2025
Efficacy of Aficamten in Patients with Obstructive Hypertrophic Cardiomyopathy and Mild Symptoms: Results from the SEQUIOA-HCM Trial
Maron M, Gimeno J, Veselka J, Barriales-Villa R, Claggett B, Coats C, Hegde S, Januzzi J, Kulac I, Masri A, Nassif M, Spertus J, Jacoby D, Heitner S, Kupfer S, Malik F, Wohltman A, Olivotto I, Zhang Y, Yang H, Shao C, Yuan Z, Zeng Q, Li X, Ma C, Wang Y, Shu Y, Chen M, Tao L, Li X, Wang J, Yu Z, Cheng X, Hong K, Zemanek D, Bundgaard H, Thune J, Jensen M, Mogensen J, Sygehus A, Hagege A, Habib G, Charron P, Lhermusier T, Trochu J, Reant P, Logeart D, Mitrovic V, Bekfani T, Edelmann F, Seidler T, Meder B, Schulze P, Stoerk S, Rassaf T, Merkely B, Zfat-Zwas D, Arad M, Halabi M, Paz O, Piltz X, Olivotto I, Targetti M, Metra M, Canepa M, Musumeci B, Emdin M, Michels M, Amin A, Knackstedt C, Oreziak A, Wojakowski W, Dudek D, Toste A, Bastos J, Barriales-Villa R, Pavia P, Blanes J, Urbano R, Alvarez A, Diaz L, Vera T, Elliott P, Coats C, Cooper R, Mahmod M, Bradlow W, Pantazis A, Esteban M, Masri A, Nassif M, Marian A, Owens D, Wheeler M, McGrew F, Bach R, Wever-Pinzon O, Collado E, Lauderdale F, Turer A, Hannawi B, Geske J, Owens A, Symanski J, Healthcare A, Kramer C, Sarswat N, Ahmad F, Abraham T, Markowitz J, Lakdawala N, Choudhury L, Jani S, Brinkley M, Bilen O, Asher C, Emani S, Sharma A, Fermin D, Lyle M, Raymer D, Darlington A, Maron M, Nielsen C, Wang A, Nagueh S, Martinez M, Desai M, Tower-Rader A, Kelly J, Rader F, Sen S, Bering P, Maurer M, Mitter S, Sherrid M, Wong T, Hussain Z, Saberi S, Naidu S, Enciso J. Efficacy of Aficamten in Patients with Obstructive Hypertrophic Cardiomyopathy and Mild Symptoms: Results from the SEQUIOA-HCM Trial. European Heart Journal 2025, ehaf364. DOI: 10.1093/eurheartj/ehaf364.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathyNew York Heart AssociationNew York Heart Association classKCCQ-CSSSecondary endpointsHypertrophic cardiomyopathyKansas City Cardiomyopathy Questionnaire Clinical Summary ScoreTreatment-emergent serious adverse eventsN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideMild symptomsOutflow tract gradientBaseline to weekModerate to severe symptomsClinical summary scoreSerious adverse eventsSymptom groupsClinically relevant outcomesPeak oxygen uptakePrimary endpointSymptomatic patientsNT-proBNPStatistically significant improvementNatriuretic peptideAficamtenAn interpretable deep-learning approach to detect biomarkers in anxious-depressed symptoms from prefrontal fNIRS signals during an autobiographical memory test
Zhang Y, Xu Y, Cheng Y, Zhao Y, Potenza M, Shi H. An interpretable deep-learning approach to detect biomarkers in anxious-depressed symptoms from prefrontal fNIRS signals during an autobiographical memory test. Asian Journal Of Psychiatry 2025, 107: 104451. PMID: 40158273, DOI: 10.1016/j.ajp.2025.104451.Peer-Reviewed Original ResearchAutobiographical Memory TestNon-anxious depressionFunctional near-infrared spectroscopyAnxious depressionMemory testDepressive symptomsAnxious-depressive symptomsNegative emotional valenceSevere mood disordersFrontal pole areasAD symptomsMood disordersEmotional valenceRight hemisphereNeuroimaging dataDiagnosed depressionSymptom groupsCognitive impairmentSymptom predictionHealthy controlsNear-infrared spectroscopyDepressionSymptomsRecall featuresArea under the receiver operating characteristic curve
2024
Post-COVID-19 condition: systemic inflammation and low functional exercise capacity
de Castro G, Gama L, Ramos A, da Silva G, de Souza Teixeira A, Cunha-Neto E, de Souza H, Marie S, Talib L, Coelho V, Kalil J, de Araujo A, Ritto A, Belon A, Santos A, Barrére A, Sawamura M, Lamas C, Baldi B, Carvalho C, Kulikowski L, Damiano R, Imamura M, Neto J, Lira F, Otoch J, Miguel E, Battistella L, Forlenza O, Busatto G, Seelaender M. Post-COVID-19 condition: systemic inflammation and low functional exercise capacity. Frontiers In Nutrition 2024, 11: 1295026. PMID: 38549752, PMCID: PMC10973152, DOI: 10.3389/fnut.2024.1295026.Peer-Reviewed Original ResearchPost-COVID-19 conditionTimed Up and Go testUp-and-go testPhysical performance testsAcute COVID-19Low handgrip strengthFollow-up assessment 6Cross-sectional studySelf-reported symptomsFollow-up assessmentQuality of lifeDiagnosing pulmonary lesionsHandgrip strengthSerum cytokine profilesSerum cytokine levelsImpact of inflammationControl groupMCP-1 levelsIL-4 concentrationMale participantsHospital dischargeSymptom questionnaireSymptom groupsFemale participantsDebilitating symptoms
2023
Characteristics and Correlates of Ten-Year Trajectories of Posttraumatic Stress Symptoms in Older U.S. Military Veterans
Moye J, Kaiser A, Cook J, Fischer I, Levy B, Pietrzak R. Characteristics and Correlates of Ten-Year Trajectories of Posttraumatic Stress Symptoms in Older U.S. Military Veterans. American Journal Of Geriatric Psychiatry 2023, 31: 889-901. PMID: 37355455, PMCID: PMC10592467, DOI: 10.1016/j.jagp.2023.05.011.Peer-Reviewed Original ResearchPTSD symptomsU.S. military veteransLow symptom groupCognitive difficultiesTrauma exposureTraumatic eventsHigher symptomsPosttraumatic stress disorder (PTSD) symptomsMore lifetime traumatic eventsSymptom groupsMilitary veteransPosttraumatic stress symptomsSelf-report measuresLower PTSD symptomsLifetime traumatic eventsPTSD symptom trajectoriesUse disordersOlder U.S. veteransLatent growth mixture modelingHigh symptom groupU.S. veteransGrowth mixture modelingEmotional agingSubstance use disordersDisorder symptomsLong COVID Clinical Phenotypes up to 6 Months After Infection Identified by Latent Class Analysis of Self-Reported Symptoms
Gottlieb M, Spatz E, Yu H, Wisk L, Elmore J, Gentile N, Hill M, Huebinger R, Idris A, Kean E, Koo K, Li S, McDonald S, Montoy J, Nichol G, O’Laughlin K, Plumb I, Rising K, Santangelo M, Saydah S, Wang R, Venkatesh A, Stephens K, Weinstein R, Weinstein R, Gottlieb M, Santangelo M, Koo K, Derden A, Gottlieb M, Gatling K, Guzman D, Yang G, Kaadan M, Hassaballa M, Jerger R, Ahmed Z, Choi M, Venkatesh A, Spatz E, Lin Z, Li S, Yu H, Liu M, Venkatesh A, Spatz E, Ulrich A, Kinsman J, Dorney J, Pierce S, Puente X, Nichol G, Stephens K, Anderson J, Morse D, Adams K, Maat Z, Stober T, O’Laughlin K, Gentile N, Geyer R, Willis M, Ruiz L, Malone K, Park J, Rising K, Kean E, Kelly M, Schaeffer K, Hannikainen P, Shughart L, Shughart H, Renzi N, Amadio G, Grau D, Watts P, Cheng D, Miao J, Shutty C, Charlton A, Hill M, Chavez S, Kane A, Nikonowicz P, Idris A, McDonald S, Gallegos D, Martin R, Elmore J, Wisk L, L’Hommedieu M, Chandler C, Eguchi M, Roldan K, Villegas N, Moreno R, Rodrigue R, Wang R, Montoy J, Kemball R, Chan V, Chavez C, Wong A, Arreguin M. Long COVID Clinical Phenotypes up to 6 Months After Infection Identified by Latent Class Analysis of Self-Reported Symptoms. Open Forum Infectious Diseases 2023, 10: ofad277. PMID: 37426952, PMCID: PMC10327879, DOI: 10.1093/ofid/ofad277.Peer-Reviewed Original Research
2022
Post-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observational study
Frontera JA, Thorpe LE, Simon NM, de Havenon A, Yaghi S, Sabadia SB, Yang D, Lewis A, Melmed K, Balcer LJ, Wisniewski T, Galetta SL. Post-acute sequelae of COVID-19 symptom phenotypes and therapeutic strategies: A prospective, observational study. PLOS ONE 2022, 17: e0275274. PMID: 36174032, PMCID: PMC9521913, DOI: 10.1371/journal.pone.0275274.Peer-Reviewed Original ResearchConceptsPost-acute sequelaeDifferent therapeutic interventionsTherapeutic interventionsTherapeutic strategiesAcute SARS-CoV-2 infectionOccupational therapySARS-CoV-2 infectionOutcome metricsSimilar therapeutic interventionsProspective cohort studyShortness of breathAnti-anxiety medicationsLogistic regression analysisCOVID-19Individual treatment programsPASC symptomsCohort studySymptom improvementUnsupervised hierarchical cluster analysisTreatment strategiesObservational studySleep disordersVariable symptomatologySymptom groupsCognitive symptomsStressful life events and trajectories of depression symptoms in a U.S. military cohort
Sampson L, Cabral H, Rosellini A, Gradus J, Cohen G, Fink D, King A, Liberzon I, Galea S. Stressful life events and trajectories of depression symptoms in a U.S. military cohort. Scientific Reports 2022, 12: 11026. PMID: 35773360, PMCID: PMC9246834, DOI: 10.1038/s41598-022-14496-0.Peer-Reviewed Original ResearchConceptsStressful life eventsDepressive symptomsSymptom groupsChildhood adversityLife eventsTrajectories of depressive symptomsLatent class growth analysisMilitary cohortChronic depressionAdult depressionDepression modelMilitary sampleAdult stressorsMental disordersSymptom-free groupSymptom patternsStressful experiencesDepressionMental healthLife experiencesYears of follow-upDifferent trajectoriesSymptomsAdversityChildhood
2019
0636 Activity-Rest Patterns and Symptoms in Inflammatory Bowel Disease
Conley S, Jeon S, Lehner V, Proctor D, Redeker N. 0636 Activity-Rest Patterns and Symptoms in Inflammatory Bowel Disease. Sleep 2019, 42: a253-a253. DOI: 10.1093/sleep/zsz067.634.Peer-Reviewed Original ResearchInflammatory bowel diseaseSymptom groupsLow symptom groupActivity-rest patternBedtime melatoninBowel diseaseCo-occurring painSymptoms of fatigueVisual analog scaleBright light therapyLower interdaily stabilityActive diseaseSymptom burdenPROMIS scalesCrohn's diseaseAnalog scaleSleep disturbancesUnpredictable courseActivity-rest rhythmsChronic diseasesAdults 18RemissionLight therapyWrist actigraphySalivary melatonin
2018
Longitudinal Changes in Symptom Cluster Membership in Inflammatory Bowel Disease
Conley S, Jeon S, Proctor DD, Sandler RS, Redeker NS. Longitudinal Changes in Symptom Cluster Membership in Inflammatory Bowel Disease. Journal Of Nursing Scholarship 2018, 50: 473-481. PMID: 29971936, PMCID: PMC6120775, DOI: 10.1111/jnu.12409.Peer-Reviewed Original ResearchConceptsSymptom cluster membershipInflammatory bowel diseaseSymptom burdenBowel diseaseLower symptom burdenPsychological symptoms groupSymptom management optionsHigh symptom burdenRetrospective longitudinal studyLatent transition analysisActive diseaseClinical factorsPain interferenceColitis FoundationSleep disturbancesCluster membershipHigh burdenMultiple symptomsSymptom groupsPhysical symptomsPsychological symptomsLow burdenSymptom clustersLongitudinal changesSymptoms
2015
Mental Health Over Time in a Military Sample: The Impact of Alcohol Use Disorder on Trajectories of Psychopathology After Deployment
Sampson L, Cohen G, Calabrese J, Fink D, Tamburrino M, Liberzon I, Chan P, Galea S. Mental Health Over Time in a Military Sample: The Impact of Alcohol Use Disorder on Trajectories of Psychopathology After Deployment. Journal Of Traumatic Stress 2015, 28: 547-555. PMID: 26625353, PMCID: PMC4681498, DOI: 10.1002/jts.22055.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTrajectories of psychopathologyPosttraumatic stress symptomsPosttraumatic stressUse disorderNational Guard membersDepressive symptomsEffect of alcohol use disorderGuard membersLifetime traumatic eventsTrajectories of depressionImpact of alcohol use disordersLatent groupsPatient Health QuestionnaireAssociated with membershipPTSD ChecklistLifetime stressorsMilitary samplePTS symptomsTraumatic eventsSymptom outcomesSymptom groupsDepressionMental healthHealth Questionnaire
2011
Social Cognitive Impairments and Negative Symptoms in Schizophrenia: Are There Subtypes With Distinct Functional Correlates?
Bell MD, Corbera S, Johannesen JK, Fiszdon JM, Wexler BE. Social Cognitive Impairments and Negative Symptoms in Schizophrenia: Are There Subtypes With Distinct Functional Correlates? Schizophrenia Bulletin 2011, 39: 186-196. PMID: 21976710, PMCID: PMC3523908, DOI: 10.1093/schbul/sbr125.Peer-Reviewed Original ResearchConceptsHigher social cognitionLower social cognitionSocial cognitive impairmentsHigh-negative symptom groupSocial cognitionNegative-symptom groupNegative symptomsCaruso Emotional Intelligence TestSocial cognitive measuresEmotional Intelligence TestSocial cognitive factorsCognitive impairmentSymptom groupsNegative symptom factorMayer-SaloveyCommon assessment instrumentsCognitive factorsCognitive measuresSubstance abuse historyIntelligence testsCore featuresAbuse historyIndependent dimensionsDistinct factorsSymptom factors
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply