2025
Pregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial
Sakmar E, Wemm S, Fogelman N, Hermes G, Sinha R, Milivojevic V. Pregnenolone reduces provoked craving and cocaine use in men and women with cocaine use disorder: A pilot trial. Drug And Alcohol Dependence 2025, 274: 112765. PMID: 40570771, DOI: 10.1016/j.drugalcdep.2025.112765.Peer-Reviewed Original ResearchCocaine use disorderCocaine useNeuroactive steroidsUse disorderTreatment of cocaine use disorderCocaine use outcomePregnenolone levelsTreatment-seeking individualsDays of cocaineChronic cocaine useExposure to stressPreg groupCocaine cuesCocaine cravingCraving responsesNeutral cuesInduce cravingCravingWeek 2CocaineChronic treatmentPilot findingsCocaine amountPrecursor pregnenoloneLinear mixed effects modelsCognitive bias modification for individuals with opioid use disorder and chronic pain did not predict changes in clinical outcomes.
Wolkowicz N, Pittman B, Schrader S, Wesolowicz D, Sofuoglu M, Heapy A, MacLean R. Cognitive bias modification for individuals with opioid use disorder and chronic pain did not predict changes in clinical outcomes. Journal Of Studies On Alcohol And Drugs 2025 PMID: 40536409, DOI: 10.15288/jsad.25-00057.Peer-Reviewed Original ResearchCognitive bias modificationAttentional biasOpioid cravingBias modificationCBM effectsSubstance use disordersPain severityChronic painClinical outcomesAddiction severityOpioid use disorderUse disorderNaturalistic settingsNeutral-cueOpioid withdrawalPain cuesCravingDiverse sampleSalient outcomesSubstance typePreliminary effectivenessPrimary clinical outcomePain catastrophizingModerate painPain intensityHealth Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study
Savitz S, Stevens M, Nath B, D'Onofrio G, Melnick E, Jeffery M. Health Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain: Retrospective Cohort Study. JMIR Formative Research 2025, 9: e66596. PMID: 40537088, DOI: 10.2196/66596.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosLong-term opioid therapyIn-person careMental illness cohortOpioid use disorderIn-personTelemedicine visitsChronic painPain medicineOpioid therapyEmergency medicineMental healthFamily practiceHealth service usageChronic opioidsPercentage of visitsIn-person visitsIn-person treatmentPoor outcomeAdministrative claims dataUse disorderMedicare Advantage patientsOptumLabs Data WarehouseVulnerable patient populationCare deliveryAn AUDacious Proposal: How to Improve Gastroenterology Fellow Training for Alcohol Use Disorder and Alcohol-Associated Liver Disease
Ilagan-Ying Y. An AUDacious Proposal: How to Improve Gastroenterology Fellow Training for Alcohol Use Disorder and Alcohol-Associated Liver Disease. Digestive Diseases And Sciences 2025, 1-4. PMID: 40512451, DOI: 10.1007/s10620-025-09144-2.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseAlcohol use disorderGastroenterology fellowsOne-hour educational interventionHealth professional traineesMultidisciplinary care modelAttitudes of providersAttitudes of cliniciansLife-saving careAddiction medicine specialistsManagement of alcohol use disorderALD-related mortalityUse disorderAlcohol use disorder pharmacotherapiesTertiary academic care centerVulnerable patient populationPrimary careCare modelHealth professionalsEducational interventionMedicine providersAddiction providersProfessional traineesLiver diseaseTreatment gapA Review of Relapse in Opioid Use Disorder
Draghmeh K, Gold M, Fuehrlein B. A Review of Relapse in Opioid Use Disorder. Current Addiction Reports 2025, 12: 58. DOI: 10.1007/s40429-025-00672-5.Peer-Reviewed Original ResearchUse disorderEnhance treatment retentionMindfulness-based therapyStress system dysregulationRelapse vulnerabilityOpioid use disorderNeurobiological mechanismsDopamine deficitMedication-assisted treatmentContingency managementTreatment retentionPsychosocial interventionsMechanisms of relapseReduce relapseBehavioral componentsReviewOpioid use disorderSignificant public health challengeSystem dysregulationPublic health challengeRelapse rateAt-risk populationsSocietal burdenEmergency therapyAt-riskRelapseExamining the moderating role of intolerance of uncertainty on pain tolerance and craving in patients with chronic pain and alcohol use disorder
Radoman M, Heilner E, McGowan C, Neree-Thompson B, Sakmar E, Sinha R. Examining the moderating role of intolerance of uncertainty on pain tolerance and craving in patients with chronic pain and alcohol use disorder. Alcohol 2025, 127: 55-61. PMID: 40513686, DOI: 10.1016/j.alcohol.2025.06.001.Peer-Reviewed Original ResearchIntolerance of uncertaintyAlcohol use disorderAlcohol use disorder groupAlcohol cravingCraving responsesUse disorderSelf-report measures of IUAlcohol-seeking behaviorMeasures of IUPain toleranceSelf-report measuresPain-related stressChronic painFifty-five adultsCognitive traitsCravingPotential treatment targetCoping behaviorsSubjective painExperimental sessionsLower pain toleranceModerating rolePsychological factorsTreatment targetControl conditionInformation Needs for Opioid Use Disorder Treatment Using Buprenorphine Product: Qualitative Analysis of Suboxone-Focused Reddit Data
Basak M, Sharif O, Lord S, Borodovsky J, Marsch L, Springer S, Nunes E, Brackett C, Archibald L, Preum S. Information Needs for Opioid Use Disorder Treatment Using Buprenorphine Product: Qualitative Analysis of Suboxone-Focused Reddit Data. Journal Of Medical Internet Research 2025, 27: e68886. PMID: 40489766, PMCID: PMC12186000, DOI: 10.2196/68886.Peer-Reviewed Original ResearchConceptsLarge-scale dataPotential rumorsSocial media platformsReddit postsInformation needsOpioid use disorder treatmentOpioid use disorderMedia platformsUse disorderDisorder treatmentRedditSocial mediaHypothesis generationInformationFood and Drug Administration-approved medicationsClinical expertsFrequent topicTreatment informationSubstance useCannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients
Mannes Z, Wall M, Alschuler D, Malte C, Olfson M, Livne O, Fink D, Keyhani S, Keyes K, Martins S, Cerdá M, Sacco D, Gutkind S, Maynard C, Sherman S, Saxon A, Hasin D. Cannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients. JAMA Health Forum 2025, 6: e251369. PMID: 40512510, PMCID: PMC12166489, DOI: 10.1001/jamahealthforum.2025.1369.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationVeterans Health Administration patientsMedical cannabis lawsOpioid use disorderPrevalence of opioid use disorderClassification of DiseasesRecreational cannabis lawsChronic painVeterans Health Administration electronic health recordClinical ModificationConsistent with overall findingsState medical cannabis lawsInternational Statistical Classification of DiseasesReceipt of prescription opioidsStatistical Classification of DiseasesElectronic health recordsInternational Classification of DiseasesNon-Hispanic whitesOpioid use disorder diagnosisOpioid use disorder prevalenceInternational Statistical ClassificationDifference-in-differences analysisCannabis lawsUse disorderBurden of opioid use disorderLong-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study
Macmadu A, Li Y, Bhondoekhan F, Chang C, Bahji A, Crystal S, Gordon K, Kerns R, Vickers-Smith R, Edelman E, Marshall B. Long-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study. Addictive Behaviors Reports 2025, 22: 100619. PMID: 40547483, PMCID: PMC12182372, DOI: 10.1016/j.abrep.2025.100619.Peer-Reviewed Original ResearchDepressive symptom severityVeterans Aging Cohort StudySymptom severityOpioid useCohort studySubstance use disordersPrescription opioid useProspective cohort studyOpioid use disorderAging Cohort StudyMental health servicesDose-response patternGeneralized estimating equation modelsVeterans Health Administration sitesUse disorderClinical characteristicsProspective cohortBidirectional associationsFollow-upStudy entryOpioidHarm reduction servicesBidirectional relationshipPLHIVAdministration siteCommon neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis
Zhang X, Zhang H, Shao Y, Li Y, Zhang F, Zhang H. Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis. Translational Psychiatry 2025, 15: 190. PMID: 40467551, PMCID: PMC12137653, DOI: 10.1038/s41398-025-03396-2.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexSuperior frontal gyrusMedian cingulate gyrusInferior frontal gyrusResting-state functional connectivityBrain reward circuitsReward circuitSUD patientsPrefrontal cortexFamily-wise errorFrontal gyrusUse disorderCortical-striatal-thalamic-cortical circuitWhole-brain rs-fMRI studiesReduced resting-state functional connectivityDorsal anterior cingulate cortexResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingHealthy controlsPatterns of substance use disordersAssociated with impulsivityStages of addictionSubstance use disordersRs-fMRI studiesBackgroundSubstance use disordersMedications for opioid use disorder shape immune responses during chronic HIV infection
Collora J, Steinhauser S, Davenport T, Lin D, Eshetu A, Zeidi S, Kim R, Frank C, Kluger Y, Springer S, Ho Y. Medications for opioid use disorder shape immune responses during chronic HIV infection. Cell Reports Medicine 2025, 6: 102159. PMID: 40460829, PMCID: PMC12208330, DOI: 10.1016/j.xcrm.2025.102159.Peer-Reviewed Original ResearchConceptsOpioid use disorderTumor necrosis factorImmune responseHIV infectionAssociated with HIV replicationCytotoxic T cell populationsRisk of opioid use disorderUse disorderPeripheral blood immune cellsI interferonChronic HIV infectionRNA expressionPartial agonist buprenorphineT cell populationsShape immune responsesBlood immune cellsType I interferonImprove immune responsesAgonist buprenorphineAgonist methadoneHIV expressionAntagonist naltrexoneHIV replicationImmune profileImmune cellsModeration of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate
Kranzler H, Jinwala Z, Davis C, Xu H, Biernacka J, Zhou H, Kember R, Gelernter J, Feinn R. Moderation of treatment outcomes by polygenic risk for alcohol‐related traits in placebo‐controlled trials of topiramate. Alcohol Clinical And Experimental Research 2025, 49: 1297-1305. PMID: 40445294, PMCID: PMC12173784, DOI: 10.1111/acer.70052.Peer-Reviewed Original ResearchConceptsHeavy drinking daysAlcohol use disorderProblematic alcohol useAlcohol-related problemsPlacebo-controlled trialModerators of treatment outcomePlacebo-controlled trial of topiramateReduce heavy drinking daysTreat alcohol use disorderAlcohol-related traitsTrial of topiramateResponse to topiramateEffects of topiramateTime to relapseGenome-wide association studiesTopiramate's effectsAUD treatmentDrinking daysUse disorderTopiramate groupPolygenic riskHeavy drinkingAlcohol usePharmacogenetic approachShort IndexThe genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
Galimberti M, Overstreet C, Gupta P, Beck S, Dao C, Deak J, Zhou H, Johnson E, Agrawal A, Stein M, Levey D, Gelernter J. The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders. Nature Mental Health 2025, 3: 700-708. DOI: 10.1038/s44220-025-00440-4.Peer-Reviewed Original ResearchGenomic structural equation modelingCannabis use disorderCannabis usePsychiatric disordersUse disorderStructural equation modelingIncreased rates of psychiatric disordersIncreasing prevalence of cannabis useRates of psychiatric disordersPrevalence of cannabis useThree-factor modelEquation modelingDepressive disorderPsychiatric traitsCannabisLocal genetic correlationDisordersGenetic correlationsMendelian randomization analysisTraitsRandomization analysisSchizophreniaADHDColocalization analysisIncreased riskSex and hormonal effects on drug cue-reactivity and its regulation in human addiction
Huang Y, Butelman E, Ceceli A, Kronberg G, King S, McClain N, Wong Y, Boros M, Drury K, Sinha R, Alia-Klein N, Goldstein R. Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction. Biological Psychiatry 2025 PMID: 40441339, DOI: 10.1016/j.biopsych.2025.05.016.Peer-Reviewed Original ResearchDrug cue-reactivityCue-reactivityPrefrontal cortexFrontal eye fieldCue-induced drug cravingVentromedial prefrontal cortexCocaine use disorderMedial prefrontal cortexAnterior prefrontal cortexDrug cravingHuman addictsUse disorderFunctional MRIEye fieldLuteal phaseCravingDevelopment of personalized treatmentsLate-follicularFollicular phaseReappraisalVmPFCDlPFCHormonal effectsProtective factorsAddictionGlobal overview of short-term alcohol policies: need for global exchange of experience and impact measurement
Al-Ansari B, Narasimha V, Matanje B, Hanafi E, Fonseca F, Butner J, Long J, Moussa D, Orsolini L, Farokhnia M, Melby K, Kathiresan P, Huh S, Bhad R, Kouimtsidis C, Baldacchino A. Global overview of short-term alcohol policies: need for global exchange of experience and impact measurement. BJPsych International 2025, 1-5. DOI: 10.1192/bji.2025.16.Peer-Reviewed Original ResearchHealth-related issuesGlobal public health concernPublic health concernControl alcohol consumptionExchange of experiencesAlcohol policyAlcohol consumptionAlcohol use disorderAlcohol industryHealth concernGlobal alcohol industryImpact measuresUse disorderAction planCOVID-19 pandemicGlobal exchangeNational policyThe Potential Use of Cannabidiol in the Treatment of Opioid Use Disorder: A Systematic Review
Shafie M, Ing K, Rostam‐Abadi Y, Weleff J, Griffin M, Ranganathan M, Aghaei A, Pratt N, Funaro M, Nia A. The Potential Use of Cannabidiol in the Treatment of Opioid Use Disorder: A Systematic Review. Addiction Biology 2025, 30: e70047. PMID: 40415392, PMCID: PMC12104536, DOI: 10.1111/adb.70047.Peer-Reviewed Original ResearchConceptsOpioid use disorderOUD outcomesUse disorderConditioned place preference paradigmPlace preference paradigmReducing withdrawal symptomsPotential of cannabidiolSubstance use disordersEfficacy of cannabidiolTreatment of opioid use disorderPreclinical studiesClinical studiesOpioid use disorder treatmentPreference paradigmAnxiety symptomsWithdrawal symptomsPsychiatric disordersEffective treatment approachTreatment optionsHuman studiesCannabidiolAnimal studiesSystematic reviewShort-term follow-upCravingGreater neuroimmune system deficit in women than men with alcohol use disorder
Zakiniaeiz Y, Hillmer A, Shi H, Pittman B, Nabulsi N, Huang Y, Bonomi R, Matuskey D, Angarita G, McKee S, Cosgrove K. Greater neuroimmune system deficit in women than men with alcohol use disorder. Biological Psychiatry 2025 PMID: 40412787, DOI: 10.1016/j.biopsych.2025.05.012.Peer-Reviewed Original ResearchTranslocator protein availabilityAlcohol-induced neurodegenerationExecutive function tasksConsequences of alcohol useAlcohol use disorderBrain imaging scansTranslocator protein levelsSex-matched controlsExecutive functionLower hippocampalTSPO availabilityFrontal cortexTranslocator proteinUse disorderNeurocognitive functionBrain regionsSex differencesAlcohol useBrain-resident immune cellsNeuroimmune mechanismsFunctional tasksSystem deficitsAUDImaging scansNeuroimmune cellsPharmacological and behavioral pain treatment strategies for patients with opioid use disorder
Ameral V, Hickey T, Reilly E, Patterson J, Sofuoglu M. Pharmacological and behavioral pain treatment strategies for patients with opioid use disorder. Expert Opinion On Pharmacotherapy 2025, 26: 1041-1054. PMID: 40366730, PMCID: PMC12202159, DOI: 10.1080/14656566.2025.2506688.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentOpioid use disorderChronic painUse disorderCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsEffective management of painPain treatment strategiesRegister of Controlled TrialsManagement of painCochrane Central RegisterAgonist treatmentPharmacological optionsTreatment strategiesPainOpioidEffective treatmentControlled trialsBehavioral treatmentTreatmentPatientsDisordersMedical careEffective managementEffective medical careNon-fatal Overdose and Associated Factors Among People Who Use Opioids: Findings From a Cross-sectional Study
Sujan M, Wickersham J, Khati A, Paudel K, Gautam K, Liautaud D, Crim H, Thapa A, Copenhaver M, Shrestha R. Non-fatal Overdose and Associated Factors Among People Who Use Opioids: Findings From a Cross-sectional Study. Journal Of Community Health 2025, 1-10. PMID: 40381076, DOI: 10.1007/s10900-025-01480-8.Peer-Reviewed Original ResearchNon-fatal overdoseOpioid dependenceCross-sectional studySuicidal ideationHistory of opioid useOpioid overdoseAlcohol use disorderNon-fatal opioid overdoseMental health symptomsAge of participantsParticipants self-reportedHarm reduction interventionsSocio-demographic characteristicsOpioid useEffective prevention strategiesUse disorderDepressive symptomsTargeted harm reduction interventionsHealth symptomsMultivariate logistic regression analysisLogistic regression analysisReduction interventionsOlder participantsCross-sector collaborationRisk of overdoseCannabis Use Disorder Among People With and Without HIV.
Haley D, So-Armah K, Justice A, Kidwai-Khan F, Xuan Z, Sayko Adams R, Fox M, Edelman E, Wrona A, Silverberg M, Satre D, Trickey A, Ingle S, McGinnis K. Cannabis Use Disorder Among People With and Without HIV. Journal Of Addiction Medicine 2025 PMID: 40358026, DOI: 10.1097/adm.0000000000001505.Peer-Reviewed Original ResearchCannabis use disorderNon-HispanicHIV statusElectronic health recordsBlack non-HispanicNational US cohortCannabis useUse disorderMultivariate logistic modelHealth recordsCohort of PLWHOlder PLWHPrescription medicationsInternational ClassificationUniversal screeningGeneral populationPLWHDemographic characteristicsPLWOHPotential harmAging populationAge groupsHIVRace/ethnicityTreatment advances
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