2025
Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors
Deiana G, He J, Cabrera-Mendoza B, Ciccocioppo R, Napolioni V, Polimanti R. Brain-wide pleiotropy investigation of alcohol drinking and tobacco smoking behaviors. Translational Psychiatry 2025, 15: 61. PMID: 39979292, PMCID: PMC11842717, DOI: 10.1038/s41398-025-03288-5.Peer-Reviewed Original ResearchConceptsImaging-derived phenotypesBrain imaging-derived phenotypesAlcohol drinkingBrain structuresProcessing of social cuesCorrelates of smoking behaviorRelationship of brain structureSequencing Consortium of AlcoholGlobal genetic correlationsSmoking behaviorSuperior longitudinal fasciculusAssociated with smoking initiationTobacco smokeTobacco smoking behaviorLatent causal variable approachesNicotine useBrain regionsPremotor cortexSocial cuesWhite matter hyperintensitiesLongitudinal fasciculusChemosensory processingCortical thicknessMendelian randomizationPleiotropic mechanisms
2012
Sex‐specific differences in GABAA‐benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving
Esterlis I, McKee SA, Kirk K, Lee D, Bois F, Stiklus SM, Seibyl JP, Krishnan‐Sarin S, O'Malley SS, Staley JK, Cosgrove KP. Sex‐specific differences in GABAA‐benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving. Addiction Biology 2012, 18: 370-378. PMID: 22353491, PMCID: PMC3378766, DOI: 10.1111/j.1369-1600.2011.00403.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffective SymptomsAnalysis of VarianceAnimalsBrainFemaleFlumazenilGABA ModulatorsHumansMaleMiddle AgedNicotinePain PerceptionReceptors, GABA-ASex CharacteristicsSmoking CessationSubstance Withdrawal SyndromeTobacco Use DisorderTomography, Emission-Computed, Single-PhotonYoung AdultConceptsMale smokersFemale smokersPain sensitivitySmoking interactionSmoking cravingBrain GABA levelsTobacco smoking behaviorSingle photon emissionPain symptomsLast cigaretteSmoking cessationGABA levelsSex-specific differencesTobacco smokeCigarette cravingNicotine dependenceBenzodiazepine receptorsSmokersSmoking behaviorReceptor availabilityBrain regionsCravingSex-specific regulationSignificant differencesSex differences
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