Cabrera Y, Walter S, Clanton T, Shaffer E, Webb C, Hergesheimer L, Smith S, Ogwang S, Adegoke O, Mahboubi P, Pizzola J, Jenkins C, Beckett L, Harvey D, Donohue M, Saito N, Diaz A, Hussen K, Okonkwo O, Rivera-Mindt M, Amaza H, Thao M, Parkins S, Ayo O, Glittenberg M, Hoang I, Germano K, Strong J, Weisensel T, Magana F, Thomas L, Guzman V, Ajayi A, Benedetto J, Talavera S, Jack C, Felmlee J, Fox N, Thompson P, DeCarli C, Forghanian-Arani A, Borowski B, Reyes C, Hedberg C, Ward C, Schwarz C, Reyes D, Gunter J, Moore-Weiss J, Kantarci K, Matoush L, Senjem M, Vemuri P, Reid R, Malone I, Thomopoulos S, Nir T, Jahanshad N, Knaack A, Fletcher E, Harvey D, Tosun-Turgut D, Chen S, Choe M, Crawford K, Yushkevich P, Das S, Jagust W, Landau S, Koeppe R, Rabinovici G, Villemagne V, LoPresti B, Perrin R, Morris J, Franklin E, Bernhardt H, Cairns N, Taylor-Reinwald L, Shaw L, Lee E, Virginia Lee M, Korecka M, Brylska M, Wan Y, Trojanowki J, Toga A, Crawford K, Neu S, Saykin A, Nho K, Foroud T, Jo T, Risacher S, Craft H, Apostolova L, Nudelman K, Faber K, Potter Z, Lacy K, Kaddurah-Daouk R, Shen L, Karlawish J, Erickson C, Grill J, Largent E, Harkins K, Weiner M, Thal L, Kachaturian Z, Frank R, Snyder P, Buckholtz N, Hsiao J, Ryan L, Molchan S, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Okonkwo O, Perrin R, Ryan L, Silverberg N, Silbert L, Kaye J, White S, Pierce A, Thomas A, Clay T, Schwartz D, Devereux G, Taylor J, Ryan J, Nguyen M, DeCapo M, Shang Y, Schneider L, Munoz C, Ferman D, Conant C, Martin K, Oleary K, Pawluczyk S, Trejo E, Dagerman K, Teodoro L, Becerra M, Fairooz M, Garrison S, Boudreau J, Avila Y, Brewer J, Jacobson A, Gama A, Kim C, Little E, Frascino J, Ferng N, Trujillo S, Heidebrink J, Koeppe R, MacDonald S, Malyarenko D, Ziolkowski J, O'Connor J, Robert N, Lowe S, Rogers V, Petersen R, Hackenmiller B, Boeve B, Albers C, Kreuger C, Jones D, Knopman D, Botha H, Magnuson J, Graff-Radford J, CrawleyW K, Schumacher M, McKinzie S, Smith S, Helland T, Lowe V, Ramanan V, Pavlik V, Faircloth J, Bishop J, Nath J, ChaudharyP M, Kataki M, Yu M, Pacini N, Barker R, Brooks R, Aggarwal R, Honig L, Stern Y, Mintz A, Cordona J, Hernandez M, Long J, Arnold A, Groves A, Middleton A, Vogler B, McCurry C, Mayo C, Raji C, Amtashar F, KlempW H, Elmore H, Ruszkiewicz J, Kusuran J, Stewart J, Horenkamp J, Greeson J, Wever K, Vo K, Larkin K, Rao L, Schoolcraft L, Gallagher L, Paczynski M, McMillan M, Holt M, Gagliano N, Henson R, LaBarge R, Swarm R, MunieN S, Cepeda S, WintertonN S, Hegedus S, Wilson T, Harte T, Bonacorsi Z, Geldmacher D, Watkins A, BargerRT B, Smelser B, Bates C, Stover C, McKinley E, Ikner G, Hendrix H, Cooper H, Mahaffey J, Robbins L, Ashley L, Natelson-Love M, Carter P, Solomon V, Grossman H, Groome A, Ardolino A, Kaplan A, Sheppard F, Burgos-Rivera G, Garcia-Camilo G, Lim J, Neugroschl J, Jackson K, Evans K, Soleimani L, Sano M, Ghesani N, Binder S, Apuango X, Sood A, Troutman A, Blanchard K, Richards A, Nelson G, HendricksonN K, Yurko E, Plenge J, Rufo V, Shah R, Duara R, Lynch B, Chirinos C, Dittrich C, Campbell D, Mejia D, Perez G, Colvee H, Gonzalez J, Gondrez J, Knaack J, Acevedo M, Cereijo M, Greig-Custo M, Villar M, Wishnia M, Detling S, Barker W, Albert M, Moghekar A, Rodzon B, Demsky C, Pontone G, Pekar J, Farrington L, Pomper M, Johnson N, Alo T, Sadowski M, Ulysse A, Masurkar A, Marti B, Mossa D, Geesey E, Petrocca E, Schulze E, Wong J, Boonsiri J, Kenowsky S, Martinez T, Briglall V, Doraiswamy Murali P, Nwosu A, Adhikari A, Hellegers C, Petrella J, James O, Wong T, Hawk T, Vaishnavi S, McCoubrey H, Nasrallah I, Rovere R, Maneval J, Robinson E, Rivera F, Uffelman J, Combs M, O'Donnell P, Manning S, King R, NietoN A, Glueck A, Mandal A, Swain A, Gamble B, Beverly Meacham M, Forenback D, Ross D, Cheatham E, Hartman E, Cornell G, Harp J, Ashe L, Goins L, Watts L, Yazell M, Mandal P, BucklerN R, Vincent S, Rudd T, Lopez O, Malia Arlene A, Chiado C, Zik C, Ruszkiewicz J, Savage K, Fenice L, Oakley M, Tacey P, Berman S, Bowser S, Hegedus S, Saganis X, Porsteinsson A, Mathewson A, Widman A, Holvey B, Clark E, Morales E, Iris Young C, Ruszkiewicz J, Hopkins K, Martin K, Kowalski N, Hunt R, Calzavara R, Kurvach R, Stephen D'Ambrosio C, Thai G, Vides B, Lieb B, McAdams-Ortiz C, Toso C, Mares I, Moorlach K, Liu L, Corona M, Nguyen M, Tallakson M, McDonnell M, Rangel M, Basheer N, Place P, Romero R, Tam S, Nguyen T, Thomas A, Frolov A, Khera A, Browning A, Kelley B, Courtney Dawson R, Mathews D, Most E, Phillips E, Nguyen L, Nunez M, Miller M, Jones Matthew R, Martinez N, Rebecca Logan C, McColl R, Pham S, Fox T, Moore T, Levey A, Brown A, Kippels A, Ellison A, Lyons C, Hales C, Parry C, Williams C, McCorkle E, Harris G, Rose H, Jooma I, Al-Amin J, Lah J, Webster J, Swiniarski J, Chapman L, Donnelly L, Mariotti L, Locke M, Vaughn P, Penn R, Carpentier S, Yeboah S, Basadre S, Malakauskas S, Lyron S, Villinger T, Burney T, Burns J, Ala Abusalim C, Dahlgren A, Montero A, Arthur A, Dooly H, Kreszyn K, Berner K, Gillen L, Scanlan M, Madison M, Mathis N, Switzer P, Townley R, Fikru S, Sullivan S, Wright E, Beigi M, Daley A, Ko A, Luong B, Nyborg G, Morales J, Durbin K, Garcia L, Parand L, Macias L, Monserratt L, Farchi M, Wu P, Hernandez R, Rodriguez T, Graff-Radford N, Marolt A, Thomas A, Aloszka D, Moncayo E, Westerhold E, Day G, Chrestensen K, Imhansiemhonehi M, McKinzie S, Stephens S, Grant S, Brosch J, Perkins A, Saunders A, Kovac D, Polson H, Mwaura I, Mejia K, Britt K, King K, Nichols K, Lawrence K, Rankin L, Farlow M, Wiesenauer P, Bryant R, Herring S, Lynch S, Wilson S, Day T, Korst W, van Dyck C, Mecca A, Miller A, Brennan A, Khan A, Ruan A, Gunnoud C, Mendonca C, Raynes-Goldfinger D, Salardini E, Hidalgo E, Cooper E, Singh E, Murphy E, May J, Stanhope J, Lam J, Waszak J, Nelsen K, Sacaza K, Hasbani M, Donahue M, Chen M, Barcelos N, Eigenberger P, Bonomi R, O'Dell R, Jefferson S, Khasnavis S, Smilowitz S, DeStefano S, Good S, Camarro T, Clayton V, Cavrel Y, Lu Y, Chertkow H, Bergman H, Hosein C, Black S, Kapadia A, Bhan A, Lam B, Scott C, Gabriel G, Bray J, Zotovic L, Gutierrez M, Masellis M, Farshadi M, Gui M, Mitchellc M, Taylor R, Endre R, Taghi-Zada Z, Hsiung R, English C, Kim E, Yau E, Tong H, Barlow L, Jennings L, Assaly M, Nunes P, Marian T, Kertesz A, Rogers J, Trost D, Wint D, Bernick C, Munic D, Grant I, Korkoyah A, Raja A, Lapins A, Ryan C, Pejic J, Basham K, Lukose L, Haddad L, Quinlan L, Houghtaling N, Sadowsky C, Martinez W, Villena T, Reynolds B, Forero A, Ward C, Brennan E, Figueroa E, Esposito G, Mallory J, Johnson K, Turner K, Seidenberg K, McCann K, Bassett M, Chadwick M, Turner R, Bean R, Sharma S, Marshall G, Haviari A, Alison Pietras C, Wallace B, Munro C, Rivera-Delpin G, Hustead H, Levesque I, Ramirez J, Karen Nolan M, Glennon K, Palou M, Erkkinen M, DaSilva N, Friedman P, Silver R, Salazar R, Polleys R, McGinnis S, Gale S, Hall T, Luu T, Chao S, Lin E, Coleman J, Epperson K, Vasanawala M, Atri A, Rangel A, Evans B, Monarrez C, Cline C, Liebsack C, Bandy D, Goldfarb D, Intorcia D, Olgin J, Clark K, King K, York K, Reade M, Callan M, Glass M, Johnson M, Gutierrez M, Goddard M, Trncic N, Choudhury P, Reyes P, Lowery S, Hall S, Olgin S, de Santiago S, Alosco M, Ton A, Jimenez A, Ellison A, Tran A, Anderson B, Carter D, Veronelli D, Lenio S, Steinberg E, Mez J, Weller J, Johns J, Mez J, Harkins J, Puleio A, Hoti I, Mwicigi J, Puleio A, Alosco M, Schultz O, Lauture M, Steinberg E, Denis R, Killiany R, Singh S, Lenio S, Qiu W, Devis Y, Obisesan T, Stone A, Ordor D, Udodong I, Okonkwo I, Khan J, Turner J, Hughes K, Kadiri O, Duffy C, Moss A, Stapleton K, Toth M, Sanders M, Ayres M, Hamski M, Fatica P, Ogrocki P, Ash S, Pot S, Chen D, Soto A, Tanase C, Bissig D, Vanya H, Russell H, Patel H, Zhang H, Wallace K, Ayers K, Gallegos M, Forloines M, Sinn M, Kahulugan Q, Isip R, Calderon S, Hamm T, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Perrin A, Tariot P, Fleisher A, Reeder S, Capote H, Emborsky A, Mattle A, Ajtai B, Benjamin Wagner C, Myers B, Slazyk D, Delaney Fragale C, Fransen E, Macnamara H, Jonathan Falletta C, Hirtreiter J, Mechtler L, King M, Asbach M, Rainka M, Zawislak R, Wisniewski S, Stephanie O'Malley C, Jimenez-Knight T, Peehler T, Aladeen T, Bates V, Wenner V, Elmalik W, Scharre D, Ramamurthy A, Bouchachi S, Kataki M, Tarawneh R, Kelley B, Celmins D, Leader A, Figueroa C, Bauerle H, Patterson K, Reposa M, Presto S, Ahmed T, Stewart W, Pearlson G, Blank K, Anderson K, Santulli R, Schwartz E, Williamson J, Jessup A, Williams A, Duncan C, O'Connell A, Gagnon K, Zamora E, Bateman J, Crawford F, Thompson D, Walker E, Rowell J, White M, Ledford P, Bohlman S, Henkle S, Bottoms J, Moretz L, Hoover B, Shannon M, Samantha Rogers C, Baker W, Harrison W, Wu C, DeMarco A, Stipanovich A, Arcuri D, Clark J, Davis J, Doyon K, Amoyaw M, Acosta M, Ronald Bailey R, Warren S, Fogerty T, Sanborn V, Riddle M, Salloway S, Malloy P, Correia S, Windon C, Blackburn M, Rosen H, Miller B, Smith A, Mba I, Echevarria J, Janavs J, Roglaski E, Yong M, Devine R, Okhravi H, Rivera E, Kalowsky T, Smith C, Rosario C, Masdeu J, Le R, Gurung M, Sabbagh M, Garcia A, Slaughter M, Elayan N, Acothley S, Pomara N, Hernando R, Pomara V, Reichert C, Brawman-Mintzer O, Acree A, Williams A, Long C, Long R, Newhouse P, Hill S, Boegel A, Seshadri S, Saklad A, Jones F, Hu W, Sotelo V, Rojas Y, Mintzer J, Longmire C, Spicer K, Barkhof F, Benke T, Chen C, Dal-Bianco P, Dewenter A, Duering M, Enzinger C, Ewers M, Exalto L, Fletcher E, Franzmeier N, Hilal S, Hofer E, Koek H, Maier A, Maillard P, McCreary C, Papma J, Pijnenburg Y, Schmidt R, Smith E, Steketee R, van den Berg E, van der Flier W, Venkatraghavan V, Venketasubramanian N, Vernooij M, Wolters F, Xu X, Horn A, Patil K, Eickhoff S, Thomalla G, Biesbroek J, Biessels G, Cheng B. Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment. Brain 2024, 147: 4265-4279. PMID: 39400198, PMCID: PMC11629703, DOI: 10.1093/brain/awae315.Peer-Reviewed Original ResearchLesion network mappingCognitive performanceCognitive domainsBrain networksWhite matter regionsCognitive disordersCognitive impairmentExtent of cognitive deficitsWMH volumeAssociated with lower cognitive performanceVentral attention networkPredicting cognitive performanceAssociated with cognitive impairmentCurrent cognitive performancePredicting cognitive functionMatter regionsBrain network connectivityLower cognitive performanceMemory clinic patientsCognitive deficitsLanguage functionBrain regionsRisk of cognitive disordersCognitive functionWhite matter hyperintensitiesBrain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons
Rivier C, Singh S, Senff J, Tack R, Marini S, Clocchiatti-Tuozzo S, Huo S, Renedo D, Papier K, Conroy M, Littlejohns T, Chemali Z, Kourkoulis C, Payabvash S, Newhouse A, Westover M, Lazar R, Pikula A, Ibrahim S, Howard V, Howard G, Brouwers H, Van Duijn C, Fricchione G, Tanzi R, Yechoor N, Sheth K, Anderson C, Rosand J, Falcone G. Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons. Neurology 2024, 103: e209687. PMID: 39052961, PMCID: PMC11760050, DOI: 10.1212/wnl.0000000000209687.Peer-Reviewed Original ResearchConceptsCare scoresUK BiobankWhite matter hyperintensitiesHealth-related behaviorsMarkers of brain healthMiddle-aged personsStroke risk factorsProspective cohort studyMultivariate linear regressionEmpower patientsSilent cerebrovascular diseaseBrain careWhite matter hyperintensities progressionDementia historyHealth declineInvestigate associationsCohort studyBrain healthNeuroimaging markersHigher scoresRisk factorsMean diffusivityCerebrovascular diseaseFractional anisotropyImaging assessmentAmyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes
Lesman-Segev O, Golan Shekhtman S, Springer R, Livny A, Lin H, Yuxia O, Zadok M, Ganmore I, Heymann A, Hoffmann C, Domachevsky L, Schnaider Beeri M. Amyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes. Scientific Reports 2024, 14: 2741. PMID: 38302529, PMCID: PMC10834442, DOI: 10.1038/s41598-024-53043-x.Peer-Reviewed Original ResearchConceptsNon-demented older adultsCognitive functionLower cognitive functionAmyloid burdenCognitive declineOlder adultsAssociations of small vessel diseaseAssociated with cognitive functionCognitive Decline studyAssociated with lower cognitive functionTreating cognitive declineAssociated with cognitive declineType 2 diabetesGray matterAssociation of amyloidIsrael DiabetesGM volumeAssess cognitionMeasures of small vessel diseaseWhite matter hyperintensitiesAlzheimer's disease biomarkersCognitionDecline studiesSmall vessel diseaseDiabetes-related characteristics
2023
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly interventionA feasibility study of the combination of intranasal insulin with oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk- Study rationale and design
Davidy T, Yore I, Cukierman-Yaffe T, Ravona-Springer R, Livny A, Lesman-Segev O, Azuri Y, Carmichael O, Kapogiannis D, Zetterberg H, Lin H, Sano M, Beeri M. A feasibility study of the combination of intranasal insulin with oral semaglutide for cognition in older adults with metabolic syndrome at high dementia risk- Study rationale and design. Mechanisms Of Ageing And Development 2023, 218: 111898. PMID: 38159613, DOI: 10.1016/j.mad.2023.111898.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentIntranasal insulinCognitive benefitsCerebrovascular diseaseMetabolic syndromeIntent-to-treat sampleEfficacy of combination therapyPlacebo-controlled feasibility trialGLP-1 receptor agonistsOlder adultsCerebral glucose utilizationAdults aged >Cerebral blood flowNeurobiological markersOral semaglutideCombination therapyReceptor agonistsGlobal cognitionImprove cognitionSafety profileOlder adults aged >White matter hyperintensitiesSemaglutideCognitive impairmentGLP-1Proteome Network Analysis Identifies Potential Biomarkers for Brain Aging
Short M, Fohner A, Skjellegrind H, Beiser A, Gonzales M, Satizabal C, Austin T, Longstreth W, Bis J, Lopez O, Hveem K, Selbæk G, Larson M, Yang Q, Aparicio H, McGrath E, Gerszten R, DeCarli C, Psaty B, Vasan R, Zare H, Seshadri S. Proteome Network Analysis Identifies Potential Biomarkers for Brain Aging. Journal Of Alzheimer’s Disease 2023, 96: 1767-1780. PMID: 38007645, PMCID: PMC10741337, DOI: 10.3233/jad-230145.Peer-Reviewed Original ResearchConceptsCardiovascular Health StudyRisk of incident dementiaFramingham Heart StudyIncident dementiaIncident all-causeOffspring cohort participantsCommunity-based cohortCognitively healthy adultsAssociated with hippocampal volumeHealth StudyBrain volumeBrain agingBurden of comorbiditiesCohort participantsHeart StudyAll-causeAssociated with total brain volumeClinical dementiaDementiaTotal brain volumeAD dementiaModules of co-expressed proteinsOlder cohortMRI brain volumesWhite matter hyperintensitiesEtiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease
Shirzadi Z, Schultz S, Yau W, Joseph-Mathurin N, Fitzpatrick C, Levin R, Kantarci K, Preboske G, Jack C, Farlow M, Hassenstab J, Jucker M, Morris J, Xiong C, Karch C, Levey A, Gordon B, Schofield P, Salloway S, Perrin R, McDade E, Levin J, Cruchaga C, Allegri R, Fox N, Goate A, Day G, Koeppe R, Chui H, Berman S, Mori H, Sanchez-Valle R, Lee J, Rosa-Neto P, Ruthirakuhan M, Wu C, Swardfager W, Benzinger T, Sohrabi H, Martins R, Bateman R, Johnson K, Sperling R, Greenberg S, Schultz A, Chhatwal J, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Trojanowki J, Toga A, Beckett L, Green R, Saykin A, Morris J, Perrin R, Shaw L, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Okonkwo O, Ryan L, Silverberg N, Fleisher A, Sacrey D, Fockler J, Conti C, Veitch D, Neuhaus J, Jin C, Nosheny R, Ashford M, Flenniken D, Kormos A, Montine T, Rafii M, Raman R, Jimenez G, Donohue M, Gessert D, Salazar J, Zimmerman C, Cabrera Y, Walter S, Miller G, Coker G, Clanton T, Hergesheimer L, Smith S, Adegoke O, Mahboubi P, Moore S, Pizzola J, Shaffer E, Sloan B, Harvey D, Forghanian-Arani A, Borowski B, Ward C, Schwarz C, Jones D, Gunter J, Kantarci K, Senjem M, Vemuri P, Reid R, Fox N, Malone I, Thompson P, Thomopoulos S, Nir T, Jahanshad N, DeCarli C, Knaack A, Fletcher E, Tosun-Turgut D, Chen S, Choe M, Crawford K, Yushkevich P, Das S, Koeppe R, Reiman E, Chen K, Mathis C, Landau S, Cairns N, Householder E, Franklin E, Bernhardt H, Taylor-Reinwald L, Korecka M, Figurski M, Neu S, Nho K, Risacher S, Apostolova L, Shen L, Foroud T, Nudelman K, Faber K, Wilmes K, Thal L, Silbert L, Lind B, Crissey R, Kaye J, Carter R, Dolen S, Quinn J, Schneider L, Pawluczyk S, Becerra M, Teodoro L, Dagerman K, Spann B, Brewer J, Vanderswag H, Ziolkowski J, Heidebrink J, Zbizek-Nulph L, Lord J, Mason S, Albers C, Knopman D, Johnson K, Villaneuva-Meyer J, Pavlik V, Pacini N, Lamb A, Kass J, Doody R, Shibley V, Chowdhury M, Rountree S, Dang M, Stern Y, Honig L, Mintz A, Ances B, Winkfield D, Carroll M, Stobbs-Cucchi G, Oliver A, Creech M, Mintun M, Schneider S, Geldmacher D, Love M, Griffith R, Clark D, Brockington J, Marson D, Grossman H, Goldstein M, Greenberg J, Mitsis E, Shah R, Lamar M, Samuels P, Duara R, Greig-Custo M, Rodriguez R, Albert M, Onyike C, Farrington L, Rudow S, Brichko R, Kielb S, Smith A, Raj B, Fargher K, Sadowski M, Wisniewski T, Shulman M, Faustin A, Rao J, Castro K, Ulysse A, Chen S, Sheikh M, Singleton-Garvin J, Doraiswamy P, Petrella J, James O, Wong T, Borges-Neto S, Karlawish J, Wolk D, Vaishnavi S, Clark C, Arnold S, Smith C, Jicha G, El Khouli R, Raslau F, Lopez O, Oakley M, Simpson D, Porsteinsson A, Martin K, Kowalski N, Keltz M, Goldstein B, Makino K, Ismail M, Brand C, Thai G, Pierce A, Yanez B, Sosa E, Witbracht M, Kelley B, Nguyen T, Womack K, Mathews D, Quiceno M, Levey A, Lah J, Hajjar I, Cellar J, Burns J, Swerdlow R, Brooks W, Silverman D, Kremen S, Tingus K, Lu P, Bartzokis G, Woo E, Teng E, Graff-Radford N, Parfitt F, Poki-Walker K, Farlow M, Hake A, Matthews B, Brosch J, Herring S, van Dyck C, Mecca A, Good S, MacAvoy M, Carson R, Varma P, Chertkow H, Vaitekunis S, Hosein C, Black S, Stefanovic B, Heyn C, Hsiung G, Kim E, Mudge B, Sossi V, Feldman H, Assaly M, Finger E, Pasternak S, Rachinsky I, Kertesz A, Drost D, Rogers J, Grant I, Muse B, Rogalski E, Robson J, Mesulam M, Kerwin D, Wu C, Johnson N, Lipowski K, Weintraub S, Bonakdarpour B, Pomara N, Hernando R, Sarrael A, Rosen H, Miller B, Perry D, Turner R, Johnson K, Reynolds B, MCCann K, Poe J, Sperling R, Johnson K, Marshall G, Yesavage J, Taylor J, Chao S, Coleman J, White J, Lane B, Rosen A, Tinklenberg J, Belden C, Atri A, Clark K, Zamrini E, Sabbagh M, Killiany R, Stern R, Mez J, Kowall N, Budson A, Obisesan T, Ntekim O, Wolday S, Khan J, Nwulia E, Nadarajah S, Lerner A, Ogrocki P, Tatsuoka C, Fatica P, Maillard P, Olichney J, Carmichael O, Bates V, Capote H, Rainka M, Borrie M, Lee T, Bartha R, Johnson S, Asthana S, Carlsson C, Perrin A, Burke A, Scharre D, Kataki M, Tarawneh R, Hart D, Zimmerman E, Celmins D, Miller D, Boles Ponto L, Smith K, Koleva H, Shim H, Nam K, Schtulz S, Williamson J, Craft S, Cleveland J, Yang M, Sink K, Ott B, Drake J, Tremont G, Daiello L, Ritter A, Bernick C, Munic D, O'Connell A, Mintzer J, Wiliams A, Masdeu J, Shi J, Garcia A, Newhouse P, Potkin S, Salloway S, Malloy P, Correia S, Kittur S, Pearlson G, Blank K, Anderson K, Flashman L, Seltzer M, Hynes M, Santulli R, Relkin N, Chiang G, Lee A, Lin M, Ravdin L, Sood A, Blanchard K, Fleischman D, Arfanakis K, Varon D, Greig M, Goldstein B, Martin K, Reist C, Sadowsky C, Martinez W, Villena T, Rosen H, Marshall G, Peskind E, Petrie E, Li G, Noble J, Voglein J, Chrem Mendez P, Surace E, Ikonomovic S, Nadkarni N, Lopera F, Ramirez L, Aguillon D, Leon Y, Ramos C, Alzate D, Baena A, Londono N, Moreno S, Laske C, Kuder-Buletta E, Graber-Sultan S, Preische O, Hofmann A, Ikeuchi T, Kasuga K, Niimi Y, Ishii K, Senda M, Cash D, Roh J, Riddle M, Menard W, Bodge C, Surti M, Takada L, Farlow M, Sanchez-Gonzalez V, Orozco-Barajas M, Renton A, Esposito B, Karch C, Marsh J, Fernanadez V, Jerome G, Herries E, Llibre-Guerra J, Johnson E, Seyfried N, Brooks W, Bechara J, Franklin E, Chen A, Chen C, Flores S, Hantler N, Hornbeck R, Jarman S, Keefe S, Koudelis D, Massoumzadeh P, McCullough A, McKay N, Nicklaus J, Pulizos C, Wang Q, Mishall S, Sabaredzovic E, Deng E, Candela M, Smith H, Hobbs D, Scott J, Xiong C, Wang P, Xu X, Li Y, Gremminger E, Ma Y, Bui R, Lu R, Martins R, Sosa Ortiz A, Daniels A, Courtney L, Mori H, Supnet-Bell, PhD (CSB) C, Xu J, Ringman J, Barthelemy N, Smith J. Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease. JAMA Neurology 2023, 80: 1353-1363. PMID: 37843849, PMCID: PMC10580156, DOI: 10.1001/jamaneurol.2023.3618.Peer-Reviewed Original ResearchConceptsSystemic vascular riskAutosomal dominant Alzheimer's diseaseLate-onset Alzheimer's diseaseVascular riskWMH volumeGray matter volumeAlzheimer's diseaseCohort studyOlder adultsDisease Neuroimaging InitiativeMAIN OUTCOMEMatter volumeCommon magnetic resonance imaging findingCommunity-based medical centerSystemic vascular risk factorsMagnetic resonance imaging (MRI) findingsWhite matter hyperintensity volumeHarvard Aging Brain StudyVascular risk factorsResonance Imaging FindingsLongitudinal cohort studyGreater WMH volumeSporadic Alzheimer's diseasePathogenic variant carriersWhite matter hyperintensitiesLeft ventricular hypertrophy and left atrial size are associated with ischemic strokes among non-vitamin K antagonist oral anticoagulant users
Das A, Gökçal E, Fouks A, Horn M, Regenhardt R, Viswanathan A, Singhal A, Schwamm L, Greenberg S, Gurol M. Left ventricular hypertrophy and left atrial size are associated with ischemic strokes among non-vitamin K antagonist oral anticoagulant users. Journal Of Neurology 2023, 270: 5578-5588. PMID: 37548681, PMCID: PMC11111216, DOI: 10.1007/s00415-023-11916-7.Peer-Reviewed Original ResearchPrior cerebrovascular eventsAtrial volume indexVentricular hypertrophyCerebrovascular eventsNOAC usersAtrial sizeIS recurrenceSevere white matter hyperintensitiesVolume indexCerebral small vessel diseaseOral anticoagulant usersChronic renal failureRisk of strokeCox regression analysisQuaternary care centerSmall vessel diseaseAge-matched controlsWhite matter hyperintensitiesMultivariable regression modelsAnticoagulant usersApixaban useDabigatran useResults112 patientsMultivariable adjustmentOral anticoagulantsImprovement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity
de Havenon A, Smith E, Sharma R, Falcone G, Bangad A, Prabhakaran S, Sheth K. Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity. Journal Of The American Heart Association 2023, 12: e029374. PMID: 37345754, PMCID: PMC10356061, DOI: 10.1161/jaha.123.029374.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesIncident strokePrimary outcomeHypertensive individualsMatter hyperintensitiesAtherosclerotic cardiovascular disease risk scoreCognitive impairmentCardiovascular disease risk scoreVascular risk factorsCurrent cigarette smokingDisease risk scoreMagnetic resonance imagingLogistic regression modelsRandomization armCerebrovascular eventsVascular riskCigarette smokingPrognostic informationRisk factorsPrognostic abilityRisk scoreCognitive declineResonance imagingDeLong testStrokeA feasibility study of the combination of intranasal insulin with dulaglutide for cognition in older adults with metabolic syndrome at high dementia risk – Study rationale and design
Davidy T, Yore I, Cukierman-Yaffe T, Ravona-Springer R, Livny A, Lesman-Segev O, Azuri Y, Carmichael O, Kapogiannis D, Zetterberg H, Lin H, Sano M, Beeri M. A feasibility study of the combination of intranasal insulin with dulaglutide for cognition in older adults with metabolic syndrome at high dementia risk – Study rationale and design. Mechanisms Of Ageing And Development 2023, 213: 111825. PMID: 37245533, PMCID: PMC12120971, DOI: 10.1016/j.mad.2023.111825.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentIntranasal insulinCognitive benefitsIntent-to-treat sampleOlder adultsCerebrovascular diseaseMetabolic syndromeCerebral glucose utilizationEfficacy of combination therapyPlacebo-controlled feasibility trialNeurobiological markersGLP-1 receptor agonistsGlobal cognitionImprove cognitionDementia riskWhite matter hyperintensitiesCognitive impairmentAdults aged >Receptor agonistsCerebral blood flowCognitionCombination therapySafety profileOlder adults aged >DulaglutideIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation indexAssociations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank
Jiang R, Noble S, Sui J, Yoo K, Rosenblatt M, Horien C, Qi S, Liang Q, Sun H, Calhoun V, Scheinost D. Associations of physical frailty with health outcomes and brain structure in 483 033 middle-aged and older adults: a population-based study from the UK Biobank. The Lancet Digital Health 2023, 5: e350-e359. PMID: 37061351, PMCID: PMC10257912, DOI: 10.1016/s2589-7500(23)00043-2.Peer-Reviewed Original ResearchConceptsPopulation-based studyPhysical frailtyHealth-related outcomesBrain structuresMental healthHealth outcomesHealth measuresTotal white matter hyperintensitiesIndicators of frailtySeverity of frailtyLower gray matter volumePoor physical fitnessWhite matter hyperintensitiesGray matter volumeUK BiobankHealth-related measuresPoor mental healthMental health measuresDirection of associationMatter hyperintensitiesUnhealthy lifestyleEarly-life risksPsychiatric disordersNumerous confoundersPreventative strategies
2022
Clinical and neuroimaging risk factors associated with the development of intracerebral hemorrhage while taking direct oral anticoagulants
Das A, Gökçal E, Regenhardt R, Warren A, Biffi A, Goldstein J, Kimberly W, Viswanathan A, Schwamm L, Rosand J, Greenberg S, Gurol M. Clinical and neuroimaging risk factors associated with the development of intracerebral hemorrhage while taking direct oral anticoagulants. Journal Of Neurology 2022, 269: 6589-6596. PMID: 35997817, PMCID: PMC10947801, DOI: 10.1007/s00415-022-11333-2.Peer-Reviewed Original ResearchConceptsCortical superficial siderosisPrior ischemic strokeDOAC usersCerebral microbleedsWhite matter hyperintensitiesIschemic strokeSevere white matter hyperintensitiesOral anticoagulant usageDirect oral anticoagulantsSingle referral centerHigh hemorrhagic riskCoronary artery diseaseAge-matched controlsMultivariable regression modelsDOAC therapyICH cohortPrior strokeOral anticoagulantsSuperficial siderosisBaseline demographicsReferral centerSmoking historyArtery diseaseConclusionsRisk factorsHemorrhage riskRacial/Ethnic Variation in White Matter Hyperintensity Progression in the ACCORDION MIND Study
Herman AL, de Havenon A, Falcone GJ, Prabhakaran S, Sheth KN. Racial/Ethnic Variation in White Matter Hyperintensity Progression in the ACCORDION MIND Study. The Neurologist 2022, 28: 157-159. PMID: 35834785, DOI: 10.1097/nrl.0000000000000454.Peer-Reviewed Original ResearchConceptsWMH progressionWhite matter hyperintensitiesLow-density lipoproteinCardiovascular riskWhite patientsBlack patientsWMH volumeSystolic blood pressure levelsWhite matter hyperintensity progressionBlack diabetic patientsBlood pressure levelsExclusion of patientsMagnetic resonance imagingDiabetes (ACCORD) trialDiabetic patientsMean SBPPrimary outcomePatient raceMultivariate regression modelMatter hyperintensitiesA1c measurementHigh riskPatientsNormal rangeCognitive decline
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