2025
Serum kynurenine metabolites and cytokine levels: diagnostic and predictive implications in acute manic episodes of bipolar disorder
Li W, Liu Z, Wang J, Wang X, Chen W, Li N, Huang J, Gou M, Zhang P, Liu R, Deng H, Yang K, Chen S, Xie T, Tian L, Yang F, Tian B, Li C, Li Y, Tan Y. Serum kynurenine metabolites and cytokine levels: diagnostic and predictive implications in acute manic episodes of bipolar disorder. Brain Behavior And Immunity 2025, 129: 485-493. PMID: 40578536, DOI: 10.1016/j.bbi.2025.06.033.Peer-Reviewed Original ResearchYoung Mania Rating ScaleKynurenine metabolitesHealthy controlsTreatment outcomesCytokine levelsKynurenine metabolite levelsManic episodes of bipolar disorderBipolar disorderAcute manic episodeMania Rating ScaleEpisodes of bipolar disorderWeeks of treatmentInterleukin (IL)-10Predicting treatment outcomePredictors of treatment outcomeManic symptom severitySerum cytokinesSerum levelsTreatment responseIL-4Diagnostic accuracyIL-10Cytokine systemManic episodesIL-81170-P: Gender Identity, Racial/Ethnic Identity, and Health Behaviors—Which High Schoolers Are at Highest Risk for Type 2 Diabetes?
SHARER A, BRIMACOMBE M, OYOLA-CARTAGENA K, DOYLE R, FINCK C, OLEZESKI C, SANTOS M. 1170-P: Gender Identity, Racial/Ethnic Identity, and Health Behaviors—Which High Schoolers Are at Highest Risk for Type 2 Diabetes? Diabetes 2025, 74 DOI: 10.2337/db25-1170-p.Peer-Reviewed Original ResearchHealth behaviorsYouth Risk Behavior SurveyType 2 diabetesRisk of obesityRegression modelsBinary logistic regression modelTransgender youthLogistic regression modelsPhysical activityRacial/ethnic groupsDevelopment of type 2 diabetesRisk Behavior SurveyUnique stressorsHealthBehavior SurveyObesityMinority stress theoryHigh riskMinority stressNon-significant relationshipT2DYouthTreatment outcomesRiskGender identityPain Reduction Following Eptacog Beta Treatment of Bleeding Episodes in Adolescents and Adults With Haemophilia A or B Complicated by Inhibitors
Buckner T, Kessler C, Castaman G, Hermans C, Jiménez‐Yuste V, Mahlangu J, Miesbach W, Oldenburg J, Recht M, Valentino L, Wheeler A, Pipe S. Pain Reduction Following Eptacog Beta Treatment of Bleeding Episodes in Adolescents and Adults With Haemophilia A or B Complicated by Inhibitors. Haemophilia 2025, e70077. PMID: 40534395, DOI: 10.1111/hae.70077.Peer-Reviewed Original ResearchInitial dosing regimensVisual analogue scaleBleeding episodesScore reductionReceiver operating characteristicEptacog betaPain reductionPain levelsTreatment responseVisual analogue scale score reductionBeta treatmentTreatment outcomesMean VAS scorePain score reductionTreat bleeding episodesVAS score reductionBaseline pain levelsAssess treatment responseEvaluate treatment responseEvaluate pain reductionControl of bleedingPredicting treatment outcomePost hoc studyPatient-reported outcomesBleed resolutionTreatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients.
Chen H, Colasurdo M, Matsukawa H, Cunningham C, Maier I, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Crosa R, Grandhi R, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Daglioglu E, Williamson R, Navia P, Chowdhry S, Altschul D, Spiotta A, Kan P. Treatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients. Interventional Neuroradiology 2025, 15910199251343283. PMID: 40530425, PMCID: PMC12176791, DOI: 10.1177/15910199251343283.Peer-Reviewed Original ResearchLow Alberta Stroke Program Early CT ScoreAlberta Stroke Program Early CT ScoreEffect of endovascular thrombectomyM2 occlusionsIntracranial hemorrhageM2 patientsAssociated with intracranial hemorrhageOdds of all-cause mortalityMulticenter retrospective studyOdds of poor outcomeMultivariate logistic regression modelAll-cause mortalityMiddle cerebral arteryStroke patientsM1 patientsM1 occlusionCT scoreRetrospective studyLogistic regression modelsPoor outcomeMultivariable adjustmentPrimary outcomeCerebral arteryTreatment outcomesEndovascular thrombectomyDeep learning in obsessive-compulsive disorder: a narrative review
Zaboski B, Bednarek L, Ayoub K, Pittenger C. Deep learning in obsessive-compulsive disorder: a narrative review. Frontiers In Psychiatry 2025, 16: 1581297. PMID: 40585546, PMCID: PMC12202444, DOI: 10.3389/fpsyt.2025.1581297.Peer-Reviewed Original ResearchDeep learningObsessive-compulsive disorderDeep learning advancesMultimodal datasetWearable sensorsMonitoring solutionsMachine learningLearning advancesObsessive-compulsive disorder researchComplex datasetsDebilitating psychiatric conditionImplementation modelIntrusive thoughtsLearningDatasetPsychiatric conditionsRepetitive behaviorsPrecision psychiatryElectronic medical recordsTreatment response predictionDiagnostic classificationClassificationNarrative reviewTreatment outcomesTreatment predictionRecommendations for Diagnosing and Quantifying treatment outcomes in clinical trials of compulsive sexual behavior disorder
Engel J, Kraus S, McCurdy L, Potenza M. Recommendations for Diagnosing and Quantifying treatment outcomes in clinical trials of compulsive sexual behavior disorder. Addictive Behaviors Reports 2025, 21: 100610. DOI: 10.1016/j.abrep.2025.100610.Peer-Reviewed Original ResearchCompulsive sexual behaviorCompulsive sexual behavior disorderTreatment of compulsive sexual behaviourSexual behavior disorderTreatment outcome studiesMechanisms of changeNeuropsychological measuresMeasures of quality of lifeParaphilic interestsPrefrontal areasClinical interviewQuantify treatment outcomesProblem behaviorsBehavioral disordersBehavioral engagementReward systemTreatment studiesTreatment trialsOutcome studiesSexual behaviorMoral judgmentTreatment outcomesDiagnostic criteriaDisordersTreatment changesThe prevalence, clinical impact, and therapeutic considerations of trauma in adults with bipolar disorder: A systematic review
Xiao K, Sayed H, Xing J, Zhang X, Ai J, Teopiz K, Ho R, Rhee T, Lo H, Guillen-Burgos H, Vinberg M, McIntyre R. The prevalence, clinical impact, and therapeutic considerations of trauma in adults with bipolar disorder: A systematic review. Journal Of Affective Disorders 2025, 119507. PMID: 40449746, DOI: 10.1016/j.jad.2025.119507.Peer-Reviewed Original ResearchBipolar disorderSevere stressful life eventsChildhood emotional maltreatmentChildhood physical maltreatmentStressful life eventsEffects of traumaImpact of traumaChildhood traumaClinical impactEmotional maltreatmentSymptom severityLife eventsPhysical maltreatmentTherapeutic considerationsIllness severityIntegrated model of careModerating effectTreatment responseTreatment outcomesSystematic reviewAssociated with poor prognosisMaltreatmentModality of treatmentNegative clinical impactHistory of traumaEngagement in a Statewide Implementation of F4C: The Positive Impact of Coparent Involvement
McCaskill C, Char S, Fish M, Buck K, Beebe R, Stover C. Engagement in a Statewide Implementation of F4C: The Positive Impact of Coparent Involvement. Journal Of Family Violence 2025, 1-12. DOI: 10.1007/s10896-025-00888-z.Peer-Reviewed Original ResearchIntimate partner violenceSubstance misuseIntimate partner violence usePartner violenceFathers' participationTreatment completionCoparentingDrug misuseAlcohol misuseFathersWorking allianceF4CTreatment motivationStatewide implementationAllianceEngagementJoint sessionPositive impactCommunity clinicsRace/ethnicityMisuseImprove engagementTreatment outcomesGroup formationRisk severityThoracic aortic aneurysm
Berger T, Dumfarth J, Kreibich M, Minatoya K, Ziganshin B, Czerny M. Thoracic aortic aneurysm. Nature Reviews Disease Primers 2025, 11: 34. PMID: 40341396, DOI: 10.1038/s41572-025-00617-2.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic diseasePathophysiological mechanismsTreatment of aortic diseaseThoracic aortic diseaseVascular smooth muscle cellsGold standard diagnostic toolSmooth muscle cellsCardiovascular risk factorsStandard diagnostic toolAortic medicineAdvanced imaging techniquesEmbryological factorsCT angiographyArterial hypertensionDiagnostic challengeAortic aneurysmAbnormal dilatationThoracic aortaAsymptomatic natureGenetic predispositionTreatment outcomesMuscle cellsMedical managementRisk factorsPreferences for Lisdexamfetamine vs Cognitive-Behavioral Therapy for Binge-Eating Disorder: Correlates and Outcomes.
Yurkow S, Ivezaj V, Pittman B, Grilo C. Preferences for Lisdexamfetamine vs Cognitive-Behavioral Therapy for Binge-Eating Disorder: Correlates and Outcomes. The Journal Of Clinical Psychiatry 2025, 86 PMID: 40338285, DOI: 10.4088/jcp.24m15552.Peer-Reviewed Original ResearchConceptsBinge-eating disorderTreatment preferencesModerate treatment outcomePatient treatment preferencesCognitive-behavioral therapyEffects of treatment preferenceTest main effectsCognitive-behavioralNo significant interaction effectsInteraction effectsBehavioral therapySignificant interaction effectCBTModerate outcomeEfficacious treatmentMain effectLisdexamfetamineTreatment outcomesParticipants' preferencesEffective interventionsEffects of treatmentDisordersRandomized controlled trialsNo preferenceLDXMethadone for Opioid Use Disorder in the Fentanyl Era: Navigating Challenges and Evolving Strategies- a Narrative Review
Osagie E, Horton J, Lawrence D, Hermes G, Garcia-Vassallo G. Methadone for Opioid Use Disorder in the Fentanyl Era: Navigating Challenges and Evolving Strategies- a Narrative Review. Current Addiction Reports 2025, 12: 44. DOI: 10.1007/s40429-025-00655-6.Peer-Reviewed Original ResearchOpioid use disorderDosing flexibilityEffective treatmentMethadone treatmentCornerstone of treatmentOpioid use disorder treatmentMethadone initiationMethadone doseDosing daysDosing considerationsDose selectionTreatment outcomesUse disorderWithdrawal managementPresence of fentanylOpioidRate of titrationDoseMethadoneFentanylSummaryThis reviewSynthetic opioidsDrug overdose deathsInitial careClinical decisionsSession Preparation, Behavioral Rehearsal and Homework Assignment: Do these Therapeutic Delivery Strategies Improve Trauma Treatment Outcomes for Youth in Community Outpatient Settings?
Lee P, Lang J, Randall K. Session Preparation, Behavioral Rehearsal and Homework Assignment: Do these Therapeutic Delivery Strategies Improve Trauma Treatment Outcomes for Youth in Community Outpatient Settings? Journal Of Child & Adolescent Trauma 2025, 1-13. DOI: 10.1007/s40653-025-00709-x.Peer-Reviewed Original ResearchTF-CBTBehavioral rehearsalTrauma-focused cognitive-behavioral therapySymptom improvementImplementing TF-CBTCognitive-behavioral therapyPosttraumatic stress symptomsPotential treatment moderatorsCommunity outpatient settingsTreatment dosageTreatment moderatorsCompleted treatmentStress symptomsChild characteristicsHomework assignmentsTherapistsTreatment completionTreatment outcomesChildren aged 3Statewide disseminationSessionsRehearsalAged 3Administrative dataChildrenInterpersonal problems as a predictor of treatment outcome in adult depression: An individual participant data meta-analysis
Gómez Penedo J, Meglio M, Flückiger C, Wienicke F, Breunese J, Menchetti M, Rucci P, Johansson R, Town J, Abbass A, Lilliengren P, Bagby R, Quilty L, Lemmens L, van Bronswijk S, Barkham M, Stiles W, Hardy G, Fonagy P, Luyten P, Constantinou M, Barber J, McCarthy K, Solomonov N, Joyce A, Cuijpers P, Driessen E. Interpersonal problems as a predictor of treatment outcome in adult depression: An individual participant data meta-analysis. Clinical Psychology Review 2025, 118: 102570. PMID: 40158500, DOI: 10.1016/j.cpr.2025.102570.Peer-Reviewed Original ResearchConceptsInterpersonal problemsInterpersonal distressAdult depressionParticipant data meta-analysisTreatment outcomesPredictors of treatment outcomeDepression treatment outcomesData meta-analysisDepressive symptom levelsIPD-MAMeta-analytic strategiesEffect of treatment typePost-treatmentTherapist effectsCommunion dimensionIndividual participant data meta-analysisSymptom levelsStudy-level meta-analysesPrimary study analysisMeta-analysisTreatment typeDepressionFollow-upEffect sizeModerating effectBrain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths
Zugman A, Ringlein G, Finn E, Lewis K, Berman E, Silverman W, Lebowitz E, Pine D, Winkler A. Brain functional connectivity and anatomical features as predictors of cognitive behavioral therapy outcome for anxiety in youths. Psychological Medicine 2025, 55: e91. PMID: 40125734, PMCID: PMC12080668, DOI: 10.1017/s0033291724003131.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyConnectome predictive modelingWeeks of cognitive-behavioral therapyCognitive behavioural therapy outcomeResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingBehaviour therapy outcomePediatric anxiety disordersBaseline anxiety severityBrain functional connectivityAnxiety disordersAnxiety severityPediatric anxietyAnxiety diagnosesAnxiety symptomsFunctional connectivityTherapy outcomeAnxietyFirst-line treatmentTreatment responseTreatment outcomesMagnetic resonance imagingPredictive of responseFirst-lineClinical outcomesGambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome?
Mestre-Bach G, Potenza M, Granero R, Håkansson A, Gómez-Peña M, Perales I, Vicó À, Uríszar J, Fernández-Aranda F, Sánchez I, Jiménez-Murcia S. Gambling disorder and problematic pornography use: Does co-occurrence influence treatment outcome? Journal Of Behavioral Addictions 2025, 14: 465-479. PMID: 40116860, PMCID: PMC11974433, DOI: 10.1556/2006.2025.00023.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyGambling disorderPornography useEmotion regulationGD severityTreatment outcomesCognitive-behavioral therapy approachCognitive-behavioral therapy sessionsTreatment outcomes of individualsCo-occurrence of GDCo-occurrenceMental health concernsImprove treatment adherenceBehavioral addictionsTreatment dropoutOutcomes of individualsWeekly sessionsTreatment adherencePsychopathologyGamblingSessionsDisordersAssociated with higher likelihoodRelapseImpulseEffect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials
Jerene D, van Kalmthout K, Levy J, Alacapa J, Deyanova N, Dube T, Mganga A, Tasca B, Bogdanov A, Efo E, Gamazina K, Garfin A, Kochanov V, Leung A, Madden N, Maraba N, McQuaid C, Mleoh L, Onjare B, Powers R, Terleiva Y, van Rest J, Gebhard A, Fielding K, Charalambous S. Effect of digital adherence technologies on treatment outcomes in people with drug-susceptible tuberculosis: four pragmatic, cluster-randomised trials. The Lancet 2025, 405: 1155-1166. PMID: 40086457, DOI: 10.1016/s0140-6736(24)02847-2.Peer-Reviewed Original ResearchDrug-susceptible tuberculosisTreatment outcomesPoor treatment outcomesPrimary outcomeDigital adherence technologiesIntervention armCluster randomised trialIntention-to-treat populationStandard of care armTuberculosis treatment outcomesDocumented treatment failureLoss to follow-upStandard of careAdherence technologiesTreatment failureTreatment startAdult patientsFollow-upPatientsTreatment statusPatient outcomesCare armTuberculosisMedicationTrialsComparison of clinical symptoms and symptom structure across different onset ages in schizophrenia inpatients
Liu Z, Wang X, Chen W, Huang J, Tong J, Wang J, Liu R, Deng H, Yang K, Li W, Chen S, Xie T, Tian L, Yang F, Tian B, Li Y, Li C, Tan Y. Comparison of clinical symptoms and symptom structure across different onset ages in schizophrenia inpatients. Schizophrenia Research 2025, 277: 177-184. PMID: 40073617, DOI: 10.1016/j.schres.2025.03.015.Peer-Reviewed Original ResearchConceptsEarly-onset schizophreniaLate-onset schizophreniaPositive and Negative Syndrome ScaleAge of onset groupsSymptom network structureNegative symptomsSchizophrenia inpatientsSymptom networksSymptom severityNegative Syndrome ScaleSevere negative symptomsClinical symptom profilesOnset groupTreatment outcomesDevelopment of personalized treatment strategiesPoor treatment outcomesGeneral psychopathologyPositive symptomsSyndrome ScaleSymptom structureDisorganized thoughtsBridge symptomsSchizophrenia patientsSchizophreniaSymptom profilesBiomechanical analysis of clear aligners for mandibular anterior teeth intrusion and its clinical application in the design of new aligner attachment
Xiao S, Cheng C, Li H, Li L, Shen C, Feng Q, Zhao Y, Duan Y, Xia L, Chu F, Fang B. Biomechanical analysis of clear aligners for mandibular anterior teeth intrusion and its clinical application in the design of new aligner attachment. Progress In Orthodontics 2025, 26: 11. PMID: 40059251, PMCID: PMC11891119, DOI: 10.1186/s40510-025-00557-3.Peer-Reviewed Original ResearchConceptsIncisor mandibular plane angleMandibular anterior teethAnterior teethAligner attachmentsExcessive alveolar bone resorptionTreatment outcomesMandibular plane angleLower anterior teethAlveolar bone resorptionClinical treatment outcomesTooth intrusionLingual inclinationOrthodontic techniquesCBCT dataBone resorptionBone wallLabial movementPlane angleClinical practiceResultsSignificant differencesClinical applicationLingual movementTeethClinical issuesConclusionThis studyKleptomania on the impulsive–compulsive spectrum. Clinical and therapeutic considerations for women
Munguía L, Baenas-Soto I, Granero R, Fábregas-Balcells M, Gaspar-Pérez A, Rosinska M, Potenza M, Cuquerella Á, Tapia-Martínez J, Cabús-Grange R, Taranilla-Castro A, Macharé-Alberni M, Talón-Navarro M, Fernández-Aranda F, Jiménez-Murcia S. Kleptomania on the impulsive–compulsive spectrum. Clinical and therapeutic considerations for women. Scientific Reports 2025, 15: 7886. PMID: 40050325, PMCID: PMC11885670, DOI: 10.1038/s41598-025-85705-9.Peer-Reviewed Original ResearchConceptsImpulsive-compulsive spectrumDSM-5 criteriaClinical groupsDSM-5Personality featuresSemi-structured clinical interviewTreatment outcomesHarm avoidance scoresCognitive behavioral treatmentHealthy control individualsSample of female patientsImpact treatment outcomesPoor treatment outcomesCompulsive featuresBehavioral treatmentHigher impulsivityAvoidance scoresClinical interviewKleptomaniaInvestigate treatment outcomesCharacteristics of peopleFemale participantsPsychopathologyClinical samplesTreatment approachesPrescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial
Mobley A, Wegman M, Bazazi A, Shenoi S, Bromberg D, Ahmad A, Kamarulzaman A, Altice F. Prescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial. International Journal Of Drug Policy 2025, 137: 104733. PMID: 39923270, PMCID: PMC11875876, DOI: 10.1016/j.drugpo.2025.104733.Peer-Reviewed Original ResearchConceptsLinkage to HIV careHIV careIncrease linkage to HIV careTreatment-as-prevention strategiesHIV treatment cascadeHIV treatment outcomesOpen-label trialCox proportional hazards modelsPatient preference trialOpioid use disorderMalaysia’s largest prison.Impact of methadoneProportional hazards modelTreatment cascadeInverse probability weighted Cox proportional hazards modelAnalytic sampleStudy participantsCareTreatment outcomesPrescribed methadoneOpioidConfounding variablesHIVUse disorderHazards model
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